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中华眼底病杂志 2005年第5期21卷 296-299页

作者：陈宜黎晓新 jonathan M.holmes 北京大学人民医院眼科中心美国纽约医学中心眼科

目的了解代谢性酸中毒诱导新生大鼠视网膜病变的发展进程,探讨其发生与血管内皮生长因子(VEGF)的关系。方法实验组新生Sprague-Dawley大鼠425只。从大鼠出生后第2天开始按535mg/kg的剂量管饲NH4Cl(浓度为50mg/ml),每天2次,管饲6d,然后... 详细信息

目的了解代谢性酸中毒诱导新生大鼠视网膜病变的发展进程,探讨其发生与血管内皮生长因子(VEGF)的关系。方法实验组新生Sprague-Dawley大鼠425只。从大鼠出生后第2天开始按535mg/kg的剂量管饲NH4Cl(浓度为50mg/ml),每天2次,管饲6d,然后进入恢复期。另选150只新生大鼠未进行管饲,作为对照组。两组大鼠分别于出生后3、5、8、10、13、20d处死。取出双眼进行视网膜铺片和二磷酸腺苷酶染色,对视网膜血管进行评估;用酶联免疫分析法进行VEGF的测定。结果实验组鼠在出生后3、5、8、10、13、20d的新生血管(NV)发生率分别为0%、9%、26%、55%、19%、0%。出生后第3天,实验组鼠VEGF的蛋白水平[(101.1±14.2)pg/mg]比对照组[(133.2±15.9)pg/mg]下降(P=0.004),出后生第8天,实验组鼠VEGF蛋白水平[(98.4±19.2)pg/mg]比对照组[(78.1±8.7)pg/mg]升高(P=0.028);出生后第5、10、13、20天,两组差异无统计学意义(P>0.05)。结论代谢性酸中毒可能损害了正在发育的视网膜血管而引起新生血管;酸中毒引起的视网膜新生血管与VEGF有关。

关键词：视网膜病,早产儿/病因学酸中毒内皮生长因子视网膜新生血管疾病模型,动物

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新疆博斯腾湖记录的亚洲内陆干旱区小冰期湿润气候研究

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中国科学（D辑） 2007年第1期37卷 77-85页

作者：陈发虎黄小忠张家武 jonathan A.holmes 陈建徽兰州大学西部环境教育部重点实验室中德干旱环境联合研究中心兰州730000 ECRC Department of GeographyUniversity College LondonLondon WC1E6BTUK

利用中国内陆干旱区最大淡水湖泊博斯腾湖中心的钻孔岩芯,在137Cs,210Pb和AMS14C测年基础上,对湖泊岩芯孢粉组合、碳酸盐含量和粒度等多指标进行了分析.结果发现,近1000年来,内陆干旱区气候变化经历了3个主要阶段,1000～1500AD干旱、150... 详细信息

利用中国内陆干旱区最大淡水湖泊博斯腾湖中心的钻孔岩芯,在137Cs,210Pb和AMS14C测年基础上,对湖泊岩芯孢粉组合、碳酸盐含量和粒度等多指标进行了分析.结果发现,近1000年来,内陆干旱区气候变化经历了3个主要阶段,1000～1500AD干旱、1500～1900AD湿润和1900AD以来的再次变干,近千年来在几百年尺度上的气候变化组合以暖干和冷湿为主.在公元1500～1900年的小冰期期间,多种代用指标均出现显著变化,孢粉蒿藜比显著增大,碳酸盐含量明显降低,而粒度明显偏粗,说明博斯腾湖流域降水增加,气候比今湿润,这与近百年来全球变暖条件下内陆干旱区出现的暖干气候形成显著对照.亚洲内陆冰芯、湖泊、河流、树轮、沙漠等记录均记录了西风环流显著影响区较为湿润的小冰期气候,出现明显的冷湿气候组合,博斯腾湖岩芯记录的湿润小冰期气候具有代表性.西风环流影响区湿润小冰期气候可能是全球性普遍降温导致有效湿度增加和因北大西洋涛动负异常而导致的西风影响区降水增加两个因素共同作用的结果.

关键词：博斯腾湖亚洲内陆干旱区近千年气候变化冷湿暖干组合湿润小冰期

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Diatom-environment relationships and a transfer function for conductivity in lakes of the Badain Jaran Desert,Inner Mongolia,China

Diatom-environment relationships and a transfer function for...

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中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Patrick Rioual Yanbin Lu Handong Yang Louis Scuderi Guoqiang Chu jonathan holmes Bingqi Zhu Xiaoping Yang Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences Environmental Change Research Centre University College London Department of Earth and Planetary Sciences University of New Mexico Environmental Change Research Centre University College LondonPearson Building Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

We describe a dataset of 26 modern diatom samples and associated environmental variables from the Badain Jaran Desert,northwest *** influence of electrical conductivity(EC) and other variables on diatom distribution was explored using multivariate analyses and generalized additive modeling of species response curves.A transfer function was derived for EC,the variable with the largest unique effect on diatom variance,as shown by partial canonical correspondence ***-averaging partial least squares regression and calibration provided the best model,with a high coefficient of determination (r = 0.91) and low prediction error(RMSEP = 0.136 logμS cm).To assess its potential for palaeosalinity and palaeoclimate reconstructions,the EC transfer function was applied to fossil diatom assemblages from Pb-dated short sediment cores collected from two subsaline lakes of the Badain Jaran *** diatom-inferred(DI) EC reconstructions were compared with meteorological data for the past 50 years and with remote sensing data for the period AD *** in DI-EC were small and their relationship with climate was ***, remote sensing data indicate that the surface areas and water depths of these lakes did not change,which suggests that water loss by evaporation is compensated by groundwater *** results suggest that the response of these lakes to climate change is mediated by non-climatic factors such as the hydrogeological setting,which control recharge from groundwater,and may be non-linear and non-stationary.

关键词： Diatoms Transfer function Electrical conductivity Saline lakes Badain Jaran Desert China

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Total En Bloc Spondylectomy for Lumbar Renal Cell Carcinoma and Review of the Literature

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Open Journal of Modern Neurosurgery 2014年第1期4卷 26-30页

作者： Darweesh Al-Khawaja Tamadur Mahasneh jonathan Li Sue-Ellen holmes Australian School of Advanced Medicine Macquarie University Sydney Australia Department of Neuropathology Royal Prince Alfred Hospital Camperdown NSW Australia Neurosurgical Department Nepean Hospital Kingswood NSW Australia Researcher Private Neurosurgical Practice Penrith NSW Australia

Introduction: Total en bloc spondylectomy (TES) is gaining increasing favour as a treatment of choice for cancers of the spine that are resistant to radiological and chemotherapeautic intervention such as renal cell carcinoma (RCC). Until recently, RCC of the lumbar spine has presented a surgical challenge due to anatomical and vascular constraints. The development of the combined posterior-anterior en bloc spondylectomy offers improved access to the lumbar region. This case report and review of the literature presents a combined posterior-anterior lumbar en bloc spondylectomy for RCC involving L3 vertebra, which we believe is the first reported in Australia. Methods: A 46-year-old male with a seven-year history of renal cell carcinoma resulting in a left nephrectomy presented with a lytic lesion involving the L3 vertebral body, extending to the epidural space and compressing the cauda equina and left L3 and L4 nerve roots on MRI. A literature review revealed ten previous cases of the posterior-anterior TES in the lumbar spine for cancerous lesions but none from Australia. Results: A posterior-anterior TES and L2-L4 fusion was performed to remove a cancerous renal cell carcinoma of L3 with wide margins. Blood loss was the major complication. The patient remains recurrence free at nineteen months post procedure. Conclusion: Despite being an aggressive and invasive procedure, TES is rapidly becoming the treatment of choice for curative and palliative care in select patients with isolated metastatic tumours of the lumbar spine.

关键词： En Bloc Spondylectomy Renal Cell Carcinoma Lumbar Spine

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Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review

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World Journal of Clinical Urology 2014年第1期3卷 20-30页

作者： Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson jonathan Masters Benji Benjamin Michael holmes Auckland Cancer Society Research Centre Faculty of Medical and Health Sciences The University of Auckland Discipline of Nutrition Faculty of Medical and Health Sciences The University of Auckland Urology Department Auckland Hospital Radiology Department Auckland Hospital Urology Department Waikato Hospital

Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe di

关键词： β-microseminoprotein Anticancer properties Immune modulation Splice variants Promoter single nucleotide polymorphism rs10993994 Biochemical recurrence

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