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Gut microbiome and pancreatic cancer cachexia:An evolving relationship

World Journal of Gastrointestinal Oncology 2022年第7期14卷 1218-1226页

作者： Andrew Hendifar Rasaq Akinsola Hayato Muranaka Arsen Osipov Shant Thomassian Natalie Moshayedi Julianne Yang jonathan jacobs Suzanne Devkota Neil Bhowmick Jun Gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States The Vatche and Tamar Manoukian Division of Digestive Diseases Department of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine David Geffen School of Medicine at UCLAUniversity of CaliforniaLos AngelesLos AngelesCA 90095United States Cedars-Sinai Medical Center Department of MedicineInflammatory Bowel and Immunobiology Research InstituteUniversity of CaliforniaLos AngelesCA 90048United States

Nearly 80% of patients with pancreatic ductal adenocarcinoma(PDAC)develop cachexia along their disease *** is characterized by progressive weight loss,muscle wasting,and systemic inflammation and has been linked to poorer outcomes and impairments in quality of *** of PDAC cachexia has historically involved a multidisciplinary effort comprised of nutritional support,pancreatic enzyme replacement therapy,and/or pharmacologic *** current interventions to mitigate PDAC cachexia,a significant proportion of patients continue to die from complications associated with cachexia underscoring the need for novel insights and treatments for this *** highlight the feasibility and effectiveness of a recent enteral feeding prospective trial at our institution to improve cachexia outcomes in patients with advanced ***,we were among the first to characterize the stool microbiome composition in patients with advanced PDAC receiving enteral feeding for the treatment of *** insights into the relationship between enteral nutritional support,cachexia,and the gut microbiome are *** promising results are discussed in the context of a potential ability to modulate the stool microbiome as a new interventional strategy to mitigate PDAC cachexia.

关键词： Gut microbiome Pancreatic cancer Stool Cachexia Inflammation Weight

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两个茄青枯菌株在不同温度条件下的全基因组基因表达分析(英文)

两个茄青枯菌株在不同温度条件下的全基因组基因表达分析(英文)

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中国植物病理学会第九届全国会员代表大会暨2010年学术年会

作者： jonathan M.jacobs Lavanya Babujee C.Allen Department of Plant Pathology University of Wisconsin-MadisonMadisonWIUSA

Ralstonia solanacearum is a soil-borne plant pathogen that causes bacterial wilt disease in more than 200 species around the world,including important crop plants such as potato,tomato, tobacco,banana and *** most str...

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Fine-scale habitats influence tree species assemblage in a miombo forest

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Journal of Plant Ecology 2017年第6期10卷 958-969页

作者： jonathan Ilunga Muledi David Bauman Thomas Drouet Jason Vleminckx Arnaud jacobs Jean Lejoly Pierre Meerts Mylor Ngoy Shutcha Ecologie Restauration Ecologique et PaysageFacultédes Sciences AgronomiquesUniversitéde LubumbashiRoute Kasapa BP 1825The Democratic Republic of the Congo Laboratoire d’Écologie Végétale et Biogéochimie(EvB) CP244Facultédes SciencesUniversitéLibre de Bruxelles50 av.F.D.RooseveltBrussels 1050Belgium Service d’Évolution Biologique etÉcologie CP160/12Facultédes SciencesUniversitéLibre de Bruxelles50 av.F.D.RooseveltBrussels 1050Belgium Herbarium de l’UniversitéLibre de Bruxelles(BRLU) Facultédes SciencesUniversitéLibre de BruxellesCP26550 av.F.D.RooseveltBrussels 1050Belgium

Aims Relationships between local habitat heterogeneity and tree commu-nities in miombo woodlands have been very little *** some studies have addressed this topic at broad scales and based on few environmental parameters,this study aims at(i)detecting fine-scale habitats(≤10 ha)on the basis of a detailed characterisation of soil explicitly considering past anthropogenic disturbances,and an exhaustive census of the tree community,and at(ii)searching for indicator tree species corresponding to the resulting *** The study was carried out in the miombo woodland of Mikembo Forest Reserve,Upper Katanga,The Democratic Republic of the congo.A complete census of the tree community was conducted in a 10-ha forest dynamics plot comprising 160 adjacent quadrats of 25×25 m,with a total of 4604 trees(diameter at breast height>10 cm).Thirty-six physicochemical soil parameters were *** the frequency distribution of soil charcoal content allowed identifying local signature of past human agriculture in the *** strategies were used to define habitats:(i)a combination of principal component analysis(PcA)on soil variables and Ward clustering and(ii)multivariate regression trees(MRT)to search for key soil parameters allowing the best prediction of species ***-habitat associations were tested by means of a robust statistical framework combining the IndVal index and torus *** Findings The forest contained 82 tree species and a significant proportion of wet miombo species(*** macroura).We detected a strong east-west edaphic gradient driven by soil texture;most chemical soil parameters followed this *** habitats were identified based on soil factors and floristic *** indicator species of these habitats were *** key soil fac-tors discriminating habitats were total calcium,available forms of phosphorus and clay *** though past agricultural practices were successfully detect

关键词： forest dynamics plot indicator species miombo multivariate regression trees(MRT) soil torus randomisation

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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K jacobs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward jonathan A Fallowfield Peter C Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

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Artificial intelligence in gastroenterology:A narrative review

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Artificial Intelligence in Gastroenterology 2022年第5期3卷 117-141页

作者： jonathan S Galati Robert J Duve Matthew O'Mara Seth A Gross Department of Medicine NYU Langone HealthNew YorkNY 10016United States Department of Internal Medicine Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNY 14203United States Division of Gastroenterology NYU Langone HealthNew YorkNY 10016United States

Artificial intelligence(AI)is a complex concept,broadly defined in medicine as the development of computer systems to perform tasks that require human *** has the capacity to revolutionize medicine by increasing efficiency,expediting data and image analysis and identifying patterns,trends and associations in large *** gastroenterology,recent research efforts have focused on using AI in esophagogastroduodenoscopy,wireless capsule endoscopy(WCE)and colonoscopy to assist in diagnosis,disease monitoring,lesion detection and therapeutic *** main objective of this narrative review is to provide a comprehensive overview of the research being performed within gastroenterology on AI in esophagogastroduodenoscopy,WCE and colonoscopy.

关键词： Artificial intelligence Colonoscopy Computer-aided detection Deep learning Endoscopy Machine learning

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2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Lee A Fleisher Joshua A Beckman Kenneth A Brown Hugh Calkins Elliott Chaikof Kirsten E Fleischmann William K Freeman James B Froehlich Edward K Kasper Judy R Kersten Barbara Riegel John F Robb Sidney C Smith Alice K jacobs Cynthia D Adams Jeffrey L Anderson Elliott M Antman Christopher E Buller Mark A Creager Steven M Ettinger David P Faxon Valentin Fuster jonathan L Halperin Loren F Hiratzka Sharon A Hunt Bruce W Lytle Rick Nishimura Joseph P Ornato Richard L Page Lynn G Tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

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