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Effect of training on resident inter-reader agreement with American College of radiology Thyroid Imaging reporting and Data System

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World Journal of radiology 2022年第1期14卷 19-29页

作者： Yang Du Meredith bara Prayash Katlariwala roger Croutze Katrin resch jonathan Porter Medica Sam Mitchell P Wilson Gavin Low Department of radiology and Diagnostic Imaging University of AlbertaEdmonton T6G 2B7AlbertaCanada

bACKGrOUND The American College of radiology Thyroid Imaging reporting and Data System(ACr TI-rADS)was introduced to standardize the ultrasound characterization of thyroid *** have shown that ACr-TIrADS reduces unnecessary biopsies and improves consistency of imaging *** its widespread adoption,there are few studies to date assessing the inter-reader agreement amongst radiology trainees with limited ultrasound *** hypothesize that in PGY-4 radiology residents with no prior exposure to ACr TIrADS,a statistically significant improvement in inter-reader reliability can be achieved with a one hour training *** To evaluate the inter-reader agreement of radiology residents in using ACr TIrADS before and after *** A single center retrospective cohort study evaluating 50 thyroid nodules in 40 patients of varying TI-rADS levels was *** standard TI-rADS scores were established through a consensus panel of three fellowship-trained staff radiologists with between 1 and 14 years of clinical experience *** PGY-4 radiology residents(trainees)were selected as blinded readers for this *** trainee had between 4 to 5 mo of designated ultrasound *** trainee had received specialized TI-rADS training prior to this *** of the readers independently reviewed the 50 testing cases and assigned a TI-rADS score to each case before and after TI-rADS training performed 6 wk *** kappa was used to measure the pooled inter-reader *** relative diagnostic performance of readers,pre-and post-training,when compared against the reference *** There were 33 females and 7 males with a mean age of 56.6±13.6 *** mean nodule size was 19±14 mm(range from 5 to 63 mm).A statistically significant superior inter-reader agreement was found on the post-training assessment compared to the pre-training assessment for the following variables:1.“Shape”(k of 0.09[slight]pre-trai

关键词： Thyroid Thyroid nodule American College of radiology Thyroid Imaging reporting and Data System Inter-reader agreement Ultrasound

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利玛窦的记忆宫殿

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作者： (美)史景迁(jonathan D. Spence)

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Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic resistance in Pseudomonas aeruginosa PAO1

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Journal of biomedical Science and Engineering 2023年第8期16卷 107-120页

作者： Godspower Oghenemaroh Sebe Supreme O. Oghenerhoro Ogbole E. jonathan Ebuka Victor Anyaogu Adeyemo David Adebowale raymond Chidozie Ntomchukwu Department of Chemical Chemistry and Biomedical Engineering University of New Haven West Haven USA Chemistry and biochemistry University of Toledo Toledo USA Department of Cell and Molecular biology University of New Haven West Haven USA Chukwuemeka Odumegwu Ojukwu University Uli Nigeria

This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic b, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic b and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. results showed a diminished potential for resistance emergence with Antibiotic b, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat. .

关键词： Pseudomonas aeruginosa PAO1 Antibiotic resistance Next-Generation Antibiotics Adjuvant Synergy Intracellular Accumulation Penetration rates Minimum Inhibitory Concentration (MIC) resistance Tra-jectory Fluorescence Quantification

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道德哲学

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作者： (英)乔纳森·沃尔夫(jonathan Wolff)

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被窃的身份

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作者： (美)乔纳森·格雷(jonathan Gray)

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理解的欲求

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作者： (英)乔纳森·李尔(jonathan Lear)

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道德哲学

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作者： (英)乔纳森·沃尔夫(jonathan Wolff)

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我国人类免疫缺陷病毒-1主要流行株外膜蛋白基因V3-V4区及其临近区域的特征性氨基酸分析

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中华医学杂志 2005年第13期85卷 897-902页

作者：梁浩邢辉 jonathan Z.Li 魏民洪坤学冯毅赵全壁陈建平全宇滕涛邵一鸣中国疾病预防控制中心艾滋病/性病预防与控制中心 Department of Medicine University of CaliforniaSanFranciscoUSA

目的鉴定我国HIV-1主要流行毒株亚型的envV3-V4区及其临近区域的特征性氨基酸,并阐明其在追踪传染源和研究疫苗中的作用。方法应用nested-PCr对157份来自我国12个省份的HIV-1毒株env区序列进行扩增,并使用AbI377型测序仪测序,然后应用bL... 详细信息

目的鉴定我国HIV-1主要流行毒株亚型的envV3-V4区及其临近区域的特征性氨基酸,并阐明其在追踪传染源和研究疫苗中的作用。方法应用nested-PCr对157份来自我国12个省份的HIV-1毒株env区序列进行扩增,并使用AbI377型测序仪测序,然后应用bLAST、GCG、MEGA和VESPA等生物学软件或程序对env基因V3-V4区及其临近区域序列进行基因型鉴定、系统树分析及特征性氨基酸鉴定。结果157份样本包括54份b′(34·40%)、61份b′/C(38·85%)和42份CrF01-AE(26·75%)毒株。系统树分析结果显示,b′亚型毒株序列均与b·CN·rL42十分接近,b′/C毒株主要与97CN54A和97CNGX6F聚成一簇。而CrF01-AE序列与THCM240和97CNGX2F聚在一起,而且分别聚成明显不同的两个亚组。特征性氨基酸分析发现,我国b′和b′/C毒株分别具有8个保守的特征性氨基酸,而且与代表株的相同位点氨基酸基本一致。而CrF01-AE重组毒株具有11个保守的特征性氨基酸,其中有9个位点与97CNGX2F和TH·CM240不一致。包括这9个特征性氨基酸的样本主要来自除云南省以外的其他省份。结论目前流行于我国的b′和b′/C毒株具有单一的共同传染源,而CrF01-AE毒株可能是通过不同输入源或不同传播途径先后从泰国传入我国的。这将对我国艾滋病防治策略的制定和正在进行的疫苗研究具有重要的指导意义。

关键词：人类免疫缺陷病毒-1 氨基酸分析特征性外膜蛋白基因流行株 HIV-1毒株 nested 基因型鉴定 env基因流行毒株方法应用分析结果亚型毒株传播途径指导意义疫苗研究防治策略传染源系统树序列 PCr GCG 生物学分析及

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SEGMENTATION AND COrrELATION OF OPTICAL COHErENCE TOMOGrAPHY AND X-rAY IMAGES FOr brEAST CANCEr DIAGNOSTICS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 71-81页

作者： jonathan G.SUN STEVEN G.ADIE ErIC J.CHANEY STEPHEN A.bOPPArT beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Department of bioengineering beckman Institute for Advanced Science and Technology 405 North Mathews Avenue UrbanaIllinois 61801USA Departments of Electrical and Computer Engineering and Internal Medicine University of Illinois at Urbana-Champaign UrbanaIllinoisUSA

Pre-operative X ray mammography and int raoperative X-ray specimen radiography are routinely used to identify breast cancer *** advances in optical coherence tomography(OCT)have enabled its 1use for the intraoperative assessment of surgical margins during breast cancer *** each modality offers distinct contrast of normal and pathological features,there is an essential need to correlate image based features between the two modalities to take adv antage of the diagnostic capabilities of each *** compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-tine intraoperative OCT imaging.X ray imaging(specimen radiography)is currently used during surgical breast cancer procedures to verify tumor margins,but cannot image tissue in *** has the potential to solve this problem by providing intrao-perative imaging of the resected specimen as well as the in situ tumor *** and micro-CT(X-ray)images are automatically segmented using different computational approaches,and quantitatively compared to determine the ability of these algorithms to automat ically differentiate regions of adipose tissue from ***,two-dimensional(2D)and three-dimensional(3D)results are *** correlations,combined with real-time intraoperative OCT,have the potential to identify possible regions of tumor within breast tissue which correlate to tumor regions identified previously on X-ray imaging(mammography or specimen radiography).

关键词： Optical imaging mammography specimen radiography segmentation breast cancer intraoperative imaging

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Protein & Cell 2016年第7期7卷 538-543页

作者： Yuan-Qin Yang Wen-Jie Dong Xiao-Fei Yin Yan-Ni XU Yu Yang Jiao-Jiao Wang Su-Jing Yuan Jing Xiao jonathan Howard DeLong Liang Chu Hai-Neng Xu Xiu- Mei Zhou ru-Wei Wang Ling Fang Xin-Yuan Liu Kang-Jian Zhang Xinyuan Institute of Medicine and biotechnology Zhejiang Sci-Tech University Hangzhou 310018 China State Key Laboratory of Cell biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Sichuan Huiyang Life Science and Technology Corp. Chengdu 610021 China College of Life Sciences Northwest Agriculture and Forestry University Yangling 712100 China Central China Normal University Wuhan 430079 China Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of radiation Oncology University of Pennsylvania Perelman School of Medicine 3400 Civic Center Blvd. Philadelphia PA 19104 USA Zhejiang Conba Pharmaceutical Co. Ltd Hangzhou 310018 China

Dear Editor, PD-L1, also known as CD274, plays a vital role in tumor cell related immune escape. It can be expressed on the cell surface of many solid tumors （brahmer et al., 2012） and inhibits T cell proliferation and cytokine production by bind- ing to the Tcell surface receptor programmed death 1 （PD-1） or b7-1 （McClanahan et al., 2015）. In 2013, targeting PD-1/ PD-L1 signaling for cancer immunotherapy was selected as the No.1 scientific breakthrough of the year by the editors of Science. Interferons （IFNs） are a group of pleiotropic cytokines, demonstrated anti-viral, anti-tumor, and immune regulatory functions （York et al., 2015）. Type I interferon binds a heterodimeric receptor composed of IFNAr1 and IFNAr2. This activates a canonical JAK/STAT signaling pathway that ultimately induces a set of interferon-stimulated genes to exert its biological activity （Ejlerskov et al., 2015）. recently, PD-L1 was reported to be downstream of IFN signaling in human oral squamous carcinoma, melanoma, and human acute myeloid leukemia blast cells （Chen et al., 2012; Furuta et al., 2014; Kronig et al., 2014）.

关键词： b16F10 Cell Acute Myeloid Leukemia blast Murine b16F10 Melanoma Cell b16F10 Tumor Cell Syngeneic Splenocytes

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