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Sexual dimorphism in cranial shape and size in geomyoid rodents:multivariate and evolutionary perspectives

Current Zoology 2022年第4期68卷 469-487页

作者： jonathan j m calede Andrew Brown Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.300 Aronoff LaboratoryColumbusOH 43210USA The Ohio State University at marion 1459 Mount Vernon AvenueMarionOH 43302USA College of Veterinary medicine Texas A&M University660 Raymond Stotzer PkwyCollege StationTX 77843USA

Geomyoid rodents provide a great study system for the analysis of sexual *** are polygynic and many inhabit harsh arid environments thought to promote sexual *** fact,there has been extensive work published on the sexual size dimorphism of individual populations and species within this rodent ***,little work has been undertaken to assess the evolutionary patterns and processes associated with this sexual *** use multivariate analyses of cranial measurements in a phylogenetic framework to determine the distribution of size and shape dimorphism among geomyoids and test for Rensch’s *** results suggest that sexual dimorphism is more common in geomyids than heteromyids,but it is not in fact *** is evidence for variation in sexual dimorphism across ***,in many taxa,geographic variation appears to overwhelm existing sexual *** find support for the repeated independent evolution of shape and size dimorphism across geomyoid taxa,but we do not find support for an association between size and shape *** is no evidence for Rensch’s rule in geomyoids,whether at the superfamily or family ***,our findings suggest that there is no single explanation for the evolution of sexual dimorphism in geomyoids and that,instead,it is the product of numerous evolutionary *** studies incorporating phylogenetic relationships will be necessary to paint a more complete picture of the evolution of sexual dimorphism in geomyoids.

关键词： Geomyidae Heteromyidae phylogenetic comparative methods morphometrics Rensch’s rule

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multivariate analyses of skull morphology inform the taxonomy and evolution of geomyoid rodents

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Current Zoology 2023年第4期69卷 456-474页

作者： Lily A.Noftza jonathan j.m.calede aBiology Program The Ohio State University at Marion1459 Mount Vernon AvenueMarionOH 43302USA Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.ColumbusOH 43210USA.

morphological analyses are critical to quantify phenotypic variation,identify taxa,inform phylogenetic relationships,and shed light on evolutionary *** work is particularly important in groups that display great morphological *** is the case in geomyoid rodents,a group that includes 2 of the most species-rich families of rodents in North America:the Geomyidae(pocket gophers)and the Heteromyidae(kangaroo rats,pocket mice,and their relatives).We assessed variation in skull morphology(including both shape and size)among geomyoids to test the hypothesis that there are statistically significant differences in skull measurements at the family,genus,and species *** sample includes 886 specimens representing all geomyoid genera and 39 *** used the geometric mean to compare size across *** used 14 measurements of the cranium and lower jaw normalized for size to compare shape among and within *** results show that skull measurements enable the distinction of geomyoids at the family,genus,and species *** is a larger amount of size variation within Geomyidae than within *** phylomorphospace analysis shows that the skull shape of the common ancestor of all geomyoids was more similar to the common ancestor of heteromyids than that of *** skulls display negative allometry whereas heteromyid skulls display positive *** heteromyids,dipodomyines,and non-dipodomyines show significantly different allometric *** analyses including fossils will be necessary to test our evolutionary hypotheses.

关键词： canalization convergent evolution Geomyidae Heteromyidae morphometrics phylomorphospace

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Dangers of scientific bias against herbal drugs for coronavirus disease 2019

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journal of Integrative medicine 2020年第6期18卷 459-461页

作者： jonathan m.Fields Integrative medicine US TamaracFL 33321USA

On may 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.

关键词： Herbal Coronavirus COVID-19 SARS-CoV-2 medicine,Chinese traditional Complementary therapies

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Real-world treatment attrition rates in advanced esophagogastric cancer

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World journal of Gastroenterology 2020年第39期26卷 6027-6036页

作者： Erica S Tsang Howard j Lim Daniel j Renouf janine m Davies jonathan m Loree Sharlene Gill Department of medicine BC CancerVancouver V5Z 4E6Canada Division of medical Oncology University of British ColumbiaVancouver V5Z 4E6Canada

BACKGROUND Over the last decade,multiple agents have demonstrated efficacy for advanced esophagogastric cancer(EGC).Despite the availability of later lines of therapy,there remains limited real-world data about the treatment attrition rates between lines of *** To characterize the use and attrition rates between lines of therapy for patients with advanced *** We identified patients who received at least one cycle of chemotherapy for advanced EGC between july 1,2017 and july 31,2018 across six regional centers in British Columbia(BC),***,treatment,and outcomes data were *** Of 245 patients who received at least one line of therapy,median age was 66 years(IQR 58.2-72.3)and 186(76%)were male,Eastern Cooperative Oncology Group(ECOG)performance status 0/1(80%),gastric vs GEj(36%vs 64%).Histologies included adenocarcinoma(78%),squamous cell carcinoma(8%),and signet ring(14%),with 31%HER2 positive.72%presented with de novo disease,and 25%had received previous *** was a high level of treatment attrition,with patients receiving only one line of therapy n=122,50%),two lines n=83,34%),three lines n=34,14%),and four lines n=6,2%).Kaplan-meier analysis demonstrated improved survival with increasing lines of therapy(median overall survival 7.7 vs 16.6 vs 22.8 vs 40.4 mo,Pmultivariable Cox regression,improved survival was associated with better baseline ECOG and increased lines of therapy(Pmet need for more efficacious early-line treatment options for patients with advanced EGC.

关键词： Esophagogastric cancer Gastric cancer Treatment attrition Systemic therapy Treatment outcomes Real-world evidence

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mind the “Gap”: A Comparison of the Weekly Training Loads of English Premier League Academy Soccer Players in Under 23, Under 18 and Under 16 Age-Groups

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journal of Science in Sport and Exercise 2023年第1期5卷 34-43页

作者： jonathan m.Taylor jonathan L.madden Frances Hunter Ben j.Thorne Shaun j.mcLaren School of Health and Life Sciences Teesside UniversityMiddlesbroughUK Leeds United Football Club LeedsUK middlesbrough Football Club MiddlesbroughUK Hintsa Performance LondonUK Department of Sport and Exercise Sciences Durham UniversityDurhamUK

Purpose The transition into full-time training represents a key period in the development of young soccer *** we compared the weekly training loads(matches,field-,and resistance-training)of English Premier-League Academy soccer players from under-16(U16),under-18(U18)and under-23(U23)age-groups during a training *** Forty players(U16 n=13,U18 n=15 and U23 n=12)were monitored using global navigation satellite systems and differential ratings of perceived exertion(dRPE).External load metrics were total distance,high-speed running distance,[absolute:≥19.8 km/h,relative:≥87%of 30-15 final-velocity(vIFT)],sprint distance(absolute:≥25.2 km/h,relative:≥80%maximal sprint speed),and dynamic stress *** load metrics were dRPE training *** Other than relative sprint distance,overall weekly external training loads were substantially greater for U18s and U23s when compared with U16s[effect size range:1.09-1.99(moderate to large);±90%confidence limits~0.45].When compared with U16s,overall internal loads were substantially greater for U18s[0.69-0.95(moderate);±~0.40],but not *** in weekly training loads between U18s and U23s were *** Substantial differences in training loads between elite U16 players and their older counterparts,indicates the need for planned increases in training loads in anticipation of the transition into full-time training.

关键词： Team-sports RPE LTAD Individualised training Training load

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Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： jonathan W.Lewis james R.Edwards Amy j.Naylor Helen m.mcGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

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Bandpass transmission spectra of a whisperinggallery microcavity coupled to an ultrathin fiber

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Photonics Research 2017年第4期5卷 362-366页

作者： FUCHUAN LEI RAFINO m.j.mURPHY jonathan m.WARD YONG YANG SíLE NIC CHORmAIC Light-matter Interactions Unit Okinawa Institute of Science and Technology Graduate University

Tapered fibers with diameters ranging from 1 to 4 μm are widely used to excite the whispering-gallery(WG)modes of microcavities. Typically, the transmission spectrum of a WG cavity coupled to a waveguide around a resonance assumes a Lorentzian dip morphology due to resonant absorption of the light within the cavity. In this paper, we demonstrate that the transmission spectra of a WG cavity coupled with an ultrathin fiber(500–700 nm)may exhibit both Lorentzian dips and peaks, depending on the gap between the fiber and the microcavity. By considering the large scattering loss of off-resonant light from the fiber within the coupling region, this phenomenon can be attributed to partially resonant light bypassing the lossy scattering region via WG modes, allowing it to be coupled both to and from the cavity, then manifesting as Lorentzian peaks within the transmission *** implies the system could be implemented within a bandpass filter framework.

关键词： WG Bandpass transmission spectra of a whisperinggallery microcavity coupled to an ultrathin fiber mode

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Characterization of coal using electron spin resonance： implications for the formation of inertinite macerals in the Witbank Coalfield, South Africa

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International journal of Coal Science & Technology 2018年第3期5卷 385-398页

作者： Ofentse m. moroeng jonathan m. Keartland R. james Roberts Nicola j. Wagner Department of Geology University of JohannesburgP.O. Box 524 Auckland Park 2006 South Africa Department of Geology University of Pretoria Mineral Sciences Building Pretoria 0002 South Africa School of Physics and materials Physics Institute University of the Witwatersrand Johannesburg 2050 South Africa

Coal contains a significant concentration of free radicals as a result of the coalification process. One of the experimental methods sensitive to the presence of radicals is electron spin resonance （ESR）, and differences in ESR spectra for different macerals may provide insight into coal-forming processes. In this study, ESR data along with the H/C atomic ratio （to infer the aromatic fraction） are used to characterize coal samples with the aim of assessing a fire-origin for dominant inertinite macerals. A medium rank C bituminous Witbank No. 4 Seam Upper coal （the parent） was density- fractionated to create vitrinite-rich and inertinite-rich samples. The parent sample consists of 42 vol% vitrinite and 49 vol% inertinite. The density-fractionated samples comprise of 81 vol% total vitrinite （dominated by collotelinite and collodetrinite）, and 63 vol% total inertinite （dominated by fusinite, semifusinite, and inertodetrinite）. The H/C ratio is 0.74 for the inertinite-rich sample, and 0.85 for the vitrinite-rich counterpart, suggesting the former sample is more aromatic. The ESR spectra obtained for the three samples were found to fit best using a Lorentzian distribution. The fit is noticeably better for the aromatic inertinite-rich sample, for which the spectrum is symmetric. This is attributed to pronounced electron mobility and exchange interactions. The higher radical content of the inertinite-rich and parent samples is attributed to the presence of specific inertinite macerals, namely： fusinite, semifusinite, and inertodetrinite. And, owing to the greater radical content of the inertinite-rich sample, the dominant inertinite macerals are interpreted to have formed through charring of plant matter.

关键词： main Karoo Basin Radical contents Origin pathways Charring Fusinite Semifusinite

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Alcohol-induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment

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Animal models and Experimental medicine 2020年第2期3卷 200-207页

作者： Esha m.Kapania Taylor jReif Aaron Tsumura jonathan m。Eby john j.Callaci Internal medicine-Pediatric Resident Rush University Medical CenterChicagoILUSA Limb Lengthening and Complex Reconstruction Fellowship Hospital for Special SurgeryNew YorkNYUSA Department of Orthopaedic Surgery and Rehabilitation Loyola University Medical CenterMaywoodILUSA Alcohol Research Program(ARP) Loyola University Chicago Stritch School of MedicineMaywoodILUSA

Nearly half of orthopaedic trauma patients are intoxicated at the time of injury, and excess alcohol consumption increases the risk for fracture nonunion. Previous studies show alcohol disrupts fracture associated Wnt signaling required for normal bone fracture repair. Intermittent parathyroid hormone(PTH) promotes bone growth through canonical Wnt signaling, however, no studies have investigated the effect of PTH on alcohol-inhibited bone fracture repair. male C57 BL/6 mice received two-3 day alcohol binges separated by 4 days before receiving a mid-shaft tibia fracture. Postoperatively, mice received PTH daily until euthanasia. Wnt/β-catenin signaling was analyzed at 9 days post-fracture. As previously observed, acute alcohol exposure resulted in a >2-fold decrease in total and the active form of β-catenin and a 2-fold increase in inactive β-catenin within the fracture callus. Intermittent PTH abrogated the effect of alcohol on β-catenin within the fracture callus. Upstream of β-catenin, alcohol-treated animals had a 2-fold decrease in total LRP6, the Wnt co-receptor, which was restored with PTH treatment. Alcohol nor PTH had any significant effect on GSK-3β. These data show that intermittent PTH following a tibia fracture restores normal expression of Wnt signaling proteins within the fracture callus of alcohol-treated mice.

关键词： ethanol fracture callus parathyroid hormone Wnt signaling pathway

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First principles insights into oxide/polymer composites: SrTiO_(3) /polyaniline/graphene

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journal of materials Science & Technology 2023年第35期166卷 250-260页

作者： Nathan D.Wood joshua S.Tse jonathan m.Skelton David j.Cooke Lisa j.Gillie Stephen C.Parker marco molinari Department of Chemical Sciences School of Applied SciencesUniversity of HuddersfieldHuddersfield HD13DHUK Department of Chemistry University of ManchesterManchester M139PLUK Department of Chemistry University of BathBath BA27AYUK

A detailed computational investigation,based on density functional theory,of the interaction of polyani-line(PANI)and graphene nanoribbons(GNRs)with SrTiO_(3) is *** adsorption of PANI in var-ious oxidation states and co-adsorption with GNRs is found to be thermodynamically ***-sorbed PANI introduces N and C 2p states into the SrTiO_(3) bandgap,while co-adsorption of PANI and GNRs leads to a bridging of the gap and semi-metallic behaviour,thus rendering the electrical properties highly sensitive to the loading of the GNRs/PANI in the *** the lattice dynamics of the composites predicts a 68-88%reduction in the lattice thermal conductivity due to reduced phonon group *** together,these findings provide insight into the growing number of experimental studies highlighting the enhanced thermoelectric performance of oxide-polymer composites and indicate co-adsorption with graphene as a facile direction for future research.

关键词： Polymer/inorganic composites Polyaniline/strontium titanate/graphene nanoribbon composites PANI/GNR/SrTiO_(3)composites Thermoelectric composites Electrical transport Thermal conductivity1 Introduction

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