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Is burnout a mediating factor between sharps injury and workrelated factors or musculoskeletal pain?

World Journal of Clinical Cases 2021年第25期9卷 7391-7404页

作者： Yong-Hsin Chen Chin-Feng Tsai Chih-jung Yeh Gwo-Ping jong Department of Public Health Chung Shan Medical UniversityTaichung 40201Taiwan Department of Occupational Safety and Health Chung Shan Medical University HospitalTaichung 40201Taiwan Division of Cardiology Department of Internal MedicineChung Shan Medical University HospitalTaichung 40201Taiwan School of Medicine Chung Shan Medical UniversityTaichung 40201Taiwan Department of Internal Medicine Chung Shan Medical University Hospital and Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Burnout,musculoskeletal pain,and sharps injuries(SIs)affect medical *** To establish a model between SIs,burnout,and the risk factors to assess the extent to which burnout affects *** This questionnaire was used for an observational and cross-sectional study,which was based on members at a hospital affiliated with a medical university in Taichung,Taiwan,in *** valid responses constituted 68.5%(1734 of 2531).The items were drawn from the Nordic Musculoskeletal Questionnaire and Copenhagen burnout inventory and concerned work experience,occupational category,presence of chronic diseases,sleep duration,overtime work,and work *** analysis,chi-square test,Fisher exact test,Multiple linear,logistic regression and Sobel test were *** present analyses were performed using SAS Enterprise Guide 6.1 software(SAS Institute Inc.,Cary,NC,United States),and significance was set at P Q3) and highwork-related burnout (> Q3) mediated the relationship between SIs and frequentlower limb pain. Similarly, frequent lower limb pain mediated the relationship ofSIs with high personal and high work-related burnout. High personal and highwork-related burnout mediated the relationships of SIs with overtime work andirregular shift work. The mediating model provides strong evidence of anassociation between mental health and *** was determined to contribute to SIs occurrence;specifically, it mediatedthe relationships of SIs with frequent musculoskeletal pain, overtime work, andirregular shift work.

关键词： Personal burnout Work-related burnout Sharps injuries Musculoskeletal pain Mediating factor Overtime work

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Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-,mitogen-activated protein kinase-,and Nrf2-dependent pathway

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World Journal of Gastroenterology 2020年第3期26卷 291-306页

作者： Su Hyuk Ko jong Ik Jeon Hyun Ae Woo jung Mogg Kim Department of Microbiology and Department of Biomedical Science Hanyang University College of Medicine and Graduate School of Biomedical Science and EngineeringSeoul 04763South Korea Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760South Korea

BACKGROUND Enterotoxigenic Bacteroides fragilis(ETBF)causes colitis and diarrhea,and is considered a candidate pathogen in inflammatory bowel diseases as well as colorectal *** diseases are dependent on ETBF-secreted toxin(BFT).Dendritic cells(DCs)play an important role in directing the nature of adaptive immune responses to bacterial infection and heme oxygenase-1(HO-1)is involved in the regulation of DC *** To investigate the role of BFT in HO-1 expression in *** Murine DCs were generated from specific pathogen-free C57BL/6 and Nrf2−/−knockout *** were exposed to BFT,after which HO-1 expression and the related signaling factor activation were measured by quantitative RT-PCR,EMSA,fluorescent microscopy,immunoblot,and *** HO-1 expression was upregulated in DCs stimulated with *** BFT activated transcription factors such as NF-κB,AP-1,and Nrf2,activation of NF-κB and AP-1 was not involved in the induction of HO-1 expression in BFT-exposed ***,upregulation of HO-1 expression was dependent on Nrf2 activation in ***,HO-1 expression via Nrf2 in DCs was regulated by mitogenactivated protein kinases such as ERK and ***,BFT enhanced the production of reactive oxygen species(ROS)and inhibition of ROS production resulted in a significant decrease of phospho-ERK,phospho-p38,Nrf2,and HO-1 CONCLUSION These results suggest that signaling pathways involving ROS-mediated ERK and p38 mitogen-activated protein kinases-Nrf2 activation in DCs are required for HO-1 induction during exposure to ETBF-produced BFT.

关键词： Bacteroides fragilis enterotoxin Dendritic cells Heme oxygenase-1 Mitogen-activated protein kinases Nrf2 Signaling

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Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

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World Journal of Gastroenterology 2014年第45期20卷 17084-17091页

作者： Mi Na Kim Seong-Joon Koh jung Mogg Kim jong Pil Im Hyun Chae jung Joo Sung Kim Seoul National University Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Microbiology Hanyang University College of Medicine Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

AIM: To investigate the effect of Clostridium difficile (C. difficile) infection in an interleukin 10-deficient (IL-10-/-) mouse model of inflammatory bowel disease.

关键词： Clostridium difficile Inflammatory bowel disease Interleukin 10-deficient mice Interferon-γ Colitis

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Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis

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Cellular & Molecular Immunology 2019年第11期16卷 851-867页

作者： Yong-Bae Kim Young-Ho Ahn Ji-Hae jung Ye-Ji Lee Jin-hwa Lee Jihee Lee Kang Tissue Injury Defense Research Center College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Physiology College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Internal Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea

Apoptotic cell clearance by phagocytes is essential in tissue *** demonstrated that conditioned medium(CM)from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial–mesenchymal transition(EMT),migration,and invasion of cancer *** 344SQ(ApoSQ)cell-induced PPARγactivity in macrophages increased the levels of PTEN,which was secreted in *** PTEN was taken up by recipient lung cancer ***-exposed CM from PTEN knockdown cells failed to enhance PTEN in 344SQ cells,restore cellular polarity,or exert anti-EMT and anti-invasive *** CM that was deficient in PPARγligands,including 15-HETE,lipoxin A4,and 15d-PGJ2,could not reverse the suppression of PPARγactivity or the PTEN increase in 344SQ cells and consequently failed to prevent the EMT ***,a single injection of ApoSQ cells inhibited lung metastasis in syngeneic immunocompetent mice with enhanced PPARγ/PTEN signaling both in tumorassociated macrophages and in tumor ***γantagonist GW9662 reversed the signaling by PPARγ/PTEN;the reduction in EMT-activating transcription factors,such as Snai1 and Zeb1;and the antimetastatic effect of the ApoSQ ***,the injection of apoptotic lung cancer cells may offer a new strategy for the prevention of lung metastasis.

关键词： Apoptotic cell clearance EMT Metastasis Exosomal PTEN PPARγligands

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High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： jung Sub Lim Sang Bum Kim Ho-Yoon Bang Gi Jeong Cheon jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

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EXPERIMENTAL ESTIMATION OF A SCALING EXPONENT FOR TIP VORTEX CAVITATION VIA ITS INCEPTION TEST IN FULL-AND MODEL-SHIP

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Journal of Hydrodynamics 2012年第5期24卷 658-667页

作者： LEE Jeung-Hoon jung Jae-Kwon LEE Kyung-Jun HAN Jae-Moon PARK Hyung-Gil SEO jong-Soo Samsung Ship Model Basin(SSMB) Marine Research InstituteSamsung Heavy IndustriesScience TownDaejeon 305-380Korea

Tip vortex cavitation noise of marine propeller became primary concems to reduce hazardous environmental impacts from commercial ship or to keep the underwater surveillance of naval ships. The investigations of the tip vortex and its induced noise are normally conducted through the model test in a water cavitation tunnel. However the Reynolds number of model-test is much smaller than that of the full-scale, which subsequently results in the difference of tip vortex cavitation inception. Hence, the scaling law between model- and full-scales needs to be identified prior to the prediction and assessment of propeller noise in full scale. From previous researches, it is generally known that the incipient caivtation number of tip vortex can be represented as a power of the Reynolds number. However, the power exponent for scaling, which is the main focus of this research, has not been clearly studied yet. This paper deals with the estimation of scaling exponent based on tip vortex cavitation inception test in both full- and model-scale ships. Acoustical measurements as well as several kind of signal processing technique for an inception criterion suggest the scaling exponent as 0.30. The scaling value proposed in this study shows slight difference to the one of most recent research. Besides, extrapolation of model-ship noise measurement using the proposed one predicts the full-scale noise measurement with an acceptable discrepancy.

关键词： tip vortex cavitation underwater radiated noise scaling exponent

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Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults： the Fifth Korea National Health and Nutrition Examination Survey

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 39-47页

作者： hee yeon kim chang wook kim chung-hwa park jong young choi kyungdo han anwar t merchant yong-moon park division of hepatology department of internal medicinecollege of medicinethe catholic university of korea222Banpo-daeroSeocho-guSeou1 06591Republic of Korea department of biostatistics college of medicinethe catholic university of korea222Banpo-daeroSeocho-guSeou1 06591Republic of Korea department of epidemiology and biostatistics arnold school of public healthuniversity of south carolinaColumbiaSC 29208USA epidemiology branch national institute of environmental health sciencesnational institutes of healthdepartment of health and human servicesResearch Triangle ParkNC 27709USA

BACKGROUND： Sarcopenia and non-alcoholic fatty liver dis- ease （NAFLD） share similar pathophysiological mechanisms, and the relationship between sarcopenia and NAFLD has been recently investigated. The study investigated whether low skel- etal muscle mass is differentially associated with NAFLD by gender in Korean adults. METHODS： We conducted a cross-sectional analysis of the data from the Fifth Korea National Health and Nutrition Examination Survey. The skeletal muscle index （SMI） was obtained by the appendicular skeletal muscle mass divided by the weight. NAFLD was defined as a fatty liver index （FLI）〉60 in the absence of other chronic liver disease. RESULTS： Among the included subjects, 18.3% （SE： 1.4%） in men and 7.0% （SE： 0.7%） in women were classified as having FLI-defined NAFLD. Most of the risk factors for FLI-defined NAFLD showed a significant negative correlation with the SMI in both genders. Multiple logistic regression analysis showed that low SMI was associated with FLI-defined NAFLD, inde- pendent of other metabolic and lifestyle parameters in both genders [males： odds ratio （OR）=1.35; 95% confidence inter- val （CI）： 1.17-1.54; females： OR=1.36; 95% CI： 1.18-1.55]. The magnitude of the association between FLI-defined NAFLD and low SMI was higher in middle aged to elderly males （OR-1.50; 95% CI： 1.22-1.84） than in males less than 45 years of age （OR=1.25; 95% CI： 1.02-1.52） and in premenopausal females （OR=l.50; 95% CI： 1.12-2.03） than in postmenopausal females （OR-1.36; 95% CI： 1.20-1.54）.CONCLUSIONS： Low SMI is associated with the risk of FLI- defined NAFLD independent of other well-known metabolic risk factors in both genders. This association may differ ac- cording to age group or menopausal status. Further studies are warranted to confirm this relationship.

关键词： Korea National Health and Nutrition Examination Survey non-alcoholic fatty liver disease sarcopenia skeletal muscle

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Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： hwa-seung YOO,Jang-woo SHIN,jung-hyo CHO,Chang-gue SON,Yeon-weol LEE,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea College of Oriental Medicine Daejeon University Daejeon 301-724 Institute ofTraditional Medicine and Bioscience Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor

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Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs

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Neural Regeneration Research 2016年第6期11卷 994-1000页

作者： Sujeong Jang Hyong-Ho Cho Song-Hee Kim Kyung-hwa Lee Yong-Bum Cho jong-Seong Park Han-Seong Jeong Department of Physiology Chonnam National University Medical School Department of Otolaryngology Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing loss in mammals. Stem cells have been confirmed to be able to differentiate into spiral ganglion neurons. Little has been reported on adipose tissue-derived stem cells（ADSCs） for repair of injured spiral ganglion neurons. In this study, we hypothesized that transplantation of neural induced-human ADSCs（NI-h ADSCs） can repair the injured spiral ganglion neurons in guinea pigs with neomycin-induced sensorineural hearing loss. NI-h ADSCs were induced with culture medium containing basic fibroblast growth factor and forskolin and then injected to the injured cochleae. Guinea pigs that received injection of Hanks＇ balanced salt solution into the cochleae were used as controls. Hematoxylin-eosin staining showed that at 8 weeks after cell transplantation, the number of surviving spiral ganglion neurons in the cell transplantation group was significantly increased than that in the control group. Also at 8 weeks after cell transplantation, immunohistochemical staining showed that a greater number of NI-h ADSCs in the spiral ganglions were detected in the cell transplantation group than in the control group, and these NI-h ADSCs expressed neuronal markers neurofilament protein and microtubule-associated protein 2. Within 8 weeks after cell transplantation, the guinea pigs in the cell transplantation group had a gradually decreased auditory brainstem response threshold, while those in the control group had almost no response to 80 d B of clicks or pure tone burst. These findings suggest that a large amount of NI-h ADSCs migrated to the spiral ganglions, survived for a period of time, repaired the injured spiral ganglion cells, and thereby contributed to the recovery of sensorineural hearing loss in guinea pigs.

关键词： guinea ganglion repair hearing adipose injured brainstem auditory neuronal cochlear

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Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

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World Journal of Gastroenterology 2006年第41期12卷 6693-6698页

作者： jung Woo Shin Neung hwa Park Seok Won jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine Ulsan University HospitalUlsanKorea

AIM： To determine the changes of quantitative hepatitis B e antigen （HBeAg） that predicts early detection of non-response or breakthrough to long-term lamivudine （LAM） therapy. METHODS： Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 too, we retrospectively analyzed 220 patients who had received LAM more than 24 too. RESULTS： The mean duration of LAM therapy was 36 （range, 24-72） mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 （24.1%） patients. Viral breakthrough was observed in 105 （47.7%） patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg： decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non-response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 （92.5%） of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four （7.5%） had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 too, 95.2% （negative predictive value） failed to achieve HBeAg seroconversion. CONCLUSION： Almost all patients who failed to show a continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough.

关键词： Hepatitis B e antigen positive chronic hepatitis B lamivudine Quantitative HBeAg levels Non- response Breakthrough

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