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Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

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World Journal of Gastroenterology 2007年第30期13卷 4072-4079页

作者： Yeon Seok Seo Ji Hoon Kim jong Eun Yeon jong-Jae Park Jae Seon Kim Kwan Soo Byun Young-Tae Bak Chang hong Lee Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University College of Medicine Seoul Korea Division of Gastroenterology and Hepatology Department of Internal Medicine Konkuk University College of Medicine Seoul Korea

AIM： To compare the antiviral efficacy of adefovir （ADV） in lamivudine （LMV）-resistant patients with LMV treatment in nucleoside-naive patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS： Forty-four patients with chronic hepatitis B （CHB） were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following： reduction in serum HBV DNA from baseline, HBV DNA negative conversion （defined as HBV DNA being undectable by the hybridization assay）, and HBV DNA response （either HBV DNA level ≤ 10^s copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level）.RESULTS： After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment （P = 0.021）. HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively （P = 0.001）. Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively （P = 0.026）. The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION： The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naive patients during the early course of treatment.

关键词： Chronic hepatitis B Lamivudine Adefovir Treatment efficacy

On-screen fingerprint sensor with optically and electrically tailored transparent electrode patterns for use on high-resolution mobile displays

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Microsystems & Nanoengineering 2020年第1期6卷 243-254页

作者： Hyun-Joon Kim-Lee Seog Woo hong Dong Kyun Kim Jinmyoung Kim hong suk Kim Seok-Whan Chung Eun-Hyoung Cho Hae-Sung Kim Byung-Kyu Lee Device Research Center Samsung Advanced Institute of Technology130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803Republic of Korea

In this study,a mutual capacitive-type on-screen fingerprint sensor,which can recognize fingerprints on a display screen to provide smartphones with full-screen displays with a minimal bezel area,is ***-screen fingerprint sensors are fabricated using an indium tin oxide transparent conductor with a sheet resistance of~10Ω/*** a transmittance of~94%(~86% with the substrate effect)in the visible wavelength range,and assembled onto a display *** at this high transmittance,the electrodes can degrade the display quality when they are placed on the *** interference between periodic display pixel arrays and sensor patterns can lead to the *** is necessary to find an appropriate sensor pattern that minimizes the Moirepattern,while maintaining the signal *** search for appropriate patterns,a numerical calculation is carried out over wide ranges of pitches and rotation *** range is narrowed for an experimental evaluation,which is used to finally determine the sensor *** the selected sensor pitches are too small to detect capacitance variations,three unit patterns are electrically connected to obtain a unit block generating a larger *** applying the selected sensor pattern and circuit driving by block,fingerprint sensing on a display is demonstrated with a prototype built on a commercial smartphone.

关键词： transparent pattern smart

Preparation of Pure Copper Powder from Acidic Copper Chloride Waste Etchant

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Journal of Materials Science & Technology 2008年第1期24卷 141-142页

作者： H.S.hong M.S.Kong J.K.Ghu J.K.Lee H.G.suk Plant Engineering Center.Institute for Advanced Engineering Yongin 449-863 Korea Dept. of Advanced Mater. Eng. Korea Polytechnic University Shihung 429-793 Korea Nano-surface Treat. Tech. Team Korea Inst. of Industrial Technology Incheon 463-130 Korea Dept. of Mater. and Met. Eng. Kangwon National University Samcheok 245-711 Korea

The method for the recycling of copper from copper chloride solution was developed. This process consists of extraction of copper, purification and particle size reduction. In the first step, reductive metal scraps were added to acidic copper chloride waste enchants produced in the PCB industry to obtain copper powder. Composition analysis showed that this powder contained impurities such as Fe, Ni, and water. So, drying and purification were carried out by using microwave and a centrifugal separator. Thereby the copper powder had a purity of higher than 99% and spherical form in morphology. The copper powder size was decreased by ball milling.

关键词： Copper chloride liquid waste Printed circuit board (PCB), Liquid waste Highpurity copper powder

Hybrid gold/DNA nanowire circuit with sub-10nm nanostructure arrays

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Microsystems & Nanoengineering 2020年第1期6卷 221-228页

作者： jong Seob Choi Hye Bin Park Jonathan HTsui Byungyou hong Deok-Ho Kim Hyung Jin Kim Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21205USA Digital Healthcare Research Center Gumi Electronics and Information Technology Research Institute(GERI)350-27GumidaeroGumiGyeongbuk 39253South Korea College of Information and Communication Engineering Sungkyunkwan UniversitySuwon 440-746South Korea Department of Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA

We report on a simple and efficient method for the selective positioning of Au/DNA hybrid nanocircuits using a sequential combination of electron-beam lithography(EBL),plasma ashing,and a molecular patterning *** nanostructures produced by the EBL and ashing process could be uniformly formed over a 12.6 in 2 substrate with sub-10 nm patterning with good pattern *** addition,DNA molecules were immobilized on the selectively nanopatterned regions by alternating surface coating procedures of 3-(aminopropyl)triethoxysilane(APS)and diamond like carbon(DLC),followed by deposition of DNA molecules into a well-defined single DNA *** single DNA nanowires were used not only for fabricating Au/DNA hybrid nanowires by the conjugation of Au nanoparticles with DNA,but also for the formation of Au/DNA hybrid *** nanocircuits prepared from Au/DNA hybrid nanowires demonstrate conductivities of up to 4.3×10^(5) S/m in stable electrical *** selective and precise positioning method capable of controlling the size of nanostructures may find application in making sub-10 nm DNA wires and metal/DNA hybrid nanocircuits.

关键词： nanowires precise method

Paraaortic lymph node metastasis in patients with intra-abdominal malignancies:CT vs PET

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World Journal of Gastroenterology 2009年第35期15卷 4434-4438页

作者： Mi-Jung Lee Mi Jin Yun Mi-suk Park Seung Hwan Cha Myeong-Jin Kim jong Doo Lee Ki Whang Kim Department of Diagnostic Radiology Research Institute of Radiological Science and Institute ofGastroenterology Yonsei University College of Medicine 134Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Nuclear medicine Yonsei University College of Medicine 134 Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Diagnostic Radiology Yonsei University Wonju College of Medicine Wonju 220-701South Korea

AIM： To compare the diagnostic accuracy of computed tomography （CT） and positron emission tomography （PET） for the preoperative detection of paraaortic lymph node （PAN） metastasis in patients with intra- abdominal malignancies. METHODS： Sixty-six patients with intra-abdominal malignancies who underwent both CT and PET before lymphadenectomy were included in this study. Histopathologicaliy, 13 patients had metastatic PAN, while 53 had non-metastatic PAN. The CT criteria for metastasis were： short diameter ：）f 〉 8 mm, Iobular or irregular shape, and/or combined ancillary findings, including necrosis, conglomeration, vessel encasement, and infiltration. The PET criterion was positive fluorodeoxyglucose （FDG） uptake. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, and accuracy of both modalities were compared with the pathologic findings, and the false positive and false negative cases with both CT and PET were ***： The sensitivity, specificity, PPV, NPV, and accuracy of CT were 61.5%, 84.9%, 50%, 90% and 80.3%, respectively. For PET, the percentages were 46.2%, 100%, 100%, 88.3%, and 89.4%. Additionally, there were 8 false positive CT cases （8/53, 15.1%） and zero false positive PET cases. Of the 13 metastatic PANs, there were 5 false negative CT scans （38.5%） and 7 （53.9%） false negative PET ***： For detecting PAN metastasis, CT is more sensitive than PET, while PET is more specific.

关键词： Malignancy Paraaortic lymph node Computed tomography Positron emission tomography Sensitivity Specificity

Contained local compression on peri-ascending aortic area for postoperative bleeding control:a case report

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The Journal of Biomedical Research 2021年第1期35卷 72-74页

作者： Su Young Yoon Si-Wook Kim Dohun Kim jong-Myeon hong Department of Thoracic and Cardiovascular Surgery 2Trauma CenterChungbuk National University HospitalCollege of MedicineChungbuk National UniversitySeowon-GuCheongju 28644Republic of Korea

After type A acute aortic dissection(AAD)repair or modified Bentall procedure,uncontrollable bleeding from the anastomotic sites of the fragile dissected tissues or aortic root area is a critical situation to a cardiac *** postoperative care,lots of blood transfusion with strict monitoring on the patient all night and subsequent reoperation for the bleeding control is usually *** managed to make contained local compression of upper half of the heart,from upper part of the right ventricle to just above the innominate vein,using bovine pericardium with closing both sides of transverse sinus in two cases of uncontrolled postoperative bleeding(bleeding from distal anastomotic site in type-A AAD and valve sitting site in modified Bentall procedure).Even though reoperations for the removal of packed gauges were done in both cases 2 days later,postoperative courses at intensive care unit were very smooth with little need for *** kind of contained local compression trial could be a useful strategy for dealing with the malignant uncontrollable bleeding from the fragile aortic tissue or root area after acute dissection or aortic root repair.

关键词： uncontrollable bleeding contained local compression aortic dissection aortic root repair

Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment

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World Journal of Gastroenterology 2008年第27期14卷 4416-4419页

作者： So Young Kwon Won Hyeok Choe Chang hong Lee jong Eun Yeon Kwan Soo Byun Department of Internal Medicine Konkuk University School of Medicine Department of Internal Medicine Korea University College of Medicine

Lamivudine has a high rate of antiviral resistance. Sequential treatment of anti-hepatitis B virus (HBV) is commonly used for lamivudine resistance. We report 4 cases of patients with rapid redetection of HBV mutants during the lamivudine retreatment. The four patients received lamivudine as an initial treatment of HBV and adefovir and lamivudine as a rescue therapy consecutively. HBV-DNA level, YMDD mutations and adefovir -resistant mutations (RFMP) were tested every 3 mo during the sequential treatment. All the patients showed YMDD mutations during the initial lamivudine therapy. After adefovir therapy for lamivudine resistance, they showed viral breakthrough. Adefovir was switched to lamivudine, however, it did not induce viral suppression at all, rather increased HBV-DNA with rapid reemergence of the YMDD mutations. All the patients had ALT flares, and hepatic decompensation occurred in two patients. After switching to adefovir combined with entecavir or lamivudine for a rescue therapy, the patients had reduction in HBV-DNA and ALT improvement. These cases demonstrated that lamivudine retreatment of patients with preexposed lamivudine resistance leads to rapid reemergence of YMDD mutation with significant viral rebounds and subsequent hepatic decompensation. Sequential administration of lamivudine in patients with a prior history of YMDD mutation should be abandoned.

关键词： Hepatitis B Lamivudine Adefovir dipivoxil Mutations

Iatrogenic atlantoaxial rotatory subluxation after thyroidectomy in a pediatric patient:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3351-3355页

作者： Woo-Joon hong Jung-Kil Lee jong-Hwan hong Moon-Soo Han Shin-Seok Lee Department of Neurosurgery Chonnam National University Hospital&Medical SchoolGwangju 61469South Korea Department of Rheumatology Department of Internal MedicineChonnam National University Medical School&HospitalGwangju 61469South Korea

BACKGROUND Atlantoaxial rotatory subluxation(AARS)is an uncommon disease with a greater prevalence among children than adults,and it is mostly associated with *** spinal injury accounts for a low percentage of ***,in AARS,20%-40%of cases are associated with surgery,and 48%are caused by ***,we describe our experience with a case of iatrogenic AARS after general *** SUMMARY A 12-year-old girl presented with right-sided torticollis and cervical motion *** patient had undergone thyroidectomy 2 mo *** tomography revealed AARS with bilateral locked *** the failure of repeated external reduction under general anesthesia,the patient underwent an open surgical *** patient gained atlantoaxial alignment without any ***-up radiographs showed a normal appearance without *** cervical spine of children is more predisposed to injury due to anatomical and biomechanical *** secondary to infection and surgery is known as Grisel’s syndrome,which involves non-traumatic *** cases of AARS after surgery and other procedures with no evidence of inflammation have been *** experience shows that surgery requiring hyperextension of the neck after general anesthesia should also be included as a risk *** Surgeons and anesthesiologists should be careful not to excessively extend the neck during pediatric ***,clinicians caring for pediatric patients with recent head and neck procedures must be aware of common AARS presentations.

关键词： Atlantoaxial joint Joint subluxation Adolescent Grisel’s syndrome Case report

Complete resection of large-cell neuroendocrine and hepatocellular carcinoma of the liver: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8277-8283页

作者： Byeong Gwan Noh Hyung-Il Seo Young Mok Park suk Kim Seung Baek hong So Jeong Lee Division of HBP Surgery and Transplantation Department of SurgeryPusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combined tumors comprising large-cell neuroendocrine carcinoma and hepatocellular carcinoma have been rarely reported in the *** SUMMARY We report a case of a 73-year-old woman with chronic hepatitis B suspected to have a malignant hepatic mass(segment 3;size,4.5 cm)and lymph node metastasis based on computed tomography and magnetic resonance *** being Child-Pugh class A,esophageal varices were *** underwent left lateral sectionectomy and lymph node *** examination revealed a collision tumor consisting of large-cell neuroendocrine(90%)and hepatocellular(10%)*** combined carcinoma had metastasized to one of the three lymph nodes *** patient recovered without any postoperative complications and was discharged in good condition on postoperative day *** chemotherapy was not *** recurrence occurred during a follow-up period of 24 *** To improve the therapeutic management of combined tumors in the liver,it is necessary to discuss each clinical experience and consider an appropriate method for the preoperative diagnosis and treatment.

关键词： Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis B Case report