检索结果-南通市图书馆

Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim Joon-Tae Kim Ji sung Lee Beom Joon Kim jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi sun Oh Dong-Eog Kim Wi-sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial

引用

Chinese Journal of Cancer 2017年第11期36卷 609-617页

作者： Kyung-hee Lee Tae Won Kim Jung-Hun Kang Jin-Soo Kim Jin-Seok Ahn sun-Young Kim Hwan-Jung Yun Young-Jun Eum sung Ae Koh Min Kyoung Kim Yong Sang Hong Jeong Eun Kim Gyeong-Won Lee Department of Hematology-Oncology Yeungnam University Medical Center Daegu 42415 South Korea Department of Oncology Asan Medical Center University of Ulsan Seoul 05505 South Korea Department of Hematology-Oncology Gyeongsang National University Hospital Jinju 52727 South Korea Department of Internal Medicine SMG-SNU Boramae Medical Center Seoul 07061 South Korea Division of Hematology-Oncology Department of Medicine Samsung Medical Center Seoul 06351 South Korea Department of Hematology.Oncology National Cancer Center Ilsan 10408 South Korea Department of Hematology-Oncology Chungnam National University Hospital Daejeon 35015 South Korea Medical Affairs Mundipharma Korea Ltd Seoul 04637 South Korea Department of Oncology Asan Medical Center University of Ulsan College of Medicine 388.1 Pungnap-dong Songpa-gu Seoul 138.736 South Korea

Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean ***: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 *** primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety ***: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety ***: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatmen

关键词： Constipation Naloxone Oxycodone Quality of life Safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Focused-Ion-Beam Induced Paramagnetic Defects in FAMn:PbI3 Perovskite Films

引用

Advances in Chemical Engineering and Science 2022年第2期12卷 87-95页

作者： Nam Joong Jeon Jangwon Seo Yanghee Kim Ji Yeong Lee Sugyeong Hong sun hee Kim Jung-Keun Lee Division of Advanced Materials Korea Research Institute of Chemical Technology Daejeon Korea Advanced Analysis Center Korea Institute of Science and Technology Seoul Korea Western Seoul Center Korea Basic Science Institute Seoul Korea Physics Department Division of Liberal Arts & Sciences Hanil University & PTS Wanju Korea

FAMn:PbI3 perovskite films were synthesized and probed mainly through electron spin resonance (ESR) spectroscopy. FAMn:PbI3 with low (~1%) Mn concentration showed a hyperfine sextet line originated from Mn++ ions. FAMn:PbI3 with high (10%) Mn concentration showed broad resonance (~500 G peak-to-peak linewidth). However, after bombardment of FAMn:PbI3 with high Mn concentration by focused ion beams (FIB), a sharp ESR peak appeared. The peak-to-peak linewidth (ΔHpp) was ~8 G regardless of the temperature. The FIB-induced defect showed Curie behavior at low temperatures (5 K - 50 K), which indicates the presence of localized electrons at the defect sites at low temperatures. The g-value increased from g = 2.0002 to 2.0016 as the temperature increased from 5 K to 50 K. Together with the ongoing search for electron spin echo (ESE), this could potentially provide a platform for realizing magnetic bits, information storage, and increased manipulation speed.

关键词： Perovskite Manganites FIB Paramagnetic Spins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of clusterin Expression by Neuronal Cell Death in Zebrafish

引用

Journal of Genetics and Genomics 2014年第11期41卷 583-589页

作者： Yun-Mi Jeong Tae-Eun Jin Jung-Hwa Choi Mi-sun Lee Hyun-Taek Kim Kyu-Seok Hwang Doo-Sang Park Hyun-Woo Oh Joong-Kook Choi Vladimir Korzh Melitta Schachner Kwan-hee You Cheol-hee Kim Department of Biology Chungnam National University Korea Research Institute of Bioscience and Biotechnology Department of Biochemistry College of MedicineChungbuk National University Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers University Center for Neuroscience Shantou University Medical College

Clusterin, a protein associated with multiple functions, is expressed in a wide variety of mammalian tissues. Although clusterin is known to be involved in neurodegenerative diseases, ageing, and tumorigenesis, a detailed analysis of the consequences of gain- or loss-of- function approaches has yet to be performed to understand the underlying mechanisms of clusterin functions. Since clusterin levels change in neurological diseases, it is likely that clusterin contributes to cell death and degeneration in general. Zebrafish was investigated as a model system to study human diseases. During development, zebrafish clusterin was expressed in the notochord and nervous system. Embryonic overexpression of clusterin by mRNA microinjection did not affect axis formation, whereas its knock-down by anti-sense morpholino treatment resulted in neuronal cell death. To analyze the function of clusterin in neurodegeneration, a transgenic zebrafish was investigated, in which nitroreductase expression is regulated under the control of a neuron-specifc huC promoter which is active between the stages of early neuronal precursors and mature neurons. Nitroreductase turns metronidazole into a cytotoxic agent that induces cell death within 12 h. After metronidazole treatment, transgenic zebrafish showed neuron-specific cell death. Interestingly, we also observed a dramatic induction of clusterin expression in the brain and spinal cord in these fish, suggesting a direct or indirect role of clusterin in neuronal cell death and thus, more generally, in neurodegeneration.

关键词： Clusterin Neuronal cell death Neurodegeneration Zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of gynecologic oncologist availability on ovarian cancer mortality

引用

World Journal of Obstetrics and Gynecology 2014年第2期3卷 71-77页

作者： Sherri L Stewart Darryl Cooney Shawn Hirsch Lauren Westervelt Thomas B Richards sun hee Rim Cheryll C Thomas Division of Cancer Prevention and Control Centers for Disease Control and Prevention Atlanta GA 30341 United States Sci Metrika LLC Research Triangle Park North Carolina NC 27703 United States

AIM: To determine the association between the distribution of gynecologic oncologist(GO) and populationbased ovarian cancer death rates. METHODS: Data on ovarian cancer incidence and mortality in the United States was supplemented with United States census data, and analyzed in relation to practicing GOs. GO locations were geocoded to link association between county variables and GO availability. Logistic regression was used to measure areas of high and low ovarian cancer mortality, adjusting for contextual variables. RESULTS: Practicing GOs were unevenly distributed in the United States, with the greatest numbers in metropolitan areas. Ovarian cancer incidence and death rates increased as distance to a practicing GO increased. A relatively small number(153) of counties within 24 miles of a GO had high ovarian cancer death rates compared to 577 counties located 50 or more miles away with high ovarian cancer death rates. Counties located 50 or more miles away from a GO practice had an almost 60% greater odds of high ovarian cancer mortality compared to those with closer practicing GOs(OR = 1.59, 95%CI: 1.18-2.15). CONCLUSION: The distribution of GOs across the United States appears to be significantly associated with ovarian cancer mortality. Efforts that facilitate outreach of GOs to certain populations may increase geographic access.

关键词： Ovarian cancer Gynecologic oncologists Mortality Access to care

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Raman microspectrometry, FT-IR and inclusion characteristics of gem garnets from Tanzania and Madagascar

引用

Journal of Geoscientific Research in Northeast Asia 2004年第2期7卷 125-135页

作者： Sang-kon Kim Maeng-eon Park Seung-gyun Baek Kyu-youl sung sun-ok Kim hee-yul Park Department of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaDepartment of Environmental Geoscience Pukyong National University Busan 608-737 KoreaMinerals and Materials Processing Division Korea Institute of Geoscience and Mineral Resources Daejeon 305-350 KoreaSchool of Gemology Identification & Dealer Open Cyber University Seoul 110-750 Korea

Chemical composition, Raman microspectrometry, and Fourier transform infrared(FT-IR)and SEM-CL (Cathodluminescence)analyses are carried out for Tanzania and Madagascar garnets for locality identification. Inclusion study was sustained after electron probe microanalysis(EPMA). Needle-like illmenites, apatites and zircons were the most common solid inclusions in Tanzania garnets. Madagascar garnets revealed rutile needles and apatites were also observed, but differences in size, shape and distribution patterns were noticed compared to Tanzania garnets. Tanzania garnets exhibited all types of observable fluid inclusions such as"fingerprint"pattern, called Type I-A, liquid-only(L) single phase fluid inclusion, called Type I-B and Type II-A(L+S), Type II-B(L+V)and Type III-A(L+Sylvite+S), Type III-B(L+S+V), while no more than two phase fluid inclusions found in both Madagascar and Korea garnets even if all examined garnets from three localities retained"fingerprint"features, so called, partially healed fractures, in common. Chemical composition, Raman microspectrometry and Fourier transform infrared(FT-IR)analysis taken turned out to be useful methods for the purpose of this study. Using consequences of SEM-CL and inclusion study, accordingly, the locality identification of gem-quality garnets is capable of being available in further application for other kinds of gemstones.

关键词：宝石石榴石局部鉴定 SEM-CI 拉曼分光计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stevens-Johnson Syndrome and Hypothermia Associated with Anti-tuberculosis Medication in a Patient with Heart Failure

引用

Chinese Medical Journal 2015年第20期128卷 2837-2838页

作者： Sang-Ok Jung Min-Ji Cho Dong-II Park sun-Young Kim Ju-Ock Kim sung-Soo Jung hee-sun Park Jeong-Eun Lee Jae-Young Moon Chae-Uk Chung Department of Internal Medicine Division of Pulmonology and Critical Care Medicine College of Medicine Chungnam National University Hospital Jung-gu Daejeon 301-721 Korea

To the Editor： Although rare, multiple adverse events associated with anti-tuberculosis （TB） medication can occur simultaneously in patients with underlying diseases. Here, we describe a 76-year-old man with several preexisting disorders in whom anti-TB medication caused multiple, simultaneous adverse events, including Stevens-Johnson syndrome （SJS）, hypothermia, and lactic acidosis.

关键词： Stevens-Johnson综合征低温钙调蛋白结合蛋白质类结核磷蛋白磷酸酶类酸中毒乳酸性心力衰竭

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Alternative Path for the Preparation of Triacetylcellulose from Unrefined Biomass

引用

Advances in Chemical Engineering and Science 2015年第1期5卷 33-42页

作者： hee Kyung Lim Ha Young Song Dal Rye Kim Jeong Ho Ko sun Ah Lee Kee-In Lee In Taek Hwang Biorefinery Research Group Green Chemistry Division Korea Research Institute of Chemical Technology Daejeon Republic of Korea Department of Green Chemistry and Environmental Biotechnology University of Science & Technology Daejeon Republic of Korea

An alternative path for the preparation of triacetylcellulose (TAC) from unrefined biomass Palm Empty Fruit Bunch (EFB) has been found with environmental benefits. The method comprises separation and regeneration of cellulose from lignocellulosic biomass dissolved in ionic liquid BMIMCl, and also modification of cellulose to TAC. The triacetylcellulose with a degree of substitution of 2.93 was obtained by the reaction of acetic anhydride at 55。C with drastically reducing number of steps currently required to produce this derivative from raw materials itself. TAC was characterized using NMR analysis. The triacetate cellulose is typically used for the creation of fibers and film base.

关键词： Ionic Liquid Palm Empty Fruit Bunch (EFB) Triacetylcellulose (TAC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model

引用

Chinese Journal of Natural Medicines 2017年第3期15卷 192-201页

作者： JANG sun-hee PARK Jisang KIM Sae-Hae CHOI Kyung-Min KO Eun-Sil CHA Jeong-Dan LEE Young-Ran JANG Hyonseok JANG Yong-Suk Department of Molecular Biology and Institute for Molecular Biology and Genetics Chonbuk National UniversityJeonju 54896Korea Department of Bioactive Material Sciences and Research Center of Bioactive Materials Chonbuk National UniversityJeonju 54896Korea Department of Efficacy Research Institute of Jinan Red GinsengJinan 55442Korea Department of Mathematics Sogang UniversitySeoul 04107Korea Department of Oral Maxillofacial Surgery Korea University Ansan HospitalAnsan 15355Korea

Red ginseng is a well-known alternative medicine with anti-inflammatory *** exerts pharmacological effects through the transformation of saponin into metabolites by intestinal *** that intestinal microflora vary among individuals,the pharmacological effects of red ginseng likely vary among *** order to produce homogeneously effective red ginseng,we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium(DSS)-induced colitis model in *** analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis,compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics *** analysis of the levels of serum IL-6 and TNF-α,inflammatory biomarkers that are increased at the initiation stage of colitis,were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control *** levels of inflammatory cytokines and mR NAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated ***,oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model,suggesting that it can be used as a uniformly effective red ginseng product.

关键词： Colitis Fermentation Inflammation Probiotics Red ginseng

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis

引用

World Journal of Gastroenterology 2013年第40期19卷 6842-6848页

作者： Jeong Ah Hwang sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung Division of Gastroenterology and Hepatology Department of Internal MedicineKonyang University College of MedicineDaejeon 302-718South Korea Department of Diagnostic Radiology Konyang University College of MedicineDaejeon 302-718South Korea

AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic ***:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ***:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan.

关键词： Acute abdomen Differential diagnosis Appendix epiploica Colonic diverticulitis Multidetector computed tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：