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Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

World Journal of Gastroenterology 2024年第9期30卷 1213-1223页

作者： Joseph Edwin Kanu jonathan soldera Post Graduate Program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric *** *** is crucial for treating and preventing these *** conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression *** competitive acid blocker(P-CAB)triple and dual therapy are new regimens for *** *** used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for *** *** To assess the efficacy of regimens containing P-CABs in eradicating *** *** This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating *** were *** criteria included case reports,case series,unpublished trials,or conference *** variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and *** eradication method were gathered by two independent ***-analysis was performed in R software,and forest plots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple *** intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention g

关键词： Helicobacter pylori infection Potassium competitive acid blockers Proton pump inhibitors Vonoprazan Amoxicillin

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Use of machine learning models for the prognostication of liver transplantation: A systematic review

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World Journal of Transplantation 2024年第1期14卷 164-188页

作者： Gidion Chongo jonathan soldera Department of Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Liver transplantation(LT)is a life-saving intervention for patients with end-stage liver ***,the equitable allocation of scarce donor organs remains a formidable *** tools are pivotal in identifying the most suitable transplant ***,scoring systems like the model for end-stage liver disease have been instrumental in this ***,the landscape of prognostication is undergoing a transformation with the integration of machine learning(ML)and artificial intelligence *** To assess the utility of ML models in prognostication for LT,comparing their performance and reliability to established traditional scoring *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines,we conducted a thorough and standardized literature search using the PubMed/MEDLINE *** search imposed no restrictions on publication year,age,or *** criteria encompassed non-English studies,review articles,case reports,conference papers,studies with missing data,or those exhibiting evident methodological *** Our search yielded a total of 64 articles,with 23 meeting the inclusion *** the selected studies,60.8%originated from the United States and China *** one pediatric study met the ***,91%of the studies were published within the past five *** models consistently demonstrated satisfactory to excellent area under the receiver operating characteristic curve values(ranging from 0.6 to 1)across all studies,surpassing the performance of traditional scoring *** forest exhibited superior predictive capabilities for 90-d mortality following LT,sepsis,and acute kidney injury(AKI).In contrast,gradient boosting excelled in predicting the risk of graft-versus-host disease,pneumonia,and *** This study underscores the potential of ML models in guiding decisions related to allograft allocation and LT,mark

关键词： Liver transplantation Machine learning models Prognostication Allograft allocation Artificial intelligence

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Risk and management of post-operative infectious complications in inflammatory bowel disease: A systematic review

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2579-2595页

作者： Reshma Kureemun Mowlah jonathan soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Indications for surgery in inflammatory bowel disease(IBD)include treatment-refractory disease or severe complications such as obstruction,severe colitis,dysplasia,or *** complications following colorectal surgery in IBD are significant,particularly in high-risk *** To gather evidence on risk factors associated with increased post-operative infectious complications in IBD and explore management strategies to reduce morbidity and *** A systematic review adhering to PRISMA-P guidelines was ***(PubMed)and Cochrane Library databases were searched using specific *** criteria encompassed studies involving patients with IBD under-going abdominal surgery with infectious complications within 30 d *** criteria included patients under 18 years and non-infectious *** papers were analyzed to identify factors contributing to post-operative infections.A narrative analysis was performed to provide eviden-ce-based recommendations for *** data were then extracted and assessed based on the Reference Citation Analysis(https://***/).RESULTS The initial database search yielded 1800 articles,with 330 articles undergoing full-text *** excluding duplicates and irrelevant papers,35 articles were included for *** factors for post-operative complications in patients with IBD included hypoalbuminemia,malnutrition,preoperative abscess,and *** blood transfusion was associated with increased infectious *** such as 5-aminosalicylates and immunomodulators did not increase post-operative *** were associated with an increased risk of *** and vedolizumab showed similar rates of infectious complic-ations compared to other *** impact of minimally invasive surgery on post-operative complications varied across ***

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Peri-operative infections Infliximab

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Insights into skullcap herb-induced liver injury

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World Journal of Hepatology 2024年第2期16卷 120-122页

作者： jonathan soldera Post Graduate Program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

This editorial addresses the growing concern of herb-induced liver injury(HILI),focusing on a unique case of Skullcap-induced HILI *** editorial underscore the significant mortality rate linked to Skullcap-induced HILI,emphasizing the importance of vigilant monitoring and *** herbal supplement usage rises,collaboration among clinicians and researchers is crucial to comprehend and address the complexities of HILI,particularly those involving Skullcap.

关键词： Herb-induced liver injury Drug induced liver injury Dietary supplements Herbal hepatotoxicity Liver transplantation

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Management of sepsis in a cirrhotic patient admitted to the intensive care unit:A systematic literature review

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World Journal of Hepatology 2023年第6期15卷 850-866页

作者： Nkola Ndomba jonathan soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Sepsis is a severe medical condition that occurs when the body's immune system overreacts to an infection,leading to life-threatening organ ***"Third international consensus definitions for sepsis and septic shock(Sepsis-3)"defines sepsis as an increase in sequential organ failure assessment score of 2 points or more,with a mortality rate above 10%.Sepsis is a leading cause of intensive care unit(ICU)admissions,and patients with underlying conditions such as cirrhosis have a higher risk of poor ***,it is critical to recognize and manage sepsis promptly by administering fluids,vasopressors,steroids,and antibiotics,and identifying and treating the source of *** To conduct a systematic review and meta-analysis of existing literature on the management of sepsis in cirrhotic patients admitted to the ICU and compare the management of sepsis between cirrhotic and non-cirrhotic patients in the *** This study is a systematic literature review that followed the PRISMA statement's standardized search *** search for relevant studies was conducted across multiple databases,including PubMed,Embase,Base,and Cochrane,using predefined search *** reviewer conducted the initial search,and the eligibility criteria were applied to the titles and abstracts of the retrieved *** selected articles were then evaluated based on the research objectives to ensure relevance to the study's *** The study findings indicate that cirrhotic patients are more susceptible to infections,resulting in higher mortality rates ranging from 18%to 60%.Early identification of the infection source followed by timely administration of antibiotics,vasopressors,and corticosteroids has been shown to improve patient *** is a useful biomarker for diagnosing infections in cirrhotic ***,presepsin and resistin have been found to be reliable markers of bacterial infection in patients with decompensated li

关键词： Sepsis Septic shock Cirrhosis Sequential organ failure assessment score Mean arterial pressure Intensive care unit

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Hepatobiliary tuberculosis in the developing world

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2305-2319页

作者： Ma Jenina Angela Esguerra-Paculan jonathan soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Hepatobiliary tuberculosis is a challenging disease that poses diagnostic difficulties due to its resemblance to other *** diagnosis may lead to inadequate treatment,thus necessitating an urgent need for accurate diagnosis and appropriate *** To systematically review case reports on hepatobiliary tuberculosis,focusing on symptomatology,diagnostic procedures,management,and outcomes to provide patient safety and ensure an uneventful *** A systematic search was conducted on PubMed from 1992 to 2022,using keywords such as hepatobiliary,liver,tuberculosis cholangitis,cholangiopathy,and *** case reports or case series in English were included in the study,and research papers published as abstracts were *** search yielded a total of 132 cases,which were further narrowed down to 17 case studies,consisting of 24 cases of hepatobiliary *** The 10 most common symptoms observed in these cases were fever,abdominal pain,weight loss,jaundice,anorexia,generalized weakness,pruritus,chills,fatigue,and chest *** findings in these cases included hepatomegaly,hepatic nodules,elevated liver enzymes,and elevated *** tomography scan and ultrasound of the abdomen were the most useful diagnostic tools *** demonstration of Mycobacterium tuberculosis confirmed the cases of hepatobiliary *** regimens commonly used included Rifampicin,Isoniazid,Pyrazinamide,and *** of the 24 cases,18 presented improvements while 4 had completely *** Hepatobiliary tuberculosis is a disease that requires accurate diagnosis and appropriate management to avoid complications.

关键词： Tuberculosis Hepatic/diagnosis Cholangitis Sclerosing/complications Ultrasonography Interventional/methods Biopsy Needle/utilization Treatment Outcome

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CLIF-SOFA and CLIF-C scores for the prognostication of acute-onchronic liver failure and acute decompensation of cirrhosis:A systematic review

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World Journal of Hepatology 2022年第12期14卷 2025-2043页

作者： Ebrahim Rashed jonathan soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Acute-on-chronic liver failure(ACLF)is a syndrome characterized by decompensation in individuals with chronic liver disease,generally secondary to one or more extra-hepatic organ failures,implying an elevated mortality *** decompensation(AD)is the term used for one or more significant consequences of liver disease in a short time and is the most common reason for hospital admission in cirrhotic *** European Association for the Study of Liver-Chronic-Liver Failure(EASL-CLIF)Group modified the intensive care Sequential Organ Failure Assessment score into CLIF-SOFA,which detects the presence of ACLF in patients with or without AD,classifying it into three *** To investigate the role of the EASL-CLIF definition for ACLF and the ability of CLIF-SOFA,CLIF-C ACLF,and CLIF-C AD scores for prognosticating ACLF or *** This study is a literature review using a standardized search method,conducted using the steps following the guidelines for reporting systematic reviews set out by the PRISMA *** specific keywords,relevant articles were found by searching PubMed,ScienceDirect,and BioMed *** databases were searched using the search terms by one reviewer,and a list of potentially eligible studies was generated based on the titles and abstracts *** data were then extracted and assessed on the basis of the Reference Citation Analysis(https://***/).RESULTS Most of the included studies used the EASL-CLIF definition for ACLF to identify cirrhotic patients with a significant risk of short-term *** primary outcome in all reviewed studies was *** of the study findings were based on an area under the receiver operating characteristic curve(AUROC)analysis,which revealed that CLIFSOFA,CLIF-C ACLF,and CLIF-C AD scores were preferable to other models predicting 28-d *** AUROC scores were higher and able to predict all-cause mortality at 90,180,and 365 d.A total

关键词： End-stage liver disease Acute-on-chronic liver failure CLIF-SOFA CLIF-C ACLF CLIF-C AD

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A rare cause of acute abdomen after a Good Friday

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World Journal of Clinical Cases 2022年第26期10卷 9539-9541页

作者： Leticia Pante Luísa Gailhard Brito Miguel Franciscatto Eduardo Brambilla jonathan soldera School of Medicine Universidade de Caxias so SulCaxias do Sul 95070-560Brazil Proctology Hospital Geral de Caxias do SulCaxias do Sul 95070-560Brazil Clinical Gastroenterology Universidade de Caxias do SulCaxias do Sul 95070-560RSBrazil

Small bowel perforation caused by an ingested fish bone is rare but can involve the appendix or Meckel’s *** report the case of a 25-year-old man who presented to the emergency department with acute abdomen caused by... 详细信息

关键词： Fish bone Foreign body Small bowel perforation Meckel diverticulum

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Cardiac stress testing and coronary artery disease in liver transplantation candidates： Meta-analysis

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World Journal of Hepatology 2018年第11期10卷 877-886页

作者： jonathan soldera Fábio Camazzola Santiago Rodríguez Ajacio Brandao School of Medicine Universidade de Caxias do Sul (UCS) Caxias do Sul 95070-560 Brazil School of Medicine Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) Porto Alegre 90050-170 Brazil Liver Transplantation Group Santa Casa de Misericórdia de Porto Alegre Porto Alegre 90020-090 Brazil

dAIMTo evaluate the diagnostic value of dobutamine stress echocardiography （DSE） and myocardial perfusion sci-ntigraphy （MPS） in predicting coronary artery disease （CAD） in cirrhotic patients listed for liver transplanta-tion （LT）, using invasive coronary angiography （ICA） as *** of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, EMBASE, MEDLINE （PubMed）, BIREME （Biblioteca Regional de Medicina）, LILACS （Latin American and Cari-bbean Health Sciences Literature）, Cochrane Library for Systematic Reviews and ***. There was reference lists of the studies retrieved were searched *** search strategy retrieved 322 references for DSE and 90 for MPS. In the fnal analysis, 10 references for DSE and 10 for MPS were included. Pooled sensitivity was 28% and 61% for DSE and MPS and specificity was 82% and 74%, for diagnosis of CAD using ICA as gold-standard, *** and MPS do not have adequate sensitivity for determination of whether CAD is present, despite having signifcant specifcity.

关键词： Myocardial perfusion imaging Coronary angiography Liver transplantation Echocardiography Stress

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Immunological crossroads:The intriguing dance between hepatitis C and autoimmune hepatitis

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World Journal of Hepatology 2024年第6期16卷 867-870页

作者： jonathan soldera Department of Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

Delving into the immunological crossroads of liver diseases,this editorial explores the dynamic interplay between hepatitis C virus(HCV)and autoimmune hepatitis(AIH).While HCV primarily manifests as a viral infection impacting the liver,previous studies unveil a captivating connection between HCV and the emergence of *** dance of the immune system in response to HCV appears to set the stage for an intriguing phenomenon-an aberrant autoimmune response leading to the onset of *** suggests a heightened presence of autoimmune markers in individuals with chronic HCV infection,hinting at a potential overlap between viral and autoimmune liver *** the intricate terrain of viral replication,immune response dynamics,and genetic predisposition,this editorial adds a layer of complexity to our understanding of the relationship between HCV and *** this immunological crossroads,we aim to unearth insights into the complex interplay,using a compelling case where AIH and primary sclerosing cholangitis overlapped following HCV treatment with direct-acting antivirals as background.

关键词： Liver diseases Hepatitis C virus Autoimmune hepatitis Primary sclerosing cholangitis Inflammatory bowel disease

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