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Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area

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Chinese Medical Journal 2017年第15期130卷 1796-1803页

作者： Joon Ha Park Tae-Kveono Lee Bing-Chun Yan Bich-Na Shin Ji Hyeon Ahn In Hye kim Jeong Hwi Cho Jae-Chul Lee In Koo Hwang jong dai kim Seongkweon Hong Young Joo Lee Moo-Ho Woll Il Jun Kang Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Traditional Chinese and Western Medicine Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou Jiangsu 225001 China Department of Physiology College of Medicine Hallym University Chuncheon 24252 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul08826 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea Department of Surgery School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Seoul 04401 Korea Department of Food Science and Nutrition Hallym University Chuncheon 24252 Korea

Background：Glehnia littoralis,as a traditional herbal medicine to heal various health ailments in East Asia,displays various therapeutic properties including antioxidant ***,neuroprotective effects of *** against cerebral ischemic insults have not yet been ***,in this study,we first examined its neuroprotective effects in the hippocampus using a gerbil model of transient global cerebral ischemia （TGCI）.Methods：Gerbils were subjected to TGCI for 5 *** extract （GLE;100 and 200 mg/kg） was administrated orally once daily for 7 days before ischemic *** was examined by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence *** was observed by immunohistochemistry for glial fibrillary acidic protein and ionized calcium-binding adapter molecule *** neuroprotective mechanisms,immunohistochemistry for superoxide dismutase （SOD） 1 and brain-derived neurotrophic factor （BDNF） was ***：Pretreatment with 200 mg/kg of GLE protected pyramidal neurons in the cornu ammonis 1 （CA1） area from ischemic insult area （F=29.770,P 〈 0.05） and significantly inhibited activationsof astrocytes （F =22.959,P 〈 0.05） and microglia （F =44.135,P 〈 0.05） in the ischemic CA1 *** addition,pretreatment with GLE significantly increased expressions of SOD1 （F =28.561,P 〈 0.05） and BDNF （F =55.298,P 〈 0.05） in CA1 pyramidal neurons of the sham-and ischemia-operated ***：Our findings indicate that pretreatment with GLE can protect neurons from ischemic insults,and we suggest that its neuroprotective mechanism may be closely associated with increases of SOD 1 and BDNF expressions as well as attenuation ofglial activation.

关键词： Antioxidant Gtial Activation Neurotrophic Factor Neuroprotection Pyramidal Neurons

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Effect of Oenanthe Javanica Extract on Antioxidant Enzyme in the Rat Liver

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Chinese Medical Journal 2015年第12期128卷 1649-1654页

作者： Choong-Hyun Lee Joon-Ha Park Jeong-Hwi Cho In-Hye kim Ji-Hyeon Ahn Jae-Chul Lee Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Eun Joo Bae II-Jun Kang Moo-Ho Won jong-dai kim Department of Pharmacy College of Pharmacy Dankook University Cheonan 330-714 South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute for Bioscience and Biotechnology Hallym University Chunchon 200-702 South Korea Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background：Oenanthe javanica （***） has been known to have high antioxidant properties via scavenging reactive oxygen *** examined the effect of *** extract （OJE） on antioxidant enzymes in the rat ***：We examined the effect of the OJE on copper,zinc-superoxide dismutase （SOD1）,manganese superoxide dismutase （SOD2）,catalase （CAT）,and glutathione peroxidase （GPx） in the rat liver using immunohistochemistry and western blot ***-Dawley rats were randomly assigned to three groups;（1） normal diet fed group （normal-group）,（2） diet containing ascorbic acid （AA）-fed group （AA-group） as a positive control,（3） diet containing OJE-fed group （OJE-group）.Results：In this study,no histopathological finding in the rat liver was found in all the experimental *** of SOD1,SOD2,CAT,and GPx immunoreactive cells and their protein levels were significantly increased in the AA-fed group compared with those in the *** the other hand,in the OJE-group,numbers of SOD1,SOD2,CAT,and GPx immunoreactive cells in the liver were significantly increased by about 190%,478%,685%,and 346%,respectively,compared with those in the *** addition,protein levels of SOD 1,SOD2,CAT,and GPx in the OJE-group were also significantly much higher than those in the ***：OJE significantly increased expressions of SOD 1 and SOD2,CAT,and GPx in the liver cells of the rat,and these suggests that significant enhancements of endogenous enzymatic antioxidants by OJE might be a legitimate strategy for decreasing oxidative stresses in the liver.

关键词： Antioxidant Enzymes Immunohistochemistry Liver Oenanthe Javanica Extract Western Blotting

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park jong-Seong Bae Taehyun Park Il Tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

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Glehnia fittoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B

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Chinese Medical Journal 2018年第6期131卷 689-695页

作者： Joon Ha Park Bich Na Shin Ji Hyeon Ahn Jeong Hwi Cho Tae-Kyeong Lee Jae-Chul Lee Yong Hwan Jeon II Jun Kang Ki-Yeon Yoo In Koo Hwang Choong Hyun Lee Yoo Hun Noh Sung-Su kim Moo-Ho Won jong dai kim Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Radiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Food Science and Nutrition Hallym University Chuncheon 24252 Korea epartment of Oral Anatomy College of Dentistry and Research Institute of Oral Biology Gangneung-Wonju National University Gangneung 25457 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seou108826 Korea Department of Pharmacy College of Pharmacy Dankook University Cheonan 31116 Korea Famenity Biomedical Research Center Famenity Inc. Gyeonggi 13837 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea

Background： Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. Methods： A total of 39 male ICR mice （12 weeks old） were randomly assigned to vehicle-treated and 100 and 200 mg/kg G. littoralis extract-treated groups （n = 13 in each group）. Vehicle and G. littoralis extract were orally administrated for 28 days. To examine neurogenic effects ofG. litmralis extract, we performed immunohistochemistry tbr 5-bromo-2-deoxyuridine （BrdU, an indicator for cell proliferation） and doublecortin （DCX, an immature neuronal marker） and double immunofluorescence staining for BrdU and neuronal nuclear antigen （NeuN, a mature neuronal marker）. In addition, we examined expressional changes of brain-derived neurotrophic factor （BDNF） and its major receptor tropomyosin-related kinase B （TrkB） using Western blotting analysis. Results： Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive （＋） and DCX＋ cells （48.0 ±3.1and 72.0 ± 3.8 cells/section, respectively） in the subgranular zone （SGZ） of the dentate gyrus （DG） and BrdU＊/NeuN＋ cells （17.0 ±1.5 cells/section） in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and YrkB （about 232% and 244% of the vehicle-treated group, respectively） were significantly increased in the DG of the mice treated with 200 mg/kg ofG. littoralis extract. Conclusion： G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases ofBDN F and TrkB proteins by G. littoralis extract treatment.

关键词： Brain-Derived Neurotrophic Factor CellProliferation Glehnia littoralis Neuroblast Differentiation Tropomyosin-Related Kinase B

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu jong Seung kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Hyperreflective photonic crystals created by shearing colloidal dispersions at ultrahigh volume fraction

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Microsystems & Nanoengineering 2024年第1期10卷 161-173页

作者： Minji kim jong Bin kim Shin-Hyun kim Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Colloidal crystallization serves as one of the most economic and scalable production methods for photonic ***,insufficient optical performance,nonuniformity and low reproducibility remain challenges for advanced high-value *** this study,we optimally formulate a photocurable dispersion of silica particles and apply shear flow to unify the orientation of the colloidal crystals,ensuring high optical performance and *** silica particles experience strong repulsion at ultrahigh volume fractions of 50%but demonstrate low mobility,leading to polycrystalline *** shear flow to the dispersions allows the silica particles to rearrange into larger crystalline domains with a unidirectional orientation along the *** shear-induced structural change produces absolute reflectivity at the stopband as high as 90%and a high transparency of 90%at off-resonant wavelengths with minimal diffusive ***,the strong interparticle repulsion ensures a uniform volume fraction of particles throughout the dispersion,reducing deviations in the optical *** intricately micropattern the photocurable dispersions using ***,the photonic films and patterns can be stacked to form multiple layers,displaying mixed structural colors and multiple reflectance peaks without sacrificing *** superior photonic materials hold promise for various optical applications,including optical components and anticounterfeiting patches.

关键词： properties. dispersion reflectivity

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Corrosion and optimum corrosion protection potential of friction stir welded 5083-O Al alloy for leisure ship

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中国有色金属学会会刊：英文版 2009年第4期19卷 898-903页

作者： Sung-Hyeon PARK jong-Shin kim Min-Su HAN Seong-jong kim Division of Maritime Transportation System Mokpo Maritime University Korea Register of Shipping Division of Marine Engineering Mokpo Maritime University

Electrochemical tests were undertaken to determine the optimum conditions in seawater for corrosion protection of friction stir-welded 5083-O Al *** trend observations show that the limiting potential that avoids the effects of hydrogen embrittlement is -1.6 V,corresponding to the crossover point between concentration polarization and activation ***,the optimum protection potential is between -1.5 and -0.7 V since the current density at these values is low in the potentiostatic *** a galvanic cell is formed in the seawater,the welds exhibit electrochemically stable *** parts in galvanic tests with various area ratios are stable and have excellent anticorrosion characteristics.

关键词：搅拌摩擦焊接保护电位海水腐蚀铝合金氧铝船舶休闲防腐

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Mechanical characteristics of fused cast basalt tube encased in steel pipe for protecting steel surface

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中国有色金属学会会刊：英文版 2009年第4期19卷 935-940页

作者： Jee-Seok WANG jong-Do kim Hee-jong YOON Division of Mechanical and Information Engineering Korea Maritime University Division of Marine System Engineering Korea Maritime University Department of Research and Development Dongdo Basalt Industry Co.Ltd

Because of the various excellent characteristics of cast basalt materials,such as,anti-corrosion,anti-wearing,good hardness,high chemical stability,of which steel may not possess,the steel-basalt composite pipes are used in severe environments for compensating the defects of *** limit of bending moment with which steel-basalt composite pipe may safely endure was calculated and the limit curvature of the composite pipe in the safe range was *** application temperature of steel-basalt pipe was examined due to a different coefficient among basalt,mortar and mild steel.

关键词：玄武岩钢管表面保护机械特性包裹熔铸化学稳定性复合管

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Corrosion characteristics of steel in seawater containing various chloride concentrations generated by electrochemical method

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中国有色金属学会会刊：英文版 2009年第B9期19卷 50-55页

作者： Seong-jong kim Seok-Ki JANG Division of Marine Engineering Mokpo Maritime University

The electro-clean system (ECS), a ballast water management system that eliminates harmful aquatic organisms in ship ballast water via electrochemically produced chloride, was developed. The current density for potentiostatic experiments subjected to seawater with an applied potential (-0.1 V) at various TRC concentrations (2×10-6, 6×10-6, 10×10-6, and 15×10-6) have similar results. The current density at -0.1 V has the highest value compared with that at -0.7 V and -0.4 V. For all concentrations, the current density increases with increasing applied potential.

关键词：含氯化物电化学方法腐蚀特性浓度海水船舶压载水钢铁电流密度

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Electrochemical Characteristics in Seawater for Cold Thermal Spray-Coated Al-Mg Alloy Layer

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 727-734页

作者： Il-Cho Park Seong-jong kim Division of Marine Engineering Mokpo National Maritime University

For corrosion protection of carbon steel in a marine environment,cold arc thermal spray coating was applied to the surface with Al and Al-Mg alloy *** surface hardness of Al and Al-Mg thermal spray coatings increased with Mg *** the various electrochemical experiments were carried out to evaluate corrosion damage characteristics of the thermal spray coating *** Al and Al-Mg thermal spray coating layers presented negative potentials compared to carbon steel in corrosion potential *** an anodic polarization experiment revealed a tendency of activation polarization with no ***,the corrosion damage of the thermal spray coating layer in galvanostatic experiment was observed mainly at the defect area,and the Al-3Mg thermal spray coating layer presented less surface damages than *** addition,the Al-3Mg thermal spray coating layer showed the lowest corrosion rate while having a sufficient driving voltage for cathodic corrosion ***,it is an optimal thermal spray material for sacrificial anode.

关键词： Corrosion protection Carbon steel Arc thermal spray coating Al-Mg alloy Marine environment

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