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Predicting major adverse cardiovascular events after orthotopic liver transplantation using a supervised machine learning model:A cohort study

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World Journal of Hepatology 2024年第2期16卷 193-210页

作者： jonathan Soldera Leandro Luis Corso Matheus Machado Rech Vinícius Remus Ballotin Lucas Goldmann Bigarella Fernanda Tomé Nathalia Moraes Rafael Sartori Balbinot Santiago Rodriguez Ajacio Bandeira de Mello Brandão Bruno Hochhegger Post Graduate Program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom Postgraduate Program in Pathology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Engineering Universidade de Caxias do SulCaxias do Sul 95070-560Brazil School of Medicine Universidade de Caxias do SulCaxias do Sul 95070-560Brazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACk.ROUND Liver transplant(LT)patients have become older and *** rate of post-LT major adverse cardiovascular events(MACE)has increased,and this in turn raises 30-d post-LT *** cardiac stress testing loses accuracy when applied to pre-LT cirrhotic *** To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional *** This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic *** developed a predictive model for post-LT MACE(defined as a composite outcome of strok.,new-onset heart failure,severe arrhythmia,and myocardial infarction)using the extreme gradient boosting(XGBoost)machine learning *** addressed missing data(below 20%)for relevant variables using the k.nearest neighbor imputation method,calculating the mean from the ten nearest neighbors for each *** modeling dataset included 83 features,encompassing patient and laboratory data,cirrhosis complications,and pre-LT cardiac *** performance was assessed using the area under the receiver operating characteristic curve(AUROC).We also employed Shapley additive explanations(SHAP)to interpret feature *** dataset was split into training(75%)and testing(25%)*** was evaluated using the Brier *** followed Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis guidelines for ***-learn and SHAP in Python 3 were used for all *** supplementary material includes code for model development and a user-friendly online MACE prediction *** Of the 537 included patients,23(4.46%)developed in-hospital MACE,with a mean age at transplantation of 52.9 *** majority,66.1%,were *** XGBoost model achieved an impressive AUROC of 0.89 during the training *** model exhibited accuracy,precision,recall,and F1-score values of 0.84,0.85,0.80,and 0.79,***

关键词： Liver transplantation Major adverse cardiac events Machine learning Myocardial perfusion imaging Stress test

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释放机遇:中英职业技术教育与培训领域合作意义深远

教育国际交流

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教育国际交流 2024年第1期 17-19页

作者： jonathan Ledger 吴之舟(译) 英国商业贸易部不详

当前,科技进步日新月异,推动全球经济快速发展,职业技术教育与培训的重要性也日益凸显。在各国致力于保持竞争力及满足劳动力需求的背景下,开展高效的职业技术教育与培训尤为迫切。本文将针对英国职业技能体系中的突出特色进行剖析,并... 详细信息

当前,科技进步日新月异,推动全球经济快速发展,职业技术教育与培训的重要性也日益凸显。在各国致力于保持竞争力及满足劳动力需求的背景下,开展高效的职业技术教育与培训尤为迫切。本文将针对英国职业技能体系中的突出特色进行剖析,并就中英技能与培训机构合作的未来重点领域和发展路径提出思考和建议,探讨职业技术教育与培训的重要意义。职业技术教育与培训最基本、最重要的职能在于满足产业的实时劳动力动态需求。

关键词：职业技术教育与培训科技进步动态需求发展路径劳动力需求经济快速发展职业技能体系思考和建议

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艺术博物馆空间的阈限性与社交潜能

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艺术设计研究 2024年第3期 84-93页

作者：周术乔纳森·黑尔烟台大学建筑学院英国诺丁汉大学工程学院建筑与建成环境系

在网络城市公共空间持续阈限和公共生活缺失的现实下,本文以阈限理论为框架,梳理了艺术博物馆从“时间阈限”到“空间阈限”的历史演化过程,及其分别在精神和身体层面的社交潜能。并以三个具有空间阈限性的当代艺术博物馆为例,分析了介... 详细信息

在网络城市公共空间持续阈限和公共生活缺失的现实下,本文以阈限理论为框架,梳理了艺术博物馆从“时间阈限”到“空间阈限”的历史演化过程,及其分别在精神和身体层面的社交潜能。并以三个具有空间阈限性的当代艺术博物馆为例,分析了介于“结构/反结构”“公共/私密”之间的空间布局和形态特征,指出其设计核心是为了弱化物质空间的存在,从而释放新的社交可能性。

关键词：艺术博物馆空间阈限性社交潜能

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Thermophilic response to feeding in adult female velvet geck.s

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Current Zoology 2020年第6期66卷 693-694页

作者： Buddhi Dayananda jonathan k.webb School of Life Sciences University of Technology SydneyBroadwayNSW 2007Australia School of Agriculture and Food Sciences The University of QueenslandBrisbaneQLD 4072Australia

Fluctuations in food availability occur in many ecosystems and pose challenges to the organisms that inhabit them(Berg et al.2017).Because lizards have significantly lower field metabolic rates than endotherms,they are often considered "low energy specialists"that can cope with food shortages(Brown and Griffin 2005).However,active reptiles that maintain high body temperatures during periods of low prey availability can still incur significant energetic costs because metabolic rates scale with body *** reduce these energetic costs,some reptile species select lower body temperatures and/or reduce their activity levels when food is scarce(Angilletta 2009).

关键词： Amalosia thermophily thermoregulation body temperatures reptiles

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麦肯锡:2024年大健康行业五大趋势

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企业家 2024年第7期 84-88页

作者：贺景怡许达仁陈曦 jonathan Medalsy 麦肯锡公司

麦肯锡公司最近调查了美国、英国和中国超过5000名消费者,探究了消费者健康领域的五大趋势,并结合调研结果对七个大健康的子领域进行部析。研究表明,老龄化健康、体重管理、肠胃健康等健康领域均呈现出较高的创新潜力和投资价值。2024... 详细信息

麦肯锡公司最近调查了美国、英国和中国超过5000名消费者,探究了消费者健康领域的五大趋势,并结合调研结果对七个大健康的子领域进行部析。研究表明,老龄化健康、体重管理、肠胃健康等健康领域均呈现出较高的创新潜力和投资价值。2024年消费健康领域五大趋势趋势一:居家健康。新冠疫情使得家用抗原自测产品变得家喻户晓。居家诊断检测提供了更便捷的体验,满足了消费者快速获得检测结果及高频检测的需求。

关键词：麦肯锡公司创新潜力五大趋势消费者健康诊断检测体重管理老龄化

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Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck.Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson Brandon J.Vilarello Tiana M.Saak.Francesco F.Caruana Liam W.Gallagher Joseph B.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck.Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck.Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck.Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York.Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have track.d longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Stick. extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas k.beissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work.we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack.of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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深海之王

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商业周刊（中文版） 2024年第9期 54-63页

作者： k.t Chellek.Olivia Solon jonathan Browning Ricardo Rey(插图) 杨飞(译) 不详

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这... 详细信息

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这个小点在离岸120英里(约193公里)的地方盘旋了好几天,任何理智的水手都不会在当时那种恶劣的天气里闲逛。接近飓风等级的狂风呼啸着穿越凶涌的大海;天空中雨雪交加。

关键词：海岸警卫队控制室显示屏竞争对手

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Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk.Science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan Mayumi k.k. Shelby Garner Rok.Fink.Ismail Tayfur jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma k.yano LaShonda Malrey‑Horne Mak.k. MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak.Maria Opazo k.ndell Oliver Luciana Peters Sohel Rahman PerihanŞimşek.Andrew Strick.in Raymond Swienton Bryan W.Brook. Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO k.be Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tok.o Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk.Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in work.hops across multiple *** aim of our research was to explore the work.hop findings to develop priority strategies for strengthening public health system *** conducted a work.hop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of k.rea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct work.hops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risk. in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework.to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk.reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Work.hops

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Inpatient management of iron deficiency anemia in pediatric patients with inflammatory bowel disease: A single center experience

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World Journal of Clinical Pediatrics 2024年第1期13卷 107-117页

作者： k.ishanth Manok.ran jonathan Spaan Giulio Cataldo Christopher Lyons Paul D Mitchell Tatyana Sare LoriA Zimmerman Paul A Rufo Center for Inflammatory Bowel Disease Boston Children's HospitalBostonMA 02115United States Institutional Centers for Clinical and Translational Research Boston Children's HospitalBostonMA 02115United States

BACk.ROUND Screening for iron deficiency anemia(IDA)is important in managing pediatric patients with inflammatory bowel disease(IBD).Concerns related to adverse reactions may contribute to a reluctance to prescribe intravenous(IV)iron to treat IDA in this *** To track.the efficacy and safety of IV iron therapy in treating IDA in pediatric IBD patients admitted to our *** A longitudinal observational cohort study was performed on 236 consecutive pediatric patients admitted to our tertiary IBD care center between September 2017 and December 2019.92 patients met study criteria for IDA,of which 57 received IV iron,17 received oral iron,and 18 were discharged prior to receiving iron *** Patients treated with IV iron during their hospitalization experienced a significant increase of 1.9(±0.2)g/dL in mean(±SE)hemoglobin(Hb)concentration by the first ambulatory follow-up,compared to patients who received oral iron 0.8(±0.3)g/dL or no iron 0.8(±0.3)g/dL(P=0.03).One out of 57(1.8%)patients that received IV iron therapy experienced an adverse *** Our findings demonstrate that treatment with IV iron therapy is safe and efficacious in improving Hb and iron levels in pediatric patients with IDA and active IBD.

关键词： Iron deficiency anemia Pediatric inflammatory bowel disease Intravenous iron therapy Inflammatory bowel disease

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