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dEXA overestimates bone mineral density in adults with knee replacements

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Sports Medicine and Health Science 2020年第4期2卷 211-215页

作者： Katharine d.harper Terry A.Clyburn Stephen J.Incavo Bradley S.Lambert department of Orthopedics&Sports Medicine Houston Methodist Hospital6445 Main StreetOutpatient CenterSuite 2500HoustonTXUnited States department of Orthopedics Washington DC VA Medical Center50 Irving St.NWWashington D.CUnited States

We examined bone mineral density(BMd)measurements made by dual-energy-xray-absorptiometry(dEXA)taken from 100 patients(♂46/♀54,66±6yr)who previously underwent single total-knee arthroplasty(TKA)to determine if automated software-based artifact detection(ASAd)adequately removes implant artifact from the dXA image before analysis and if potential inaccuracies could be overcome through manual artifact correction(MAC).We also sought to determine if software-based inaccuracies would result in fracture risk misclassification(Low-BMd/Osteopenia=Young-Adult T-Scored,limbs with implants had higher BMd(+12.0±1.7%,pd to control limbs resulting in a 2.5±0.2%overestimation of total-body BMd(single implant).Consequently,the prevalence of osteopenia in 95%of patients who would have been observed to have low leg BMd(18/19 patients)and 80%of those found to have low total-body BMd(4/5 patients)would have gone *** overestimation was eliminated when using *** results reveal a potential issue with ASAd for total-body dEXA scans in TKA patients and highlight the importance of careful review and MAC in those with joint replacements before making diagnostic decisions.

关键词： dual-energy-xray-absorptiometry dXA dEXA Bone density Total joint replacement Arthroplasty Osteopenia Osteoporosis

Maturity-associated considerations for training load,injury risk,and physical performance in youth soccer:One size does not fit all

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Journal of Sport and Health Science 2021年第4期10卷 403-412页

作者： Chris Towlson Jamie Salter Jack d.Ade Kevin Enright Liam d.harper Richard M.Page James J.Malone department of Sport Health and Exercise ScienceUniversity of HullHull HU67RXUK School of Sport York St John UniversityYork YO317EXUK Liverpool FC Academy Liverpool Football ClubLiverpool L337EDUK Research Institute for Sport and Exercise Sciences L3Liverpool John Moores UniversityLiverpool L33AUK Human and Health Sciences University of HuddersfieldHuddersfield HD13DHUK department of Sport and Physical Activity Edge Hill UniversityOrmskirk L394QPUK School of Health Sciences Liverpool Hope UniversityLiverpool L169JDUK

Biological maturation can be defined as the timing and tempo of progress to achieving a mature *** estimation of age of peak height velocity(PHV)or percentage of final estimated adult stature attainment(%EASA)is typically used to inform the training process in young *** youth soccer,maturity-related changes in anthropometric and physical fitness characteristics are diverse among individuals,particularly around *** this time,players are also at an increased risk of sustaining an overuse or growth-related *** a result,the implementation of training interventions can be *** purpose of this review was to(1)highlight and discuss many of the methods that can be used to estimate maturation in the applied setting and(2)discuss the implications of manipulating training load around PHV on physical development and injury *** have provided key stakeholders with a practical online tool for estimating player maturation status(Supplementary Maturity Estimation Tools).Whilst estimating maturity using predictive equations is useful in guiding the training process,practitioners should be aware of its *** increase the accuracy and usefulness of data,it is also vital that sports scientists implement reliable testing protocols at predetermined time-points.

关键词： Growth Injury Maturation Soccer Training

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Wilson's disease in two siblings from Ecuador:Two case reports

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World Journal of Clinical Cases 2025年第3期13卷 50-60页

作者： Enrique Carrera jonathan Alvarado Martina Astudillo Galo Pillajo department of Gastroenterology and Hepatology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador Faculty of Medicine Pontificia Universidad Catolica del EcuadorQuito 170143PichinchaEcuador department of Radiology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador

BACKGROUNd Wilson's disease(Wd)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and *** and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are *** diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life *** clinical presentations and outcomes of Wd can vary within a single *** SUMMARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having Wd during a family *** male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer *** developed progressive neurological deterioration during an irregular treatment with d-penicillamine due to medication *** condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of *** female patient,diagnosed at age 10,exhibited only biochemical *** treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up *** discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic *** Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.

关键词： Wilson disease Kayser-Fleischer rings Copper chelator d-penicillamine Trientine tetrahydrochloride Case report

Re-determination of Phoebe’s orbit

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Re-determination of Phoebe’s orbit

High-resolution geological maps of central London, UK： Comparisons with the London Underground

中国天文学会恒星分会2004年学术年会

作者： d.harper G.dourneau Wellcome Trust Sanger Institute Wellcome Trust Genome CampusHinxtonCambridge CB10 1SAUK Observatoire Aquitain des Sciences de l’Universe UMR 5804 Laboratoire d’Astrodynamique d’Astrophysique et d’A’eronomie de Bordeaux （L3AB）2rue de l’Observatoire 33270 Floirac France

In order to improve the orbit of Phoebe, the 9th satellites of the Saturnian system, we made 101 new observations in 2003, using a CCd detector of large size (2048 × 2048 pixels) mounted on the 1.56m

关键词： Planets and satellite - Saturn - Phoebe - Orbit determination

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Geoscience Frontiers 2016年第2期7卷 273-286页

作者： jonathan d. Paul department of Earth Sciences Bullard Laboratories University of Cambridge Madingley Rise Cambridge CB3 0EZ UK

This study presents new thickness maps of post-Cretaceous sedimentary strata beneath central London. 〉1100 borehole records were analysed. London Clay is thickest in the west; thicker deposits extend as a narrow finger along the axis of the London Basin. More minor variations are probably governed by periglacial erosion and faulting. A shallow anticline in the Chalk in north-central London has resulted in a pronounced thinning of succeeding strata. These results are compared to the position of London Underground railway tunnels. Although tunnels have been bored through the upper levels of London Clay where thick, some tunnels and stations are positioned within the underlying, more lithologically variable, Lower London Tertiary deposits. Although less complex than other geological models of the London Basin, this technique is more objective and uses a higher density of borehole data. The high resolution of the resulting maps emphasises the power of modelling an expansive dataset in a rigorous but simnle fashion.

关键词： London London Underground London Clay Lambeth Group Chalk Tunnelling Boreholes

Hierarchical methodology to evaluate the quality of disparate axle load data sources for pavement design

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第2期9卷 261-279页

作者： Steven Wood jonathan d.Regehr Transportation division City of WinnipegWinnipegMB R3B 1B9Canada department of Civil Engineering University of ManitobaMB R3T 5V6Canada

Axle load data are an essential input for pavement design,yet for most North American agencies,there is uncertainty about the quality of axle load data obtained from weigh-inmotion(WIM)systems,the applicability of these data for pavement design,and potential opportunities to integrate axle load data from disparate *** article presents a novel and practical methodology to evaluate the quality of axle load data from WIM systems and roadside weigh scales through a series of hierarchical analyses designed to test data *** applied using data from Manitoba,Canada,the methodology quantified the uncertainty of axle loads measured at the weigh scales and piezo-quartz WIM,concluding that both could be used for pavement design *** collected at piezo-polymer WIM sites exhibited poorer data validity;however,application of site-specific temperature correction factors significantly improved data validity at these *** article describes how other data quality dimensions,including spatial coverage,temporal coverage,and long-term data availability,could be considered when determining the suitability of disparate axle load data sources for pavement *** of the methodology enables a pragmatic evaluation of the quality and limitations of commonlyavailable axle load data,revealing uncertainties and data needs relevant for pavement design practice.

关键词： Road engineering Pavement design Axle load Weigh-in-motion data quality Truck traffic

Controlling human platelet activation with calcium-binding nanoparticles

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Nano Research 2020年第10期13卷 2697-2705页

作者： david Cabrera Karen Walker Sandhya Moise Neil d.Telling Alan G.S.harper School of Pharmacy and Bioengineering Keele UniversityGuy Hilton Research CenireThormburrow DriveHartshill Stoke-on Trent ST47QBUK ?Central Electron Microscope Unit School of Life SciencesKeele UniversityNewcastle-under LIymeStaffordshireST55BGUK department of Chemical Engineering University of BathBath BA27AYUK School of Medicine Keele UniversityNewcastle-under-LymeStaffordshireST55BGUK

Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium *** these cytosolic calcium rises would provide a method to inhibit platelet activation and prevent the unwanted blood clots that causes heart attack and *** we have predicted that calcium accumulation within the lumen of an infolded portion of the platelet plasma membrane called the open canalicular system(OCS)is essential for maintaining this cytosolic calcium *** to its nanometer dimensions of the OCS,it has been difficult to measure or interfere with the predicted luminal calcium *** we utilise iron oxide magnetic nanoparticles coated with the known calcium chelator,citrate,to create calcium-binding *** were used to assess whether an OCS calcium store plays a role in controlling the dynamics of human platelet activation and *** demonstrate that citrate-coated nanoparticles are rapidly and selectively uptaken into the OCS of activated human platelets,where they act to buffer the accumulation of calcium *** with these calcium-binding nanoparticles reduced thrombin-evoked cytosolic calcium rises,and slowed platelet aggregation and clot retraction in human *** contrast,nanoparticles that cannot bind calcium have no *** study demonstrates that the OCS acts as a key source of calcium for maintaining cytosolic calcium rises and accelerating platelet aggregation,and that calcium-binding nanoparticles targeted to the OCS could provide an anti-platelet therapy to treat patients at risk of suffering heart attacks or strokes.

关键词： nanochelators human platelets open canalicular system calcium signaling nanoparticles

An enhanced functional ability questionnaire(faVIQ) to measure the impact of rehabilitation services on the visually impaired

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 77-85页

作者： James Stuart Wolffsohn jonathan Jackson Olivia Anne Hunt Charles Cottriall Jennifer Lindsay Richard Gilmour Anne Sinclair Robert harper Aston University Life and Health SciencesOphthalmic Research Group Australian College of Optometry Royal Victoria Hospital Oxford Eye Hospital Royal Victoria Hospital Belfast Altnagelvin Area Hospital Low Vision Clinic Fife Low Vision Centre for the Blind Manchester Royal Eye Hospital and Manchester Academic and Health Science Centre Central Manchester University Hospitals NHS Foundation Trust

AIM: To develop a short,enhanced functional ability Quality of Vision(faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale,items and scoring of the visual related difficulties experienced by patients with visual impairment. · METHOdS: Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. ·RESULTS: Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate(r =0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.·CONCLUSION: The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

关键词： quality of life visual impairment low vision functional ability sensitivity specificity