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Bleeding after endoscopic papillectomy and its risk factors:A single center experience of 196 cases

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 613-619页

作者： Jin Ho Choi Won Chul Kim Joo kyung Park jong kyun lee kyu Taek lee Kwang Hyuck lee Department of Medicine Division of GastroenterologySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Background:Endoscopic papillectomy(EP)is an effective method to remove an ampulla of Vater(AoV)adenoma with minimal *** reviewed the clinical outcomes and prognosis of patients undergoing EP,including tumor recurrence and adverse ***:A total of 196 patients who underwent EP from January 2004 to December 2017 were *** information was collected through electronic medical records,and risk factors to predict postprocedural bleeding were analyzed using a multivariate logistic regression ***:A total of 93.9%patients(184/196)underwent complete *** the follow-up period,14.7%patients(27/184)experienced tumor recurrence,and two of seven surgically resected tumors were malignant.A total of 45.4%patients(89/196)experienced adverse events related to *** bleeding occurred in 16.3%of the patients(32/196),and they were all successfully treated with endoscopic hemostasis and conservative *** most frequent site of delayed bleeding was the distal end of the papillary orifice,and 56.3%(18/32)patients of delayed bleeding were classified as having mild severity,the others had moderate *** adenomatous polyposis(FAP)[odds ratio(OR)=3.80,95%confidence interval(CI):1.01-14.29;Pleeding was increased in patients with FAP syndrome and male patients,and post-EP bleeding occurred most commonly in the distal part of the AoV.

关键词： Ampullary neoplasm Endoscopic papillectomy Post-procedural bleeding Risk factor

Is cholecystectomy a reasonable treatment option for simple gallbladder polyps larger than 10 mm?

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World Journal of Gastroenterology 2015年第14期21卷 4248-4254页

作者： Hye Yon Park Se Hoon Oh Kwang Hyuck lee jong kyun lee kyu Taek lee Division of Gastroenterology Department of Internal MedicineSamsung medical centerSungkyunkwan University School of Medicine

AIM: To determine the relevance of the 10-mm size criterion of the generally accepted surgical indication for gallbladder polyps(GBPs).METHODS: We collected data of patients who were confirmed to have GBPs through cholecystectomy at Samsung Medical Center between January 1997 andDecember *** the patients who underwent cholecystectomy for GBP, those with a definite evidence for malignancy such as adjacent organ invasion, metastasis on preoperative imaging studies, polyp larger than 20 mm, absence of preoperative imaging study results, and patients having gallstones were *** retrospectively collected and analyzed information on patient's clinical characteristics, symptoms, ultrasonographic findings, and blood laboratory ***: A total of 836 patients who had undergone cholecystectomy were retrospectively *** hundred eighty patients(93%) had benign polyps, whereas 56 patients(7%) had malignant *** the 56 patients with malignancy, 4 patients(7%) had borderline GBP(10-12 mm) and a patient had small GBP(< 10 mm) with T2 *** conducted an ROC curve analysis to verify the 10-mm size criteria(AUC = 0.887, SD = 0.21, P < 0.001).In the ROC curve for polyp size and malignancy, sensitivity and specificity of the 10-mm size criterion was 98.2% and 19.6%, *** specificity of the 11-mm and 12-mm size criteria was 44.6% and 56%, respectively, whereas the sensitivity of these two size criteria was *** defined the GBPs of 10 to 12 mm as a borderline-sized GBP, which were found in 411 patients(49%).In this group, there was a significant difference in age between patients with benign and malignant GBPs(47 years vs 60 years, P < 0.05).CONCLUSION: GBPs larger than 13 mm need immediate excision whereas for borderline-sized GBPs detected in young patients, careful medical observation can be a rational decision.

关键词： Gallbladder polyp Gallbladder cancer Cholecystecto

Improved MIMO Signal Detection Based on DNN in MIMO-OFDM System

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Computers, Materials & Continua 2022年第2期70卷 3625-3636页

作者： Jae-Hyun Ro jong-Gyu Ha Woon-Sang lee Young-Hwan You Hyoung-kyu Song Department of Convergence Engineering for Intelligent Drone Sejong UniversitySeoul05006Korea Department of Information and Communication Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea Department of Computer Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

This paper proposes the multiple-input multiple-output(MIMO)detection scheme by using the deep neural network(DNN)based ensemble machine learning for higher error performance in wireless communication *** the MIMO detection based on the ensemble machine learning,all learning models for the DNN are generated in offline and the detection is performed in online by using already learned *** the offline learning,the received signals and channel coefficients are set to input data,and the labels which correspond to transmit symbols are set to output *** the online learning,the perfectly learned models are used for signal detection where the models have fixed bias and *** performance improvement,the proposed scheme uses the majority vote and the maximum probability as the methods of the model combinations for obtaining diversity gains at the MIMO *** simulation results show that the proposed scheme has improved symbol error rate(SER)performance without additional receive antennas.

关键词： MIMO DNN ensemble machine learning ML

Combination of cell signaling molecules can facilitate MYOD1-mediated myogenic transdifferentiation of pig fibroblasts

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1662-1674页

作者： Jinsol Jeong Kwang-Hwan Choi Seung-Hun Kim Dong-kyung lee jong-Nam Oh Mingyun lee Gyung Cheol Choe Chang-kyu lee Department of Agricultural Biotechnology Animal Biotechnology Majorand Research Institute of Agriculture and Life ScienceSeoul National UniversitySeoul 08826South Korea Present address:Research and Development Center Space F corporationHwasung-siGyeonggi-do 18471South Korea Institute of Green Bio Science and Technology Seoul National UniversityPyeong ChangKangwon-do 25354South Korea

Background:Myogenic transdifferentiation can be accomplished through ectopic MYOD1 expression,which is facilitated by various signaling pathways associated with *** this study,we attempted to transdifferentiate pig embryonic fibroblasts(PEFs)myogenically into skeletal muscle through overexpression of the pig MYOD1 gene and modulation of the FGF,TGF-β,WNT,and cAMP signaling ***:The MYOD1 overexpression vector was constructed based on comparative sequence analysis,demonstrating that pig MYOD1 has evolutionarily conserved domains across various *** forced MYOD1 expression through these vectors triggered the expression of endogenous muscle markers,transdifferentiated muscle cells from fibroblasts were not ***,various signaling molecules,including FGF2,SB431542,CHIR99021,and forskolin,along with MYOD1 overexpression were applied to enhance the myogenic *** modified conditions led to the derivation of myotubes and activation of muscle markers in PEFs,as determined by qPCR and ***,a sarcomere-like structure was observed,indicating that terminally differentiated skeletal muscle could be obtained from transdifferentiated ***:In summary,we established a protocol for reprogramming MYOD1-overexpressing PEFs into the mature skeletal muscle using signaling *** myogenic reprogramming can be used as a cell source for muscle disease models in regenerative medicine and the production of cultured meat in cellular agriculture.

关键词： MYOD1 Pig Sequence analysis Skeletal muscle Transdifferentiation

Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy

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Asian Journal of Andrology 2016年第6期18卷 937-941页

作者： jong Jin Oh Ohsung Kwon Jung Keun lee Seok-Soo Byun Sang Eun lee Sangchul lee Sung kyu Hong Department of Urology Seoul National University Bundang Hospital Seongnam Korea.

The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio （NLR）, a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi （〉12）-core transrectal ultrasound （TRUS） biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen （PSA） levels ranging from 4 to 10 ng ml^-1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We excluded patients who had evidence of acute prostatitis, a history of prostate surgery, and any systemic inflammatory disease. A multivariate logistic regression model was used to analyze prostate cancer detection. After adjusting for confounding factors, predictive values were determined according to the receiver operating characteristic-derived area under the curve, both including and excluding the NLR variable. In univariate analyses, NLR was a significant predictor of prostate cancer detection （P 〈 0.001）. In multivariate analyses, a higher NLR was significantly associated with prostate cancer detection after adjusting for other factors （OR = 1.372, P = 0.038）. The addition of NLR increased the accuracy from 0.712 to 0,725 （P = 0.005） in the multivariate model for prostate cancer detection. NLR may be a potentially useful clinical marker in the detection of prostate cancer among men with a PSA level in the 4-10 ng ml^-1 range. These findings are derived from a retrospective analysis and should be validated in larger populations through prospective studies.

关键词： inflammation lymphocyte neutrophil prostate biopsy prostate cancer

Formation of interfacial brittle phases sigma phase and IMC in hybrid titanium-to-stainless steel joint

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 7-11页

作者： Min Ku lee Jung Gu lee jong Keuk lee Sung Mo HONG Sang Hoon lee Jin Ju PARK Jae Woo KIM Chang kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The microstructures of the brazed joints for commercially pure Ti and stainless steel were investigated by the applications of various filler alloys including Ag-, Ti-, Zr- and Ni-based alloys. Generally, the dissimilar joints between Ti and stainless steel were dominated by the Ti-based intermetallic compounds （IMCs）, e.g. （Ti, Zr）2（Fe, Ni）, TiFe, TiCu, and Ti2（Fe, Ni）, due to a significant dissolution of Ti from the base metal. The （Fe-Cr） cr phase was also observed near the stainless steel due to a segregation of Cr into the interface region. This research demonstrates empirically that the brittleness of the Ti and stainless steel joint can not be avoided only by applying single braze alloy or single insert metal, and thus an introduction of additional suitable interlayer between the filler alloy and the base metal is necessary to prevent the brittleness of the joint.

关键词： brazing titanium stainless steel intermetallic compounds (IMCs)

Rice Transcription Factor OsDOFll Modulates Sugar Transport by Promoting Expression of Sucrose Transporter and SWEET Genes

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Molecular Plant 2018年第6期11卷 833-845页

作者： Yunfei Wu Sang-kyu lee Youngchul Yoo Jinhuan Wei Suk-Yoon Kwon Sang-Won lee jong-Seong Jeon Gynheung An Crop Biotech Institute and Graduate School of Biotechnology Kyung Hee University Yongin 17104 Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Korea

Sucrose is produced in mesophyll cells and transferred into phloem cells before it is delivered long- distance to sink tissues. However, little is known about how sucrose transport is regulated in plants. Here, we identified a T-DNA insertional mutant of Oryza sativa DNA BINDING WITH ONE FINGER 11 （OsDOF11）, which is expressed in the vascular cells of photosynthetic organs and in various sink tissues. The osdofll mutant plants are semi-dwarf and have fewer tillers and smaller panicles as compared with wild-type （WT） plants. Although sucrose enhanced root elongation in young WT seedlings, this enhance- ment did not occur in osdof11 seedlings due to reduced sucrose uptake. Sugar transport rate analyses revealed that less sugar was transported in osdofll plants than in the WT. Expression of four Sucrose Transporter （SUT） genes-OsSUT1, OsSUT3, OsSUT4, and OsSUT5-as well as two Sugars Will Eventually be Exported Transporters （SWEET） genes, OsSWEETll and OsSWEET14, was altered in various organs of the mutant, including the leaves. Chromatin immunoprecipitation assays showed that OsDOFll directly binds the promoter regions of SUT1, OsSWEETll, and OsSWEET14, indicating that the expression of these transporters responsible for sucrose transport via apopiastic loading is coordinately controlled by OsDOFll. We also observed that osdofll mutant plants were less susceptible to infection byXanthomonas oryzae pathovar oryzae, suggesting that OsDOFll participates in sugar distribution during pathogenic in- vasion. Collectively, these results suggest that OsDOFll modulates sugar transport by regulating the expression of both SUT and SWEET genes in rice.

关键词： OsDOF11 phloem loading rice SUT SWEET Xanthomonas oryzae

High-efficiency single and tandem fullerene solar cells with asymmetric monofluorinated diketopyrrolopyrrole-based polymer

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Journal of Energy Chemistry 2022年第1期31卷 236-245,I0007页

作者： Shafket Rasool Quoc Viet Hoang Doan Van Vu Chang Eun Song Hang Ken lee Sang kyu lee jong-Cheol lee Sang-Jin Moon Won Suk Shin Institute of Chemical Technology(KRICT) 141 Gajeong-roYuseongDaejeon 34114Republic of Korea Advanced Materials and Chemical Engineering University of Science and Technology(UST)217 CajeongroYuseongDaejeon 34113Republic of Korea Vietnam Standards and Quality Institute(VSQI) Directorate for StandardsMetrology and Quality(STAMEQ)No.8.Hoang Quoc VietCau GiayHanoiViet Nam

Design and synthesis of low bandgap(LBG) polymer donors is inevitably challenging and their processability from a non-halogenated solvent system remains a hurdle to overcome in the area of highperformance polymer solar cells(PSCs).Due to a high aggregation tendency of LBG polymers,especially diketopyrrolopyrrole(DPP)-based polymers coupled with bithiophenes in the polymer backbones,their widespread adoption in non-ha logena ted solvent-processed PSCs has been ***,a novel LBG DPP-based polymer,called PDPP4 T-1 F with asymmetric arrangement of fluorine atom,has been successfully synthesized and showed an outstanding power conversion efficiency(PCE) of 10.10% in a singlejunction fullerene-based ***,an impressive PCE of 13.21% has been achieved in a tandem device from a fully non-halogenated solvent system,which integrates a wide bandgap PDTBTBz-2 F polymer in the bottom cell and LBG PDPP4 T-1 F polymer in the top *** achieved efficiency is the highest value reported in the literature to date in fullerene-based tandem *** found that a uniformly distributed interpenetrating fibril network with nano-scale phase separation and anisotropy of the polymer backbone orientation for efficient charge transfer/transport and suppressed charge recombination in PDPP4 T-1 F-based PSCs led to outstanding PCEs in single and tandem-junction PSCs.

关键词： Low bandgap polymers Diketopyrrolopyrrole Tandem polymer solar cells Non-halogenated solvent Monofluoro-bithiophene

It is necessary to exam bottom and top slide smears of EUS-FNA for pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 553-558页

作者： jong-chanb lee Haeryoung Kim Hyoung Woo Kim jongchan lee kyu-hyun Paik Jingu Kang Jin-Hyeok Hwang Jaihwan Kim Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Pathology Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine Chungbuk National University College of Medicine Chungbuk National University Hospital Department of Internal Medicine The Catholic University of Korea Daejeon St. Mary’s Hospital Department of Internal Medicine Kangdong Sacred Heart Hospital of Hallym University Medical Center

Background: Despite many reports on the diagnostic yield of cytology from endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA), inter-slide differences are unknown. This prospective study aimed to compare diagnostic yield and cellular characteristics of bottom slides(BS) and top slides(TS) from EUSFNA cytology performed without an on-site cytopathologist. Methods: In patients with suspected pancreatic cancer on previous imaging explorations, a single endoscopist performed EUS-FNA and obtained 2 sets of cytology slide(8 BS and 8 TS), 1 cellblock slide, and 1 biopsy slide. Both slide sets were randomly assigned. A cytopathologist with more than 10 years of expertise in pancreatic cytopathology blindly inspected and compared two slide sets. Results: In total, 73 specimens [42 head(57.5%), 16 body(21.9%), and 15 tail(20.5%)] were acquired for final analysis. Seventy-one cases were finally diagnosed with pancreatic cancer. The sensitivity and specificity of BS were 80.3% and 100.0%; and of TS 78.9% and 100.0%, respectively. In analyzing inter-slide difference, 66 cases(90.4%) showed consistent results between BS and TS. However, seven(9.6%) were positive only in one slide sets(4 BS and 3 TS). The proportions of specimens more than moderate and high cellularity were 75.3% and 60.3% in both slide sets( P > 0.99), and the proportion of artifact-free sets were 50.7%, and 52.1% for the BS and TS, respectively( P = 0.869). Conclusions: Although BS and TS exhibited highly consistent diagnostic yields in cytologic smears from EUS-FNA, the proportion of inter-slide discordance is clinically considerable. Both slide sets need to be examined if there is no on-site cytopathologist.

关键词： Endoscopic ultrasound-guided fine-needle aspiration Pancreatic neoplasm Cytology