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Agronomic Management Strategies to Reduce the Yield loss Associated with Spring Harvested Corn in Ontario

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American Journal of Plant Sciences 2015年第2期6卷 372-384页

作者： Kris J. Mahoney jonathan H. Klapwyk Greg A. Stewart W. Scott Jay David C. Hooker University of Guelph Ridgetown Campus Ridgetown Canada Independent Author Elora Canada Ontario Ministry of Agriculture Food and Rural Affairs Guelph Canada

Some growers in northern corn (Zea mays l.) producing regions forgo the typical autumn harvest for various reasons, but not without the risk of significant yield loss. Therefore, strategies are needed for managing the risks to yield when harvesting corn in spring. Field experiments, with various management strategies, were initiated in Ontario, Canada near Belmont and Ridgetown in 2009 and near Belmont, Ridgetown, and lucan in 2010. Management strategies investigated the use of hybrids with a range in maturity, the use of standard and reduced plant populations, and the use of a foliar fungicide applied around tasseling. The parameters examined were stay-green in autumn, lodging in spring, and grain yield, moisture, and test weight of corn harvested in autumn and spring. Standard corn production practices consist of using a full-season hybrid planted at 80,000 plants·ha-1 with no late-season fungicide application;however, if over-wintered at Belmont, corn managed using these practices resulted in a 23.1% yield loss (12.1 vs 9.3 Mg·ha-1) averaged across years when the crop was harvested in the spring. An overwintering management strategy for corn was identified, which consisted of planting at a reduced plant population (60,000 plants·ha-1) and spraying the crop with QUIlT® (azoxystrobin + propiconazole at 200 g a.i. ha-1) at the VT to R1 growth stage. Averaged across all hybrids, this strategy minimized yield losses through improvements on corn standability with only a 3.5% yield loss at Ridgetown and a 13.2% yield loss at Belmont. Furthermore, grain test weights for corn with the overwintering strategy were similar to or greater than corn overwintered with the standard production practice. However, weather conditions have the potential to overwhelm any management strategy. In spite of the favorable data indicating reduced risks with a spring harvest, lodging was still higher than expected and yield losses would likely be unacceptable for most gro

关键词： Fungicide Hybrid Plant Population lodging Stay-Green Yield

Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. leongamomlert Stephen M. Edwards jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny l. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda l. Hall lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya lophatananon Sarah l. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John l. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, lMTK2 and KlK2/3. The MSMB and KlK2/3 genes may be useful for PCa screening, and the lMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

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Distinct hippocampal pathways mediate dissociable roles of c...

中国神经科学学会第十二届全国学术会议

作者： Chun Xu Sabine Krabbe Jan Gründemann Paolo Botta jonathan P.Fadok Fumitaka Osakada Dieter Saur Benjamin F.Grewe Mark J.Schnitzer Edward M.Callaway Andreas lüthi University of Basel laboratory of Cellular Pharmacology Nagoya University

Memories about sensory experiences are tightly linked to the context in which they were formed. Memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the underlying neuronal circuits are poorly understood. By combining trans-synaptic viral tracing and optogenetic manipulation, we found that the ventral hippocampus（v HC） and the amygdala, two key brain structures encoding context and emotional experiences, interact via multiple parallel pathways. A projection from the v HC to the basal amygdala mediates fear behavior elicited by a conditioned context, whereas a parallel projection from a distinct subset of v HC neurons onto midbrain-projecting neurons in the central amygdala is necessary for context-dependent retrieval of cued fear memories. Our findings demonstrate that two fundamentally distinct roles of context in fear memory retrieval are processed by distinct v HC output pathways, thereby allowing for the formation of robust contextual fear memories while preserving context-dependent behavioral flexibility.

关键词： memory retrieval fear hippocampus amygdala rabies trans-synaptic tracing optogenetics contextual fear fear renewal

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Protein & Cell 2016年第7期7卷 538-543页

作者： Yuan-Qin Yang Wen-Jie Dong Xiao-Fei Yin Yan-Ni XU Yu Yang Jiao-Jiao Wang Su-Jing Yuan Jing Xiao jonathan Howard Delong liang Chu Hai-Neng Xu Xiu- Mei Zhou Ru-Wei Wang ling Fang Xin-Yuan liu Kang-Jian Zhang Xinyuan Institute of Medicine and Biotechnology Zhejiang Sci-Tech University Hangzhou 310018 China State Key laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Sichuan Huiyang life Science and Technology Corp. Chengdu 610021 China College of life Sciences Northwest Agriculture and Forestry University Yangling 712100 China Central China Normal University Wuhan 430079 China Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Radiation Oncology University of Pennsylvania Perelman School of Medicine 3400 Civic Center Blvd. Philadelphia PA 19104 USA Zhejiang Conba Pharmaceutical Co. Ltd Hangzhou 310018 China

Dear Editor, PD-l1, also known as CD274, plays a vital role in tumor cell related immune escape. It can be expressed on the cell surface of many solid tumors （Brahmer et al., 2012） and inhibits T cell proliferation and cytokine production by bind- ing to the Tcell surface receptor programmed death 1 （PD-1） or B7-1 （McClanahan et al., 2015）. In 2013, targeting PD-1/ PD-l1 signaling for cancer immunotherapy was selected as the No.1 scientific breakthrough of the year by the editors of Science. Interferons （IFNs） are a group of pleiotropic cytokines, demonstrated anti-viral, anti-tumor, and immune regulatory functions （York et al., 2015）. Type I interferon binds a heterodimeric receptor composed of IFNAR1 and IFNAR2. This activates a canonical JAK/STAT signaling pathway that ultimately induces a set of interferon-stimulated genes to exert its biological activity （Ejlerskov et al., 2015）. Recently, PD-l1 was reported to be downstream of IFN signaling in human oral squamous carcinoma, melanoma, and human acute myeloid leukemia blast cells （Chen et al., 2012; Furuta et al., 2014; Kronig et al., 2014）.

关键词： B16F10 Cell Acute Myeloid leukemia Blast Murine B16F10 Melanoma Cell B16F10 Tumor Cell Syngeneic Splenocytes

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白松种源试验对整枝的反应

湖南林业科技 1984年第4期 56-58页

作者： jonathan W.Wright 李果明

白松(Pinus strobus l.)是一种能生产优质木材的速生树种。在原生林内能产生无枝茎干(净材)。然而,由于自然整枝能力低,大多数人工林内生长的白松,很少产生净材。即使小的枝条也会保存20年,产生净材可能需要60年。在优良

关键词：白松种源试验自然整枝速生树种优质木材针叶树种树干直径茎干平均树高轮伐期

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冰湖溃决洪水威胁高亚洲基础设施（英文）

Science Bulletin 2023年第13期 1361-1365页

作者：聂勇邓纤 Hamish D.Pritchard jonathan l.Carrivick Farooq Ahmed Christian Huggel 刘丽君王文勒斯木初 Jida Wang 张华宇张波吕其元张镱锂 Mountain Science Data Center Institute of Mountain Hazards and Environment Chinese Academy of Sciences University of Chinese Academy of Sciences British Antarctic Survey School of Geography and waterleeds University of Leeds Gilgit-Baltistan Disaster Management Authority Department of Geography University of Zürich College of Hydrology and Water Resources Hohai University Department of Geography and Geospatial Sciences Kansas State University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

青藏高原及其周边地区冰湖灾害频发,目前对其灾害特征及导致的破坏缺乏系统的分析.本研究旨在揭示冰湖灾害过去和未来的变化趋势及其对基础设施造成的影响,以指导区域及跨境流域冰湖灾害防控技术和策略的构建.研究梳理了1900-2022年间...

青藏高原及其周边地区冰湖灾害频发,目前对其灾害特征及导致的破坏缺乏系统的分析.本研究旨在揭示冰湖灾害过去和未来的变化趋势及其对基础设施造成的影响,以指导区域及跨境流域冰湖灾害防控技术和策略的构建.研究梳理了1900-2022年间发生的298例冰湖灾害事件,发现其呈增长的趋势,尤其是1964年以来的部分冰湖灾害严重损坏了下游基础设施,不同类型冰湖灾害在空间分布、爆发和成灾特征等方面存在明显差异.例如,西斯帕冰川阻塞湖在2019-2022年连续爆发了5次溃决洪水,最近一次冲毁了下游中巴公路的桥梁和路基,影响中巴经贸.高山区冰川冰湖变化、交通和水电等基础设施及人口增长,致使冰湖灾害风险上升.为此,重大基础设施的规划应充分考虑相关风险,建立防控措施以保障人员和基础设施安全.

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2011年ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS颅外颈动脉和椎动脉疾病患者处理指南(续前) 美国心脏病学会基金会/美国心脏协会实践指南顾问委员会、美国卒中协会、美国神经科学护理协会、美国神经外科医师协会、美国放射学学会、美国神经放射学学会?

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国际脑血管病杂志 2013年第10期 721-758页

作者： Thomas G.Brott jonathan l.Halperin Suhny Abbara J.Michael Bacharach John D.Barr Ruth l.Bush Christopher U.Cates Mark A.Creager Susan B.Fowler Gary Friday Robert H.Rosenwasser Allen J.Taylor 曲东锋陈兴洲南京脑血管疾病分册杂志社

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证...

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证据）或经导管血管造影显示同侧颈内动脉内径减少>50%[20,70,83,359]（B级证据）且预期围手术期卒中或死亡发生率低于6%,应行CEA。2对于血管内介入治疗风险中等或较低的有症状患者,当无创性成像显示同侧颈内动脉内径

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2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： lee A Fleisher Joshua A Beckman Kenneth A Brown Hugh Calkins Elliott Chaikof Kirsten E Fleischmann William K Freeman James B Froehlich Edward K Kasper Judy R Kersten Barbara Riegel John F Robb Sidney C Smith Alice K Jacobs Cynthia D Adams Jeffrey l Anderson Elliott M Antman Christopher E Buller Mark A Creager Steven M Ettinger David P Faxon Valentin Fuster jonathan l Halperin loren F Hiratzka Sharon A Hunt Bruce W lytle Rick Nishimura Joseph P Ornato Richard l Page lynn G Tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

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