The publication of the first study to use gene editing tech-niques in human embryos (Liang et al., 2015) has drawn outrage from many in the scientific community. The presti-gious scientific journals Nature and Scien...
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The publication of the first study to use gene editing tech-niques in human embryos (Liang et al., 2015) has drawn outrage from many in the scientific community. The presti-gious scientific journals Nature and Science have published commentaries which call for this research to be strongly discouraged or halted all together (Lanphier et al., 2015; Baltimore et al., 2015). We believe this should be ques- tioned. There is a moral imperative to continue this research.
用嗅觉测量法-气相色谱联用(GC-O),火焰离子检测器-气相色谱联用(GC-FID),质谱-气相色谱联用(GC-MS)三种气相色谱检测方法和常压化学离子化飞行时间质谱(APCI-TOFMS),质子传递反应质谱(PTR-MS)两种直接质谱检测方法来比较测定干辣椒中的挥发性香味成分。干辣椒的挥发性香味成分的大体描述最后由感官评定来确定。三种较显著的风味分别是:辣椒味、煮熟蔬菜味和青草味。用气质联用顶空分析法共有63种挥发性香味成分被分离出来。而嗅觉测量法-气相色谱联用(GC-O)认为其中的11种成分决定了辣椒的香味活跃程度。在所有的方法中普遍认为:3-甲基正丁醛是最活跃的香味成份,其次是2-甲基正丁醛。确定挥发性香味成分的多少主要是受测定方法的影响。色谱方法之间有很强的相关性(ρ=0.946)。直接质谱法相关性不显著(ρ=0.613)。经过不同方法的分析,我们发现,用GC-MS,GC-FID和PTR-MS三种方法检测出的挥发性香味成分并没有显著的不同,显著性的差异主要存在于PCI-TOFMS法和其工艺的不同(P<0.01).(Int J Mass Spectrom223-224(2003)55-65)
BACKGROUND Acute esophageal variceal hemorrhage(AEVH)is a common complication of cirrhosis and might precipitate multi-organ failure,causing acute-on-chronic liver failure(ACLF).AIM To analyze if the presence and grad...
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BACKGROUND Acute esophageal variceal hemorrhage(AEVH)is a common complication of cirrhosis and might precipitate multi-organ failure,causing acute-on-chronic liver failure(ACLF).AIM To analyze if the presence and grading of ACLF as defined by European Society for the Study of the Liver-Chronic Liver Failure(EASL-CLIF)is able to predict mortality in cirrhotic patients presenting *** Retrospective cohort study executed in Hospital Geral de Caxias do *** from medical records from 2010 to 2016 were obtained by searching the hospital electronic database for patients who received *** records were reviewed in order to determine the diagnosis of cirrhosis and AEVH,including 97 ***-Meier survival analysis was used for univariate analysis and a stepwise approach to the Cox regression for multivariate *** All-cause mortality for AEVH patients was 36%,40.2%and 49.4%for 30-,90-and 365-day,*** prevalence of ACLF was 41.3%.Of these,35%grade 1,50%grade 2 and 15%grade *** multivariate analysis,the non-use of non-selective beta-blockers,presence and higher grading of ACLF and higher Model for End-Stage Liver Disease scores were independently associated with higher mortality for 30-day with the addition of higher Child-pugh scores for 90-day *** Presence and grading of ACLF according to the EASL-CLIF criteria was independently associated with higher 30-and 90-day mortality in cirrhotic patients admitted due to AEVH.
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