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转移性儿童及青少年分化型甲状腺癌基因与临床特征的关系

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中华医学杂志 2024年第20期104卷 1837-1843页

作者：潘逸缙鞠高达慕转转孙郁青孙迪梁军林岩松中国医学科学院北京协和医学院北京协和医院核医学科疑难重症及罕见病国家重点实验室核医学分子靶向诊疗北京市重点实验室北京北京大学国际医院肿瘤内科北京

目的探讨转移性儿童及青少年分化型甲状腺癌(caDTC)基因与临床特征的关系。方法横断面研究, 纳入2020年12月至2022年12月就诊于北京协和医院存在淋巴结或远处转移性的caDTC患者, 根据纳排标准共入组67例患者。比较不同基因组间临床病理... 详细信息

目的探讨转移性儿童及青少年分化型甲状腺癌(caDTC)基因与临床特征的关系。方法横断面研究, 纳入2020年12月至2022年12月就诊于北京协和医院存在淋巴结或远处转移性的caDTC患者, 根据纳排标准共入组67例患者。比较不同基因组间临床病理特征及摄碘差异, 并以12岁为界行亚组分析。结果 67例caDTC中, 确诊年龄[M(Q1, Q3)]为13.2(9.7, 16.9)岁, 男23例, 女44例。68.7%(46/67)的患者存在远处转移(M1期)。68.7%(46/67)检测出致病性或可能致病性基因突变, RET或NTRK融合(简称RET/NTRK)最多[43.3%(29/67)], BRAF V600E突变次之[19.4%(13/67)], 仅1例为NRAS Q61R突变。将患者分为RET/NTRK融合组(n=29)、BRAF突变组(n=12)、其他突变组(n=4)及无突变组(n=21)(1例患者因合并NRAS Q61R突变和BRAF V600E突变未纳入基因突变亚型分组比较)。基因特征分组比较显示, 相较于BRAF突变组, RET/NTRK融合组的中位确诊年龄较小[12.6(9.3, 15.9)比17.2(15.5, 18.1)岁, P<0.001], 突变负荷≥2的比例更高(10.4%比8.3%, P=0.027), 差异均有统计学意义。46例M1期患者中, 71.7%(33/46)初始摄碘, 30.4%(14/46)发展为碘难治性(RAIR)。年龄分组比较中, 相较≥12岁组, <12岁组男性比例更高(51.9%比22.5%, P=0.013)和BRAF V600E突变发生率更低(0比32.5%, P<0.001)。结论 RET/NTRK在转移性caDTC中发生率最高, 并呈现低龄化和高远处转移率的特征, 尽管转移性病灶多数初始摄碘, 但易发生RAIR。应重视RET/NTRK融合在低龄caDTC侵袭性及碘抵抗发生中的潜在作用。

关键词：甲状腺肿瘤分化型甲状腺癌儿童及青少年基因检测放射性碘难治转移性

Effect of Modified Biochar with Organic Fertiliser on the Growth and Development of Chinese Rose

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Advances in Bioscience and Biotechnology 2024年第6期15卷 344-359页

作者： Liyuan mu Hongyin Zhou Junlei Wang Sijing sun Haichan Yang Naiming Zhang Li Bao College of Resources and Environment Yunnan Agricultural University Kunming China Yunnan Engineering Research Centre for Soil Fertilisation and Pollution Remediation Kunming Yunnan School of Plant Protection Yunnan Agricultural University Kunming China

In order to reduce the waste of resources and environmental pollution caused by excessive application of chemical fertilizers, improve the utilization rate of fertilizers, and promote the large-scale and high-quality development of the Chinese rose industry. In this experiment, corn stover biochar, phosphoric acid modified biochar and organic fertilizer were used as test materials, and the effects of mixed application of modified biochar and organic fertilizer on the growth and development of Chinese rose as well as soil physicochemical properties were investigated by using the method of pot planting test. The results showed that modified biochar with organic fertilizer had the most significant effect on the enhancement of soil pH, organic matter content and soil carbon-to-nitrogen ratio. After 120 d of planting, modified biochar with organic fertilizer had the most significant effect on the enhancement of plant height and crown width of Chinese rose;both organic fertilizer and modified biochar with organic fertilizer significantly increased the chlorophyll content of Chinese rose. The number of flowers and the number of branches were the highest in the modified biochar with organic fertilizer treatment. In conclusion, the application of modified biochar with organic fertilizer can better improve the soil pH, and increase the soil organic matter content and carbon-to-nitrogen ratio to change the biological traits of Chinese rose. The results of this study provide a theoretical basis for the reduction of chemical fertilizers and the resource utilization of agricultural wastes and guarantee the sustainable development of the cut flower industry.

关键词： Biochar Modified Biochar Chinese Rose Organic Fertiliser

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-sun Yi Sangmi Jun Bum-Tae Kim jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

A holistic perspective on Earth system science

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Science China Earth Sciences 2024年

作者： Yongfei ZHENG Zhengtang GUO Nianzhi JIAO mu mu Shilong PIAO Suiyan FU Dinghui YANG Maoyan ZHU State Key Laboratory of Lithospheric and Environmental Coevolution School of Earth and Space SciencesUniversity of Science and Technology of China State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Ocean and Earth Sciences Xiamen University Department of Atmospheric and Oceanic Sciences Fudan University School of Environment Peking University School of Earth and Space Sciences Peking University Department of Mathematical Sciences Tsinghua University Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences

Earth system can be categorized into three parts, solid Earth system, surface Earth system, and sun-Earth space system. These three subsystems not only have mutual transmission and coupling relationships in both energy and matter but also involve multiple scales from microscopic to macroscopic. Earth system science is characterized by its globality and unity with a holistic view and a systematic view at multiple scales in both space and time. It focuses not only on the physical, chemical and biological interactions between various geospheres but also on the properties, behaviors, processes, and mechanisms of the entire Earth and its spheres. Although significant progress has been made in the study of internal disciplines of these three subsystems,there is still insufficient understanding of their overall behavior and interactions between individuals, thus facing challenges of different types and levels. The solid Earth system is composed of the crust, mantle, and core. Existing observational techniques struggle to penetrate deep into the mantle, making direct observation and data acquisition difficult; the extreme environments within Earth, such as high temperature, high pressure, and strong magnetic fields, also pose great challenges to observational equipment and scientific experiments. The surface Earth system is an open complex mega-system, in which there are complex interactions and feedback mechanisms among its geospheres(such as atmosphere, hydrosphere, biosphere, pedosphere and lithosphere), leading to difficulties in understanding of its overall behavior and long-term evolution. Biological activities have become increasingly significant in affecting the surface Earth system. The coupling between the internal and external Earth systems becomes more complex. Distinguishing and quantifying the impacts of Earth spherical interactions and biological activities on the surface Earth system is a major challenge. The sun-Earth space system involves multiple physical

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基于画像技术的教师研修路径智能推荐研究

电化教育研究 2024年第2期45卷 106-112页

作者：胡小勇孙硕穆肃华南师范大学教育信息技术学院广东广州510631 华南师范大学教育人工智能研究院广东广州510631

教师是教育的第一资源,研修是促进教师专业发展的重要方式。在大数据、数字画像等新技术赋能下,优化教师研修路径以提升教师发展质量变得尤为重要。文章构建了多模态数据和画像技术支持的教师研修路径智能推荐模型,包括数据伴随式采集... 详细信息

教师是教育的第一资源,研修是促进教师专业发展的重要方式。在大数据、数字画像等新技术赋能下,优化教师研修路径以提升教师发展质量变得尤为重要。文章构建了多模态数据和画像技术支持的教师研修路径智能推荐模型,包括数据伴随式采集分类与预处理、教师画像生成、研修路径算法三个模块,实现教师研修特征与优质研修资源的智能匹配。在教师研修路径动态优化方面,模型通过提供基于画像的个性化导研服务、基于知识图谱的资源关联推荐、基于群体智能的群体路径发现、基于目标导向的过程评价和基于研修行为的智能预警,满足教师的个性化研修需求,为发掘研修数据潜能、促进教师智能研修模式创新提供参考。

关键词：教师画像教师专业发展多模态数据个性化研修智能推荐

METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang mu Ji-hang Yuan Shu-han sun Hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

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多发性骨髓瘤免疫治疗及免疫微环境研究进展

白血病．淋巴瘤 2024年第4期33卷 199-202页

作者：孙洗月郝牧中国医学科学院血液病医院(中国医学科学院血液学研究所)、实验血液学国家重点实验室、国家血液系统疾病临床医学研究中心、细胞生态海河实验室天津300020

国际骨髓瘤学会(IMS)年会是国际骨髓瘤领域顶级学术交流会,会议报道内容体现骨髓瘤最前沿的基础和临床研究进展。2023年第20届IMS年会报道了骨髓瘤微环境改变、免疫治疗以及新治疗靶点的发掘等方面的最新研究进展,促进了多发性骨髓瘤及... 详细信息

国际骨髓瘤学会(IMS)年会是国际骨髓瘤领域顶级学术交流会,会议报道内容体现骨髓瘤最前沿的基础和临床研究进展。2023年第20届IMS年会报道了骨髓瘤微环境改变、免疫治疗以及新治疗靶点的发掘等方面的最新研究进展,促进了多发性骨髓瘤及浆细胞疾病的学科交流。

关键词：多发性骨髓瘤免疫疗法免疫微环境国际骨髓瘤学会

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煤化工场景下光储氢热微网能量管理策略研究

电网技术 2024年第8期48卷 3197-3206,I0044页

作者：孙逊邢小文牟树君范玉建韩小寒北京低碳清洁能源研究院北京市昌平区102211

针对煤化工场景下的光储氢热微网系统各设备的协调运行问题,满足煤化工“安稳长满优”运行要求,通过深入分析系统内光储氢热运行特点及煤化工生产用电要求,提出了一种基于能量预测和实时功率控制相结合的能量管理策略。首先以用电成本... 详细信息

针对煤化工场景下的光储氢热微网系统各设备的协调运行问题,满足煤化工“安稳长满优”运行要求,通过深入分析系统内光储氢热运行特点及煤化工生产用电要求,提出了一种基于能量预测和实时功率控制相结合的能量管理策略。首先以用电成本最低为目标,结合光伏及煤化工生产用热用氢预测曲线,建立系统能量预测模型,提出一种适用于煤化工与新能源耦合的光储氢热系统能量管理策略,规划各设备的日运营模式;其次,考虑制氢、储热、储能的运行边界、光伏预测误差及现场电网约束,基于制氢、储热、储能的动态响应特性,设计一种设备分级控制策略以动态调整功率设定值,在尽可能消纳新能源的前提下保证系统稳定运行;最后,基于国能智深控制器EDPF-NT和远宽公司MT8020实时仿真器,搭建能量管理半实物仿真平台。通过仿真结果分析,该策略可节省约19.8%的日用电费用,同时可以充分利用新能源,保证系统用电运行安全。

关键词：煤化工光储氢热能量管理策略半实物仿真

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利用Florida探针评价规范化牙周探诊训练在本科生教学中的作用

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上海口腔医学 2024年第3期33卷 332-336页

作者：许沐馨孙青常州市中医医院钟楼院区/常州市口腔医院牙周病科江苏常州213003

目的:利用Florida探针系统评价规范化牙周探诊训练在本科生牙周临床探诊教学中的作用。方法:选取2022年5月—2022年11月于常州市口腔医院牙周病科实习的20名本科生作为研究对象,随机分为2组,每组10人。实验组接受规范化牙周探诊训练,对... 详细信息

目的:利用Florida探针系统评价规范化牙周探诊训练在本科生牙周临床探诊教学中的作用。方法:选取2022年5月—2022年11月于常州市口腔医院牙周病科实习的20名本科生作为研究对象,随机分为2组,每组10人。实验组接受规范化牙周探诊训练,对照组未接受训练,2组学生使用传统探针和Florida探针分别进行一例患者的左、右侧半口探诊,并由一名牙周专科医师使用Florida探针对同一患者进行全口探诊,与2组学生的探诊结果分别进行比较。采用SPSS 26.0软件包对所得数据进行统计学分析。结果:牙周专科医师探诊深度(PD)值与实验组本科生无显著差异(P>0.05),而与对照组有显著差异(P0.05),后牙区有统计学差异(P<0.05)。2组患者均认为,Florida探针系统探诊舒适度更高。结论:规范化牙周探诊训练有助于提高本科生临床探诊能力,使用Florida探针系统不仅可以评价教学效果,还可以提高患者舒适度,值得在本科生牙周探诊教学课程中进一步推广。

关键词：牙周探诊规范化牙周探诊训练 Florida探针本科生教学