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The effect of platform switching on the levels of metal ion release from different implant–abutment couples

International Journal of Oral Science 2016年第2期8卷 117-125页

作者： Ghada O Alrabeah jonathan c knowles Haralampos Petridis Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute University College London London UK Prosthodontic Unit Department of Restorative Dentistry UCL Eastman Dental Institute University College London London UK

The improved peri-implant bone response demonstrated by platform switching may be the result of reduced amounts of metal ions released to the surrounding tissues. The aim of this study was to compare the levels of metal ions released from platform-matched and platform-switched implant-abutment couples as a result of accelerated corrosion. Thirty-six titanium alloy （Ti-6AI-4V） and cobalt-chrome alloy abutments were coupled with titanium cylinders forming either platform-switched or platform-matched groups （n = 6）. In addition, 18 unconnected samples served as controls. The specimens were subjected to accelerated corrosion by static immersion in 1% lactic acid for 1 week. The amount of metal ions ion of each test tube was measured using inductively coupled plasma mass spectrometry. Scanning electron microscope （SEM） images and energy dispersive spectroscopy X-ray analyses were performed pre- and post-immersion to assess corrosion at the interface. The platform-matched groups demonstrated higher ion release for vanadium, aluminium, cobalt, chrome, and molybdenum compared with the platform-switched groups （P〈 0.05）. Titanium was the highest element to be released regardless of abutment size or connection （P〈0.05）. SEM images showed pitting corrosion prominent on the outer borders of the implant and abutment platform surfaces. In conclusion, implant-abutment couples underwent an active corrosion process resulting in metal ions release into the surrounding environment. The highest amount of metal ions released was recorded for the platform-matched groups, suggesting that platform-switching concept has a positive effect in reducing the levels of metal ion release from the implant-abutment couples.

关键词： corrosion dental implants ion release peri-implant bone loss platform-switching titanium

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Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

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Bioactive Materials 2021年第1期6卷 123-136页

作者： Ahmed El-Fiqi Nandin Mandakhbayar Seung Bin Jo jonathan c.knowles Jung-Hwan Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Glass Research Department National Research CentreCairo12622Egypt Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute256 Grays Inn RoadLondonWC1X 8LDUK The Discoveries centre for Regenerative and Precision Medicine UCL CampusLondonUK Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea UcL Eastman-Korea Dental Medicine Innovation centre Dankook UniversityCheonan31116Republic of Korea

Therapeutic options are quite limited in clinics for the successful repair of infected/degenerated *** the prevalent treatment is the complete removal of the whole infected tissue,this leads to a loss of tissue function and serious *** the dental pulp infection,as one of the most common dental problems,was selected as a clinically relevant case to regenerate using a multifunctional nanotherapeutic *** this,a mesoporous bioactive glass nano-delivery system incorporating silicate,calcium,and copper as well as loading epidermal growth factor(EGF)was designed to provide antibacterial/pro-angiogenic and osteo/odontogenic multiple therapeutic ***-functionalized cu-doped bioactive glass nanospheres(cu-BGn)were prepared to be 50–60 nm in size,mesoporous,positive-charged and *** cu-BGn could release bioactive ions(copper,calcium and silicate ions)with therapeutically-effective *** cu-BGn treatment to human umbilical vein endothelial cells(HUVEc)led to significant enhancement of the migration,tubule formation and expression of angiogenic gene(*** endothelial growth factor,VEGF).Furthermore,the EGF-loaded cu-BGn(EGF@cu-BGn)showed pro-angiogenic effects with antibacterial activity against ***,a pathogen commonly involved in the pulp *** note,under the co-culture condition of HUVEc with ***,the secretion of VEGF was *** addition,the osteo/odontogenic stimulation of the EGF@cu-BGn was evidenced with human dental pulp stem *** local administration of the EGF@cu-BGn in a rat molar tooth defect infected with *** revealed significant in vivo regenerative capacity,highlighting the nanotherapeutic uses of the multifunctional nanoparticles for regenerating infected/damaged hard tissues.

关键词： Nanotherapeutics Mesoporous bioglass nanospheres copper ion/Growth factor Antibacterial/angiogenesis Osteogenesis/odontogenesis

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企业宗旨的目标是什么?

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企业家信息 2022年第6期 4-7页

作者：乔纳森·诺尔斯汤姆·亨塞克汉娜·格罗夫艾利森·詹姆斯战略咨询公司Type 2 consulting 雷鸟全球管理学院不详

如今的企业领导者承受着必须提出企业宗旨的压力,就像20世纪80年代的领导者要有远见、90年代的领导者要发表使命宣言一样。这样关注企业在经济体乃至更广泛的社会中的作用,的确有许多积极的方面,但可能会让对速度、捷径和高速前进的追... 详细信息

如今的企业领导者承受着必须提出企业宗旨的压力,就像20世纪80年代的领导者要有远见、90年代的领导者要发表使命宣言一样。这样关注企业在经济体乃至更广泛的社会中的作用,的确有许多积极的方面,但可能会让对速度、捷径和高速前进的追求凌驾于踏实行动之上。本文旨在帮助高管领导者明白自己要定义什么:企业宗旨的目标。

关键词：企业宗旨企业领导者使命宣言经济体

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