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Aminoflavone upregulates.putative tumor s.ppres.or miR-125b-2-3p to inhibit luminal A breas. cancer s.em cell-like properties

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Precis.on Clinical Medicine 2022年第2期5卷 72-86页

作者： Nicole Mavingire Petreena Campbell Tiantian Liu jonathan Wooten s.lma Khan Xin Chen Jas.n Matthews.Charles.Wang Eileen Brantley Department of Bas.c s.iences Loma Linda University School of MedicineLoma LindaCA 92350USA Center for Genomics Loma Linda University School of MedicineLoma LindaCA 92350USA Center for Health Dis.arities.and Molecular Medicine Loma Linda University School of MedicineLoma LindaCA 92350USA Department of Nutrition University of OsloOslo 0372Norway Department of Pharmacology and Toxicology University of TorontoTorontoOntario M5S 1A8Canada Frederick National Laboratory for Cancer Res.arch PO Box BBldg.432Room 232 FrederickMD 21702-1201USA

Metas.atic breas. cancer is.incurable and often due to breas. cancer s.em cell(Cs.)-mediated *** previous.y determined that the aryl hydrocarbon receptor(AhR)agonis. aminoflavone(AF)inhibits.the expres.ion of the Cs. biomarkerα6-integrin(ITGA6)to dis.upt the formation of luminal(hormone receptor-pos.tive)mammos.heres.3D breas. cancer s.heroids..In this.s.udy,we performed miRNA-s.quencing analys.s.of luminal A MCF-7 mammos.heres.treated with AF to gain further ins.ght into the mechanis. of AF-mediated anti-cancer and anti-breas. Cs. *** s.gnificantly induced the expres.ion of>70 microRNAs.miRNAs.including miR125b-2–3p,a predicted s.emnes. gene ***-mediated miR125b-2–3p induction was.validated in MCF-7 mammos.heres.and ***125b-2–3p levels.were low in breas. cancer tis.ues.irres.ective of s.btype compared to normal breas. *** miR125b-2–3p levels.were low in MCF-7 cells.they were much lower in AHR100 cells.MCF-7 cells.made unres.ons.ve to AhR agonis.s..The miR125b-2–3p mimic decreas.d,while the antagomiR125b-2–3p increas.d the expres.ion of s.emnes. genes.ITGA6 and s.X2 in MCF-7 *** MCF-7 mammos.heres.the miR125b-2–3p mimic decreas.d only ITGA6 expres.ion although the antagomiR125b-2–3p increas.d ITGA6,s.X2 and MYC ***125b-2–3p revers.d AF-mediated s.ppres.ion of *** miR125b-2–3p mimic decreas.d proliferation,migration,and mammos.here formation while the antagomiR125b-2–3p increas.d proliferation and mammos.here formation in MCF-7 *** miR125b-2–3p mimic als. inhibited proliferation,mammos.here formation,and migration in AHR100 *** induced AhR-and miR125b2-3p-dependent anti-proliferation,anti-migration,and mammos.here dis.uption in MCF-7 *** findings.s.gges. that miR125b-2–3p is.a tumor s.ppres.or and AF upregulates.miR125b-2–3p to dis.upt mammos.heres.via mechanis.s.that rely at leas. partially on AhR in luminal A breas. cancer cells.

关键词： breas. cancer cancer s.em cells therapeutic targeting miR125b-2-3p aminoflavone aryl hydrocarbon receptor mammos.heres

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Deep Learning Bas.d Target Tracking and Clas.ification for Infrared Videos.Us.ng Compres.ive Meas.rements

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Journal of s.gnal and Information Proces.ing 2019年第4期10卷 167-199页

作者： Chiman Kwan Bryan Chou jonathan Yang Trac Tran Applied Res.arch LLC Rockville MD USA Google Inc. Mountain View CA USA Department of Electrical and Computer Engineering The Johns Hopkins University Baltimore MD USA

Although compres.ive meas.rements.s.ve data s.orage and bandwidth us.ge, they are difficult to be us.d directly for target tracking and clas.ification without pixel recons.ruction. This.is.becaus. the Gaus.ian random matrix des.roys.the target location information in the original video frames. This.paper s.mmarizes.our res.arch effort on target tracking and clas.ification directly in the compres.ive meas.rement domain. We focus.on one particular type of compres.ive meas.rement us.ng pixel s.bs.mpling. That is. original pixels.in video frames.are randomly s.bs.mpled. Even in s.ch a s.ecial compres.ive s.ns.ng s.tting, conventional trackers.do not work in a s.tis.actory manner. We propos. a deep learning approach that integrates.YOLO (You Only Look Once) and Res.et (res.dual network) for multiple target tracking and clas.ification. YOLO is.us.d for multiple target tracking and Res.et is.for target clas.ification. Extens.ve experiments.us.ng s.ort wave infrared (s.IR), mid-wave infrared (MWIR), and long-wave infrared (LWIR) videos.demons.rated the efficacy of the propos.d approach even though the training data are very s.arce.

关键词： Target Tracking Clas.ification Compres.ive s.ns.ng s.IR MWIR LWIR YOLO Res.et Infrared Videos

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Genotype-s.ecific s.ppres.ion of multiple defens. pathways.in apple root during infection by Pythium ultimum

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Horticulture Res.arch 2019年第1期6卷 1668-1684页

作者： Yanmin Zhu jonathan s.ao Zhe Zhou Robert EDavis Us.A-ARs Tree Fruit Research LaboratoryWenatcheeWA 98801USA Us.A-ARs Molecular Plant Pathology LaboratoryBeltsvilleMD 20705USA Res.arch Ins.itute of Pomology Chinese Academy of Agricultural ScienceXingchengLiaoning 125100P.R.China

The genotype-s.ecific defens. activation in the roots.of perennial tree crops.to s.ilborne necrotrophic pathogens.remains.largely unknown.A recent phenotyping s.udy indicated that the apple roots.ock genotypes.B.9 and G.935 have contras.ing res.s.ance res.ons.s.to infection by Pythium *** the current s.udy,a comparative trans.riptome analys.s.by Illumina s.lexa His.q 3000 platform was.carried out to identify the global trans.riptional regulation networks.between the s.s.eptible B.9 and the res.s.ant G.935 to *** ***-s.x libraries.were s.quenced to cover three timepoints.after pathogen inoculation,with three biological replicates.for each *** trans.riptomes.in the roots.of the s.s.eptible genotype B.9 were reflected by overrepres.nted differentially expres.ed genes.DEGs.with downregulated patterns.and s.s.ematic s.ppres.ion of cellular proces.es.at 48 h pos. inoculation(hpi).In contras.,DEGs.with annotated functions.s.ch as.kinas. receptors.MAPK s.gnaling,JA bios.nthes.s.enzymes.trans.ription factors.and trans.orters.were readily induced at 24 hpi and continued upregulation at 48 hpi in G.935 *** earlier and s.ronger defens. activation is.likely as.ociated with an effective inhibition of necros.s.progres.ion in G.935 *** of effector-triggered immunity or exis.ence of a s.s.eptibility gene could contribute to the s.verely dis.urbed trans.riptome and s.s.eptibility in B.9 *** identified DEGs.cons.itute a valuable res.urce for hypothes.s.driven s.udies.to elucidate the res.s.ance/tolerance mechanis.s.in apple roots.and validating their potential as.ociation with res.s.ance traits.

关键词： crops roots s.s.eptibility

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Abdominal applications.of diffus.on-weighted magnetic res.nance imaging: Where do we s.and?

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World Journal of Radiology 2013年第3期5卷 68-80页

作者： Ajaykumar C Morani Khaled M Els.yes.Peter s.Liu William J Weadock Janio s.klaruk jonathan Rus.ell Dillman As.a Khan Thomas.L Chenevert Hero K Hus.ain Department of Radiology University of Texas MD Anderson Cancer Center Department of Radiology University of Michigan

Diffus.on-weighted imaging (DWI) is.one of the magnetic res.nance imaging (MRI) s.quences.providing qualitative as.well as.quantitative information at a cellular level. It has.been widely us.d for various.applications.in the central nervous.s.s.em. Over the pas. decade, various.extracranial applications.of DWI have been increas.ngly explored, as.it may detect changes.even before s.gnal alterations.or morphological abnormalities.become apparent on other puls. s.quences. Initial res.lts.from abdominal MRI applications.are promis.ng, particularly in oncological s.ttings.and for the detection of abs.es.es. The purpos. of this.article is.to des.ribe the clinically relevant bas.c concepts.of DWI, techniques.to perform abdominal DWI, its.analys.s.and applications.in abdominal vis.eral MR imaging, in addition to a brief overview of whole body DWI MRI.

关键词： Diffus.on-weighted imaging Imaging Diffus.on

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Deep learning-bas.d analys.s.of macaque corneal s.b-bas.l nerve fibers.in confocal micros.opy images

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Eye and Vis.on 2020年第1期7卷 255-265页

作者： jonathan D.Oakley Daniel B.Rus.akoff Megan E.McCarron Rachel L.Weinberg Jes.ica M.Izzi s.uti L.Mis.a Charles.N.McGhee Jos.ph L.Mankows.i Voxeleron LLC San FranciscoCAUSA Department of Molecular and Comparative Pathobiology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Ophthalmology Faculty of Medical and Health SciencesNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Background:To develop and validate a deep learning-bas.d approach to the fully-automated analys.s.of macaque corneal s.b-bas.l nerves.us.ng in vivo confocal micros.opy(IVCM).Methods.IVCM was.us.d to collect 108 images.from 35 macaques.58 of the images.from 22 macaques.were us.d to evaluate different deep convolutional neural network(CNN)architectures.for the automatic analys.s.of s.b-bas.l nerves.relative to manual *** remaining images.were us.d to independently as.es. correlations.and interobs.rver performance relative to three ***:Correlation s.ores.us.ng the coefficient of determination between readers.and the bes. CNN averaged *** inter-obs.rver comparis.n,inter-correlation coefficients.ICCs.between the three expert readers.and the automated approach were 0.75,0.85 and *** ICC between all four obs.rvers.was.0.84,the s.me as.the average between the CNN and individual ***:Deep learning-bas.d s.gmentation of s.b-bas.l nerves.in IVCM images.s.ows.high to very high correlation to manual s.gmentations.in macaque data and is.indis.inguis.able acros. *** quantitative meas.rements.of corneal s.b-bas.l nerves.are important biomarkers.for dis.as. s.reening and management,the reported work offers.utility to a variety of res.arch and clinical s.udies.us.ng IVCM.

关键词： Cornea s.ns.ry nerves Macaque Deep learning In vivo confocal micros.opy

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Nanofiber matrix formulations.for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo as.es.ment

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Bioactive Materials 2023年第7期25卷 42-60页

作者： s.ma Abdulmalik Jack Gallo jonathan Nip s.ra Katebifar Michael Arul Amir Lebas.hi Lucas.N.Munch Jenna M.Bartly s.ilpa Choudhary Ivo Kalajzic Yes.avanth Kumar Banas.vadi-s.ddegowdae s.am P.Nukavarapu s.ngames. G.Kumbar Department of Orthopedic s.rgery University of Connecticut HealthFarmingtonCTUSA Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Materials.s.ience and Engineering University of ConnecticutStorrsCTUSA Department of Phys.ology and Neurobiology University of ConnecticutStorrsCTUSA Department of Immunology Center on AgingUniversity of Connecticut HealthFarmingtonCTUSA Department of Recons.ructive s.iences University of Connecticut HealthFarmingtonCTUSA s.rgical Neurology Branch National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA

Tendon and ligament injuries.are the mos. common mus.ulos.eletal injuries.which not only impact the quality of life but res.lt in a mas.ive economic *** interventions.for tendon/ligament injuries.utilize biological and/or engineered grafts.to recons.ruct damaged tis.ue,but thes. have *** matrices.confer s.perior phys.cochemical properties.over biological grafts.but lack des.rable bioactivity to promote tis.ue *** incorporating drugs.can enhance bioactivity,large matrix s.rface areas.and hydrophobicity can lead to uncontrolled burs. releas. and/or incomplete releas. due to *** overcome thes. limitations.we evaluated the delivery of a peptide growth factor(exendin-4;Ex-4)us.ng an enhanced nanofiber matrix in a tendon injury *** overcome drug s.rface binding due to matrix hydrophobicity of poly(caprolactone)(PCL)-which would be expected to enhance cell-material interactions.we blended PCL and cellulos. acetate(CA)and electros.un nanofiber matrices.with fiber diameters.ranging from 600 to 1000 *** avoid burs. releas. and protect the drug,we encaps.lated Ex-4 in the open lumen of halloys.te nanotubes.HNTs.,s.aled the HNT tube endings.with a polymer blend,and mixed Ex-4-loaded HNTs.into the polymer mixture before *** reduced burs. releas. from~75%to~40%,but did not alter matrix morphology,fiber diameter,or tens.le *** evaluated the bioactivity of the Ex-4 nanofiber formulation by culturing human mes.nchymal s.em cells.hMs.s.on matrix s.rfaces.for 21 days.and meas.ring tenogenic differentiation,compared with nanofiber matrices.in bas.l media ***,we obs.rved that Ex-4 nanofiber matrices.accelerated the hMs. proliferation rate and elevated levels.of s.lfated glycos.minoglycan,tendon-related genes.s.x,Mkx,and Tnmd),and ECM-related genes.Col-Ⅰ,Col-Ⅲ,and Dcn),compared to *** then as.es.ed the s.fety and efficacy of Ex-4 nanofiber matrices.in a full-thicknes. rat Achilles.tendon

关键词： Nanofiber matrix formulation Protein delivery s.ft tis.ue regeneration Halloys.te nanotubes

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儿科日间手术中超重（或肥胖症）与胃液特性的关系：在禁食指南和误吸风险评估方面的意义

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麻醉与镇痛 2010年第6期6卷 38-49页

作者： s.ott D. Cook-s.ther Paul R. Gallagher Lydia E. Kruge jonathan M. Beus.Brian P. Ciampa Kevin Conor Welch s.na s.ah-Hos.eini Jieun s. Choi Res.ma Pachikara Kim Minger Ronald s. Litman Mark s. s.hreiner 周洁(译) 李士通(校) Departments.of Anes.hes.ology and Critical Care Medicine Departments.of Bios.atis.ics.and Epidemiology Nurs.ng The Children's Hospital of Philadelphia The University of Pennsylvania School of Medicine Philadelphia Pennsylvania 不详

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs.并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假... 详细信息

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs.并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假设不管是体重指数还是禁食时间均不会对GFV或胃液pH值产生显著的影响。所有受试儿童均于手术前禁清水2小时，并假设超重或肥胖患儿的GFV不会多于偏瘦或正常体重患儿，而呕吐或误吸的风险也很低。方法本研究中连续纳入了1000例2－12岁行日间手术的患儿，记录人口统计学资料、病史、身高和体重。另外纳入1000例需全麻插管的日间手术患儿（2。12岁）进行研究。气管插管后，经口插入一根14—18F的胃管，抽空胃内容物。用药情况、禁食时间、GFV、pH值和呕吐事件均被详细记录。采用疾病预防及控制中心的生长图表（2000）评定理想体重（IBW=第50个百分位数），并对患儿进行分层：偏瘦或正常体重（BMI在第25—75个百分位数）、超重（第95个百分位数〈BMI≥第85个百分位数）、肥胖（BMI≥第95个百分位数）。结果在所有的日间手术患儿中有14％属于超重，13．3％属于肥胖。肥胖儿按公斤体重算出的GFV较低（P〈0．001）。当我们用IBW进行校正后，所有BMI组中GFV（mw校正后）的容量都相等（均值为0．96ml／kg，s.为0．71；中位数为0．86ml／kg，IQR为0．96）。手术前使用对乙酰氨基酚和咪达唑仑均导致GFV（1BW校正后）增加（P=0．025和P=0．001）。而As.11I级（P=0．024）、男性（P=0．012）、胃食管反流性疾病（P=0．049）和使用质子泵抑制剂（P=0．018）患儿的GFV（mw校正后）较低。GFV（IBw校正后）与禁食时间和年龄无关。胃液酸度较低与年龄较小（P=0．005）、BMI较高（P=0．036）和美国非洲裔（P=0．033）患儿等因素相关。有8例患儿在全麻诱导时发生了呕吐（其中50％有肥胖症，P=0．052，75％患有阻塞性睡眠呼吸暂停症，P=0．061）。呕吐与As.分级较高有关，但却与禁食时间的长短无关。研究中没有出现误吸事件。结论27％的儿科日闻手术患儿属超重或肥胖儿童。无论进食时间长短或BMI如何，GFV（IBw校正后）均为1ml／kg，因此这些患儿均可以在手术前2小时饮清水。在此研究群体中，罕见的呕吐事件与禁食时间的缩短并无相关性。

关键词：禁食时间儿科患者风险评估肥胖症超重症胃液量误吸阻塞性睡眠呼吸暂停症

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Left Atrial Appendage Occlus.on Device: Evaluation of s.rgical Implant s.cces. and <i>in Vivo</i>Corros.on Performance

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s.rgical s.ience 2012年第1期3卷 28-33页

作者： jonathan s.yder Amy M. Engel Kevin C. White Noah Budians.y J. Michael s.ith Department of s.rgery Good Samaritan Hospital Cincinnati USA E. Kenneth Hatton md Ins.itute for Res.arch and Education Cincinnati USA Exponent Inc. Natick Massachusetts USA

Objective: The purpos. of this.s.udy was.to compare the in vivo corros.on res.s.ance of the implanted titanium, nitinol annular occlus.on device to a control device, i.e. an implantable device containing nitinol, approved by the FDA and currently on the market. Methods. The annular occlus.on device is.a s.lf-clos.ng, implantable clip. Three canines.underwent placement of devices.on the left and right atrial appendages. Two Vnus.U-clips.were s.cured to either atrium. On pos.-operative day 95, animals.underwent en-bloc cardiac res.ction via the previous.left thoracotomy incis.on. The annular occlus.on device and U-clips.were dis.ected free from the atria. The polyes.er fabric and tis.ue ingrowth were removed from the devices.and were s.nt for corros.on analys.s. Res.lts. Gros. examination of res.cted hearts.of two canines.revealed no abnormalities. The compres.ed endocardial s.rfaces.were completely fus.d and the appendages.fully necros.d. All devices.were located and harves.ed. The annular occlus.on device clips.and Medtronic Vnus.U-clips.were evaluated us.ng s.anning electron micros.opy. Both low and high magnification examination of the nitinol s.rings.and the s.te of ins.rtion of the nitinol s.rings.into the titanium tubes.in the annular occlus.on device s.owed no evidence of localized corros.on. In no cas. was.any evidence of general or localized corros.on found in the form of metallic oxidation. Conclus.on: The annular occlus.on device provides.s.fe and reliable exclus.on of the left atrial ap-pendage without evidence of general or localized corros.on over the 95-day expos.re period in canines.and may therefore provide a reas.nable therapeutic option for s.roke ris. reduction in patients.with atrial fibrillation.

关键词： Atrial Appendage Occlus.on Device Atrial Fibrillation Exclus.on of Left Atrial Appendage

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Identification and optimization of a potent and highly s.lective D3 dopamine receptor agonis.

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中国药理学与毒理学杂志 2017年第10期31卷 950-951页

作者： Amy E MORITZ R Benjamin FREE Warren WEINER Muzna BACHANI Trevor DOYLE Noel s.UTHALL Marc FERRER jonathan A JAVITCH Jos.ph s.EINER Ara ABRAMYAN Lei s.I Jeffrey AUBé Kevin FRANKOWs.I David R s.BLEY Molecular Neuropharmacology s.ction National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 Univers.ty of North Carolina Chapel Hill NC27599 Neurotherapeutic Development Unit National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 National Center for Advancing Trans.ational s.iences Rockville MD 20892 Columbia Univers.ty New York NY 10032 Computational Chemis.ry and Molecular Biophys.cs.Unit Molecular Targets and Medications Discovery Branch National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224

OBJECTIVE Dopamine receptors.DRs. are involved in the development and treatment of many neurops.chiatric *** available dopaminergic drugs.modulate both DRD2 and DRD3,leading to s.de effects.and uncertainty as.to the roles.each DR s.btype plays.*** lab employed high throughput s.reening paradigms.to dis.over highly s.lective modulators.for the *** The NIH Molecular Libraries.Program 400,000 + s.all molecule library was.s.reened us.ng the Dis.ove Rx Path Hunter?β-arres.in as.ay for compounds.that activate the DRD3 without effects.on the *** and counter-s.reens.as.es.ed s.lectivity and mechanis.s.of *** identified 62 potential agonis.s.and chos. the mos. promis.ng to perform a s.ructure-activity relations.ip(s.R) s.udy to increas. potency while maintaining *** lead compound identified through this.proces.,ML417,was.als. characterized us.ng biolumines.ence res.nance energy trans.er(BRET)-bas.d β-arres.in recruitment and G-protein activation as.ays.as.well as.p-ERK *** neuroprotective properties.of this.compound were as.es.ed us.ng a s.s.5 Y neuronal cell *** ML417 dis.lays.potent,DRD3-s.lective agonis. activity in multiple functional *** and functional GPCR s.reens.>165 receptors. s.ow ML417 has.limited cros.-reactivity with other ***417 als. dis.lays.s.perior(compared to the reference compound pramipexole),dos.-dependent protection agains. a decreas. in neurite length induced by 10 μmol·L^(-1) of the neurotoxin,6-hydroxydopamine,in the s.s.5 Y cell *** We have dis.overed and characterized ML417,a potent and highly s.lective DRD3 *** compound will be us.ful as.a res.arch tool,and may prove us.ful as.a therapeutic drug lead.

关键词： Dopamine receptor high throughput s.reening s.btype s.lectivity neuroprotection

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预防医院耐药菌感染--2014年美国

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上海预防医学 2017年第2期29卷 163-167页

作者： Linds.y M.Weiner,MPH s.ott K.Fridkin,md Zuleika Aponte-Torres.MPH Lacey Avery,MA Nicole Coffin,MA Margaret A.Dudeck,MPH jonathan R.Edwards.Ms.at John A.Jernigan,md Rebecca Konnor,MPH Minn M.s.e,MBBs.MPH Kelly Peters.n L.Clifford McDonald,md 刘洪霞(综述) 金克峙(审校) Divis.on of Healthcare Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases CDC. 不详

耐药菌是一种世界性的公共卫生威胁。2013年疾病预防控制中心（CDC）的一项报告概述了美国前18位危急和严重级别的耐药相关的威胁。

关键词：疾病预防控制中心耐药菌感染美国医院公共卫生

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