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New prognostic model for patients with advanced gastric cancer:Fluoropyrimidine/platinum doublet for first-line chemotherapy

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World Journal of Gastroenterology 2021年第48期27卷 8357-8369页

作者： Dong-Hoe Koo Min-hee Ryu Mi-Yeon Lee Mee-sun Moon Yoon-Koo Kang Division of Hematology/Oncology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Biostatistics Department of R&D ManagementKangbuk Samsung HospitalSeoul 03181South Korea

BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic *** To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were *** A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk *** the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with *** new model is simpler than the old and more easily predicts OS.

关键词： Stomach neoplasms Chemotherapy Prognosis Validation Gastric cancer

SPECIFIC IDENTIFICATION OF HERPES SIMPLEX VIRUS IN HUMAN ESOPHAGUS WITH RAPID IN SITU HYBRIDIZATION IN 5 CASES

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Chinese Medical Sciences Journal 2008年第2期23卷 126-128页

作者： Ying-lan Gao sung-sun Kim Chang-woo Han Yoo-duk Choi jong-hee Nam Sang-woo Juhng Jun-shuo Jin Ling-fei Kong Chang-soo Park Department of Pathology Henan Provincial People＇s Hospital Zhengzhou 450003 Department of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Department of Surgery Inha University Medical School Incheon 400-712 South Korea

HUMAN herpes simplex virus esophagitis （HSVE） was first reported in 1940 by Johnson. ^1HSVE usually occurs in immunocompromised patients,such as those with acquired immunodeficiency syndrome （AIDS）, 2-4 malignancies, cutaneous burns, connective tissue diseases, inflammatory bowel disease, those taking immuno-suppressive therapy, and those undergoing organ transplantation,5 etc. In the immunocompetent individuals, HSVE is rare, having been reported in 39 cases and mainly affecting young males^6,7 The aim of this study was to delineate the clinical experience in the diagnosis of HSVE using rapid in situ hybridization and assess the various detection methods.

关键词： herpes simplex virus esophagus oligonucleotide DNA probe in situ hybridization

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin Kim Yong-hee Kim Myeong-Geun Oh Ki-Jung Kim Sang-Eun Jung Ju-hee Jin sun-Uk Kim Kwan-Sik Min Buom-Yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

Animal plant warfare and secondary metabolite evolution

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Natural Products and Bioprospecting 2013年第1期3卷 1-7页

作者： Steffen WÖLL sun hee KIM Henry Johannes GRETEN Thomas EFFERTH Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg-UniversityMainzGermany Institute of Biomedical Sciences(ICBAS) University of PortoPortugal

The enduring discussion,why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of *** recent years,the concept of an animal plant warfare emerged,which focused on the co-evolution between plants and *** a reaction to herbivory,plants developed mechanical defenses such as thorns and hard shells,which paved the way for adapted animal *** evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest *** a result of this selective pressure,animals developed special enzymes,*** P450 monooxigenases(CYP450)that metabolize xenobiotic *** a next step in the evolutionary competition between plants and animals,plants evolved to produce non-toxic pro-drugs,which become toxic only after ingestion by animals through metabolization by enzymes such as *** these sequestered evolutionary developments call to mind an arms race,the term animal plant warfare has been *** evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays.

关键词： natural products phytochemicals liver metabolism cytochrome P450 monooxigenase ABC-transporter herbivore

Visible light induced catalytic properties of CdSe-graphene nanocomposites and study of its bactericidal effect

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Chinese Chemical Letters 2014年第6期25卷 941-946页

作者： Kefayat Ullah Young-hee Kim Byung-Eui Lee sun-Bok Jo Lei Zhu Shu Ye Won-Chun Oh Department of Advanced Materials Science﹠Engineering Hanseo University Department of Immunology College of MedicineSoonchunhyang UniversityCheonan 330-721Republic of Korea Department of Chemistry Soonchunhyang UniversityAsanChungnam 336-745Republic of Korea

A novel composite, CdSe-graphene, was synthesized using facile hydrothermal method. The structural characteristics studies of the synthesized composites were investigated by X-ray diffraction （XRD）, scanning electron microscope （SEM）, transmission electron microscope （TEM）, Brunauer, Emmett, Teller specific surface area （BET） and X-ray photoelectron spectroscopy （XPS）. The photocatalytic activity was investigated by the degradation of methylene blue as standard dye. The degradation of M8 was calculated based on the decrease in concentration of the dye with respect to regular time intervals. The reusability tests were done to investigate the stability of the used catalysts. Additionally the antibacterial activity of CdSe-graphene was also investigated using bacterium Streptococcus aureus （S. aureus）.

关键词： Semiconductors Hydrothermal method Antimicrobial Photocatalysis

Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

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Neural Regeneration Research 2013年第12期8卷 1061-1070页

作者： Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin jong-Il Park Kyu-Sik Jo Bo-hee Lee Soo-Wan Chae sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung Department of Psychiatry Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea Muju Chunma Native Local Industrial Center Muju 568-844 Republic of Korea Clinical Trial Center for Functional Foods Chonbuk National University HospitalJeonju 561-756 Republic of Korea Department of Pharmacology Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea

Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer＇s disease, we established a rat model of AIzheimer＇s disease by injecting A325-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer＇s disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while EIIman method showed significant decrease in the activity of acetylcholinesterase in all three regions （prefrontal cortex, medial septum and hippocampus）. These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer＇s disease.

关键词： neural regeneration neuroprotective effect Traditional Chinese medicine Gastrodia elata Blume Alzheimer's disease Morris water maze test choline acetyltransferase acetylcholinesterase grants-supported paper neuroregeneration

Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

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World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： Joon Mee Kim Mee-Yon Cho Jin hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim hee Kyung Chang Eunsil Yu Eun sun Jung Mee Soo Chang jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang sun Hoo Park Hye Seung Han Young Bae Kim Ho sung Park Yang Seok Chae Kye Won Kwon hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词： Intraepithelial neoplasia Stomach Dysplasia Adenoma Carcinoma Japanese Western Consensus Vienna

Cardiac metastasis from colorectal cancer:A case report

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World Journal of Gastroenterology 2009年第21期15卷 2675-2678页

作者： Pyong Wha Choi Chul Nam Kim sun hee Chang Woo Ik Chang Chang Young Kim Hyun Min Choi Department of Surgery Ilsan Paik HospitalInje University College of Medicine Department of Diagnostic Pathology Ilsan Paik HospitalInje University College of Medicine Department of Chest Surgery Ilsan Paik HospitalInje University College of Medicine Department of Internal Medicine Ilsan Paik HospitalInje University College of Medicine

The heart is an unusual site of metastasis from any malignancy. We report a case of cardiac metastasis from colorectal cancer. A 70-year-old woman was referred with a presumptive diagnosis of sigmoid colon cancer with cardiac myxoma. Two-dimensional echocardiography showed a 4 cm x 4.5 cm mobile mass on the lateral right atrial wall, and computed tomography revealed a low attenuated Iobulating mass in the right atrium. The patient underwent anterior resection for sigmoid colon cancer （T4N2）. Thereafter, she experienced progressive shortness of breath. Therefore, a cardiac operation was performed 2 wk after the colorectal operation. Histological examination revealed adenocarcinoma, which was identical to the primary lesion. Although two- dimensional echocardiography has become the diagnostic test of choice for detecting cardiac tumors, in patients with colorectal cancer showing a cardiac mass, further diagnostic evaluation such as a magnetic resonance imaging might be necessary.

关键词： Heart Cardiac metastasis Colorectalcancer Atrial myxoma Magnetic resonance imaging

ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions

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动物学研究(英文) 2023年第5期44卷 848-859页

作者： Ming-Hong sun Wen-Jie Jiang Xiao-Han Li Song-hee Lee Geun Heo Dongjie Zhou Zhi Chen Xiang-Shun Cui Department of Animal Science Chungbuk National UniversityCheongjuSouth Korea 28644Korea College of Animal Science and Technology Yangzhou UniversityYangzhouJiangsu 225009China

Activating transcription factor 6(ATF6),one of the three sensor proteins in the endoplasmic reticulum(ER),is an important regulator of ER stress-induced ***6 resides in the ER and,upon activation,is translocated to the Golgi apparatus,where it is cleaved by site-1 protease(S1P)to generate an amino-terminal cytoplasmic *** recent studies have made progress in elucidating the regulatory mechanisms of ATF6,its function during early porcine embryonic development under high-temperature(HT)stress remains *** this study,zygotes were divided into four groups:control,HT,HT+ATF6 knockdown,and HT+PF(S1P inhibitor).Results showed that HT exposure induced ER stress,which increased ATF6 protein expression and led to a decrease in the blastocyst ***,ATF6 expression was knocked down in HT embryos under microinjection of ATF6 double-stranded RNA(dsRNA).Results revealed that ATF6 knockdown(ATF6-KD)attenuated the increased expression of CHOP,an ER stress marker,and Ca2+release induced by *** addition,ATF6-KD alleviated homeostasis dysregulation among organelles caused by HT-induced ER stress,and further reduced Golgi apparatus and mitochondrial dysfunction in HT ***2 is an important downstream effector of *** showed that ATF6-KD reduced the occurrence of AIFM2-mediated embryonic apoptosis at *** together,our findings suggest that ATF6 is a crucial mediator of apoptosis during early porcine embryonic development,resulting from HT-induced ER stress and disruption of organelle homeostasis.

关键词： ATF6 Embryo High temperature ER stress Organelle homeostasis