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Gouty destruction of a patellar tendon reconstruction and novel revision reconstruction technique: A case report

World Journal of Orthopedics 2024年第7期15卷 675-682页

作者： Carl C Edge jonathan Widmeyer Omar Protzuk Maya Johnson robert O’Connell Department of Orthopaedic Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports Medicine OrthowestCarroltonGA 30117United States

BACKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in *** typically manifested as intraarticular crystals or tophi,gout can also cause pathology at *** deposition within tendinous structures put them at risk for traumatic and degenerative ***,allografts can also be at risk of rupture in the setting of severe *** present the case of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUMMARY A 56-year-old female presented to clinic after feeling her left knee pop and collapse beneath her while descending *** had a history of tophaceous gout and left patellar tendon rupture with reconstruction and multiple revisions over the course of 19 *** patient presented with pain and extensor lag.A magnetic resonance image demonstrated a ruptured patellar tendon allograft reconstruction and avulsion fracture at the tibial *** patient was treated with a novel intervention of Achilles allograft with bone block in a unique configuration with a dermal allograft incorporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to active flexion over the course of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal activities and *** Failed patellar tendon reconstruction due to gouty infiltration is treated with dermal allograft augmented Achilles tendon reconstruction with bone block.

关键词： Gout Patella Reconstruction Dermal allograft Revision Case report

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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染患者时安全有效

12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染...

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第十届全国疑难及重症肝病大会

作者： Kathleen B.Schwarz Philip Rosenthal Karen F.Murray jonathan robert honegger Winita Hardikar Rosemary Hague Naveen Mittal Benedetta Massetto Diana Brainard Rebecca Begley Bandita Parhy Jiang Shao Michael R.Narkewicz Girish S.Rao Suzanne Whitworth Sanjay Bansal William F.Balistreri Johns Hopkins Hospital University of California San Francisco University of Washington School of Medicine and Seattle Children's Hospital The Ohio State University Medical Center The Royal Children's Hospital

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC...

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC)用于6至<12岁的患者中时的数据,其SVR12率分别为99%-100%。本研究评估了全口服LDV/SOF FDC疗法用于3至<6岁

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Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben Zhong Tang jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li Zhong-Yu Yu Jiamin Wang Zhaoyang Liu Chao Jiang Zhen-Feng Chen Xiaoyu Wu Ming-Xing Li Hong Yang Zhao-Xi Wang jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

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The heterogeneity of store-operated calcium entry in melanoma

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Science China(Life Sciences) 2016年第8期59卷 764-769页

作者： robert Hooper M.Raza Zaidi jonathan Soboloff Fels Institute for Cancer Research and Molecular Biology Lewis Katz School of Medicine at Temple University Department of Medical Genetics & Molecular Biochemistry Lewis Katz School of Medicine at Temple University

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry(SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

关键词： melanoma STIM1 Orail metastasis

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Current taxane formulations and emerging cabazitaxel delivery systems

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Nano Research 2018年第10期11卷 5193-5218页

作者： Boyang Sun robert M. Straubinger jonathan F. Lovell Department of Biomedical Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Chemical and Biological Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Pharmaceutical Sciences University at Buffalo State University of New York Buffalo NY 14214 USA

Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes （i.e. paclitaxel and docetaxel） have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

关键词： cabazitaxel Jevtana taxanes drug delivery systems nanocarriers

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Physical-based training data collection approach for data-driven lithium-ion battery state-of-charge prediction

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能源与人工智能(英文) 2021年第3期5卷 194-200页

作者： Jie Li Will Ziehm jonathan Kimball robert Landers Jonghyun Park Department of Mechanical and Aerospace Engineering Missouri University of Science and TechnologyRollaMO 65401USA Department of Electrical and Computer Engineering Missouri University of Science and TechnologyRollaMO 65401USA

Data-Driven approaches for State of Charge(SOC)prediction have been developed considerably in recent ***,determining the appropriate training dataset is still a challenge for model development and validation due to the considerably varieties of lithium-ion batteries in terms of material,types of battery cells,and operation *** work focuses on optimization of the training data set by using simple measurable data sets,which is important for the accuracy of predictions,reduction of training time,and application to online *** is found that a randomly generated data set can be effectively used for the training data set,which is not necessarily the same format as conventional predefined battery testing protocols,such as constant current cycling,Highway Fuel Economy Cycle,and Urban Dynamometer Driving *** randomly generated data can be successfully applied to various dynamic battery operating *** the ML algorithm,XGBoost is used,along with Random Forest,Artificial Neural Network,and a reduced-order physical battery model for *** XGBoost method with the optimal training data set shows excellent performance for SOC prediction with the fastest learning time within 1 s,a short running time of 0.03 s,and accurate results with a 0.358%Mean Absolute Percentage Error,which is outstanding compared to other Data-Driven approaches and the physics-based model.

关键词： Machine learning Random signal Battery soc Dynamic current Battery modeling Estimation XGBoost

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Familiarity with a female does not affect a male＇s courtship intensity in garter snakes Thamnophis sirtalis parietalis

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Current Zoology 2012年第6期58卷 805-811页

作者： Richard SHINE jonathan K. WEBB Amanda LANE robert T. MASON School of Biological Sciences A08 University of Sydney NSW 2006 Australia Department of Zoology Oregon State University Cordley Hall 3029 Corvallis Oregon 97331-2914 USA

Abstract In many animal species, males direct more intense courtship towards females they have not previously encountered, than towards females with which they have previously mated. To test the factors responsible for this ＂Coolidge Effect＂, we need studies on a wide range of taxa - including those with mating systems in which we would not expect （based on current theory） that such an effect would be evident. The Coolidge Effect has been documented in several lizard species, but has not been looked for （and would not be expected） in snakes. We conducted experimental trials with red-sided garter snakes Thamnophis sirtalis parietalis at a communal den in Manitoba, to see whether previous exposure to a female （either courting, or courting plus mating） modified male mate choice or courtship intensity. In keeping with prediction from theory （but contrary to an early anecdotal report）, male garter snakes did not modify their courtship behaviour based upon their familiarity （or lack thereof） with a specific female. At least in large courting aggregations, male snakes may maximize their fitness by basing mate-choice upon immediate attributes of the female （body size, condition, mated status） and the intensity of competition （numbers and sizes of rival males） rather than information derived from previous sexual encounters .

关键词： Coolidge Effect Courtship Mate choice Mating system Reptile

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Off-Policy Reinforcement Learning with Gaussian Processes

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IEEE/CAA Journal of Automatica Sinica 2014年第3期1卷 227-238页

作者： Girish Chowdhary Miao Liu robert Grande Thomas Walsh jonathan How Lawrence Carin Oklahomas State University Duke University Massachusetts Institute of Technology

An off-policy Bayesian nonparameteric approximate reinforcement learning framework,termed as GPQ,that employs a Gaussian processes(GP)model of the value(Q)function is presented in both the batch and online *** conditions on GP hyperparameter selection are established to guarantee convergence of off-policy GPQ in the batch setting,and theoretical and practical extensions are provided for the online *** results demonstrate GPQ has competitive learning speed in addition to its convergence guarantees and its ability to automatically choose its own bases locations.

关键词： Convergence Approximation algorithms Function approximation Learning (artificial intelligence) Gaussian processes

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Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review

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World Journal of Gastroenterology 2014年第7期20卷 1833-1838页

作者： Peter P Stanich robert Pilarski jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer Division of Gastroenterology Hepatology and Nutritionthe Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of Human Genetics the Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Pathology the Ohio State University Wexner Medical CenterColumbusOH 43210United States

AIM: To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten (PTEN) hamartoma tumor syndrome (PHTS) and to perform a systematic literature review rega... 详细信息

关键词： Adenoma Bannayan-Riley-Ruvalcaba syndrome Colon polyps Colorectal cancer Cowden syndrome Endoscopy Ganglioneuroma Hamartoma Hyperplastic Phosphatase and tensin homolog on chromosome ten

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