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Propulsion and Power Research 2020年第1期9卷 37-50页

作者： jonathan Brulatout François Garnier Patrice Seers Mechanical Engineering Department École de Technologie Supérieure1100 Notre-Dame Street WestMontrealH3C 1K3Canada

Interaction between fuel and air in a combustion chamber is one of the main drivers of the mixing ***,flow visualizations are limited by high droplet density in the ***,the ability of large eddy simulations(LES)to resolve large scales of flow offers good perspectives on capturing flow structures issued from the interaction between the Lagrangian(fuel droplets)and Eulerian(ambient gas)*** study examined these interactions first during a single injection using 3D and 2D criteria for both *** for the 3D criteria,the spray shape was analyzed in parallel to the Q-criteria applied to the Eulerian phase,making it possible to relate the spray deformations to some specific Eulerian ***,2D criteria were the fuel mass-fraction field and Eulerian streamlines,both taken in the mid-plane of the *** last analysis allows for identifying certain mechanisms involved in the Eulerian phase’s structure generation and relates it to high fuel-concentration areas in the fuel mass-fraction visualizations.

关键词： Diesel fuel spray Large eddy simulation Multiple injection coherent structures Lagrangian-Eulerian interaction Air-spray interactions

Genetic epidemiology of irritable bowel syndrome

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World Journal of Gastroenterology 2015年第40期21卷 11353-11361页

作者： Jasbir Makker Sridhar chilimuri jonathan N Bella Department of Medicine Bronx-Lebanon Hospital Center and Albert Einstein College of Medicine

Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(c-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS.

关键词： Irritable bowel syndrome Single-nucleotide polymor

An Overview on the composition and Age of Upper crust of Proto-Tethyan Lajishan Intra-oceanic Arc,NE Tibet Plateau

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 285-302页

作者： FU changlei HE Xiaohu YAN Zhen jonathan cAITcHISON XIAO Wenjiao WANG Bingzhang LI Wufu LI Yusen SinoProbe Laboratory Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of the Northern Qinghai–Tibet Plateau Geological Processes and Mineral Resources Qinghai Geological Survey InstituteXining 810012China Department of Geology School of Earth SciencesYunnan UniversityKunming 650091China School of Earth and Environmental Sciences University of QueenslandBrisbane 4072Australia Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Resources China University of GeosciencesBeijing 100083China

Identification and anatomy of oceanic arcs within ancient orogenic belt are significant for better understanding the tectonic framework and closure process of paleo-ocean *** article summarizes the geological,geochemical,and geochronological characteristics of upper crust of Proto-Tethyan Lajishan intra-oceanic arc and provides new data to constrain the subduction evolution of the South Qilian *** intra-oceanic arc volcanic rocks,including intermediate-mafic lava,breccia,tuff,and minor felsic rocks,are distributed along southern part of the Lajishan ophiolite *** and isotopic compositions indicate that the intermediate-mafic lava were originated from depleted mantle contaminated by sediment melts or hydrous fluids,whereas the felsic rocks were likely generated by partial melting of juvenile mafic crust in intra-oceanic arc *** from felsic rocks yield consistent and concordant ages ranging from 506 to 523 Ma,suggesting these volcanic rocks represent the relicts of upper crust of the cambrian intra-oceanic *** with the cambrian forearc ophiolite and accretionary complex,we suggest that the cambrian intra-oceanic arc in the Lajishan ophiolite belt is belonging to the intra-oceanic arc system which was generated by south-directed subduction in the South Qilian Ocean at a relatively short interval between approximately 530 and 480 Ma.

关键词： volcanic rocks intra-oceanic arc U-Pb age Lajishan ophiolite belt South Qilian Ocean Proto-Tethyan realm

cLIF-SOFA and cLIF-c scores for the prognostication of acute-onchronic liver failure and acute decompensation of cirrhosis:A systematic review

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World Journal of Hepatology 2022年第12期14卷 2025-2043页

作者： Ebrahim Rashed jonathan Soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BAcKGROUND Acute-on-chronic liver failure(AcLF)is a syndrome characterized by decompensation in individuals with chronic liver disease,generally secondary to one or more extra-hepatic organ failures,implying an elevated mortality *** decompensation(AD)is the term used for one or more significant consequences of liver disease in a short time and is the most common reason for hospital admission in cirrhotic *** European Association for the Study of Liver-chronic-Liver Failure(EASL-cLIF)Group modified the intensive care Sequential Organ Failure Assessment score into cLIF-SOFA,which detects the presence of AcLF in patients with or without AD,classifying it into three *** To investigate the role of the EASL-cLIF definition for AcLF and the ability of cLIF-SOFA,cLIF-c AcLF,and cLIF-c AD scores for prognosticating AcLF or *** This study is a literature review using a standardized search method,conducted using the steps following the guidelines for reporting systematic reviews set out by the PRISMA *** specific keywords,relevant articles were found by searching PubMed,ScienceDirect,and BioMed *** databases were searched using the search terms by one reviewer,and a list of potentially eligible studies was generated based on the titles and abstracts *** data were then extracted and assessed on the basis of the Reference citation Analysis(https://***/).RESULTS Most of the included studies used the EASL-cLIF definition for AcLF to identify cirrhotic patients with a significant risk of short-term *** primary outcome in all reviewed studies was *** of the study findings were based on an area under the receiver operating characteristic curve(AUROc)analysis,which revealed that cLIFSOFA,cLIF-c AcLF,and cLIF-c AD scores were preferable to other models predicting 28-d *** AUROc scores were higher and able to predict all-cause mortality at 90,180,and 365 d.A total

关键词： End-stage liver disease Acute-on-chronic liver failure cLIF-SOFA cLIF-c AcLF cLIF-c AD

Hydrogen peroxide ingestion with injury to upper gastrointestinal tract

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World Journal of clinical cases 2017年第10期5卷 378-380页

作者： jonathan V Martin choichi Sugawa Michael and Marian Ilitch Department of Surgery 6-C University Health Center

Hydrogen peroxide is a common over-the-counter solution that has developed a growing body of literature regarding toxic ingestion. Intentional ingestion of high concentration hydrogen peroxide for health purposes has gained popularity in certain patient populations; purported benefits are due to the increased oxygen released into the blood stream. We present for evaluation one such case with associated imaging that presented to our urban medical center. A brief review of the literature was also performed noting current recommendations regarding both outcomes and indications for endoscopy as well as hyperbaric oxygen therapy following ingestion of hydrogen peroxide. Our patient was a 51-year-old white female who presented with foamy hematemesis after ingesting 10 drops of 35% hydrogen peroxide as part of a home remedy to cleanse her colon and improve blood oxygenation. In addition to hematemesis,she also reported diffuse abdominal pain with sore throat and hoarse voice. Her imaging demonstrated portal venous gas and gastric edema. She was admitted for hyperbaric oxygen therapy and underwent upper endoscopy demonstrating diffuse esophagitis and gastritis with white exudate and multiple petechiae. She was later discharged home in stable condition and was lost to follow-up.

关键词： Hydrogen peroxide caustic injury Hyperbaric oxygen therapy Ingestion of hydrogen peroxide Arterial gas emboli

Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants

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Bioactive Materials 2023年第12期30卷 154-168页

作者： Sandra Sefa jonathan Espiritu Hanna cwieka Imke Greving Silja Flenner Olga Will Susanne Beuer D.c Florian Wieland Regine Willumeit-Romer Berit Zeller-Plumhoff Institute of Metallic Biomaterials Helmholtz Zentrum HereonGeesthachtGermany Syntellix AG HannoverGermany Institute of Materials Physics Helmholtz Zentrum HereonGeesthachtGermany Molecular Imaging North competence center Kiel UniversityKielGermany Fraunhofer Institut für Integrierte Systeme und Bauelementetechnologie(IISB) ErlangenGermany

The utilization of biodegradable magnesium(Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic *** such alloy,magnesium-10 weight percent gadolinium(Mg-10Gd),has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone *** studies have demonstrated that Mg-10Gd exhibits favorable osseointegration;however,it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium(Ti).A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone *** address this,we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element *** using the methods outlined,the vascular porosity,lacunar porosity and the lacunar-canaliculi network(LcN)morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was *** investigation revealed that within our observation period,the degradation of Mg-10Gd implants was associated with significantly lower(pcunar density in the surrounding bone,compared to ***,the LcN morphology and the fluid flow analysis did not significantly differ for both implant *** summary,a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd *** implies potential disparities in bone remodelling rates when compared to Ti *** findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture,contributing to a deeper understanding of the implications for successful osseointegration.

关键词： Biodegradable magnesium implants Lacunar-canalicular network(LcN) Vascular porosity Synchrotron radiation micro computed tomography(SRμcT) Transmission x-ray microscopy(TXM)

clinical utilities and biological characteristics of melanoma sentinel lymph nodes

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World Journal of clinical Oncology 2016年第2期7卷 174-188页

作者： Dale Han Daniel c Thomas jonathan S Zager Barbara Pockaj Richard L White Stanley PL Leong Department of Surgery Yale University School of Medicine Department of cutaneous Oncology Moffitt Cancer Center Mayo clinic Division of Surgical Oncology Carolinas Medical CenterLevine Cancer Institute center for Melanoma Research and Treatment California Pacific Medical Center

An estimated 73870 people will be diagnosed with melanoma in the United States in 2015,resulting in 9940 *** majority of patients with cutaneous melanomas are cured with wide local ***,current evidence supports the use of sentinel lymph node biopsy(SLNB) given the 15%-20% of patients who harbor regional node *** importantly,the presence or absence of nodal micrometastases has been found to be the most important prognostic factor in earlystage melanoma,particularly in intermediate thickness *** review examines the development of SLNB for melanoma as a means to determine a patient's nodal status,the efficacy of SLNB in patients with melanoma,and the biology of melanoma metastatic to sentinel lymph *** randomized trials have guided the development of practice guidelines for use of SLNB for melanoma and have shown the prognostic value of *** the rapidly advancing molecular and surgical technologies,the technical aspects of diagnosis,identification,and management of regional lymph nodes in melanoma continues to evolve and to ***,there is ongoing research examining both the role of SLNB for specific clinical scenarios and the ways to identify patients who may benefit from completion lymphadenectomy for a positive *** further data provides sufficient evidence to alter national consensusbased guidelines,SLNB with completion lymphadenectomy remains the standard of care for clinically node-negative patients found to have a positive SLN.

关键词： Melanoma Metastasis Review Biologic characteristics Sentinel lymph node Sentinel lymph node biopsy

Aquaculture sustainability through alternative dietary ingredients:Microalgal value-added products

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Engineering Microbiology 2022年第4期2卷 54-63页

作者： John N.Idenyi jonathan c.Eya Amechi S.Nwankwegu Emeka G.Nwoba Department of Biology/Gus R.Douglass Institute West Virginia State UniversityInstituteWV 25112USA Department of Biotechnology Ebonyi State UniversityP.M.B053AbakalikiNigeria college of Resources and Environment Southwest University1 Tiansheng RoadBeibei DistrictChongqing 400716China Algae R&D centre Environmental and Conservation SciencesMurdoch University90 South StreetMurdochWestern Australia 6150Australia centre for Water Energy and WasteHarry Butler InstituteMurdoch University90 South StreetMurdochWestern Australia 6150Australia

Aquaculture contributes remarkably to the global economy and food security through seafood production,an important part of the global food supply *** success of this industry depends heavily on aquafeeds,and the nutritional composition of the feed is an important factor for the quality,productivity,and profitability of aquaculture *** sustainability of the aquaculture industry depends on the accessibility of quality feed ingredients,such as fishmeal and fish *** traditional feedstuffs are under increasing significant pressure due to the rapid expansion of aquaculture for human consumption and the decline of natural fish *** this review,we evaluated the development of microalgal molecules in aquaculture and expanded the use of these high-value compounds in the production of aquaculture ***-derived functional ingredients emerged as one of the promising alternatives for aquafeed production with positive health *** compounds found in microalgae,including carotenoids(lutein,astaxanthin,and𝛽-carotene),essential amino acids(leucine,valine,and threonine),𝛽-1-3-glucan,essential oils(docosahexaenoic acid and eicosapentaenoic acid),minerals,and vitamins,are of high nutritional value to aquaculture.

关键词： Aquaculture Aquafeed Microalgae Nutrition Sustainability

camera traps reveal the natural corridors used by mammalian species in eastern Mexico

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Ecological Processes 2022年第1期11卷 711-722页

作者： jonathan O.Huerta‑Rodríguez Octavio c.Rosas‑Rosas Lauro López‑Mata JoséL.Alcántara‑carbajal Luis A.Tarango‑Arámbula Programa de Recursos Genéticos y Productividad‑Ganadería Colegio de Post‑graduadosCampus MontecilloTexcocoMexico Programa de Innovación en Manejo de Recursos Naturales Colegio de PostgraduadosCampus San Luis PotosíSan Luis PotosíMexico Programa de Dinámica y conservación de Bosques y Selvas Macroecología y BiodiversidadColegio de PostgraduadosCampus MontecilloTexcocoMexico

Background:Habitat loss and fragmentation in the Sierra Madre Oriental(SMO)ecological corridor have negative impacts on the movement and distribution of mammalian species that are of great ecological and evolutionary *** of the SMO ecological corridor that is located in the state of Hidalgo is less studied despite being a potential dispersal route for *** objectives of this study were to evaluate the presence and activity of terrestrial mammals in the riparian and non‑riparian zones of ***:camera traps detected 15 mammalian species(i.e.,14 native and 1 domestic)in the non‑riparian zone,and 12 mammalian species in the riparian zone(i.e.,10 wild and 2 domestic).The riparian corridor was mainly used by opportunistic medium‑sized carnivores,while large carnivores and their potential prey were more frequent in the non‑riparian ***:Our findings suggest terrestrial mammals avoid the use of natural corridors due to the presence of domestic dogs,cattle and humans and look for new dispersal routes to move through their habitat and find the resources they need to *** though some species can use disturbed corridors to move and find resources,they will change their activity patterns to avoid contact with humans and potential threats like *** is,therefore,crucial to identify not one,but several corridors that must be preserved to improve the connectivity of terrestrial mammals in disturbed landscapes.

关键词： Activity Jaguar cattle Detectability Dog Herbivore Disturbance Prey Relative abundance

A cK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR

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Journal of Molecular cell Biology 2017年第3期9卷 195-208页

作者： Stephanie Bilodeau Veronique caron jonathan Gagnon Alexandre Kuftedjian Andre Tremblay Research center CHU Sainte-Justine Montreal Quebec H3T 1C5 Canada Department of Biochemistry and Molecular Medicine Faculty of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada Department of Obstetrics & Gynecology Faculty of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada

Farnesoid X receptor （FXR） is a ligand-activated nuclear receptor that plays a central role in regulating genes involved in bile acid homeostasis, and fat and glucose metabolism. Here, we demonstrate a post-translational interplay between FXR phosphoryl- ation, SUMOylation, and ubiquitination that directs the receptor into an activation-degradation pathway in hepatocytes. We iden- tify a non-canonical SUMOylation motif termed pSuM that conjugates SUM02 at Lys-325 of FXR under the direct control of casein kinase 2 （cK2）, which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327. Lys-325 SUMOylation is indispensable to the promotion of efficient ligand activation and transcriptional coactivation of FXR. constitutive pSuM activation using a phospho-mimic Ser-327 mutant or catalytic cK2 expression strongly induces SUM02 conjugation, which directs FXR ubiquitination and proteasome-dependent degradation. We also determine that such SUMOylation-dependent ubiquitination of FXR is mediated by the E3 ubiquitin ligase RNF4, which is required to achieve maximal induction of FXR and optimal up- or downregulation of responsive genes involved in bile acid homeostasis and liver regeneration. Our findings identify a highly regulated atypical SUMO conjugation motif that serves to coordinate FXR transcriptional compe- tence, thereby expanding the intricate dynamics of the SUMOylation process used by incoming signals to govern metabolic gene regulation.

关键词： farnesoid receptor SUMOylation ubiquitination 26S proteasome bile acid