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Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

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Nano Research 2018年第2期11卷 1082-1098页

作者： Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae jong hwa jung Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National University Jinju Republic of Korea School of Pharmacy Chung-Ang University Seoul Republic of Korea

Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein, we report a selective mitochondria-targeting probe 1, which was synthesized by incorporating a triphenyl phosphine with a cyanostilbene and a long alkyl chain moiety. Probe 1 was found to display fluorescence via aggregation-induced emission （AIE）. The low molecular-weight cyanostilbene-based probe 1, with and without an anticancer drug, formed a narrow homogeneous nanorod with ca. 110 nm of length or nanopartides with ca. 20 nm diameter in aqueous media. The self-assembled cyanostilbene nanoparticles （N1） selectively accumulated in the mitochondria of cancer cells and emitted fluorescence. N1 was also able to deliver an anticancer drug, doxorubicin （DOX）, to the mitochondria with high efficiency. More importantl~ N1 exhibited highly selective cytotoxicity for cancer cells over normal cells. The great potential applications of this self-assembled nanoparticle to biological systems result from its ability to aggregate in the mitochondria. This aggregation led to a significant increase in the generation of intraceUular reactive oxygen species and to a decrease in the mitochondrial membrane potential in cancer cells. Furthermore, tumor tissue uptake experiments in mice proposed that the self-assembled N1 had the ability to internalize and deliver the anticancer drug into tumor tissues effectively. Moreover, both N1 and Nl-encapsulated doxorubicin （N1-DOX） effectively suppressed tumor growth in a xenograft model in vivo. Taken together, our findings indicate that applications of N1 as a mitochondrial targeting probe, drug delivery platform, and chemotherapeutic agent provide a unique strategy for potential image-guided therapy as well as a site-specific delivery system to cancer cells.

关键词： aggregation-inducedemission,chemotherap3 drug deliver3 mitochondria-targeting,fluorescence imaging

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Time-dependent effect of combination therapy with erythropoietin and granulocyte colony-stimulating factor in a mouse model of hypoxic-ischemic brain injury

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Neuroscience Bulletin 2014年第1期30卷 107-117页

作者： Ji Hea Yu jung hwa Seo jong Eun Lee Ji Hoe Heo Sung-Rae Cho Department and Research Institute of Rehabilitation Medicine Yonsei University College of Medicine Brain Korea 21 PLUS Project for Medical Science Yonsei University Graduate Program of Nano Science and Technology Yonsei University Department of Anatomy Yonsei University College of Medicine Department of Neurology Yonsei University College of Medicine Yonsei Stem Cell Center Avison Biomedical Research CenterYonsei University College of Medicine Rehabilitation Institute of Neuromuscular Disease Yonsei University College of Medicine

Erythropoietin （EPO） and granulocyte colony- stimulating factor （G-CSF） are likely to play broad roles in the brain. We investigated the effects of combination therapy with EPO and G-CSF in hypoxic- ischemic brain injury during the acute, subacute, and chronic phases. A total of 79 C57BL/6 mice with hypoxic-ischemic brain injury were randomly assigned acute （days 1-5）, subacute （days 11-15）and chronic （days 28-32） groups. All of them were treated with G-CSF （250 μg/kg） and EPO （5 000 U/kg） or saline daily for 5 consecutive days. Behavioral assessments and immunohistochemistry for angiogenesis, neuro- genesis, and astrogliosis were performed with an 8-week follow-up. Hypoxia-inducible factor-1 （HIF-1） was also measured by Western blot analysis. The results showed that the combination therapy with EPO and G-CSF in the acute phase significantly improved rotarod performance and forelimb-use symmetry compared to the other groups, while subacute EPO and G-CSF therapy exhibited a modest improvement compared with the chronic saline controls. The acute treatment significantly increased the density of CD31^＋（PECAM-1） and a-smooth muscle actin^＋ vessels in the frontal cortex and striatum, increased BrdU^＋/PSA- NCAM^＋ neurogenesis in the subventricular zone, and decreased astroglial density in the striatum. Furthermore, acute treatment significantly increased the HIF-1 expression in the cytosol and nucleus, whereas chronic treatment did not change the HIF-1 expression, consistent with the behavioral outcomes. These results indicate that the induction of HIF-1 expression by combination therapy with EPO and G-CSF synergistically enhances not only behavioral function but also neurogenesis and angiogenesis while decreasing the astroglial response in a time- dependent manner.

关键词： erythropoietin granulocyte colony-stimulating factor hypoxia-inducible factor-1 hypoxic-ischemic brain injury

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Circulating miRNAs in Ageing and Ageing-Related Diseases

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Journal of Genetics and Genomics 2014年第9期41卷 465-472页

作者： hwa Jin jung Yousin Suh Department of Genetics and Medicine Albert Einstein College of MedicineBronxNY 11363USA Ageing Research Institute Guangdong Medical College

MicroRNAs （miRNAs） are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles （MVs）, or in complex with other factors such as RNA-binding proteins and high-density lipoprotein （HDL） particles. These cell-free, circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells. Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases. We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets.

关键词： Circulating miRNAs Ageing Ageing-related disease Biomarkers

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Patterns and determinants of plant richness by elevation in a mountain ecosystem in South Korea: area, mid-domain effect,climate and productivity

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Journal of Forestry Research 2015年第4期26卷 905-917页

作者： Chang-Bae Lee jung-hwa Chun Korea Green Promotion Agency 121 DunsanbukroSeoguDaejeon 302-831Republic of Korea Division of Forest Ecology Korea Forest Research Institute57 HoegiroDongdaemunguSeoul 130-712Republic of Korea

We examined patterns of plant species richness on an elevation gradient and evaluated the effects of cli- matic variables including mean annual temperature and precipitation, area, the mid-domain effect and productivity on species richness along two transects on Mt. Seorak, South Korea. A total of 235 plant species of 72 families and 161 genera were recorded from 130 plots along the two transects. Two different patterns, monotonic decline and a unimodal shape, were observed for woody plants with the change in elevation along the two transects, whereas multimodal patterns were observed for all plant species considered together and for herbaceous plants. Area and productivity showed significant relationships with total plant richness. Climatic variables were better predictors than other variables for variation by elevation in woody plant richness, whereas productivity was a more important variable for herbaceous plant richness. Although area was an important variable for predicting species richness pat- terns, the effects differed by transect and plant group. No empirical evidence was linked to the mid-domain *** elevational patterns may characterize different groups in the same taxon and there might be fundamental differences in the mechanisms underlying these richness patterns.

关键词： Area Climatic variables Elevationalpatterns Plant richness Productivity

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Multi-View Multi-Modal Head-Gaze Estimation for Advanced Indoor User Interaction

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Computers, Materials & Continua 2022年第3期70卷 5107-5132页

作者： jung-hwa Kim Jin-Woo Jeong Department of Computer Engineering Kumoh National Institute of TechnologyGumi39177Korea Department of Data Science Seoul National University of Science and TechnologySeoul01811Kore

Gaze estimation is one of the most promising technologies for supporting indoor monitoring and interaction ***,previous gaze estimation techniques generally work only in a controlled laboratory environment because they require a number of high-resolution eye *** makes them unsuitable for welfare and healthcare facilities with the following challenging characteristics:1)users’continuous movements,2)various lighting conditions,and 3)a limited amount of available *** address these issues,we introduce a multi-view multi-modal head-gaze estimation system that translates the user’s head orientation into the gaze *** proposed system captures the user using multiple cameras with depth and infrared modalities to train more robust gaze estimators under the aforementioned *** this end,we implemented a deep learning pipeline that can handle different types and combinations of *** proposed system was evaluated using the data collected from 10 volunteer participants to analyze how the use of single/multiple cameras and modalities affect the performance of head-gaze *** various experiments,we found that 1)an infrared-modality provides more useful features than a depth-modality,2)multi-view multi-modal approaches provide better accuracy than singleview single-modal approaches,and 3)the proposed estimators achieve a high inference efficiency that can be used in real-time applications.

关键词： Human-computer interaction deep learning head-gaze estimation indoor monitoring

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Diversity patterns and phylogenetic structure of vascular plants along elevational gradients in a mountain ecosystem, South Korea

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Journal of Mountain Science 2018年第2期15卷 280-295页

作者： CHUN jung-hwa LEE Chang-Bae Division of Forest Ecology National Institute of Forest Science Global Resources Division Korea Forestry Promotion Institute

Recently, a phylogenetic diversity and community structure analysis as complementary to species-centric approaches in biodiversity studies provides new insights into the processes of community assembly. In this study, we analyzed species and phylogenetic diversity and community structures for woody and herbaceous plants along two elevational transects on Mt. Baekhwa, South Korea. The species richness and phylogenetic diversity of woody plants showed monotonic declining patterns with increasing elevation along all transects, whereas herbaceous plants showed different patterns, such as no relationship and a reversed unimodal pattern, between the study transects. The main drivers of these patterns were climate and habitat variables for woody and herbaceous plants, respectively. In addition, the phylogenetic community structure primarily showed phylogenetic clustering regulated by deterministic processes, especially environmental filtering, such as climate or habitat factors, along the two transects, although herbaceous plants along a transect depicted phylogenetic randomness as a result of a neutral process. Our findings suggest that deterministic and neutral processes may simultaneously control the community structures along small-scale elevational gradients such as local transects, although the deterministic process may be the predominant type.

关键词： Community structure Deterministicprocess Elevational gradient Neutral process Phylogenetic diversity Species richness

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Helmet-based noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1939-1943页

作者： Mi hwa Park Min Jeong Kim Ah Jin Kim Man-jong Lee jung-Soo Kim Division of Pulmonology Department of Internal MedicineInha University HospitalIncheon 22332South Korea Division of Critical Care Medicine Department of Internal MedicineInha University HospitalIncheon 22332South Korea

BACKGROUND Noninvasive ventilation(NIV)reduces intubation rates,mortalities,and lengths of hospital and intensive care unit stays in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Helmet-based NIV is better tolerated than oronasal mask-based ventilation,and thus,allows NIV to be conducted for prolonged periods at higher pressures with minimal air *** SUMMARY A 73-year-old man with a previous diagnosis of COPD stage 4 was admitted to our medical intensive care unit with chief complaints of cough,sputum,and dyspnea of several days’*** 10 mo,he had been on oxygen at home by day and had used an oronasal mask-based NIV at *** intensive care unit admission,he breathed using respiratory accessory *** and signs of infection were detected,and infiltration was observed in the right lower lung field by chest ***,we diagnosed AECOPD by communityacquired *** admission,respiratory distress steadily deteriorated and invasive mechanical ventilation became ***,the patient refused this option,and thus,we selected helmet-based NIV as a salvage *** 3 d of helmet-based NIV,his consciousness level and hypercapnia recovered to his pre-hospitalization *** Helmet-based NIV could be considered as a salvage treatment when AECOPD patients refuse invasive mechanical ventilation and oronasal mask-based NIV is ineffective.

关键词： Acute exacerbation of chronic obstructive pulmonary disease Noninvasive ventilation Helmet Case report

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Molecular targeted therapy for hepatocellular carcinoma:Current and future

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World Journal of Gastroenterology 2013年第37期19卷 6144-6155页

作者： jung Woo Shin Young-hwa Chung Department of Internal Medicine University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center

Hepatocellular carcinoma(HCC)is one of the most frequent tumors *** majority of HCC cases occur in patients with chronic liver *** regular surveillance to detect small HCC in these patients,HCC is often diagnosed at an advanced *** HCC is highly resistant to conventional systemic therapies,the prognosis for advanced HCC patients remains *** introduction of sorafenib as the standard systemic therapy has unveiled a new direction for future research regarding HCC ***,given the limited efficacy of the drug,a need exists to look beyond *** molecular targeted agents that inhibit different pathways involved in hepatocarcinogenesis are under various phases of clinical development,and novel targets are being assessed in *** review aims to summarize the efforts to target molecular components of the signaling pathways that are responsible for the development and progression of HCC and to discuss perspectives on the future direction of research.

关键词： Hepatocellular carcinoma Targeted therapy Molecular agents Sorafenib

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Ventral hernia after high-intensity focused ultrasound ablation for uterine fibroids treatment:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11204-11209页

作者： jung-Woo Park hwa Yeon Choi Department of Obstetrics and Gynecology Dong-A University College of MedicineBusan 49201South Korea

BACKGROUND High-intensity focused ultrasound(HIFU) ablation is a minimally invasive approach in gynecology that is used to manage uterine *** this procedure is safe and effective,adverse outcomes are becoming a major *** SUMMARY We present a case of ventral hernia that occurred as a rare and delayed complication of HIFU ablation for uterine fibroids *** patient came to the hospital with abdominal bloating that occurred 6 mo after ultrasound-guided HIFU ablation for managing uterine *** ventral hernia,which occurred due to atrophied muscle layers following the procedure,was confirmed by imaging studies and intraoperative *** required a hernia repair with mesh and hysterectomy for definitive treatment of uterine *** High-intensity ultrasound ablation should be performed only on appropriate *** should be educated about potential complications of the procedure and the possibility of subsequent ***-procedural long-term follow-up for detecting delayed adverse effects is important.

关键词： Uterine fibroids High-intensity focused ultrasound ablation Conservative treatment Ventral hernia Complication Case report

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Intraoperative neurophysiological monitoring in spinal surgery

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World Journal of Clinical Cases 2015年第9期3卷 765-773页

作者： jong-hwa Park Seung-Jae Hyun Department of Neurosurgery Spine CenterSeoul National University Bundang Hospital Seoul National University College of Medicine

Recently, many surgeons have been using intraoperative neurophysiological monitoring(IOM) in spinal surgery to reduce the incidence of postoperative neurological complications, including level of the spinal cord, cauda equina and nerve root. Several established technologies are available and combined motor and somatosensory evoked potentials are considered mandatory for practical and successful IOM. Spinal cord evoked potentials are elicited compound potentials recorded over the spinal cord. Electrical stimulation is provoked on the dorsal spinal cord from an epidural electrode. Somatosensory evoked potentials assess the functional integrity of sensory pathways from the peripheral nerve through the dorsal column and to the sensory cortex. For identification of the physiological midline, the dorsal column mapping technique can be used. It is helpful for reducing the postoperative morbidity associated with dorsal column dysfunction when distortion of the normal spinal cord anatomy caused by an intramedullary cord lesion results in confusion in localizing the midline for the myelotomy. Motor evoked potentials(MEPs) consist of spinal, neurogenic and muscle MEPs. MEPs allow selective and specific assessment of the functional integrity of descending motor pathways, from the motor cortex to peripheral muscles. Spinal surgeons should understand the concept of the monitoring techniques and interpret monitoring records adequately to use IOM for the decision making during the surgery for safe surgery and a favorable surgical outcome.

关键词： Motor-evoked potentials Somatosensoryevoked potentials Intraoperative neurophysiological monitoring Direct wave Spinal surgery

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