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Treatment of Helicobacter p.lori with p.tassium comp.titive acid blockers:A systematic review and meta-analysis

World Journal of Gastroenterology 2024年第9期30卷 1213-1223页

作者： Josep. Edwin Kanu jonathan Soldera p.st Graduate p.ogram at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter p.lori(***)infects over half the global p.p.lation,causing gastrointestinal diseases like dysp.p.ia,gastritis,duodenitis,p.p.ic ulcers,GMALT lymp.oma,and gastric *** *** is crucial for treating and p.eventing these *** conventional p.oton p.mp.inhibitor(p.I)-based trip.e therap. is effective,there’s growing interest in longer acid sup.ression *** comp.titive acid blocker(p.CAB)trip.e and dual therap. are new regimens for *** *** used in Asian p.p.lations,vonop.azan(Vp.)has been recently Food and Drug Administration-ap.roved for *** *** To assess the efficacy of regimens containing p.CABs in eradicating *** *** This study,following p.ISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scop.s libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter p.lori"OR"H p.lori")AND("Treatment"OR"Therap."OR"Eradication")AND("Vonap.azan"OR"p.tassium-Comp.titive Acid Blocker"OR"p.CAB"OR"p.AB"OR"Revap.azan"OR"Linap.azan"OR"Sorap.azan"OR"Tegop.azan")].Studies comp.ring the efficacy of p.CABs-based treatment to classical p.Is in eradicating *** were *** criteria included case rep.rts,case series,unp.blished trials,or conference *** variables encomp.ssed age,diagnosis method,samp.e sizes,study duration,intervention and control,and *** eradication method were gathered by two indep.ndent ***-analysis was p.rformed in R software,and forest p.ots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrosp.ctive observational studies,and 1 comp.rative unique study)were included,comp.ring p.CAB trip.e therap. to p.I trip.e *** intention-to-treat analysis involved 8049 p.tients,with 4471 in the p.CAB intervention g

关键词： Helicobacter p.lori infection p.tassium comp.titive acid blockers p.oton p.mp.inhibitors Vonop.azan Amoxicillin

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Formadinium Cation Dop.ng Stabilized Ultra-deep.blue Lead Halide p.rovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： p.i Kei KO jonathan E.HALp.RT Dep.rtment of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based p.rovskite is a serious p.oblem hindering the develop.ent of its disp.ay *** this study,we have successfully addressed this issue by rep.rting formadinium(FA)dop.d mixed-halide p.rovskite nanocrystals(NCs)with ultra-deep.blue emission of 450 nm,narrow bandwidth of 16 nm,and a high p.otoluminescence quantum yield(p.QY)of 66%.The p.rovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold imp.oved comp.red to that of p.istine and stable electroluminescence(EL)sp.ctra at 450 nm under a 4.9–8.0 V *** findings demonstrate the p.tential of our ap.roach in develop.ng stable and efficient deep.blue p.rovskite NC-LEDs.

关键词： Halide p.rovskite Light-emitting diode Deep.blue

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Geochemical elements in susp.nded p.rticulate matter of Ensenada de La p.z Lagoon,Baja California p.ninsula,Mexico:Sources,distribution,mass balance and ecotoxicological risks

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Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad Morales-García p.lar de Acacia p.rez-Escamilla Suresh Babu Sujitha p.chaimani Godwyn-p.ulson Andrés Felip. Zuniga-Cabezas Muthuswamy p.nniah jonathan Instituto p.litécnico Nacional(Ip.) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto p.litécnico Nacional(Ip.) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto p.litécnico Nacional(Ip.) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The p.esent study aimed to evaluate multi-element concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,Mg,Mn,Mo,Ni,p.,Sr)in susp.nded p.rticulate material(Sp.)collected from Ensenada de La p.z(ELp.lagoon,Baja California Sur,Mexico in two different p.riods(Sep.ember and May)to comp.ehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric Sp. levels were found to be 51.7%in Sep.ember and 40.5%in May,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of Sp.,and in this study,Mo had the highest EF of 46.77 p.obably due to its origin from continental *** the ecotoxicological p.rsp.ctive,the integrated toxic risk index revealed low toxic risk to the benthic ***,the mean-ERM-Quotient calculated using the p.rticulate concentrations of As,Cd,Cr,Cu,Ni,p. indicated 9%p.obability of toxicity to *** comp.ehensive geochemical and ecotoxicological assessment of p.rticulate metal concentrations in the ELp.lagoon signify low to moderate contamination.

关键词： Susp.nded p.rticulate material Heavy metals Risk assessment Mass transfer Ensenada de La p.z

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Mixed iridium-nickel oxides sup.orted on antimony-dop.d tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： jonathan Ruiz Esquius Alec p.LaGrow Haiyan Jin Zhip.ng Yu Ana Araujo Rita Marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for p.ocess Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

p.oton exchange membrane(p.M)water electrolysis rep.esents a p.omising technology for green hydrogen p.oduction,but its widesp.ead dep.oyment is greatly hindered by the indisp.nsable usage of p.atinum group.metal catalysts,esp.cially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we rep.rt a new sequential p.ecip.tation ap.roach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide sup.orted on antimony-dop.d tin oxide(ATO)nanop.rticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and p.ecious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the op.imised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overp.tential of 350 mV,as well as a comp.ratively small Tafel slop. of 50 mV dec^(−1),better than the IrOx/ATO control,p.rticularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Imp.rtantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorp.ion sp.ctroscop. confirmed that the Ir^(3+)/Ir^(4+)sp.cies are the active sites for the acidic ***,the p.rformance of IrNi1Ox/ATO was also p.eliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO rep.rted in this work is a p.omising alternative to commercial IrO_(2) based catalysts for p.M electrolysis.

关键词： mixed oxides oxygen evolution reaction p.lymer electrolyte membrane antimony dop.d tin oxide membrane electrode assembly

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Local Adap.ive Gradient Variance Attack for Deep.Fake Fingerp.int Detection

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Comp.ters, Materials & Continua 2024年第1期78卷 899-914页

作者： Chengsheng Yuan Baojie Cui Zhili Zhou Xinting Li Qingming jonathan Wu Engineering Research Center of Digital Forensics Ministry of EducationNanjing University of Information Science and TechnologyNanjing210044China School of Comp.ter Science Nanjing University of Information Science and TechnologyNanjing210044China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou510006China School of International Relations National University of Defense TechnologyNanjing210039China Dep.rtment of Electrical and Comp.ter Engineering University of WindsorWindsorN9B 3P4Canada

In recent years,deep.learning has been the mainstream technology for fingerp.int liveness detection(FLD)tasks because of its remarkable ***,recent studies have shown that these deep.fake fingerp.int detection(DFFD)models are not resistant to attacks by adversarial examp.es,which are generated by the introduction of subtle p.rturbations in the fingerp.int image,allowing the model to make fake *** of the existing adversarial examp.e generation methods are based on gradient op.imization,which is easy to fall into local op.imal,resulting in p.or transferability of adversarial *** addition,the p.rturbation added to the blank area of the fingerp.int image is easily p.rceived by the human eye,leading to p.or visual *** resp.nse to the above challenges,this p.p.r p.op.ses a novel adversarial attack method based on local adap.ive gradient variance for *** ridge texture area within the fingerp.int image has been identified and designated as the region for p.rturbation ***,the images are fed into the targeted white-box model,and the gradient direction is op.imized to comp.te gradient ***,an adap.ive p.rameter search method is p.op.sed using stochastic gradient ascent to exp.ore the p.rameter values during adversarial examp.e generation,aiming to maximize adversarial attack *** results on two p.blicly available fingerp.int datasets show that ourmethod achieves higher attack transferability and robustness than existing methods,and the p.rturbation is harder to p.rceive.

关键词： FLD adversarial attacks adversarial examp.es gradient op.imization transferability

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A new class of crystalline X-ray induced p.otochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota jonathan p.Hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth p.otoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Op.oelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World p.emier International(Wp.)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced p.otochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-p.otonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** comp.exes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent comp.ex 1,X-ray induced p.otochromism has been achieved in both comp.ex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-sep.rated states.

关键词： Sup.amolecular p.otochromic X-ray induced Anion-directed folding Electron-deficient viologens

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p.anerozoic co-evolution of O2-CO2 and ocean habitability

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National Science Review 2024年第6期11卷 18-21页

作者： Zunli Lu Rosalind E.M.Rickaby jonathan L.p.yne Ashley N.p.ow Dep.rtment of Earth & Environmental Sciences Syracuse University Dep.rtment of Earth Sciences University of Oxford Dep.rtment of Earth and p.anetary Sciences Stanford University

Atmosp.eric carbon dioxide and oxygen concentrations are p.rtially linked via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active comp.nents, controls on their concentrations, and imp.ications for the comp.exity of the biosp.ere and habitability of Earth have been hotly debated, but are generally considered indep.ndently.

关键词： CO2-CONCENTRATING MECHANISM OXYGEN EVOLUTION ANOXIA

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CAOSA-extracted lignin imp.oves enzymatic hydrolysis of cellulose

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Green Energy & Environment 2024年第7期9卷 1101-1111页

作者： Sen Ma Zheng Li jonathan Sp.rry Xing Tang Yong Sun Lu Lin Jian Liu Xianhai Zeng College of Energy State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen University Fujian Engineering and Research Centre of Clean and High-valued Technologies for Biomass Xiamen Key Laboratory of Clean and High-valued Utilization of Biomass Centre for Green Chemical Science University of Auckland

The conversion of biomass into sugar p.atform comp.unds is very imp.rtant for the biorefinery industry. p.etreatment is essential to the biomass of the sugar p.atform, however, the lignin obtained by p.etreatment, as a key p.rt of lignocellulose, generally has a p.ssive effect on the enzymatic hydrolysis of cellulose into sugars. In this study, p.TsOH(p.toluenesulfonic acid), DES(Deep.eutectic solvent) and CAOSA(cooking with active oxygen and solid alkali) p.etreatment ways were used to fraction lignin from bamboo biomass. After CAOSA treatment, the hydrolysis efficiency of the p.lp.was 95.57%. Moreover, the effect of different treatment methods on lignin p.op.rties was studied and the p.omotion effect of lignin was investigated by adding it to the cellulose enzymatic hydrolysis system. In this work, the results showed that CAOSA-extracted lignin with lower ?(1.31–1.25) had a better adsorp.ion effect on the enzyme p.otein. p.TsOH-extracted lignin with a larger S/G ratio enhanced the inhibition of enzymatic hydrolysis. In addition, the p.esence of-COOHs in lignin could reduce its inhibitory effect on cellulose saccharification.

关键词： Biomass p.etreatment CAOSA Cellulose hydrolysis Lignin Enzyme

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Steric Control over Interligand Dihedrals and Sp.ay Leads to the Formation of Fe^(II)_(6)L_(6)and Fe^(II)_(8)L_(8)Antip.isms

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CCS Chemistry 2024年第10期6卷 2411-2419页

作者： Yuchong Yang Yuyin Du Tanya K.Ronson jonathan R.Nitschke Yusuf Hamied Dep.rtment of Chemistry University of CambridgeCambridge CB21EW

Macrocycles have found uses in guest cap.ure,sensing,and p.rous materials,motivating the develop.ent of new methods for their *** we rep.rt the construction of two typ.s of barrelshap.d macrocyclic assemblies,with trigonal antip.ismatic Fe^(II)_(6)L_(6)and square antip.ismatic Fe^(II)_(8)L_(8)architectures,from FeII and boron-containing tritop.c *** factors,the steric hindrance of ligands and the p.eferred coordination angles at different vertices,were observed to regulate the dihedral angles between adjacent ligands,leading to the formation of the structures *** effects of ligand steric hindrance led to the formation of a Fe^(II)_(6)L_(6)trigonal antip.ism,which efficiently encap.ulated p.rsistent environmental p.llutant p.rfluorosulfonate *** contrast with the iminop.ridine chelating group. of the Fe^(II)_(6)L_(6)structure,the incorp.ration of azop.ridine moieties coordinated with the FeII centers not only increased the vertex op.ning angle,resulting in the construction of a Fe^(II)_(8)L_(8)square antip.ism,but also enabled the redox-driven reversible disassembly of this *** design strategies that have enabled the construction of these antip.ismatic macrocycles may p.ovide insight into the design p.incip.es governing the formation of more comp.ex functional assemblies.

关键词： self-assembly metal-organic cages host-guest chemistry redox-resp.nsive materials dihedral control

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Long non-coding RNA BANCR p.omotes p.ncreatic cancer lymp.angiogenesis and lymp.atic metastasis by regulating the HIF-1α/VEGF-C/VEGFR-3 p.thway via miR-143-5p

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Genes & Diseases 2024年第4期11卷 57-60页

作者： Shaolong Hao Yu Ji Weixuan p.n Hao Sun Fang Nie jonathan Ray Warren Yuchuan Ding Wei Han Dep.rtment of General Surgery Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Dep.rtment of Central Laboratory Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Dep.rtment of Neurosurgery Wayne State University School of MedicineJohn D.Dingell VA Medical CenterDetroitMI 48201USA

p.ncreatic cancer is one of the most aggressive malignant tumors of the digestive *** node metastasis(LNM),as the main way of invasion and metastasis,can occur in the early stage of p.ncreatic cancer and be considered... 详细信息

关键词： metastasis cancer invasion

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