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Dysfunctional stem and progenitor cells impair fracture healing with age

world Journal of Stem Cells 2019年第6期11卷 281-296页

作者： Diane R wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer jonathan w lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li Department of Mechanical and Energy Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202United States Department of Medicinal Chemistry and Molecular Pharmacology Purdue UniversityWest LafayetteIN 47907United States Department of Physical Therapy Indiana University- Purdue University IndianapolisIndianapolisIN 46202United States Division of Biomedical Science Marian University College of Osteopathic MedicineIndianapolisIN 46222United States Department of Chemistry Purdue UniversityWest LafayetteIN 47907 United States Richard L. Roudebush VA Medical Center IndianapolisIN 46202United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States Department of Biology Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.

关键词： Fracture healing Aging Bone Angiogenesis Mesenchymal stem cells Endothelial progenitor cells

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Childhood opportunity and appropriate use of child safety restraints in motor vehicle collisions

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world Journal of Pediatric Surgery 2024年第2期7卷 142-149页

作者： Stephanie Y Chen Iris Garcia Shadassa Ourshalimian Chantel lowery Pradip P Chaudhari Ryan G Spurrier Pediatric Surgery Children's Hospital Los AngelesLos AngelesCaliforniaUSA Injury Prevention Program Children's Hospital Los AngelesLos AngelesCaliforniaUSA Emergency and Transport Medicine Children's Hospital Los AngelesLos AngelesCaliforniaUSA Pediatrics University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA Surgery University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA

Objectives Safety restraints reduce injuries from motor vehicle collisions(MVCs)but are often improperly applied or not *** Childhood Opportunity Index(COI)reflects social determinants of health and its study in pediatric trauma is *** hypothesized that MVC patients from low-opportunity neighborhoods are less likely to be appropriately *** A retrospective cross-sectional study was performed on children/adolescents≤18 years old in MVCs between January 1,2011 and December 31,*** were identified from the Children's Hospital Los Angeles trauma *** outcome was safety restraint use(appropriately restrained,not appropriately restrained).COI levels by home zip codes were stratified as very low,low,moderate,high,and very *** regression controlling for age identified factors associated with safety restraint *** Of 337 patients,73.9%were appropriately restrained and 26.1%were not appropriately *** with appropriately restrained patients,more not appropriately restrained patients were from low-COI(26.1%vs 20.9%),high-COI(14.8%vs 10.8%)and very high-COI(10.2%vs 3.6%)*** analysis demonstrated no significant associations in appropriate restraint use and *** was a non-significant trend that children/adolescents from moderate-COI neighborhoods were more likely than those from very low-COI neighborhoods to be appropriately restrained(OR=1.82,95%CI 0.78,4.28).Conclusion Injury prevention initiatives focused on safety restraints should target families of children from all neighborhood types.

关键词： MVC restrained neighborhood

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Preclinical Evaluation of Pharmaceutical Compositions and Their Components for Urinary Health

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Open Journal of Obstetrics and Gynecology 2020年第1期10卷 151-165页

作者： Francesco De Seta jonathan wayne lowery Oladipupo Ogunbekun OMS II Bryan Larsen Institute for Maternal and Child Health “IRCCS Burlo Garofolo” Trieste Italy Department of Medicine Surgery and Health Sciences University of Trieste Trieste Italy Marian University Indianapolis IN USA

Background: The need for products that treat or prevent urinary tract infections without resort to antibiotics that may select for resistant bacterial strains has created a need to develop antibiotic-free therapeutics. Objective: To conduct an exploratory evaluation of intrinsic antimicrobial activity of a panel of compounds alone or in combination against urinary pathogens and probiotic organisms as well as their effect on biofilm formation and immune activity in infected cultured bladder epithelial cells. Results: Of the compounds tested, 1% citric acid was most consistently inhibitory to urinary pathogens as were combinations containing citric acid. Two combinations of compounds were tested and both showed antimicrobial activity when challenged with 1 × 105 bacteria/mL. The two combination products and D-mannose did not inhibit probiotic microorganisms and one composition increased the inhibitory potential of probiotic organisms. Results obtained with biofilm studies were variable, but probiotic biofilm was enhanced under some circumstances. Biofilms of some urinary pathogens were reduced by antimicrobial mixtures. A strong cytokine response was elicited when T24 bladder epithelial cells were infected for one hour with urinary pathogens and a modest reduction in cytokine response was recorded with some combinations of test compounds. Conclusion: Citric acid alone and mixtures of various compositions containing citric acid inhibited the growth and biofilm formation by 4 uropathogens. Probiotic organisms grew in the presence of mannose and citric acid-containing combinations. One of the combinations enhanced probiotic activity of Lactobacilli against uropathogens. when infecting T24 cell monolayers with uropathogens, potential modulation of inflammatory activity was demonstrated.

关键词： Urinary Pathogen Antibacterial Inflammation Bladder Epithelial Cells

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Dreamweaver 3宝典

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丛书名：网络实用技术丛书

2000年

作者：（美）Joseph w.lowery 李航等译

书中通过大量实例，详细介绍了Dreamweaver的使用方法和技巧，并讲述了如何在Dreamweaver中运用Fireworks和Flash。本书内容丰富、思路清晰、图文并茂，实用性和权威性很强。

ISBN: (纸本)7111082095

关键词：制作网页软件工具

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Fireworks 3宝典

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丛书名：美国IDG“宝典”丛书

2000年

作者：（美）Joseph w.lowery 熊胜峰等译

本书是网页制作所用的软件工具宝典，书中提供了大量的提示和实际操作的例子，指导读者如何最大限度地发挥Fireworks功效。

ISBN: (纸本)7505363689

本书是网页制作所用的软件工具宝典，书中提供了大量的提示和实际操作的例子，指导读者如何最大限度地发挥Fireworks功效。

关键词：制作网页软件工具

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Dreamweaver 4宝典 2版

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丛书名：美国计算机“宝典”丛书

2001年

作者：（美）Joseph w.lowery 任娅等译

本书从漫游Dreamweaver界面入手，在带领读者尝试建立一个简单的网站后，开始详细介绍网页开发中各种元素的使用方法，如文本、图形、图像、声音、影像、动画等，并涉及到图层、行为、时间链、CSS等页面开发技术内容。

ISBN: (纸本)7505370499

关键词：制作基本知识网页软件工具

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Dreamweaver UltraDev 4宝典

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丛书名：美国计算机“宝典”丛书

2002年

作者：（美）Joseph w.lowery 许辉跃等译

本书详细介绍了UltraDev 4的各种功能，深入剖析了UltraDev在静态和动态web页面制作方面的各种技巧，并且以丰富详实的范例讲解了如何将UltraDev的各种功能完美地应用到具体实践中。

ISBN: (数字)7505374370

ISBN: (纸本)7505374370

关键词：制作网页软件工具

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Fireworks 2宝典

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丛书名：美国IDG“宝典”丛书

2000年

作者：（美）（J.w.洛厄里）Joseph w.lowery 熊胜峰等译

Fireworks 2 宝典

ISBN: (纸本)7505355813

Fireworks 2 宝典

关键词：制作软件工具网页

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The Effects of Offset Loading Versus Traditional Loading in the Bench Press Exercise on Muscle Thickness and Strength in Trained Males

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Journal of Science in Sport and Exercise 2023年第4期5卷 302-313页

作者： Matthew Sharp Charlie Ottinger Raad Gheith Matthew Stefan Ryan lowery Salvatore LoDuca Jacob wilson Research Division Applied Science and Performance Institute33607 TampaFLUSA Offset Ventures LLC 11357 WhitestoneNYUSA

Purpose This study compared the effects of offset loading(OSL)versus traditional loading(TDL)in the bench press exercise on pectoral muscle thickness and bench press strength over a 4-week ***:Twenty male participants aged 18-45 years with at least 5 years of bench press experience and a bench press one-repetition maximum equal to or greater than their body mass were randomly assigned to OSL and TDL *** and after the 4-week mesocycle,pectoral muscle thickness was assessed via ultrasonography and muscle strength was assessed by bench press one-repetition *** were explored with two-way mixed ANOVA and non-clinical magnitude-based ***:No group-by-time interaction was detected for any variable(P>0.05).when compared to small magnitudes,the pectoralis major muscle thickness changes were likely greater in OSL compared to TDL for the dominant(ES=0.70;87%likely greater)and nondominant pectoralis(ES=0.77;91%likely greater)as well as the sum of both pectorals(ES=0.80;92%likely greater).Similarly,a likely greater effect for absolute(ES=0.57;82%likely)and relative(ES=0.67;85%likely)bench press strength was seen with ***:Magnitude-based inferences interpreted here support the notion that OSL may be an advantageous training modality to enhance pectoral muscle thickness and bench press strength.

关键词： Resistance training Offset loading Bilateral movement Asymmetrical loading Performance

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Dreamweaver 2宝典 G

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丛书名：美国IDG“宝典”丛书

2000年

作者：（美）（J.w.洛厄里）Joseph w.lowery 于纲等译

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