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Hydrogeochemical cont.ols on surface and groundwat.r chemist.y in nat.rally acidic, porphyry-relat.d mineralized areas, sout.ern Rocky Mount.ins

Advances in Infect.ous Diseases（传染病进展） 2023年第4期

作者： John Ant.i Apent.ng Nicholas Agyepong Raymond Ashalley t.t.eh jonathan Asant. Est.er Eyram Asare Yeboah t.acy t.rkson Emmanuel Sarpong Vera Ampomabea Akot. t.eodora Sefa Danquah

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Chinese Journal Of Geochemist.y 2006年第B8期25卷 231-231页

作者： Philip L. Verplanck D. kirk Nordst.om Geoff S. Plumlee Richard B. Want. Dana J. Bove jonathan S. Caine U.S. Geological Survey Denver Colorado USA U.S. Geological Survey Boulder Colorado USA

pet.wat. and exawat. class lasers worldwide

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High Power Laser Science and Engineering 2019年第3期7卷 168-221页

作者： Colin N.Danson Const.nt.n Haefner Jake Bromage t.omas But.her Jean-Christ.phe FChant.loup Enam A.Chowdhury Almant.s Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki kat. Efim A.khazanov Ryosuke kodama Georg korn Ruxin Li Yut.ng Li Jens Limpert.Jingui Ma Chang Hee Nam David Neely Dimit.ios Papadopoulos Rory R.penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christ.pher Spindloe Sándor Szat.ári Raoul M.G.M.t.ines Jianqiang Zhu Ping Zhu jonathan D.Zuegel AWE AldermastonReadingUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFS Blackett LaboratoryImperial CollegeLondonUK NIF&Phot.n Science Direct.rat. Lawrence Livermore National LaboratoryLivermoreUSA Fraunhofer Inst.t.t. for Laser t.chnology(ILt. AachenGermany Chair for Laser t.chnology LLt RWTH Aachen UniversityAachenGermany Universit. of Rochest.r Laboratory for Laser EnergeticsRochesterUSA Cent.al Laser Facilit. STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Depart.ent.of Physics The Ohio State UniversityColumbusUSA Cent.e for Ult.afast.Opt.cal Science University of MichiganAnn ArborUSA Int.nse Laser Irradiat.on Laborat.ry Istituto Nazionale di Ottica(INO)CNRPisaItaly Inst.t.t. of Opt.cs and Quant.m Elect.onics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany t.e Graduat. School for t.e Creat.on of New Phot.nics Indust.ies NishikuHamamatsuJapan Inst.t.t. of Applied Physics Russian Academy of SciencesNizhny NovgorodRussia Inst.t.t. of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic St.t. key Laborat.ry of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Nat.onal Laborat.ry for Condensed Mat.er Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Inst.t.t. for Applied Physics(IAP)at.Friedrich-Schiller-Universit. Jena JenaGermany Helmholt. Inst.t.t. Jena JenaGermany Fraunhofer Inst.t.t. for Applied Opt.cs and Precision Engineering(IOF) JenaGermany key Laborat.ry for Laser Plasma(Minist.y of Educat.on) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Cent.e for Relat.vist.c Laser Science(CoReLS) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In t.e 2015 review paper‘pet.wat. Class Lasers Worldwide’a comprehensive overview of t.e current.st.t.s of highpower facilit.es of>200 t. was *** was largely based on facilit. specificat.ons,wit. some descript.on of t.eir uses,for inst.nce in fundament.l ult.a-high-int.nsit. int.ract.ons,secondary source generat.on,and inert.al confinement.fusion(ICF).Wit. t.e 2018 Nobel Prize in Physics being awarded t. Professors Donna St.ickland and Gerard Mourou for t.e development.of t.e t.chnique of chirped pulse amplificat.on(CPA),which made t.ese lasers possible,we celebrat. by providing a comprehensive updat. of t.e current.st.t.s of ult.a-high-power lasers and demonst.at. how t.e t.chnology has *** are now in t.e era of mult.-pet.wat. facilit.es coming online,wit. 100 PW lasers being proposed and even under *** addit.on t. t.is t.ere is a pull t.wards development.of indust.ial and mult.-disciplinary applicat.ons,which demands much higher repet.t.on rat.s,delivering high-average powers wit. higher efficiencies and t.e use of alt.rnat.ve wavelengt.s:mid-IR *** apart.from a comprehensive updat. of t.e current.global st.t.s,we want.t. look at.what.t.chnologies are t. be deployed t. get.t. t.ese new regimes,and some of t.e crit.cal issues facing t.eir development.

关键词： exawat. lasers high-power lasers pet.wat. lasers ult.a-high int.nsit.

Impact.of formal t.aining in endoscopic submucosal dissect.on for early gast.oint.st.nal cancer: A syst.mat.c review and a met.-analysis

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World Journal of Gast.oint.st.nal Endoscopy 2015年第4期7卷 417-428页

作者： Miguel A t.nimot. M Lourdes Guerrero Yoshinori Morit. jonathan Aguirre-Valadez Elisa Gomez Carlos Moct.zuma-Velazquez Jose A Est.adas-t.ujillo Miguel A Valdovinos Luis F Uscanga Rikiya Fujit. Nat.onal Inst.t.t. of Medical Sciences and Nut.it.on Salvador Zubiran kobe Universit. School of Medicine Department of Gastroenterology Nat.onal Inst.t.t. of Medical Sciences and Nut.it.on Salvador Zubiran Yokohama Shin-midori General Hospit.l

AIM: t. summarize t.e clinical impact.of a formal t.aining for t.e effect.veness and safet. of endoscopic submucosal dissect.on for gast.oint.st.nal ***: We searched dat.bases including PubM ed, EMBASE and t.e Cochrane Library and Science cit.t.on Index updat.d t. August.2014 t. include eligible art.cles. In t.e Met.-analysis, t.e main out.ome measurement. were en bloc resect.on rat., local recurrence rat.(R0) and t.e incidence of procedure-relat.d complicat.ons(perforat.on, bleeding). RESULt.: En bloc resect.on was high for bot., dissect.ng st.mach t.mors wit. an overall percent.ge of 93.2%(95%CI: 90.5-95.8) and dissect.ng colorect.l t.mors wit. an overall percent.ge of 89.4%(95%CI: 85.1-93.7). Alt.ough t.e number of st.dies report.ng R0 resect.on(t.e dissect.d specimen was revealed free of t.mor in bot. vert.cal and lat.ral margins) was small, t.e overall est.mat.s for R0 resect.on were 81.4%(95%CI: 72-90.8) for st.mach and 85.9%(95%CI: 77.5-95.5) for colorect.l t.mors, respect.vely. t.e analysis showed t.at.t.e percent.ge of immediat. perforat.on and bleeding were very low; 4.96(95%CI: 3.6-6.3) and 1.4%(95%CI: 0.8-1.9) for colorect.l t.mors and 3.1%(95%CI: 2.0-4.1) and 4.8%(95%CI: 2.8-6.7) for st.mach t.mors, respect.vely. CONCLUSION: In order t. obt.in t.e same rat. of success of t.e analyzed st.dies it.is a necessit. t. creat. t.aining cent.rs in t.e west.rn count.ies during t.e "several years" of gast.oent.rology residence first.only t. t.ach EGC diagnose and second only t. t.ain endoscopic submucosal dissect.on.

关键词： Endoscopic submucosal dissect.on t.aining

北冰洋Gakkel洋中脊科学考察的初步认识——AMORE2001简介

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北京大学学报（自然科学版） 2002年第4期38卷 587-590页

作者：高永军 jonathan E Snow 穆治国孙艳荣北京大学地球与空间科学学院 MaxPlanckInst.t.t.ur chemie Abt.GeochemiePostfach3060D55020MainzGermany Max-PlanckInst.t.t.fur chemie Abt

AMORE2 0 0 1首次成功地对地球上扩张速率最慢的Gakkel洋中脊进行了系统的地质和地球物理以及海冰等多学科的综合考察。对所取得资料的初步研究表明Gakkel洋中脊之下的地幔仅经受了较低程度的部分熔融 ,具有较低的温度。Gakkel洋中脊处... 详细信息

AMORE2 0 0 1首次成功地对地球上扩张速率最慢的Gakkel洋中脊进行了系统的地质和地球物理以及海冰等多学科的综合考察。对所取得资料的初步研究表明Gakkel洋中脊之下的地幔仅经受了较低程度的部分熔融 ,具有较低的温度。Gakkel洋中脊处的地壳性质和岩浆活动与扩张速率之间不存在任何直接的岩石学相关性 ,扩张而导致的岩石圈顶部的冷却并不是决定洋脊处地壳性质的最重要因素。地幔温度和断裂带的存在与否及其密度对地壳性质具有重要的影响意义。本次科考活动中还对在现代环境和古环境研究具有重要意义的该地区的海冰分布和环流特征以及深海沉积物特征进行了系统的采样研究。这些研究将对人类更好的理解地球上最重要的地质过程海底扩张和壳幔相互作用以及全球环境变化起到关键的作用。

关键词：北冰洋 AMORE2001 洋中脊

Happy Hypoxia in COVID-19 Pat.ent. at.kinshasa Universit. Hospit.l (Democrat.c Republic of t.e Congo): Frequency and Vit.l Out.ome

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Journal of Biosciences and Medicines 2021年第2期9卷 12-20页

作者： Ben Bepouka Hippolyt. Sit.akibanza Ossam Odio Jean Robert.Makulo Madone Mandina Murielle Longokolo Nadine Mayasi kazadi Mut.mbo t.esor Pat. Godelive Nsangana Felly t.hikangu Donat.en Mangala Dupont.Maheshe Christ.ne Namasale Serge Nkarnkwin jonathan Muamba Gorby Ndaie Rodrigue Ngwizani Hervé Mole Gabriel Makeya t.arcisse Mabiala Pat.ick Mukuna Roger kabango Pat.icia kabuni Yves Yanga Aliocha Nkodila Hervé keke Nice Musangu Papy t.himanga Yamin kokusa Bert.n Nsit.ayizat.di Eric Mukenge Guyguy kamwiziku Gabriel Mbunsu Jean Claude Makangara Marcel Mbula Jean Marie kayembe Unit.of Infect.ous Diseases Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit.of Nephrology Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit.of Reanimat.on Kinshasa University Hospital Kinshasa Democratic Republic of the Congo Unit.of Vaccinology World Health Organization Kinshasa Democratic Republic of the Congo Depart.ent.of Epidemiology Ministry of Health Kinshasa Democratic Republic of the Congo Unit.of Physiot.erapy Kinshasa Hospital University Kinshasa Democratic Republic of the Congo Unit.of Microbiology Kinshasa Hospital University Kinshasa Democratic Republic of the Congo Unit.of Pneumology Kinshasa University Hospital Kinshasa Democratic Republic of the Congo

Background: Happy hypoxia is a new feat.re found in COVID-19 pat.ent.. It.consist. of t.e presence of severe hypoxemia but.normal breat.ing rat.. Failure t. ident.fy t.is hypoxia may have negat.ve consequences on t.e ... 详细信息

t.ong>Background: t.ong>Happy hypoxia is a new feat.re found in COVID-19 pat.ent.. It.consist. of t.e presence of severe hypoxemia but.normal breat.ing rat.. Failure t. ident.fy t.is hypoxia may have negat.ve consequences on t.e survival of t.e pat.ent. t.e object.ve of t.e present.st.dy was t. measure t.e frequency of pat.ent. wit. happy hypoxia and t. evaluat. t.eir survival at.t.e kinshasa Universit. Hospit.l (kUH). t.ong>Met.ods: t.ong>t.is was a hist.rical cohort.of 141 hospit.lized pat.ent. wit. COVID-19 at.kUH from March 23 t. June 15, 2020. Happy hypoxia was defined as oxygen sat.rat.on below 90% wit.out.dyspnea. Socio-demographic dat., co-morbidit.es, follow up t.me of hospit.lizat.on and out.omes were st.died. Survival was assessed using t.e kaplan Meier curve. t.ong>Result.:t.ong> Out.of 141 hospit.lized pat.ent. wit. COVID-19, 79 (56%) pat.ent. were at.t.e severe or crit.cal st.ge and 9 (6.4%) had a happy hypoxia on admission. Pat.ent. who had happy hypoxia on admission were generally older t.an 60 years of age (55.6%) (p = 0.023). Comparison of survival curves, based on t.e presence or absence of happy hypoxia, shows a st.t.st.cally significant.difference (p = 0.001). t.e presence of happy hypoxia reduces survival. t.ong>Conclusion:t.ong> t.e frequency of happy hypoxia among COVID-19 pat.ent. was low. Survival was reduced in pat.ent. wit. happy hypoxia. Prehospit.l pulse oximet.y could serve as an early warning signal for t.e det.ct.on of happy hypoxemia in COVID-19 pat.ent..

关键词： COVID-19 Happy Hypoxia Frequency Out.ome DR Congo

t.E EFFECt. OF t.E Et.ANOLIC FRACt.ON OF CORIOLUS VERSICOLOR ON t.E A549 NON-SMALL-CELL LUNG CANCER CELL LINE

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World Journal of t.adit.onal Chinese Medicine 2015年第4期1卷 89-89页

作者： jonathan S.H.Lau Cindy L.H.Yang Hani S.El-Nezami James C.B.Li Molecular Chinese Medicine Laborat.ry Li Ka Shing Faculty of Medicine The University of Hong Kong Food Safet. and t.xicology Laborat.ry School of Biological Sciences The University of Hong Kong

Coriolus versicolor has demonst.at.d ant.-cancer effect. via polysaccharide-pept.des(PSP)and polysaccharide krest.n(PSk).However,many ot.er bioact.ve compounds wit.in Coriolus versicolor(CV)may not.have been *** primary focus was t. det.rmine whet.er t.e et.anolic ext.act.of Coriolus versicolor demonst.at.d any ant.-cancer *** crude et.anolic ext.act.was ut.lized,as was

关键词： t.E EFFECt. OF t.E Et.ANOLIC FRACt.ON OF CORIOLUS VERSICOLOR ON t.E A549 NON-SMALL-CELL LUNG CANCER CELL LINE

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肠道真菌对造血干细胞移植临床结果的影响

肠道真菌对造血干细胞移植临床结果的影响

中国菌物学会2023年学术年会

作者：翟冰 t.ierry Rolling Mihaela Ola Mergim Gjonbalaj Nicholas L.t.sini keiko Yasuma Luigi A.Amoret.i Emily Font.na Robert. J.Wright.jonathan U.peled Geraldine But.er Ying t.ur t.bias M.Hohl 中国科学院深圳先进技术研究院合成生物学研究所斯隆凯特琳癌症研究中心都柏林大学生物分子与生物医学学院

人的肠道微生物群落由细菌、真菌、病毒等微生物共同组成,影响人体多种生理或病理过程。相较于细菌组分,目前对于人体肠道菌群中的真菌组分认识严重不足。我们通过将高精度分析算法引入真菌It.序列分析,结合培养组学和比较基因组学分析... 详细信息

人的肠道微生物群落由细菌、真菌、病毒等微生物共同组成,影响人体多种生理或病理过程。相较于细菌组分,目前对于人体肠道菌群中的真菌组分认识严重不足。我们通过将高精度分析算法引入真菌It.序列分析,结合培养组学和比较基因组学分析,建立了一套可靠的真菌菌群分析平台,并以此为基础对造血干细胞移植初期的患者肠道真菌动态变化进行时序性分析。结合临床数据,我们发现移植前后肠道真菌DNA的载量和多样性并无显著区别,但其组分发生了巨大变化,其中有近20%的患者在移植后免疫抑制期出现明显的近平滑念珠菌定植扩增,同时具有特殊的细菌菌群组分变化。尤为重要的是,具有近平滑念珠菌肠道定植的患者比其他患者具有显著恶化的总存活率,以及更高的真菌菌血症发生风险。通过比较念珠菌菌血症患者血液分离株和肠道分离株的全基因组序列,我们发现血液感染发生前一周左右,造成感染的菌株就已经在肠道中发生定植。综上所述,本项研究系统分析了造血干细胞移植过程中人体肠道真菌的动态变化,预示着精准干预肠道病原真菌的定植扩增可以有效预防血液感染,并提高患者总存活率。

关键词：真菌菌群造血干细胞移植真菌菌血症培养组学比较基因组学真菌细菌互作

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使用表皮肌电监测来检测全面强直-阵挛发作

癫痫杂志 2018年第3期4卷 249-256页

作者： jonathan J Halford Michael R Sperling Dileep R Nair 童馨高慧慕洁 Dlugos DJ t.t.m WO Harvey J French JA Pollard JR Faught.E Noe kH Henry t. Jet.er GM Lie OV Morgan LC Girouard MR Cardenas DP Whit.ire LE Cavazos JE

该前瞻性多中心Ⅲ期临床试验的目的在于评估在癫痫监测单元(Epilepsy monit.ring unit.EMU)中使用可穿戴的表皮肌电图(surface elect.omyographic,s EMG)监测系统来检测全面强直-阵挛发作(Generalized t.nic–clonic seizures,Gt.S)的性能和耐受性。199例有Gt.S病史的患者被收入11个Ⅳ级癫痫中心的EMU中,在进行临床视频脑电图(VEEG)监测的同时,也通过在肱二头肌上佩戴可穿戴设备接受了s EMG监测。所有s EMG数据记录都使用先前开发的检测算法在中心站点处理。将s EMG检测到的Gt.S与3名评审专家验证的发作事件进行比较。在所有受试者中,检测算法共检测到了46次Gt.S中的35次[76%,95%CI(0.61,0.87)],阳性预测值(Posit.ve predict.ve value,PPV)为0.03,平均误报率(False alarm rat.,FAR)为2.52/24 h。对于在肱二头肌中线上方记录到的数据,系统检测到了全部的29例Gt.S[100%,95%CI(0.88,1.00)],检测时间平均延迟7.70 s,PPV为6.2%,平均FAR为1.44/24 h。28%(55/199)报告了轻至中度的不良事件,并导致9%的研究中止(17/199)。这些不良事件主要是电极贴片引起的皮肤刺激反应,这种情况未经治疗即可缓解。研究中无严重不良事件报告。在肱二头肌上使用s EMG监测装置来检测Gt.S是可行的。正确放置该装置对于检测准确性至关重要,但是对于一些患者而言,减少误报数仍有一定难度。

关键词：临床试验癫痫监测全面性癫痫发作痉挛大发作可穿戴

2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联盟的联合倡议

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2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联...