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Long non-coding RNA BANCR promotes pancreatic cancer lymphangiogenesis and lymphatic metastasis by regulating the HIF-1α/VEGF-C/VEGFR-3 pathway via miR-143-5p

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Genes & Diseases 2024年第4期11卷 57-60页

作者： Shaolong Hao Yu Ji Weixuan Pan Hao Sun Fang Nie jonathan Ray Warren Yuchuan Ding Wei Han Department of General Surgery Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Department of Central Laboratory Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China Department of Neurosurgery Wayne State University School of MedicineJohn D.Dingell VA Medical CenterDetroitMI 48201USA

Pancreatic cancer is one of the most aggressive malignant tumors of the digestive *** node metastasis(LNM),as the main way of invasion and metastasis,can occur in the early stage of pancreatic cancer and be considered... 详细信息

关键词： metastasis cancer invasion

A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada jonathan Cuccia Rachael Coates Blak. Nassar Ethan Littlefield Elizabeth C.Martin Adam T.Melvin Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimick.ng the magnitude of fluid shear stress(FSS)found in human vasculature was designed and *** device provides a platform to evaluate the effects of FSS on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of FSS on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk.*** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk.analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an FSS magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation mark.r k.67 in the MCF-7 cell line at a single cell *** understand possible mechanisms for enhanced k.67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERk.Ak.,and JAk.*** demonstrated that after shearing the cells phosphorylation of p-Ak.,p-mTOR,and p-STAT3 were ***,there was no change in p-ERk./*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that FSS can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

Navigating treatment resistance:Janus k.nase inhibitors for ulcerative colitis

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World Journal of Clinical Cases 2024年第24期12卷 5468-5472页

作者： jonathan Soldera Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

The management of refractory ulcerative colitis(UC)and acute severe UC(ASUC)is challenging due to the lack.of standardized approaches in cases resistant to multiple *** this editorial,I investigate the efficacy and safety of Janus k.nase inhibitors,particularly upadacitinib and tofacitinib,in controlling severe and refractory disease.I highlight a notable case report by Xu et al,which explores the case of a patient with primary nonresponse to two classes of biologics and two fecal microbiota transplants who exhibited a remark.ble response to ***,I discuss the use of tofacitinib in refractory UC and ASUC,either as monotherapy or in combination with biologics,which has shown promising response ***,emerging evidence of upadacitinib efficacy in ASUC is ***,these cases emphasize the complex nature of managing refractory ASUC and the potential of small-molecule therapies to achieve *** research is needed to refine treatment strategies for patients with treatment-resistant UC.

关键词： Inflammatory bowel disease Ulcerative colitis Janus k.nase inhibitor Upadacitinib Tofacitinib Infliximab

Immunological crossroads:The intriguing dance between hepatitis C and autoimmune hepatitis

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World Journal of Hepatology 2024年第6期16卷 867-870页

作者： jonathan Soldera Department of Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

Delving into the immunological crossroads of liver diseases,this editorial explores the dynamic interplay between hepatitis C virus(HCV)and autoimmune hepatitis(AIH).While HCV primarily manifests as a viral infection impacting the liver,previous studies unveil a captivating connection between HCV and the emergence of *** dance of the immune system in response to HCV appears to set the stage for an intriguing phenomenon-an aberrant autoimmune response leading to the onset of *** suggests a heightened presence of autoimmune mark.rs in individuals with chronic HCV infection,hinting at a potential overlap between viral and autoimmune liver *** the intricate terrain of viral replication,immune response dynamics,and genetic predisposition,this editorial adds a layer of complexity to our understanding of the relationship between HCV and *** this immunological crossroads,we aim to unearth insights into the complex interplay,using a compelling case where AIH and primary sclerosing cholangitis overlapped following HCV treatment with direct-acting antivirals as back.round.

关键词： Liver diseases Hepatitis C virus Autoimmune hepatitis Primary sclerosing cholangitis Inflammatory bowel disease

Identity and Identification: William Langland Wrote The Romance of William of Palerne

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Journal of Literature and Art Studies 2024年第7期14卷 553-566页

作者： jonathan Pack.r(k.untouris) Athens Greece

This essay shows that William Langland/Longe Wille wrote The Romance of William of *** brings forward evidence from its text in two main ways:(1).synchronically,*** the text;and(2).diachronically,‘across time’.There is a comparison between this c.1360-61 work.and the previous 1191-4 NE Old French/Picard poem Le Roman de Guillaume de Palerne specifically of three passages from each.

关键词： Langland William of Palerne Guillaume de Palerne Piers Plowman medieval studies attribution

The Association between Perceived Injustice Following Traumatic Injury and Its Impact on Pain-Related, Mental Health and Functional Health Outcomes: A Systematic Review

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Pain Studies and Treatment 2024年第2期12卷 33-47页

作者： jonathan k.lly Dominic Harmon Medical School University of Limerick Limerick Ireland

Back.round: There is growing evidence suggesting that those who suffer traumatic injury display high levels of perceived injustice which impedes their recovery, both physically and mentally. Aim: The aim of this systematic review was to examine the association between perceived injustice and pain-related, mental health and functional outcomes in patients who have suffered a traumatic injury. Methods: In May 2023, a systematic review of the literature was performed on the electronic databases of PubMed, Google Scholar, Embase, and the Cochrane Database of Systemic Reviews. Papers were collected and analysed as per PRISMA guidelines for systematic reviews. The outcomes of interest were pain intensity, pain interference, disability, depression, anxiety, and quality of life. The initial search identified 59 papers. Of these papers, five studies met the inclusion criteria and were subsequently analysed (N = 1172). Each of the papers was published in peer-reviewed journals in the English language. Individuals with pain or pathology prior to the trauma and those who were not hospitalised following the trauma were excluded from the study. Results: Of the papers reviewed, each study indicated significant associations between perceived injustice and pain, disability, depression, anxiety, post-traumatic stress disorder, as well as reduced return to work.status. Conclusion: This systematic review investigated the relationship between perceived injustice and pain-related, mental health, and functional outcomes in trauma patients. The results highlight the negative role that perceived injustice has on recovery following traumatic injury. Further, it provok.s the need for future research regarding the implementation of therapeutic interventions and the development of predictive models of injustice.

关键词： Perceived Injustice Trauma Pain Outcomes Mental Health Outcomes Disability

Geochemical elements in suspended particulate matter of Ensenada de La Paz Lagoon,Baja California Peninsula,Mexico:Sources,distribution,mass balance and ecotoxicological risk.

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Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad Morales-García Pilar de Acacia Pérez-Escamilla Suresh Babu Sujitha Pichaimani Godwyn-Paulson Andrés Felipe Zuniga-Cabezas Muthuswamy Ponniah jonathan Instituto Politécnico Nacional(IPN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto Politécnico Nacional(IPN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto Politécnico Nacional(IPN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,Mg,Mn,Mo,Ni,Pb,Sr)in suspended particulate material(SPM)collected from Ensenada de La Paz(ELP)lagoon,Baja California Sur,Mexico in two different periods(September and May)to comprehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric SPM levels were found to be 51.7%in September and 40.5%in May,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of SPM,and in this study,Mo had the highest EF of 46.77 probably due to its origin from continental *** the ecotoxicological perspective,the integrated toxic risk.index revealed low toxic risk.to the benthic ***,the mean-ERM-Quotient calculated using the particulate concentrations of As,Cd,Cr,Cu,Ni,Pb indicated 9%probability of toxicity to *** comprehensive geochemical and ecotoxicological assessment of particulate metal concentrations in the ELP lagoon signify low to moderate contamination.

关键词： Suspended particulate material Heavy metals Risk.assessment Mass transfer Ensenada de La Paz

Blastomas of the digestive system in adults:A review

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1030-1042页

作者： Yu Liu Tony El Jabbour jonathan Somma Yuk.hiro Nak.nishi Saverio Ligato Hwajeong Lee Zhi-Yan Fu Department of Pathology LSU Health Sciences Center School of MedicineNew OrleansLA 70112United States Department of Pathology Hartford HealthCareHartfordCT 06102United States Department of Pathology Moffitt Cancer CenterTampaFL 33612United States Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States

Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast *** review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and *** is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to *** addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma break.oint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been *** is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic ***,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially *** approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular *** treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some *** vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of *** review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关键词： Adult blastomas Gastroblastoma Hepatoblastoma Pancreatoblastoma Digestive system

Optimizing ASReview Simulations:A generic Multiprocessing Solution for“Light-data'and“Heavy-data'Users

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Data Intelligence 2024年第2期6卷 320-343页

作者： Sergei Romanov Abel Soares Siqueira jonathan de Bruin Jelle Teijema Laura Hofstee Rens van de Schoot Applied Data Science Department of Information and Computing ScienceFaculty of ScienceUtrecht University Netherlands eScienceCenter AmsterdamNL Department of Research and Data Management Services Information Technology ServicesUtrecht UniversityUtrechtthe Netherlands Department of Methodology and Statistics Faculty of Social and Behavioral SciencesUtrecht University

Active learning can be used for optimizing and speeding up the screening phase of systematic *** simulation studies mimick.ng the screening process can be used to test the performance of different machine-learning models or to study the impact of different training *** paper presents an architecture design withamultiprocessing computational strategyforrunningmanysuch simulation studiesinparallel,using the ASReview Mak.ta work.low generator and k.bernetes software for deployment with cloud *** provide a technical explanation of the proposed cloud architecture and its *** addition to that,we conducted 1140 simulations investigating the computational time using various numbers of CPUs and RAM *** analysis demonstrates the degree to which simulations can be accelerated with multiprocessing computing *** parallel computation strategy and the architecture design that was developed in the present paper can contribute to future research with more optimal simulation time and,at the same time,ensure the safe completion of the needed processes.

关键词： Active learning Systematic review Simulation study Multiprocessing Cloud architecture