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南海永暑礁微型软体动物对晚全新世快速气候变化的响应(英文)

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微体古生物学报 2005年第1期22卷 39-46页

作者：冯伟民 jonathan a.todd 蓝王秀蔡华伟中国科学院南京地质古生物研究所南京210008 Department of Palaeontology The Natural History Museum Cromwell Road London SW7 5BD UK

近2000年来的地球环境变化日益受到人们的关注,许多替代指标被用来指示快速的气候变化。本文试图通过南海永暑礁泻湖微型软体动物丰度和分异度的研究及其与北半球温度异常的对比,来阐述微型软体动物对快速气候变化的响应。研究表明,软... 详细信息

近2000年来的地球环境变化日益受到人们的关注,许多替代指标被用来指示快速的气候变化。本文试图通过南海永暑礁泻湖微型软体动物丰度和分异度的研究及其与北半球温度异常的对比,来阐述微型软体动物对快速气候变化的响应。研究表明,软体动物丰度变化的三个高值和三个低值较好地对应于北半球温度异常,显示了微型软体动物丰度对快速气候变化的灵敏反应。尤其重要的是“小冰期”和“中世纪暖期”被证明在南海也发生过。这表明快速的气候变化事件也会影响到热带海区。研究还证实另一次温暖的气候事件发生在大约 850A.D.—680A.D.之间。文中对软体动物分异度与气候变化的关系也作了探讨,并表明软体动物丰度和分异度是指示气候变化的有用指标。

关键词：气候变化南海永暑礁温度异常丰度分异度北半球软体动物晚全新世响应

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： Jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-Smith jonathan D.todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

Biogenic production of DMSP and its degradation to DMS—their roles in the global sulfur cycle

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Science China(Life Sciences) 2019年第10期62卷 1296-1319页

作者： Xiao-Hua Zhang Ji Liu Jingli Liu Guipeng Yang Chun-Xu Xue Andrew R. J. Curson jonathan D. todd MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266071China School of Biological Sciences University of East AngliaNorwich NR4 7TJUK

Dimethyl sulfide(DMS) is the most abundant form of volatile sulfur in Earth’s oceans, and is mainly produced by the enzymatic clevage of dimethylsulfoniopropionate(DMSP). DMS and DMSP play important roles in driving the global sulfur cycle and may affect climate. DMSP is proposed to serve as an osmolyte, a grazing deterrent, a signaling molecule, an antioxidant, a cryoprotectant and/or as a sink for excess sulfur. It was long believed that only marine eukaryotes such as phytoplankton produce DMSP. However, we recently discovered that marine heterotrophic bacteria can also produce DMSP, making them a potentially important source of DMSP. At present, one prokaryotic and two eukaryotic DMSP synthesis enzymes have been *** heterotrophic bacteria are likely the major degraders of DMSP, using two known pathways: demethylation and *** phytoplankton and some fungi can also cleave DMSP. So far seven different prokaryotic and one eukaryotic DMSP lyases have been identified. This review describes the global distribution pattern of DMSP and DMS, the known genes for biosynthesis and cleavage of DMSP, and the physiological and ecological functions of these important organosulfur molecules, which will improve understanding of the mechanisms of DMSP and DMS production and their roles in the environment.

关键词： marine microorganism dimethylsulfoniopropionate (DMSP) dimethyl sulfide (DMS) DMSP biosynthesis DMSP cleavage

Mesenteric metastases from mature teratoma of the testis:A case report

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Asian Journal of Urology 2020年第3期7卷 322-325页

作者： Zoe Loh todd G.Manning jonathan S.O’Brien Marlon Perera Nathan Lawrentschuk Department of Surgery University of MelbourneAustin HealthMelbourneAustralia The Young Urology Researchers Organisation(YURO) Australia Faculty of Medicine University of QueenslandBrisbaneAustralia Department of Surgical Oncology Peter MacCallum Cancer CentreMelbourneAustralia Olivia Newton-John Cancer Research Institute MelbourneAustralia

Metastatic spread of testicular cancer has been well documented,with 95% of cases involving para-aortic retroperitoneal lymph *** lymphatic basins do not lie within the canonical drainage pathway of the testes and represent a rare site of *** mechanisms of spread to the mesentery have been described,including direct extension and haematogenous *** present a case of a previously-well 43-year-old man who presented with right scrotal discomfort and intermittent lower back pain,who was found to have mesenteric metastases from a non-seminomatous germ cell tumour of the *** lymphadenopathy that lies outside of standard resection templates remains a complex surgical *** we present the first case in the English medical literature with co-existing supradiaphragmatic axillary and mediastinal nodal disease.

关键词： Nonseminomatous germ cell tumour Retroperitoneal lymph node dissection Mesentery Metastases Testicular cancer

Dysfunctional stem and progenitor cells impair fracture healing with age

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World Journal of Stem Cells 2019年第6期11卷 281-296页

作者： Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer jonathan W Lowery M Terry Loghmani Philip S Low todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li Department of Mechanical and Energy Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202United States Department of Medicinal Chemistry and Molecular Pharmacology Purdue UniversityWest LafayetteIN 47907United States Department of Physical Therapy Indiana University- Purdue University IndianapolisIndianapolisIN 46202United States Division of Biomedical Science Marian University College of Osteopathic MedicineIndianapolisIN 46222United States Department of Chemistry Purdue UniversityWest LafayetteIN 47907 United States Richard L. Roudebush VA Medical Center IndianapolisIN 46202United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States Department of Biology Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.

关键词： Fracture healing Aging Bone Angiogenesis Mesenchymal stem cells Endothelial progenitor cells

肿瘤组织中细胞间粘附分子-1表达的PET/近红外荧光跨模态靶向成像表征

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分子影像学杂志 2021年第1期44卷 1-7页

作者：李淼 BARNHART todd E ENGLE jonathan W 西安交通大学第一附属医院医学影像科陕西西安710061 威斯康星大学麦迪逊分校医学物理系美国麦迪逊53705

目的验证基于双标记细胞间粘附分子-1(ICAM-1)单抗示踪剂,进行胰腺癌组织中ICAM-1的正电子发射断层(PET)/近红外荧光(NIRF)跨模态靶向成像的可行性。方法采用流式细胞术测定2种胰腺癌细胞系BxPC-3、MIA PaCa的ICAM-1表达水平。通过生物... 详细信息

目的验证基于双标记细胞间粘附分子-1(ICAM-1)单抗示踪剂,进行胰腺癌组织中ICAM-1的正电子发射断层(PET)/近红外荧光(NIRF)跨模态靶向成像的可行性。方法采用流式细胞术测定2种胰腺癌细胞系BxPC-3、MIA PaCa的ICAM-1表达水平。通过生物耦联和配位反应制备NIRF荧光团和[^(89)Z]锆核素双标记示踪剂。在上述细胞系构建的裸鼠皮下移植瘤模型(简称模型鼠)中,测试示踪剂的特异性、跨模态成像性能和生物分布特性;尝试在BxPC-3模型鼠中进行解剖前/后离体组织器官NIRF光学成像。最后采用组织病理学方法确认ICAM-1在移植瘤组织中的分布。结果BxPC-3与MIAPaCa细胞系的ICAM-1表达水平有显著差异(P<0.05)。PET/NIRF跨模态成像和放射性生物分布实验显示,在2种模型鼠中,肿瘤的示踪剂摄取峰值的差异也有统计学意义(P<0.05)。PET/NIRF成像所显示的肿瘤位置相互吻合。解剖切除瘤体前后,荧光信号随瘤体转移,周围组织几乎无残留信号。免疫组织化学染色显示,这2种移植瘤组织的ICAM-1表达水平差异与其示踪剂浓聚水平差异正相关(P<0.05)。结论本研究确认了以ICAM-1为靶标的双标记单抗示踪剂,用于胰腺癌组织临床前靶向跨模态成像是可行的,这为同时实现肿瘤活体全身成像和肿瘤组织原位可视化提供了例证,揭示了基于ICAM-1靶向成像的病灶检测、手术导航等临床转化应用的潜力。

关键词：细胞间粘附分子-1 靶标肿瘤多模态分子影像

The Use of PCA3 Can Reduce the Number of Prostate Biopsies Performed in a Community-Based Urologic Practice

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Open Journal of Urology 2013年第5期3卷 200-205页

作者： Bradley M. Boelkins Christopher M. Whelan Richard J. Kahnoski jonathan todd Bolthouse Brian R. Lane Michigan State University East Lansing USA

Purpose: It is now generally accepted that PSA screening identifies many prostate cancers that are low-risk and may not need treatment. PCA3 is a prostate cancer-specific marker with improved diagnostic accuracy when compared with PSA in research studies. It remains unknown whether PCA3 testing can reduce the unnecessary diagnosis and treatment of prostate cancer in routine practice. We evaluated whether the use of PCA3 in clinical practice decreases the number of biopsies being performed in response to PSA testing. Methods: 64 consecutive patients undergoing PCA3 measurement in a single community-based urology practice were analyzed for rates of biopsy performance and prostate cancer detection. Results: Median PSA was 5.0 (range: 0.4 - 38.6) and 50% had undergone prior biopsy without evidence of cancer. Median PCA3 score was 13.6 (range: 1.6 - 133.0) with 14 patients having an elevated PCA3 (>35). Prostate biopsy was avoided in 50 of 64 patients (78%). Of the 11 patients undergoing biopsy for abnormal PCA3, 7 had prostate cancer (64%). At >2-year median follow-up, 39 of the remaining 50 patients (78%) avoided subsequent biopsy. Only 5 prostate cancers were diagnosed during follow-up. Conclusions: When used in routine clinical practice, PCA3 appears to reduce the number of biopsies being performed in response to elevated PSA. Given the increasing interest in strategies to reduce unnecessary prostate cancer diagnosis and treatment, this FDA-approved and widely-available molecular test appears to achieve these goals. Further testing will clarify the role of PCA3 in initial and subsequent prostate cancer screening paradigms.

关键词： Prostate Cancer Prostate Cancer Antigen 3 (PCA3) Prostate Biopsy

南沙群岛永暑礁晚全新世软体动物记录与古环境变化

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热带海洋学报 2005年第4期24卷 41-50页

作者：冯伟民 jonathan A T 蓝琇陈木宏中国科学院南京地质古生物研究所江苏南京210008 Department of Palaeontology The Natural History Museum Cromwell Road London SW7 5BD UK 中国科学院南海海洋研究所广东广州510301

对南沙群岛永暑礁南永3井软体动物的丰度、营养结构、化学元素和堆积速率的定量分析表明,晚全新世永暑礁潟湖经历了数次相对开放与封闭、与外海交流时强时弱以及盐度多次显著变化的过程。与氧同位素和北半球晚全新世快速气候事件的进一... 详细信息

对南沙群岛永暑礁南永3井软体动物的丰度、营养结构、化学元素和堆积速率的定量分析表明,晚全新世永暑礁潟湖经历了数次相对开放与封闭、与外海交流时强时弱以及盐度多次显著变化的过程。与氧同位素和北半球晚全新世快速气候事件的进一步对比表明,晚全新世快速变化的气候事件也波及到南海,由此造成的潟湖水动力环境、古盐度和沉积速率的变化深刻地影响着软体动物的发育。基于软体动物的替代指标和氧同位素变化的综合分析,初步划分了晚全新世永暑礁潟湖7个变化阶段。

关键词：软体动物替代指标环境变化晚全新世永暑礁溻湖南海

Mesenchymal Stem Cell Allograft Improved Pain Management in Dogs with Osteoarthritis

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Journal of Biosciences and Medicines 2023年第11期11卷 181-189页

作者： jonathan R. T. Lakey Wenyi Guo Michael Alexander Mike K. S. Chan Michelle B. F. Wong todd Scott Department of Surgery University of California Irvine Irvine USA Department of Biomedical Engineering University of California Irvine Irvine USA Department of Pancreatic Surgery General Surgery Qilu Hospital of Shandong University Jinan China European Wellness Biomedical Group Edenkoben Germany Baden R&D Laboratories GmbH Sabine Conrad Ferdinand-Laselle-Strasse Edenkoben Germany Crestwood Veterinary Clinic Edmonton Canada

Background: Osteoarthritis is one of the most common bone diseases, triggered by bone destruction stemming from the inflammatory response of chondrocytes. The disease progresses slowly, but halting its progression or finding a cure remains elusive. The treatment of pain associated with osteoarthritis has yielded unsatisfactory results. In recent years, mesenchymal stem cells (MSCs) have emerged as a potential avenue for addressing the condition. In this study, we used MSCs to treat companion dogs with osteoarthritis. Methods: For this study, 26 animals were included in this study to assess the pain and mobility one month after treatment. The pain scores were obtained from owners using a questionnaire based on the Helsinki Chronic Pain Index, and the Liverpool Osteoarthritis in Dogs (LOAD) Owner questionnaire to assess the mobility of the dogs from stem cell infusion. Results: Questionnaires were administered to dog owners before and one month after treatment, and we found that dogs treated with MSCS experienced an 81.2% ± 6.8% reduction in pain and a 77.9% ± 10.1% increase in mobility, whereas most of the dogs in the untreated control group experienced disease progression. Conclusions: The transplantation of stem cells into companion pets is a promising and expanding opportunity for pet owners with aging and arthritic dogs. MSCs may play an important role in the treatment of OA without complications in companion pets.

关键词： Stem Cell Therapy Canine Pain Osteoarthritis Mesenchymal Stem Cell