检索结果-南通市图书馆

In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3d pancreatic tumor stroma co-cultures via passive particle tracking

引用

Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： dustin P.Jones William Hanna Gwendolyn M.Cramer jonathan P.Celli department of Physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including paracrine crosstalk with stromal partners,and biophysical interactions with surrounding cells and *** elucidating the role of physical force and the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3d)tumor *** systems provide the ability to systematically isolate,manipulate,and evaluate impact of stromal components and extracellular mechanics in a platform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires complementary methods for in situ measurements of the local mechanical ***,in 3d tumor/fbroblast co-culture models of pancreatic canocer,a discase characterized by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe dynamic mechanical *** videos of fuorescently labeled polystyrene micro-spheres embedded in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear modulus and *** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dependent on culture geometry with contrast ing behavior for embedded and overlay *** addition to potential application to screening stroma targeted therapeutics,this work also provides insight into how the compoition and plating geometry impact the mechanical propertios of 3d cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3d tumor models matrix remodeling mechanobiology stromal depletion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pembrolizumab as a novel therapeutic option for patients with refractory thymic epithelial tumor:A case report

引用

World Journal of Clinical Cases 2021年第5期9卷 1139-1147页

作者： jonathan Wong-Chong Maureen Bernadach Angeline Ginzac Hugo Veyssière Xavier durando département d’Oncologie Médicale Centre Jean PERRINClermont-Ferrand 63011France UFR Médecine UniversitéClermont AuvergneClermont-Ferrand 63011France division de Recherche Clinique Délégation Recherche Clinique et InnovationCentre Jean PERRINClermont-Ferrand 63011France INSERM U1240 Imagerie Moléculaire et Stratégies ThéranostiquesUniversitéClermont AuvergneClermont-Ferrand 63011France Centre d’Investigation Clinique UMR501Clermont-Ferrand 63011France

BACKGROUNd Thymic epithelial carcinomas are rare and have a poor *** of thymic epithelial carcinoma is multimodal and includes surgery,post-operative radiation therapy,adjuvant and neoadjuvant chemotherapy,or exclusive chemotherapy based on disease ***,there is currently no standard treatment regimen for metastatic and recurrent thymic *** SUMMARY A 45-year-old Caucasian male,with no past medical history,presented with hepatalgia and a cervical mass.A computed tomography(CT)scan showed multiple suspect lesions in the lungs,liver,and anterior mediastinum associated with mediastinal and cervical ***-guided percutaneous biopsies of the liver lesions and anterior mediastinal mass were performed,confirming the histopathology of thymic epithelial *** consisted of several chemotherapy regimens and radiation therapy,administered between April 2016 and december *** patient achieved complete metabolic *** positron emission tomography/CT performed in June 2019 showed disease relapse,with reappearance of a large hypermetabolic hepatic mass and involvement of mediastinal and axillary lymph *** pembrolizumab(200 mg,every 3 wk)was administered after two prior systemic *** patient’s response to treatment was last documented on March 5,*** Pembrolizumab was successful in treatment of a patient with programmed deathligand 1-negative metastatic thymic carcinoma,pretreated with chemotherapy.

关键词： Thymic epithelial carcinoma Programmed death-ligand 1 negative Pembrolizumab Immune checkpoint Metastasis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigating the impact of preoperative corneal astigmatism orientation on the postoperative spherical equivalent refraction following intraocular lens implantation

引用

Eye and Vision 2018年第1期5卷 70-77页

作者： Richard N.McNeely Salissou Moutari Eric Pazo jonathan E.Moore Cathedral Eye Clinic 89-91 Academy StreetBelfastCounty Antrim BT12 LSNorthern IrelandUK Biomedical Sciences Research Institute University of UlsterColeraineNorthern IrelandUK School of Mathematics and Physics Queens University BelfastBelfastNorthern IrelandUK

Background:To investigate the impact of the orientation of preoperative corneal astigmatism on achieving the postoperative target refraction following monofocal intraocular lens(IOL)***:This study enrolled 339 eyes who had uneventful cataract surgery or refractive lens exchange(RLE)with subsequent monofocal IOL *** were initially categorized dependent upon axial length and then on the orientation of preoperative anterior corneal *** 1 had against-the-rule(ATR)anterior corneal astigmatism,group 2 had with-the-rule(WTR)anterior corneal astigmatism,and group 3 had oblique(OB)anterior corneal *** preoperative corneal astigmatism was determined by the IOLMaster(Carl Zeiss Meditec AG).Postoperative refraction was completed for all eyes,and the results were calculated and compared for the separate ***:In eyes with axial lengths greater than 22.0 mm and less than 25.0 mm there was a significant difference between the magnitude of preoperative corneal astigmatism between groups 2 and 3 with 0.827±0.376 d in group 2,and 0.677±0.387 d in group *** mean postoperative spherical equivalent(SE)prediction error was−0.132±0.475 d in group 1,0.026±0.497 d in group 2,and−0.130±0.477 d in group *** was a significant difference between groups 1 and *** was no significant difference in the magnitude of preoperative corneal astigmatism and postoperative SE prediction error between the anterior corneal astigmatism orientation groups in eyes with axial lengths of less than or equal to 22.0 mm and greater than or equal to 25.0 ***:The orientation of preoperative anterior corneal astigmatism significantly affected the postoperative biometry prediction error in eyes with astigmatism of 1.75 d or less in eyes with the axial length between 22.0 mm and 25.0 ***,the results were not clinically significant.

关键词： Biometry accuracy Prediction error Corneal astigmatism With-the-rule astigmatism Against-the-rule astigmatism Oblique astigmatism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1 Gbps free-space deep-ultraviolet communications based on Ⅲ-nitride micro-LEds emitting at 262 nm

引用

Photonics Research 2019年第7期7卷 19-25页

作者： Xiangyu He Enyuan Xie Mohamed Sufyan Islim Ardimas Andi Purwita jonathan J.d.McKendry Erdan Gu Harald Haas Martin d.dawson Institute of Photonics Department of PhysicsUniversity of StrathclydeGlasgow G11RDUK Li-Fi R&d Centre the University of EdinburghInstitute for Digital CommunicationsEdinburgh EH9 3JLUK

The low modulation bandwidth of deep-ultraviolet(UV) light sources is considered as the main reason limiting the data transmission rate of deep-UV communications. Here, we present high-bandwidth Ⅲ-nitride microlight-emitting diodes(μLEds) emitting in the UV-C region and their applications in deep-UV communication systems. The fabricated UV-C μLEds with 566 μm2 emission area produce an optical power of 196 μW at the 3400 A∕cm2 current density. The measured 3 dB modulation bandwidth of these μLEds initially increases linearly with the driving current density and then saturates as 438 MHz at a current density of 71 A∕cm2, which is limited by the cutoff frequency of the commercial avalanche photodiode used for the measurement. A deep-UV communication system is further demonstrated. By using the UV-C μLEd, up to 800 Mbps and 1.1 Gbps data transmission rates at bit error ratio of 3.8 × 10-3 are achieved assuming on-off keying and orthogonal frequency-division multiplexing modulation schemes, respectively.

关键词： communications Ⅲ-nitride micro-LEds

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Challenging Nanopores with Analyte Scope and Environment

引用

Journal of Analysis and Testing 2019年第1期3卷 61-79页

作者： Buddini I.Karawdeniya Y.M.Nuwan d.Y.Bandara jonathan W.Nichols Robert B.Chevalier James T.Hagan Jason R.dwyer department of Chemistry University of Rhode IslandRichard E.Beaupre Center for Chemical and Forensic Sciences140 Flagg Rd.KingstonRI 02881USA Present Address:department of Mechanical Engineering Lyle School of EngineeringSouthern Methodist UniversityDallasTX 75275USA Present Address:Nova Biomedical 200 Prospect StreetWalthamMA 02454-9141USA

Nanopores are nanofluidic channels formed through thin membranes that can deliver standout single-molecule and single-particle sensing *** targets include small molecules and nanoparticles,and the dNA,protein,and glycan biopolymers underpinning genomics,proteomics,and ***-notably even in the simplest implementation,resistive-pulse sensing-does not inherently require sample labeling and,thus,offers the potential for general sensing util-ity combined with the prospective benefits of reduced sample processing requirements.A key pursuit for biopolymer sens-ing is the characterization of monomer *** review article will provide an overview of the use of nanopores for general chemical sensing and-omics-related applications,*** broad analyte scope provides fertile ground for a discussion of principles governing nanopore sensing and considerations useful for guiding nanopore *** nanopores to be effective in the face of broad analyte scope,stringent requirements on analytical performance must be met within the particular analyte class without sacrificing the operational flexibility necessary to be responsive across classes presenting very different physical and chemical *** sample-driven challenges provide a unifying framework for discussing aspects of nanopore fabrication,properties,and integration;sensing paradigms,performance,and prospects;fundamental electrokinetic and interfacial phenomena;and practical challenges facing the use and further development of nanopore devices.

关键词： Nanopore Single-molecule sensing Nanofluidics Point-of-care Silicon nitride Resistive pulse Wearable sensors Quality assurance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spatial heterogeneity of flesh-cell osmotic potential in sweet cherry affects partitioning of absorbed water

引用

Horticulture Research 2020年第1期7卷 2104-2113页

作者： Eckhard Grimm daniel Pflugfelder Jan Hahn Moritz jonathan Schmidt Hendrik dieckmann Moritz Knoche Institut für Gartenbauliche Produktionssysteme Leibniz Universität HannoverAbteilung ObstbauHerrenhäuser Straße 2D-30419 HannoverGermany Forschungszentrum Jülich IBG-2:PflanzenwissenschaftenWilhelm-Johnen-StraßeD-52428 JülichGermany Laser Zentrum Hannover e.V. Hollerithallee 8D-30419 HannoverGermany

A fleshy fruit is commonly assumed to resemble a thin-walled pressure vessel containing a homogenous carbohydrate *** sweet cherry(Prunus avium L.)as a model system,we investigate how local differences in cell water potential affect H2O and d2O(heavy water)*** partitioning of H2O and d2O was mapped nondestructively using magnetic resonance imaging(MRI).The change in size of mesocarp cells due to water movement was monitored by optical coherence tomography(OCT,non-destructive).Osmotic potential was mapped using microosmometry(destructive).Virtual sections through the fruit revealed that the H2O distribution followed a net pattern in the outer mesocarp and a radial pattern in the inner *** patterns align with the disposition of the vascular bundles.d2O uptake through the skin paralleled the acropetal gradient in cell osmotic potential gradient(from less negative to more negative).Cells in the vicinity of a vascular bundle were of more negative osmotic potential than cells more distant from a vascular *** revealed net H2O uptake was the result of some cells loosing volume and other cells increasing volume.H2O and d2O partitioning following uptake is non-uniform and related to the spatial heterogeneity in the osmotic potential of mesocarp cells.

关键词： potential Spatial bundle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accurate Force Field development for Modelling Macromolecular Assemblies Containing diketopyrrolopyrrole and Thiophene

Accurate Force Field Development for Modelling Macromolecula...

引用

2019中国化学会第十五届全国计算（机）化学学术会议

作者：江玲 jonathan d.Hirst Hainam do 宁波诺丁汉大学 School of Chemistry University of Nottingham department of Chemical and Environmental Engineering University of Nottingham Ningbo China

It is challenging to find sufficiently accurate force fields for applications where equilibrium structures generated from classical molecular dynamics simulations are employed in post quantum chemistry calculations.1 One particular application is in the study of optical and electronic properties of materials and biomolecules. Many semiconducting polymers, molecular crystals and biological chromophores of interest exhibit complex chemical structures with extended-conjugation that prevent the use of standard force fields. Furthermore, large conjugated molecules require to use many atom types and parameters. They also tend to be system specific in most cases and not transferable.2 Thus, parameterising force fields for conjugated systems using existing approaches can be time demanding. In addition, it is desirable that the equilibrium structures generated from classical molecular dynamics simulations are as close as possible to those that would have been generated using the same level of theory as the post electronic structure calculations. We present a scheme, utilising the force matching procedure,3,4 to systematically parameterise new force fields for large conjugated systems. We apply the method to both conjugated polymers and molecular crystals that contain diketopyrrolopyrrole（dPP） and thiophene units. These systems have recently been found to have low band gap, which exhibit high effciency for photovoltaic devices. We use the newly parameterised force fields to model these systems and our molecular dynamics simulation results will help in the understanding of the molecular level origins of the high-efficiency of these classes of materials.

关键词： Conjugated Molecules Force Fields development Force-Matching Molecular dynamics Simulation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

人类在地球表面系统中的地位与作用——人与环境系统某些理论问题的探讨

引用

中国人口·资源与环境 1993年第2期3卷 77-81页

作者： jonathan d.Phillips 李荣升赵善伦

在研究人类对环境的影响时,若把人类因素作为地球表面系统的一个组成部分,该系统是不稳定的,在干扰破坏后不能恢复平衡;若把人类因素当做系统外的成分,则系统对人类的影响是稳定的,在非灾难性干扰破坏后,系统能恢复到接近原来存在的状态... 详细信息

在研究人类对环境的影响时,若把人类因素作为地球表面系统的一个组成部分,该系统是不稳定的,在干扰破坏后不能恢复平衡;若把人类因素当做系统外的成分,则系统对人类的影响是稳定的,在非灾难性干扰破坏后,系统能恢复到接近原来存在的状态,此结论由对系统物质流和能量流的计算来证明。

关键词：地球环境人类

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Searching for ductile superconducting Heusler X_(2)YZ compounds

引用

npj Computational Materials 2023年第1期9卷 919-927页

作者： Noah Hoffmann Tiago F.T.Cerqueira Pedro Borlido Antonio Sanna jonathan Schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of T_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Snapshot Mueller spectropolarimeter imager

引用

Microsystems & Nanoengineering 2023年第5期9卷 271-279页

作者： Tianxiang dai Thaibao Phan Evan W.Wang Soonyang Kwon Jaehyeon Son Myungjun Lee jonathan A.Fan department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Equipment R&d Team 4 Mechatronics ResearchSamsung Electronics Co.LtdGyeonggi-do 18848Republic of Korea

We introduce an imaging system that can simultaneously record complete Mueller polarization responses for a set of wavelength channels in a single image *** division-of-focal-plane concept combines a multiplexed illumination scheme based on Fourier optics together with an integrated telescopic light-field imaging ***-resolved imaging is achieved using broadband nanostructured plasmonic polarizers as functional pinhole *** recording of polarization and wavelength information on the image sensor is highly *** also develop a calibration approach based on a customized neural network architecture that can produce calibrated measurements in *** a proof-of-concept demonstration,we use our calibrated system to accurately reconstruct a thin film thickness map from a four-inch *** anticipate that our concept will have utility in metrology,machine vision,computational imaging,and optical computing platforms.

关键词： polarization image Snapshot

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：