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Patient-centric dose equivalency pilot study of incobotulinumtoxin a(xeomin)*** a(dysport)in the treatment of glabellar frown lines

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Plastic and Aesthetic Research 2015年第1期2卷 12-16页

作者： jonathan bank Nicole A.Phillips Laurie A.Casas Department of Surgery Section of Plastic and Reconstructive SurgeryUniversity of Chicago Medical CenterChicagoIL 60026USA Department of Surgery Division of Plastic SurgeryBrigham and Women’s HospitalBostonMA 02115USA

Aim:Incobotulinumtoxin A(xeomin)has been proposed as an alternative to abobotulinumtoxin A(dysport)and onabotulinumtoxin A(Botox)in the treatment of glabellar frown lines.A recent study is comparing abobotulinumtoxin A and onabotulinumtoxin A revealed equivalent efficacy with a dose conversion ratio of 2.5:*** sought to establish effectiveness and dosing equivalency of incobotulinumtoxin A *** ***:Inclusion criteria for this pilot study included patients of a single surgeon(LAC)who had previously received a constant dose of abobotulinumtoxin A over at least four consecutive treatment sessions for the previous 12 months to achieve an 85-90%elimination of dynamic glabellar frown *** primary outcome sought dose comparison between established maintenance abobotulinumtoxin A dosing and incobotulinumtoxin A first-time dosing.A 2:1 conversion(abobotulinumtoxin A:incobotulinumtoxin A)was chosen in most *** outcomes were patient-reported onset of effect,physician-assessed effect at 10-12 weeks,pain associated with administration,and patient perceived need for re-treatment at 2 ***:A total of 32 subjects were *** mean dose of incobotulinumtoxin A was 17.1 units(±6.1,the median dose 20 units).The mean dose of abobotulinumtoxin A was 27.6(±11.7,the median dose 27.5 units).The mean difference in treatment units was 10.5(95%confidence interval,P<0.001).Among 30 patients who reported effect onset,the median was 8.5 days,with a range of *** 10-12 weeks,muscle paralysis was assessed to be 69.2%(±27.3),vs.90.3%(±1.8)with abobotulinumtoxin A(P<0.001).The majority of patients rated pain of administration as equal or greater to that of abobotulinumtoxin A(63%and 22%,respectively).Three patients(9%)required re-treatment at 2 weeks with abobotulinumtoxin A due to lack of effective treatment with incobotulinumtoxin *** A re-treatment was chosen by the ***:We found incobotulinumtoxin A at 17.1

关键词： Abobotulinumtoxin A glabellar frown lines incobotulinumtoxin A rhytids

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A Preliminary Feasibility Study on Wind Resource and Assessment of a Novel Low Speed Wind Turbine for Application in Africa

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Energy Engineering 2022年第3期119卷 997-1015页

作者： Kehinde Adeyeye Nelson Ijumba jonathan Colton African Centre of Excellence Energy for Sustainable DevelopmentUniversity of RwandaKigaliRwanda School of Engineering University of KwaZulu NatalDurbanSouth Africa George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaUSA

This paper posits that a low-speed wind turbine design is suitable for harnessing wind energy in *** wind turbines consisting of propeller designs are commonly used across the world.A major hurdle to utilizing wind energy in Africa is that conventional commercial wind turbines are designed to operate at wind speeds greater than those prevalent in most of the continent,especially in sub-Sahara Africa(SSA).They are heavy and expensive to purchase,install,and *** a result,only a few countries in Africa have been able to include wind energy in their energy *** this paper,the feasibility of a novel low-speed wind turbine based on a Ferris wheel is demonstrated for low wind speed applications in *** performance of Ferris wheel wind turbines(FWT)with 61m(200 ft),73m(240 ft)and 104m(341 ft)diameter rims and an 800kW generator are evaluated for selected African *** research also compares the Weibull wind distribution of the African cities of interest.A comparison between the FWT and the conventional commercial wind turbines in terms of efficiency,rated wind speed,cost,performance,and power to weight is *** show that the FWT has the potential for economic power generation at rated wind speeds of 6.74m/s,which are lower than the average of 12 m/s for conventional wind turbines and have lower power to weight ratios of 5.2 kW/tonne as compared to 6.0-9.2 kW/tonne for conventional wind turbines.

关键词： Wind energy conventional wind turbines ferris wheel wind turbine energy access sub-sahara africa wind speed

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Livestock induces strong spatial heterogeneity of soil CO2, N2O and CH4 emissions within a semi-arid sylvo-pastoral landscape in West Africa

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Journal of Arid Land 2017年第2期9卷 210-221页

作者： Mohamed H ASSOUMA Dominique SERCA Frederic GUERIN Vincent BLANFORT Philippe LECOMTE Ibra TOURE Alexandre ICKOWICZ Raphael J MANLAY Martial BERNOU jonathan VAYSSIERES CIRAD-UMR Selmet Campus International Baillarguet Montpellier 34398 France DP PPZS ISRA-LNERV BP 2057 Dakar Hann Senegal Laboratoire d'Aerologie-OMP Universite Paul Sabatier 14 Avenue Edouard Belin Toulouse 31400 France Geosciences Environnement Toulouse UMR 5563 & UR 234 IRD Universite Paul Sabatier Avenue Edouard Belin 14 Toulouse 31400 France CILSS 03 BP 7049 Ouagadougou Burkina Faso AgroParisTech-UMR Eco&Sols 2 place Viala Montpellier SupAgro Montpellier 34060 France IRD-UMR Eco&Sols 2 place Viala Montpellier SupAgro Montpellier 34060 France

Greenhouse gas （GHG） emissions from the surface soils and surface water receiving animal excreta may be important components of the GHG balance of terrestrial ecosystems, but the associated processes are poorly documented in tropical environments, especially in tropical arid and semi-arid areas. A typical sylvo-pastoral landscape in the semi-arid zone of Senegal, West Africa, was investigated in this study. The study area （706 km2 of managed pastoral land） was a circular zone with a radius of 15 km centered on a borehole used to water livestock. The landscape supports a stocking rate ranging from 0.11 to 0.39 tropical livestock units per hectare depending on the seasonal movements of the livestock. Six landscape units were investigated （land in the vicinity of the borehole, natural ponds, natural rangelands, forest plantations, settlements, and enclosed plots）. Carbon dioxide （CO2）, nitrous oxide （N2O） and methane （CH4） fluxes were measured with static chambers set up at 13 sites covering the six landscape units, and the 13 sites are assumed to be representative of the spatial heterogeneity of the emissions. A total of 216 fluxes were measured during the one-year study period （May 2014 to April 2015）. At the landscape level, soils and surface water emitted an average 19.8 t C-CO2 eq/（hm2.a）（CO2： 82%, N2O： 15%, and CH4： 3%）, but detailed results revealed notable spatial heterogeneity of GHG emissions. CO2 fluxes ranged from 1148.2 （±91.6） mg/（m2.d） in rangelands to 97,980.2 （±4,861.7） mg/（m2.d） in surface water in the vicinity of the borehole. N2O fluxes ranged from 0.6 （±0.1） mg/（m2.d） in forest plantations to 22.6 （±10.8） mg/（m2.d） in the vicinity of the borehole. CH4 fluxes ranged from -3.2 （±0.3） mg/（m2.d） in forest plantations to 8788.5 （±2295.9） mg/（m2.d） from surface water in the vicinity of the borehole. This study identified GHG emission ＂hot spots＂ in the landscape. Emissions from the surface soils were significantly higher in the landscape units most freq

关键词： greenhouse gases soil surface water livestock landscape Senegal

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Assessment of Heavy Metals Concentration in Shore Sediments from the bank of River Benue, North-Central Nigeria

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Journal of Geoscience and Environment Protection 2018年第4期6卷 35-48页

作者： Ejembi Emmanuel Terver Sombo jonathan Ugwanyi Department of Natural and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Department of Physics University of Agriculture Makurdi Nigeria

Heavy metals are elements, whose density is greater than water. They are generated from our environment. Rocks, sediments, plants, water and aerosol particles represent the carriers of heavy metals. An accumulated amount of heavy metal in the body, either by inhalation, food or drinking water, can cause an adverse health effect to human. The Benue river passed through the town of makurdi, was high population of the inhabitant of Benue State dwells. The industrial and agricultural activities carried out in this region, increase the concentration of heavy metals. This may result to adverse health effect on the inhabitant of Makurdi. The objectives of this work were to determine the heavy metal concentration and its site contaminations along the bank of river Benue, Makurdi. An inductively coupled plasma optical emission spectrometry (ICP-OES) was used to determine the heavy metals concentration. The metals concentrations (Iron, Copper, Manganese, Lead, Zinc, Chromium, Arsenic, and Cadmium) of the three stations were found. This ranges from 3.55 - 9454.0 mg/kg, 0.20 - 8928.0 mg/kg and 2.80 - 13,657 mg/kg for stations 1, 2 and 3. With Fe recorded as the highest concentration in the sediment, this value is compared with the World Health Organisation (WHO) and World Surface Rock Average (WSRA) standard. The assessment on contamination status of heavy metals in the riverbank, showed low degree of contamination in stations 1 and 2, and moderate degree in station 3. The degree of enrichment to heavy metals in all the stations is deficient to minimal. The evaluation of the results of pollution load index (PLI) from this present study indicated PLI 1 in stations 1 and 3. Hence stations 1 and 3 are polluted, while station 2 is not polluted with heavy metals.

关键词： Heavy Metals Site Contamination Parameter ICP-OES

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Assessment of Radionuclide Content of Shore Sediments Collected from the bank of River Benue, North-Central Nigeria

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Journal of Geoscience and Environment Protection 2017年第12期5卷 57-65页

作者： Terver Sombo Ejembi Emmanuel jonathan Ugwuanyi Department of Physics University of Agriculture Makurdi Nigeria Department of Natural and Applied Sciences Namibia University of Science and Technology Windhoek Namibia

Ionizing Radiation emitted from radionuclide has an adverse effect on human health. A continuing population exposure to naturally occurring radioactive materials (NORMS) found in our environment is one of the major scientific subjects that attract public attention. The assessment of radionuclide content of shore sediments of river Benue-North Central Nigeria was carried out using gamma-ray spectrometry. The activity concentrations of U-238, Th-232 and K-40 were found to have an average concentration of 1.17, 3.31 and 405.95 Bq·kg-1 respectively. The values gotten from present study were compared with the world average values. World average values of U-238, Th-232 and K-40 are 50 Bq·kg-1, 50 Bq·kg-1 and 500 Bq·kg-1 respectively. The mean concentration of daughter radionuclides generated from U-238, Th-232 was 4.32, 10.37, 5.24, 3.86, 11.87, and 6.52 for Bi-212, Pb-212, Bi-214, Pb-214, Ra-226 and Ac-228, respectively. The mean of the absorbed dose, Annual effective dose equivalent, for radium equivalent activity, and external hazard index, were evaluated to be 19.45 nGy·h-1, 23.82 μSv·y-1, 37.16 Bq·kg-1, 0.10 mSv·y1, below the permissible limit of 57 nGy·h-1, 70 μSv·y-1, 370 Bq·kg-1 and 1 mSv·y-1 respectively. These shore sediments from river Benue are therefore, radiologically safe for construction and other domestic and industrial purposes.

关键词： Radionuclides Sediments Gamma Spectrometry Radiological Parameter

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危机时代的小额信贷、社会企业与反贫困--穆罕默德·尤努斯教授在北京大学的演讲

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经济科学 2009年第3期 5-14页

作者：穆罕默德.尤努斯 jonathan Richter 卢新月孟加拉乡村银行(Grameen bank) 北京大学

非常高兴能够重返北大。北大授予我名誉教授的头衔，为了名副其实，我想我应该偶尔出现一下，来到你们中间，与你们分享我身边发生的一切，给你们扼要地讲述一下我的工作，告诉你们我的最新动向。这次汇报尤为重要，因为我们正处于严重... 详细信息

非常高兴能够重返北大。北大授予我名誉教授的头衔，为了名副其实，我想我应该偶尔出现一下，来到你们中间，与你们分享我身边发生的一切，给你们扼要地讲述一下我的工作，告诉你们我的最新动向。这次汇报尤为重要，因为我们正处于严重的危机之中——金融危机。你们在中国可以感受到危机带来了一些影响，然而在许多国家，这简直是一场灾难。

关键词：金融危机小额信贷北京大学穆罕默德社会企业反贫困努斯名誉教授

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The hydrogenation of levulinic acid to γ-valerolactone over Cu–ZrO2 catalysts prepared by a pH-gradient methodology

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Journal of Energy Chemistry 2019年第9期28卷 15-24页

作者： Igor Orlowski Mark Douthwaite Sarwat Iqbal James S.Hayward Thomas E.Davies jonathan K.Bartley Peter J.Miedziak Jun Hirayama David J.Morgan David J.Willock Graham J.Hutchings Cardiff Catalysis Institute School of Chemistry Cardiff University Main Building Park Place Cardiff CF10 3AT UK School of Chemistry Joseph Bank Laboratories Beevor St University of LincolnLincoln LN6 7DL UK School of Applied Sciences University of South WalesPontypridd CF37 4AT UK Institute for Catalysis Hokkaido UniversitySapporo Hokkaido 001-0021 Japan

A novel pH gradient methodology was used to synthesise a series of Cu–ZrO2 catalysts containing different quantities of Cu and *** of the catalysts were highly selective to the desired product,γ-valerolactone, and are considerably more stable than Cu–ZrO2 catalysts prepared by other co-precipitation methods for this *** and further investigation of these catalysts by XRD, BET, SEM and XPS provided insight into the nature of the catalytic active site and the physicochemical properties that lead to catalyst *** consider the active site to be the interface between Cu/CuOxand ZrOx and that lattice Cu species assist with the dispersion of surface Cu through the promotion of a strong metal support *** enhanced understanding of the active site and roles of lattice and surface Cu will assist with future catalyst *** such, we conclude that the activity of Cu–ZrO2 catalysts in this reaction is dictated by the quantity of Cu–Zr interface sites.

关键词： Cu–ZrO2 Hydrogenation Levulinic acid γ-Valerolactone

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投资中国银行业,是祸、还是福?

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中国经贸 2006年第1期 58-59页

作者： jonathan Anderson 瑞士银行

当2005年6月中旬，美国银行（bank of America）宣布将以高达30亿美元的价格购买中国建设银行（China Construction bank）9％的股权，这将成为中国历史上银行业乃至整个经济领域金额最高的并购。可以想像，到2007年，外资银行以及其他... 详细信息

当2005年6月中旬，美国银行（bank of America）宣布将以高达30亿美元的价格购买中国建设银行（China Construction bank）9％的股权，这将成为中国历史上银行业乃至整个经济领域金额最高的并购。可以想像，到2007年，外资银行以及其他外资投资者有可能控制中国整个银行业超过六分之一的股权。

关键词：中国银行业投资者中国建设银行外资银行美国银行经济领域中国历史股权购买价格

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大贵州滩下三叠统岩石和化学地层对比

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贵州地质 2011年第3期28卷 161-166,218页

作者：李晓伟喻美艺 jonathan L.Payne Brian M.Kelly 贵州大学资源与环境工程学院贵州贵阳550001 斯坦福大学地质与环境科学学院美国加州94305

南盘江盆地中的大贵州滩为一个自晚二叠世末期开始发育,至晚三叠世初期停止生长的孤立型碳酸盐岩台地。早期的研究工作主要集中于台地内部、北部斜坡和盆地边缘,并认为大贵州滩下三叠统地层格架的几何形态近于对称。本次研究以下三叠统... 详细信息

南盘江盆地中的大贵州滩为一个自晚二叠世末期开始发育,至晚三叠世初期停止生长的孤立型碳酸盐岩台地。早期的研究工作主要集中于台地内部、北部斜坡和盆地边缘,并认为大贵州滩下三叠统地层格架的几何形态近于对称。本次研究以下三叠统岩石地层对比为基础,借助早三叠世期间δ13C波动频繁且幅度较大的特点进行化学地层对比后发现:台地南缘二-三叠系地层为不整合接触,南缘下三叠统的地层缺失严重;与之前的认识不同,台地南、北两缘下三叠统的地层格架的几何形态表现出明显的不对称特点。

关键词：大贵州滩下三叠统碳同位素岩石地层地层格架

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Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

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