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The effects of anti-vascular endothelial growth factor agents on human retinal pigment epithelial cells under high glucose conditions

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 203-210页

作者： jong Rok Oh Jung Woo Han yoon Kyung Kim Young-Hoon Ohn Tae Kwann Park Department of Ophthalmology Soonchunhyang UniversityCollege of MedicineSoonchunhyang University Bucheon HospitalBucheonKorea

AIM： To investigate the effects of high glucose levels and anti-vascular endothelial growth factor（VEGF） agents（bevacizumab,ranibizumab and aflibercept） on retinal pigment epithelium（RPE） ***： ARPE-19 cells were cultured at different glucose levels（5.5 mmol/L,25 mmol/L,and 75 mmol/L）.Cell viability was evaluated by MTT assay at 3d after treatment with *** migration ability was measured by wound healing assay at 3d.A cell death detection kit was used to assess apoptosis at 3 and 14 *** proliferation was assessed by EdU assay at *** culture medium was treated with anti-VEGF agents at clinically relevant *** experiment was then repeated at a different glucose ***： The viability and migration of ARPE-19 cells were significantly decreased in the presence of 75 mmol/L as compared to 5.5 mmol/L *** percentage of TUNEL-positive cells was significantly increased and the proliferative potential was decreased with 75 mmol/L compared to 5.5 mmol/L *** were no significant differences in the results between 25 mmol/L and 5.5 mmol/L *** the presence of 75 mmol/L glucose,the groups treated with anti-VEGF showed decreased cell viability and proliferation and increased ***,there were no significant differences between the anti-VEGF ***： High glucose level decreases the viability,wound healing ability,and proliferation of RPE cells,while increasing ***,anti-VEGF agents interfered with the physiological functions of RPE cells under high-glucose conditions,accompanied by decreases in cell viability and proliferation.

关键词： retinal pigment epithelium anti-vascularendothelial growth factor high glucose

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Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo Young Lee Yumi Seo Ui yoon Choi jong-Hyun Kim Jin Han Kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

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Comparative study of rendezvous techniques in post-liver transplant biliary stricture

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World Journal of Gastroenterology 2012年第41期18卷 5957-5964页

作者： Jae Hyuck Chang In Seok Lee Ho jong Chun jong Young Choi Seung Kyoo yoon Dong Goo Kim Young Kyoung You Myung-Gyu Choi Sok Won Han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Surgery College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

AIM： To investigate the usefulness of a new rendezvous technique for placing stents using the Kumpe （KMP） catheter in angulated or twisted biliary strictures. METHODS： The rendezvous technique was performed in patients with a biliary stricture after living donor liver transplantation （LDLT） who required the exchange of percutaneous transhepatic biliary drainage catheters for inside stents. The rendezvous technique was performed using a guidewire in 19 patients （guidewire group） and using a KMP catheter in another 19 （KMP catheter group）. We compared the two groups retrospectively. RESULTS： The baseline characteristics did not differ between the groups. The success rate for placing insidestents was 100% in both groups. A KMP catheter was easier to manipulate than a guidewire. The mean pro- cedure time in the KMP catheter group （1012 s, range： 301-2006 s） was shorter than that in the guidewire group （2037 s, range： 251-6758 s, P = 0.022）. The cu- mulative probabilities corresponding to the procedure time of the two groups were significantly different （P = 0.008）. The factors related to procedure time were the rendezvous technique method, the number of inside stents, the operator, and balloon dilation of the stric- ture （P 〈 0.05）. In a multivariate analysis, the rendez- vous technique method was the only significant factor related to procedure time （P = 0.010）. The procedural complications observed included one case of mild acute pancreatitis and one case of acute cholangitis in the guidewire group, and two cases of mild acute pancre- atitis in the KMP catheter group. CONCLUSION： The rendezvous technique involving use of the KIVlp catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stric- ture that represents a viable alternative to the guide- wire rendezvous technique,

关键词： Rendezvous Biliary stricture Liver trans-plantation Endoscopic retrograde cholangiography Percutaneous transhepatic biliary drainage

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Increased incidence of indeterminate pancreatic cysts and changes of management pattern: Evidence from nationwide data

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Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 294-301页

作者： Jaewoo Park Jinkyeong Park yoon Suk Lee Kwangrok Jung In Ho Jung jong-Chan Lee Jin-Hyeok Hwang Jaihwan Kim Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnamKorea Department of Internal Medicine Kyung Hee University Hospital at GangdongSeoulKorea Department of Internal Medicine Inje University College of MedicineIlsan Paik HospitalGoyangKorea

Background:Pancreatic cysts are ***,most studies are based on data collected from individual *** present study aimed to evaluate the changes of management patterns for pancreatic cystic lesions(PCLs)by analyzing large epidemiologic ***:Between January 2007 and December 2018,information regarding pancreatic cystic lesions was acquired from the nationwide Health Insurance Review and Assessment Service database in ***:The final number of patients with pancreatic cysts was 165277 among the total claims for reimbursement of 855983 associated with PCLs over 12 *** total number of claims were increased from 19453 in 2007 to 155842 in 2018 and the prevalence increased from 0.04%to 0.23%.For 12 years,2874(1.7%)had pancreatic cancer and 8212(5.0%)underwent surgery,and 36 had surgery for twice(total 8248 pancreatectomy).After ruling out claims from the first 3 years of washout period,the incidence increased from 9891 to 24651 and the crude incidence rate of PCLs expanded from 19.96 per 100000 to 47.77 per *** to specific neoplasm codes(D136 or D377),the use of pancreatic cyst code(K862)has been remarkably increased and the most common since *** annual number of pancreatectomies increased from 518 to 861 between 2007 and 2012,and decreased to 596 until *** percentage of pancreatic cancer in patients who received pancreatectomy increased from 5.6%in 2007 to 11.7%in ***:The incidence of PCLs is rapidly *** PCLs,indeterminate cyst is increasing outstandingly.A trend of decreasing in the number of resections and increasing cancer rates among resected cysts may be attributed to the updated international guidelines.

关键词： Pancreatic cyst Incidence Prevalence Pancreatectomy Big data

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The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice

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Asian Journal of Andrology 2013年第4期15卷 487-491,I0007页

作者： Jin-Wook Kim Mi-Mi Oh Cheol-Yong yoon Jae-Hyun Bae Je-jong Kim Du-Geon Moon Department of Urology Korea University Medical Center Guro Hospital Seou1152-703 Korea and Department of Urology Korea University College of Medicine Seou1152 703 Korea

Population studies have suggested an association between diabetes and the symptoms of testosterone deficiency. Recently, the expression of the androgen receptor （AR） has been shown to be decreased in diabetic patients. Furthermore, diabetes has been shown to induce global methylation. In this study, we used an animal model to investigate whether diabetes results in increased methylation of the AR promoter and whether these changes are associated with the decreased expression of AR in penile cavernosal smooth muscle tissue. Twenty C57BL/6J mice were divided into two groups, receiving either high- （mature diabetic） or low- （mature control） caloric meals for 14 weeks. Another 10 mice were killed at 1 week （young control）. Animals in the mature diabetic group showed decreased testosterone levels, although this was not statistically significant. In both control groups, no significant methylation was observed in the AR promoter region CpG island （-85 to ＋339）. In the mature diabetic group, significant methylation was observed at ＋ 185 and ＋200 of the AR promoter. These changes were associated with increased homeostatic model assessment for insulin resistance （HOMA-IR） and decreased corpus cavernosal tissue mass and expression of AR mRNA and protein. We conclude that in these animals, insulin resistance increased the methylation of the GC-rich regions of the AR promoter, leading to decreased AR expression.

关键词： androgen receptor (AR) diabetes DNA methylation

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Flash‑Induced High‑Throughput Porous Graphene via Synergistic Photo‑Effects for Electromagnetic Interference Shielding

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纳微快报:英文版 2023年第11期15卷 1-18页

作者： Jin Soo Lee Jeong‑Wook Kim Jae Hee Lee Yong Koo Son Young Bin Kim Kyoohee Woo Chanhee Lee Il‑Doo Kim Jae Young Seok jong Won Yu Jung Hwan Park keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea Department of Printed Electronics Nano‑Convergence Manufacturing Systems Research DivisionKorea Institute of Machinery and Materials(KIMM)156 Gajeongbuk‑RoYuseong‑GuDaejeon 34103Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology232 Gongneung‑roNowon‑guSeoul 01811Republic of Korea Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61 Daehak‑roGumiGyeongbuk 39177Republic of Korea

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference(EMI)shielding materials in future mobility and wearable applications to prevent signal noise,transmission inaccuracy,system malfunction,and health ***,we report on the synthesis of lightweight and flexible flash-induced porous graphene(FPG)with excellent EMI shielding *** broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films,forming 5×10 cm^(2)-size porous graphene with a hollow pillar structure in a few *** resulting material demonstrated low density(0.0354 g cm^(−3))and outstanding absolute EMI shielding effectiveness of 1.12×10^(5) dB cm^(2) g^(−1).The FPG was characterized via thorough material analyses,and its mechanical durability and flexibility were confirmed by a bending cycle ***,the FPG was utilized in drone and wearable applications,showing effective EMI shielding performance for internal/external EMI in a drone radar system and reducing the specific absorption rate in the human body.

关键词： Porous graphene Flash lamp Photo-pyrolysis High-throughput Electromagnetic interference shielding

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Clinical outcome after pulmonary metastasectomy from primary hepatocellular carcinoma:Analysis of prognostic factors

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World Journal of Gastroenterology 2008年第37期14卷 5717-5722页

作者： jong-Bum Kwon Khun Park Young-Du Kim jong-Hee Seo Seok-Whan Moon Deog-Gon Cho Yong-Whan Kim Dong-Goo Kim Seung-Kew yoon Hyeon-Woo Lim Department of Thoracic and Cardiovascular Surgery the Catholic University of KoreaSeoul 137-701 Korea Department of Surgery the Catholic University of KoreaSeoul 137-701 Korea Department of Internal Medicine the Catholic University of KoreaSeoul 137-701 Korea Department of Preventive Medicine the Catholic University of KoreaSeoul 137-701 Korea

AIM： To review the surgical outcomes in terms of the surgical indications and relevant prognostic factors. METHODS： Sixteen patients underwent therapeutic lung surgery between March 1999 and May 2006. The observation period was terminated on May 31, 2007. The surgical outcomes and the clinicopathological factors were compared. RESULTS： There was no mortality or major morbidity encountered in this study. The mean follow-up period after metastasectomy was 26.7 ＋ 28.2 （range： 1-99 mo）, and the median survival time was 20 mo. The 1- and 5-year survival rates were 56% and 26%, respectively. At the end of the follow-up, 1 patient died from hepatic failure without recurrence, 6 died from hepatic failure with a recurrent hepatocellular carcinoma （HCC）, and 4 died from recurrent HCC with cachexia. Among several clinical factors, Kaplan Meier analysis revealed as a treatment for the that liver transplantation primary lesion, grade of cell differentiation, and negative evidence HBV infection were independent predictive factors. On Cox＇s proportional hazard model, there were no significant factors affecting survival after pulmonary metastasectomy in patients with HCC. CONCLUSION： A metastasectomy should be performed before other treatments in selected patients, Although not significant, patients with liver transplantation of a primary HCC survived longer, Liver transplantation might be the most beneficial modality that can offer patients better survival, A multi- institutional and collaborative study would be needed for identifying clinical prognostic factors predicting survival in patients with HCC and lung metastasis.

关键词： Hepatocellular carcinoma Pulmonary metastasis Metastasectomy Liver transplantation Thoracoscopy

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Rice Transcription Factor OsDOFll Modulates Sugar Transport by Promoting Expression of Sucrose Transporter and SWEET Genes

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Molecular Plant 2018年第6期11卷 833-845页

作者： Yunfei Wu Sang-Kyu Lee Youngchul Yoo Jinhuan Wei Suk-yoon Kwon Sang-Won Lee jong-Seong Jeon Gynheung An Crop Biotech Institute and Graduate School of Biotechnology Kyung Hee University Yongin 17104 Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Korea

Sucrose is produced in mesophyll cells and transferred into phloem cells before it is delivered long- distance to sink tissues. However, little is known about how sucrose transport is regulated in plants. Here, we identified a T-DNA insertional mutant of Oryza sativa DNA BINDING WITH ONE FINGER 11 （OsDOF11）, which is expressed in the vascular cells of photosynthetic organs and in various sink tissues. The osdofll mutant plants are semi-dwarf and have fewer tillers and smaller panicles as compared with wild-type （WT） plants. Although sucrose enhanced root elongation in young WT seedlings, this enhance- ment did not occur in osdof11 seedlings due to reduced sucrose uptake. Sugar transport rate analyses revealed that less sugar was transported in osdofll plants than in the WT. Expression of four Sucrose Transporter （SUT） genes-OsSUT1, OsSUT3, OsSUT4, and OsSUT5-as well as two Sugars Will Eventually be Exported Transporters （SWEET） genes, OsSWEETll and OsSWEET14, was altered in various organs of the mutant, including the leaves. Chromatin immunoprecipitation assays showed that OsDOFll directly binds the promoter regions of SUT1, OsSWEETll, and OsSWEET14, indicating that the expression of these transporters responsible for sucrose transport via apopiastic loading is coordinately controlled by OsDOFll. We also observed that osdofll mutant plants were less susceptible to infection byXanthomonas oryzae pathovar oryzae, suggesting that OsDOFll participates in sugar distribution during pathogenic in- vasion. Collectively, these results suggest that OsDOFll modulates sugar transport by regulating the expression of both SUT and SWEET genes in rice.

关键词： OsDOF11 phloem loading rice SUT SWEET Xanthomonas oryzae

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Recent progress on MOF/MXene nanoarchitectures:A new era in coordination chemistry for energy storage and conversion

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Journal of Energy Chemistry 2023年第11期86卷 409-436,I0009页

作者： Sada Venkateswarlu Sowjanya Vallem Muhammad Umer N.V.V.Jyothi Anam Giridhar Babu Saravanan Govindaraju Younghu Son Myung jong Kim Minyoung yoon Department of Chemistry and Green-Nano Materials Research Center Kyungpook National UniversityDaegu 41566Republic of Korea Department of Chemistry Gachon UniversitySeongnam 1320Republic of Korea Department of Physics Gachon UniversitySeongnam 13120Republic of Korea Center for Superfunctional Materials Department of ChemistryUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemistry Sri Venkateswara UniversityTirupati 517502Andhra PradeshIndia Department of Civil Engineering Yeungnam UniversityGyeongsan 38541GyeongbukRepublic of Korea Department of Bionanotechnology Gachon UniversitySeongnam 13120Republic of Korea

The development of urbanization and industrialization leads to rapid depletion of fossil ***,the production of fuel from renewable resources is highly *** energy conversion and storage is a benign technique with reliable output and is *** an exceptional electrochemical catalyst with tunable properties like a huge specific surface area,porous channels,and abundant active sites is critical ***,Metal-organic frameworks(MOFs)and two-dimensional(2D)transition-metal carbides/nitrides(MXenes)have been extensively investigated in the field of electrochemical energy conversion and ***,advances in the research on MOFs are hampered by their limited structural stability and conventionally low electrical conductivity,whereas the practical electrochemical performance of MXenes is impeded by their low porosity,inadequate redox sites,and ***,researchers have been designing MOF/MXene nanoarchitectures to overcome the limitations in electrochemical energy conversion and *** review explores the recent advances in MOF/MXene nanoarchitectures design strategies,tailoring their properties based on the morphologies(0D,1D,2D,and 3D),and broadening their future opportunities in electrochemical energy storage(batteries,supercapacitors)and catalytic energy conversion(HER,OER,and ORR).The intercalation of MOF in between the MXene layers in the nanoarchitectures functions synergistically to address the issues associated with bare MXene and MOF in the electrochemical energy storage and *** review gives a clear emphasis on the general aspects of MOF/MXene nanoarchitectures,and the future research perspectives,challenges of MOF/MXene design strategies and electrochemical applications are highlighted.

关键词： Metal-organicframework MXene MoF/MXene nanoarchitecture Battery Supercapacitor Electrochemical catalysis

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Randomized controlled trial of sodium phosphate tablets vs polyethylene glycol solution for colonoscopy bowel cleansing

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World Journal of Gastroenterology 2014年第42期20卷 15845-15851页

作者： yoon Suk Jung Chang Kyun Lee Hyo jong Kim Chang Soo Eun Dong Soo Han Dong Ⅱ Park Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Internal Medicine Kyung Hee University School of Medicine Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine

AIM: To compare efficacy, patient compliance, acceptability, satisfaction, safety, and adenoma detection rate of sodium phosphate tablets (NaP, CLICOLONTM) to a standard 4 L polyethylene glycol (PEG) solution for bowe... 详细信息

关键词： Sodium phosphate tablets Polyethylene glycol Colonoscopy Bowel preparation

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