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Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein improves diagnostic accuracy for hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第28期27卷 4687-4696页

作者： han Ah Lee Yoo Ra Lee Young-Sun Lee Young Kul Jung Ji Hoon Kim Hyunggin An Hyung Joon Yim Yoon Tae Jeen jong Eun Yeon Kwan Soo Byun Yeon Seok Seo Department of Internal Medicine Korea University College of MedicineSeoul 02841South Korea Department of Biostatistics Korea University Anam HospitalSeoul 02841South Korea

BACKGROUND Diagnostic accuracy of various tumor markers and their combinations for hepatocellular carcinoma(HCC)was not fully *** To evaluate the diagnostic accuracy of alpha-fetoprotein(AFP),the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and protein induced by vitamin K absence or antagonist-II(PIVKA-II)and their combination for HCC *** Patients with newly detected liver mass or elevated serum AFP levels were considered *** AFP level,AFP-L3 fraction,and PIVKA-II level were measured at the first *** In total,622 patients were included;355 patients(57.1%)had chronic liver disease,and 208(33.4%)had liver *** was diagnosed in 160 patients(25.7%).The area under the receiver operating characteristics curves(AUROCs)of the serum AFP,AFP-L3 fraction,AFP-L3,and PIVKA-II levels for the diagnosis of HCC were 0.775,0.792,0.814,and 0.834,respectively.A novel diagnostic model was developed by classifying patients in a 1:1 ratio into training and validation *** the binary regression analysis of the training cohort,the AFP,AFP-L3 fraction,and PIVKA-II(ALPs)score was calculated as follows:ALPs score=3.8×[serum AFP level(ng/mL)×AFP-L3 fraction(%)×0.01]+0.2×PIVKA-II level(mAU/mL).The AUROC of the ALPs score for diagnosis of HCC was 0.878,significantly higher than that of serum AFP level(P<0.001),AFP-L3 fraction(P<0.001),PIVKA-II level(P=0.036),and AFP-L3 level(P=0.006).The optimal ALPs score cut-off was 5.3(sensitivity,85.0%,specificity 80.1%).The validation cohort showed similar *** The ALPs score calculated using serum AFP level,AFP-L3 fraction,and PIVKA-II level showed improved accuracy in HCC diagnosis.

关键词： Alpha-fetoprotein Lens culinaris agglutinin-reactive fraction of alphafetoprotein Protein induced by vitamin K absence or antagonist-II Hepatocellular carcinoma

Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome

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World Journal of Gastroenterology 2007年第22期13卷 3141-3143页

作者： Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park jong Eun Joo Department of Internal Medicine Eulji University Hospital Seoul Korea Department of Radiology Eulji University Hospital Seoul Korea Department of Pathology Eulji University Hospital Seoul Korea

Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle.

关键词： Intrahepatic Cholangiocarcinoma Metastasis Skeletal muscle Budd-Chiari syndrome

Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B

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World Journal of Gastroenterology 2008年第11期14卷 1781-1784页

作者： Soon Woo Nam Si Hyun Bae Seung Woo Lee Yeon Soo Kim Sang Bum Kang jong Young Choi Se Hyun Cho Seung Kew Yoon Joon-Yeol han Jin Mo Yang Young Suk Lee Division of Gastroenterology and Hepatology Department ofInternal medicineMedical College of the Catholic University ofKoreaDaejeon St.Mary's Hospital#62 Daeheung-dongChung-guDaejeonRepublic of Korea

AIM： To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and naive chronic hepatitis B, we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS： Eighty patients who had received lamivudine treatment for various periods and had a lamivudineo resistant liver function abnormality were enrolled. Forty of these patients received adefovir treatment combined with lamivudine treatment for ≥ 2 mo, while the other 40 received adefovir alone. We assessed the levels of hepatitis B virus （HBV） DNA at 0, 12 and 48 wk and serum alanine aminotransferase （ALT） levels after 0, 12, 24 and 48 wk of adefovir treatment in each group. RESULTS： We found serum ALT became normalized in 72 （87.5%） of the 80 patients, and HBV DNA decreased by ≥ 2 Ioglo copies/mL in 60 （75%） of the 80 patients at the end of a 48-wk treatment. HBV DNA levels were not significantly different between the groups. The improvements in serum ALT were also not significantly different between the two groups. CONCLUSION： These findings suggest short-term overlap lamivudine treatment results in no better virological and biological outcomes than non-overlap adefovir monotherapy.

关键词： Adefovir dipivoxil Chronic hepatitis B Hepatitis B virus DNA Overlap

Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy

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World Journal of Pediatrics 2023年第3期19卷 283-287页

作者： Jee Woo Kim Jee Yeon Baek Ji Young Lee Sung Min Lim Ji-Man Kang Won Kee Ahn Seung Min Hahn Jung Woo han Chuh Joo Lyu jong Gyun Ahn Department of Pediatrics Severance Children's HospitalYonsei University College of Medicine50-1 Yonsei-RoSeodaemun-guSeoul 03722South Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Pediatric Hematology and Oncology Department of PediatricsYonsei University College of MedicineYonsei University Health SystemSeoulSouth Korea Department of Pediatric Hemato-Oncology Yonsei Cancer CenterYonsei University Health SystemSeoulSouth Korea

Cervical lymphadenopathy in children is a common disease entity that is accompanied by a variety of processes,ranging from benign disease to *** the cause of cer-vical lymphadenopathy in children is often benign[1-4],the presence of enlarged lymph nodes can cause anxiety to parents because of its association with *** should be considered for the histologic diagnosis of persistent or unex-plained cervical lymphadenopathy in ***,biopsy is an invasive examination method,and it is difficult to clinically determine whether biopsy is needed in children with unexplained cervical ***,clini-cians should be aware of the differential diagnosis of lymph node enlargement in children and should identify situations in which malignancy may be *** this study,we aimed to identify the etiology of pediatric cervical lymphadenopathy using biopsy and to analyze the risk factors associated with malignancy in children with cervical lymphadenopathy.

关键词： malignancy cervical diagnosis

Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells

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Science Bulletin 2018年第8期63卷 477-487页

作者： Jung Hyun Im Seon In Hwang jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon Hyuk-Jin Cha Hyung-Min Chung hans R. Scholer Jung Keun Hyun DongWook han Department of Stem Cell Biology School of Medicine Konkuk University Seoul 05029 Republic of Korea Department of Nanobiomedical Science Dankook University Graduate School Cheonan 330714 Republic of Korea Department of Biochemistry School of Medicine Konkuk University Seoul 05029 Republic of Korea Department of Cell and Developmental Biology Max Planck Institute for Molecular Biomedicine 48149 Munster Germany Department of Life Sciences College of Natural Sciences Sogang University Seoul 04107 Republic of Korea KU Open-lnnovation Center. Institute of Biomedical Science & Technology Konkuk University Seoul 05029 Republic of Korea Department of Advanced Translational Medicine School of Medicine Konkuk University Seoul 05029 Republic of Korea

Embryonic stem cells （ESCs） maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers-namely super-enhancers （SEs）, on which BRD4, a member of the bromodomain and extraterminal domain （BET） family is highly enriched-could regulate pluripotency-related transcrip- tion factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stern cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treat- ment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQI could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy.

关键词： Bromodomain and extraterminal domain (BET) JQ1 Pluripotent stem cells

Development of Human Papillomavirus Detection and Genotyping system based on automated DPO-based 18-plex PCR without any cross-reactivity.

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Development of Human Papillomavirus Detection and Genotyping...

COMPARISON OF MEASURING METHODS OF ADAPTATION LUMINANCE AT THRESHOLD ZONE OF THE KOREAN TUNNEL ROAD

24th International Papillomavirus Conference and Clinical Workshop

作者： Jeong-Hyun han HyeonJi Lee jong-Kee Kim Seegene Institute of Life Sciences 65-5 Bangyi-DongSongpa-GuSeoul138-050Korea Seegene Institute of Life Sciences 65-5 Bangyi-DongSongpa-GuSeoul138-050Korea Seegene Institute of Life Sciences 65-5 Bangyi-DongSongpa-GuSeoul138-050Korea

＜正＞Currently,commercially available major products to diagnose human papillomavirus（HPV）are based on probe-hybridization method to detect and/or genotype ***,main defect of these Methods is high false positive rate due to cross- reactivity between probes and various kinds of viral DNA or PCR amplicons used for hybridization To overcome this limitation,

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COMPARISON OF MEASURING METHODS OF ADAPTATION LUMINANCE AT T...

Functional magnetic resonance imaging of cerebellar activation and lateralization during verbal and visuospatial tasks

4th Lighting Conference of China,Japan and Korea

作者： jong-Sung han Min-Wook Lee Hoon Kim Dept.of Electrical and Electronic Engineering Kangwon National University

In order to calculate the accurate luminance value of the threshold zone,the adaptation luminance of the access zone must be measured in *** methods to calculate and measure the threshold luminance are categorized two methods:the veiling luminance method and the L20 *** two methods were used simultaneously to measure the adaptation luminance of the tunnel access zone,the source from which to calculate the lighting level of the threshold zone,and to verify the accuracy of the method to calculate the threshold *** the basis of the measured data each threshold luminance was calculated and its results were analyzed.

关键词： threshold luminance adaptation luminance veiling luminance method L20 method

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Neural Regeneration Research 2010年第3期5卷 226-231页

作者： Mi-Hyun Choi Su-Jeong Lee Jae-Woong Yang Jin-Seung Choi Hyung-Sik Kim Jeong-han Yi Gye-Rae Tack Soon-Cheol Chung Byung-Chan Min Se-Jin Park jong-Rak Park Jae-Hoon Jun Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Biomedical & Health Science Konkuk University Department of Industrial & Management Engineering Hanbat National University Division of Technology Services National Center for Standard Reference Data Korea Research Institute of Standards and Science Department of Photonic Engineering Chosun University

BACKGROUND： Previous studies have analyzed cerebral activation and lateralization of cognitive functions, as well as cerebellar function with reference to high-level cognitive processing. However, there has been very little research on systematization and diversification. In particular, there are no reports on cerebellar lateralization, although reliable results have been reported on cerebral lateralization. OBJECTIVE： This study analyzed cerebellar activation and lateralization in relation to verbal and visuospatial tasks using functional magnetic resonance imaging （fMRI）. DESIGN, TIME AND SETTING： A block design for fMRI observation was performed at the fMRI Laboratory, Brain Science Research Center, Korea Advanced Institute of Science and Technology from May 2006 to September 2008. PARTICIPANTS： Sixteen healthy, male, college students, aged （23.3 ± 0.5） years, and 16 healthy, male, college students, aged （21.5 ± 2.3） years, participated in the study, respectively. METHODS： Verbal and visuospatial tasks were presented while functional brain images were acquired using a 3T fMRI system. Verbal analogy testing required the subject to select the word with the same relationship as one of the given words. Verbal antonym testing required the subject to select the word with a different meaning among four words. Visuospatial tasks involved selecting a shape that corresponded to a given figure with four examples, as well as selecting a development figure of a diagram. MAIN OUTCOME MEASURES： Changes in cerebellar activation and lateralization between two cognition tasks. RESULTS： Bilateral hemisphere Iobules VI and IX, right hemisphere Iobule VIII, bilateral hemisphere Iobules Crus I, and vermis Iobule IV, V, and Vl were closely related to verbal tasks in comparison to visuospatial tasks. Conversely, bilateral hemisphere Iobules IV and V, as well as the right hemisphere Iobule VI, were closely related to visuospatial tasks compared to verbal tasks. There was no great differe

关键词： cerebellum lateralization functional magnetic resonance imaging verbal and visuospatial tasks neuroimaging neural regeneration

SPECIFIC IDENTIFICATION OF HERPES SIMPLEX VIRUS IN HUMAN ESOPHAGUS WITH RAPID IN SITU HYBRIDIZATION IN 5 CASES

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Chinese Medical Sciences Journal 2008年第2期23卷 126-128页

作者： Ying-lan Gao Sung-sun Kim Chang-woo han Yoo-duk Choi jong-hee Nam Sang-woo Juhng Jun-shuo Jin Ling-fei Kong Chang-soo Park Department of Pathology Henan Provincial People＇s Hospital Zhengzhou 450003 Department of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Department of Surgery Inha University Medical School Incheon 400-712 South Korea

HUMAN herpes simplex virus esophagitis （HSVE） was first reported in 1940 by Johnson. ^1HSVE usually occurs in immunocompromised patients,such as those with acquired immunodeficiency syndrome （AIDS）, 2-4 malignancies, cutaneous burns, connective tissue diseases, inflammatory bowel disease, those taking immuno-suppressive therapy, and those undergoing organ transplantation,5 etc. In the immunocompetent individuals, HSVE is rare, having been reported in 39 cases and mainly affecting young males^6,7 The aim of this study was to delineate the clinical experience in the diagnosis of HSVE using rapid in situ hybridization and assess the various detection methods.

关键词： herpes simplex virus esophagus oligonucleotide DNA probe in situ hybridization