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第十三届国际核工程大会

作者： jonathan s.pitt Mirna Urquidi-Macdonald Digby D.Macdonald John H.Mahaffy The Pennsylvania state University The Pennsylvania state University The Pennsylvania state University The Pennsylvania state University

＜正＞ Activity transport in Pressurized Water Reactors （PWRs） is a major concern with respect to both safety and plant operation. Activity transport from the core to other serviceable parts of the primary heat transport loop increases the exposure levels of maintenance workers during repairs, and affects the operation of the plant. The primary cause of activity transport is the activation of isotopes found in the primary coolant as a

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Methodology for Comparing Coupling Algorithms for Fluid-structure Interaction Problems

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World Journal of Mechanics 2014年第2期4卷 54-70页

作者： Jason P. sheldon scott T. Miller jonathan s. pitt Applied Research Laboratory The Pennsylvania State University State College USA

The multi-physics simulation of coupled fluid-structure interaction problems, with disjoint fluid and solid domains, requires one to choose a method for enforcing the fluid-structure coupling at the interface between solid and fluid. While it is common knowledge that the choice of coupling technique can be very problem dependent, there exists no satisfactory coupling comparison methodology that allows for conclusions to be drawn with respect to the comparison of computational cost and solution accuracy for a given scenario. In this work, we develop a computational framework where all aspects of the computation can be held constant, save for the method in which the coupled nature of the fluid-structure equations is enforced. To enable a fair comparison of coupling methods, all simulations presented in this work are implemented within a single numerical framework within the *** [1] finite element library. We have chosen the two-dimensional benchmark test problem of Turek and Hron [2] as an example to examine the relative accuracy of the coupling methods studied;however, the comparison technique is equally applicable to more complex problems. We show that for the specific case considered herein the monolithic approach outperforms partitioned and quasi-direct methods;however, this result is problem dependent and we discuss computational and modeling aspects which may affect other comparison studies.

关键词： Fluid-structure Interaction FsI Finite Element Method Monolithic Coupling Partitioned Coupling Dirichlet-Neumann Coupling Multi-Physics

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Antitumor efficacy of anti-CTLA4 antibody is dependant on gut microbiota.

Antitumor efficacy of anti-CTLA4 antibody is dependant on gu...

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第十届全国免疫学学术大会

作者： Marie Vetizou jonathan M. pitt Romain Daillère Laurence Zitvogel Gustave Roussy Cancer Campus INsERM U1015

The cytotoxic T lymphocyte antigen-4(CTLA-4)-blocking antibody ipilimumab is an FDA and EMEA-approved treatment for metastatic melanoma,which induces immune-mediated long-term control in 15%of ***,ipilimumab also results in substantial immune related side effects including grade III-IV *** uncouple efficacy and toxicity we analyzed the mode of action of anti-CTLA4 therapy in preclinical mouse ***,the gut microbiota was

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