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SoxC transcription factors in retinal development and regeneration

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Neural Regeneration Research 2017年第7期12卷 1048-1051页

作者： Kun-Che Chang jonathan Hertz Department of Ophthalmology School of Medicine Stanford University Palo Alto CA USA

Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells（RGCs）through complex signaling *** the mechanisms that regulate RGC development remain unclear,uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace *** we review recent studies that provide strong evidence that the Sry-related high-mobility-group C（SoxC）subfamily of transcription factors（TFs）are necessary and sufficient for axon guidance and RGC fate *** findings also uncover novel SoxC-dependent mechanisms that serve as master regulators during important steps of RGC *** example,we review work showing that SoxC TFs regulate RGC axon guidance and direction through the optic chiasm towards their appropriate targets in the *** also review work demonstrating that Sox11 subcellular localization is,in part,controlled through small ubiquitin-like post-translational modifier（SUMO）and suggest compensatory cross-talk between Sox4 and ***,Sox4 overexpression is shown to positively drive RGC differentiation in human induced pluripotent stem cells（hi PSCs）.Finally,we discuss how these findings may contribute to the advancement of regenerative and cell-based therapies to treat glaucoma and other optic nerve neuropathies.

关键词： Sox4 Soxl 1 retinal ganglion cell optic nerve regeneration SUMOylation cell transplantation stern cell

Non-exercise estimated cardiorespiratory fitness and cancer incidence:The NIH-AARP diet and health study

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运动与健康科学(英文) 2023年第6期12卷 739-746页

作者： Baruch Vainshelboim jonathan Myers Charles EMatthews Center for Tobacco Research Division of Medical OncologyDepartment of Internal MedicineThe Ohio State UniversityColumbusOH 43214USA Cardiology Division Veterans Affairs Palo Alto Health Care System/Stanford UniversityPalo AltoCA 94304USA Metabolic Epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is *** study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and *** The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline(1995–1996)(men(n=238,835)and women(n=163,713))and were followed until December 31,*** exposure variable was NEE-CRF expressed in metabolic ***-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline *** outcomes were total cancer incidence and incidence of prostate,breast,lung,and colorectal *** proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk *** During 13.7±3.2 years of follow-up(mean±SD),64,344 men and 31,315 women developed a new *** every 1-metabolic equivalent higher NEE-CRF,the hazard ratios and 95%confidence intervals(95%CIs)were 0.96(95%CI:0.94–0.97)and 0.88(95%CI:0.84–0.92)of total and colorectal cancer incidence among men,and 0.95(95%CI:0.93–0.97)and 0.94(95%CI:0.91–0.97)of total and breast cancer incidence among women,respectively(all p<0.001).NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in *** These results suggest that higher CRF levels,as assessed by the applied non-exercise estimated method,may provide preventive benefits against the development of cancer,while low CRF could potentially serve as a modifiable cancer risk *** NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complemen

关键词： Aerobic capacity Breast cancer Cancer risk Colorectal cancer VO_(2max)

ACTIVATABLE SMART PROBES FOR MOLECULAR OPTICAL IMAGING AND THERAPY

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 45-61页

作者： jonathan F.LOVELL GANG ZHENG Institute of Biomaterials and Biomedical Engineering Department of Medical Biophysics University of Toronto Division of Biophysics and Bioimaging Ontario Cancer Institute TorontoOntario M5G 1L7Canada

Recent years have seen the design and implementation of many optical activatable smart *** probes are activatable because they change their optical properties and are smart because they can identify specific *** broad class of detection agents has allowed previously unperformed visualizations,facilitating the study of diverse biomolecules including enzymes,nucleic acids,ions and reactive oxygen *** to be robust in an in vivo environment,these probes have been used in tissue culture cells and in live small *** emerging class of smart probes has been designed to harness the potency of singlet oxygen generating *** the discrimination of activatable agents with the toxicity of photosensitizers represents a new and powerful approach to disease *** review highlights some applications of activatable smart probes with a focus on developments of the past decade.

关键词： Optical imaging photodynamic therapy activatable imaging probes

Pancreatic sphincterotomy:Technique,indications,and complications

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World Journal of Gastroenterology 2007年第30期13卷 4064-4071页

作者： jonathan M Buscaglia Anthony N Kalloo Division of Gastroenterology and Hepatology Johns Hopkins University School of Medicine Johns Hopkins Hospital Baltimore MD 21205 United States

Pancreatic sphincterotomy serves as the cornerstone of endoscopic therapy of the pancreas. Historically, its indications have been less well-defined than those of endoscopic biliary sphincterotomy, yet it plays a definite and useful role in diseases such as chronic pancreatitis and pancreatic-type sphincter of Oddi dysfunction. In the appropriate setting, it may be used as a single therapeutic maneuver, or in conjunction with other endoscopic techniques such as pancreatic stone extraction or stent placement. The current standard of practice utilizes two different methods of performing pancreatic sphincterotomy: a pull-type sphincterotome technique without prior stent placement, and a needle-knife sphincterotome technique over an existing stent. The complications associated with pancreatic sphincterotomy are many, although acute pancreatitis appears to be the most common and the most serious of the early complications. As such, it continues to be reserved for those endoscopists who perform a relatively high-volume of therapeutic pancreaticobiliary endoscopic retrograde cholangio-pancreatography.

关键词： Pancreas Sphincterotomy Endoscopic Technique Indications Complications

Controversies in the treatment of Crohn’s disease: The case for an accelerated step-up treatment approach

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World Journal of Gastroenterology 2008年第17期14卷 2670-2677页

作者： Amandeep K Shergill jonathan P Terdiman Veterans Affairs Medical Center Division of Gastroenterology University of California Division of Gastroenterology University of California

The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biological agents in the former versus initial treatment with steroids in the latter, with escalation to immunomodulators or biological drugs in patients proven to be steroid refractory or steroid dependent. Top-down therapy has been associated with higher rates of mucosal healing. If mucosal healing proves to be associated with better long-term outcomes, such as a decreased need for hospitalization and surgery, top-down therapy may be the better approach for many patients. The main concern with the top-down approach is the toxicity of the immunomodulators and biological agents, which have been linked with infectious complications as well as an increased risk of lymphoma. It is unlikely that one strategy will be best for all patients given the underlying heterogeneity of CD presentation and severity. Ultimately, we must weigh the safety and efficacy of the therapies with the risks of the disease itself. Unfortunately our ability to risk stratify patients at diagnosis remains rudimentary. The purpose of this paper is to review the data that supports or refutes the differing treatment paradigms in CD, and to provide a rationale for an approach, termed the "accelerated step-up" approach, which attempts to balance the risks and benefits of our currently available therapies with the risk of disease related complications as we understand them in 2008.

关键词： Crohn's disease Top-down Step-up Anti-tumor necrosis factor antibodies Immunomodulators Mucosal healing

Flu DRiPs in MHC Class Ⅰ Immunosurveillance

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Virologica Sinica 2019年第2期34卷 162-167页

作者： Jiajie Wei jonathan W.Yewdell Cellular Biology Section Laboratory of Viral DiseasesNational Institute of Allergy and Infectious DiseasesNational Institutes of Health

Since the publication of the DRiP(defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8^+T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.

关键词： Influenza A virus(IAV) MHC-restricted cytotoxicity Immune responses MHC class Ⅰ DRiP

Ecofriendly E-Nose Based in PLA and Only 0.3 wt%of CNTs

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Journal of Renewable Materials 2019年第4期7卷 355-363页

作者： Laura Ribba jonathan Cimadoro Silvia Goyanes Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de FísicaLaboratorio de Polímeros y Materiales Compuestos(LP&MC)Instituto de Física de Buenos Aires(IFIBA-CONICET)Ciudad Universitaria(1428)Ciudad Autónoma de Buenos AiresArgentina

In this work,conductive polymer nanocomposites were developed based on a biodegradable and biobased polymer(poly(lactic acid)),with the incorporation of only 0.3 wt%of carbon nanotubes(CNTs)to be used as volatile solvent *** correct dispersion of the nanofiller was achieved thanks to a CNT non-covalent modification with an azo-dye(disperse orange 3)which allowed to reach the percolation for electric conduction in values as low as 0.3 wt%.The chemo-resistive properties of the developed sensors were investigated by exposure to organic vapors(ethanol,tetrahydrofuran and toluene)and water vapor,showing good *** addition,considering the manipulation to which the sensor will be exposed,wear resistance was characterized,finding that the incorporation of CNTs produced an increase in more than a 50%.

关键词： Poly(lactic acid) carbon nanotubes sensor CPC organic solvent vapor DO3

LHCb gets closer to discovering the second doubly charmed baryon

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 25-26页

作者： Marek Karliner jonathan L.Rosner School of Physics and Astronomy Tel Aviv UniversityTel Aviv 69978Israel Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637USA

Recently the LHCb Collaboration [1] published the results of a search for the doubly charmed baryon ■. No significant signal is seen in the mass range from 3.4 to3.8 Ge V. To put this result in context, the ■baryon was seen by LHCb in decay modes ΛcK-π^+π^+[2](2017) and ■^+cπ^+[3](2018). The weighted average of the ■^++cc mass is 3621.24±0.65 (stat.)±0.31 (syst.) MeV [3].

关键词： doubly closer LHCb

Nearly invariant subspaces for shift semigroups

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Science China Mathematics 2022年第9期65卷 1895-1908页

作者： Yuxia Liang jonathan R.Partington School of Mathematical Sciences Tianjin Normal UniversityTianjin 300387China School of Mathematics University of LeedsLeeds LS 29JTUK

Let{T(t)}_(t≥0) be a C_(0)-semigroupon an infinite-dimensional separable Hilbert space;a suitable definition of near{T(t)^(*)}_(t≥0) invariance of a subspace is presented in this paper.A series of prototypical examples for minimal nearly{S(t)^(*)}_(t≥0) invariant subspaces for the shift semigroup{S(t)}_(t≥0) on L^(2)(0,∞)are demonstrated,which have close links with near T_(θ)^(*)invariance on Hardy spaces of the unit disk for an inner functionθ.Especially,the corresponding subspaces on Hardy spaces of the right half-plane and the unit disk are related to model *** work further includes a discussion on the structure of the closure of certain subspaces related to model spaces in Hardy spaces.

关键词： nearly invariant subspace C_(0)-semigroup shift semigroup model space