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Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson brandon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph b.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg jonathan b.overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

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Simulation training in endoscopic skull base surgery: A scoping review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 73-81页

作者： Joel James Alexandria L.I race David A.Gudis jonathan b.overdevest City University of New York School of Medicine New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Columbia University Vagelos College of Physicians and SurgeonsColumbia University Irving Medical CenterNew York-Presbyterian HospitalNew YorkNew YorkUSA

Objective:Proficiency in endoscopic endonasal skull base surgery requires both substantial baseline training and progressive lifelong *** simulation models continue to evolve in an effort to optimize trainee education and preoperative preparation and improve surgical *** current scoping review systematically reviews all available literature and synthesizes the current paradigms of simulation models for endoscopic skull base surgery training and skill ***:In accordance with Preferred Reporting Items for Systemic Review and Meta-Analyses guidelines,we systematically searched PubMed,Embase,CINAHL,and Cochrane *** were categorized according to the type of simulation models ***:We identified 238 unique references,with 55 studies ultimately meeting inclusion *** these,19 studies described cadaveric dissection models,17 discussed three-dimensional(3D)printed models,14 examined virtual surgical planning and augmented reality-based models,and five 5 articles described task ***:There are a wide variety of simulation models for endoscopic skull base surgery,including high-fidelity cadaveric,virtual reality,and 3D-printed *** models are an asset for trainee development and preoperative surgical preparation.

关键词： resident education skull base surgery surgical simulation training virtual reality virtual surgical planning

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Carotid artery injury in endoscopic endonasal surgery: Risk factors, prevention, and management

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 54-60页

作者： Rahul K.Sharma Alexandria L.I race jonathan b.overdevest David A.Gudis Department of Otolaryngology-Head and Neck Surgery Columbia University Irving Medical CenterNewYork-Presbyterian HospitalNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical CenterNashvilleTennesseeUSA

Objective:Endoscopic approaches for sinus and skull base surgery are increasing in *** objective of this narrative review is to characterize risk factors for internal carotid artery injury in endoscopic endonasal surgery(EES),highlight preventative measures,and illustrate key management *** Sources:Comprehensive literature ***:Relevant literature was reviewed using PubMed/***:Carotid artery injury in EES is rare,with most studies reporting an incidence below 0.1%.Anatomic aberrancies,wide dissection margins,as well as specific provider and hospital factors,may increase the risk of *** teams,comprehensive preoperative imaging,patient risk assessment,and formal training in vascular emergencies may reduce the *** protocols should emphasize proper visualization of the injury site,fluid replacement,rapid packing,angiography,and endovascular techniques to achieve ***:While EES is a relatively safe procedure,carotid artery injury is a devastating complication that warrants full consideration in surgical *** preventative measures include identifying patients with notable risk factors and obtaining preoperative *** teams and management protocols are ultimately necessary to reduce morbidity and mortality.

关键词： carotid injury complications internal carotid pituitary pituitary adenoma pituitary tumor skull base surgery surgical outcomes transphenoidal

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Pediatric sinonasal and skull base lesions

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 118-124页

作者： Charles A.Riley Christian P.Soneru jonathan b.overdevest Marc L.Otten David A.Gudis Department of Otolaryngology Head and Neck SurgeryNew York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA Department of Neurological Surgery New York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA

Pediatric skull base lesions are complex and challenging *** and comprehensive management of this diverse group of disorders requires the expertise of an experienced multidisciplinary skull base *** endoscopic skull base surgery has evolved due to technologic and surgical advancements,multidisciplinary team approaches,and continued *** principles continue to advance the care delivered to the pediatric *** approach and management of these lesions varies considerably based on tumor anatomy,pathology,and surgical *** understanding of the nuances of skull base reconstruction unique to the pediatric population is critical for successful outcomes.

关键词： Pediatrics Endoscopic sinus surgery Endoscopic skull base surgery Juvenile nasopharyngeal angiofibroma Meningoencephalocele Pituitary adenoma Craniopharyngioma Clival chordoma Chondrosarcoma

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Exclusively endoscopic surgical resection of esthesioneuroblastoma: A systematic review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 66-72页

作者： Daniel b.Spielman Andi Liebowitz Maeher Grewal Chetan Safi jonathan b.overdevest Alfred M.Iloreta brett E.Youngerman David A.Gudis Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian Hospital-Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery The Mount Sinai Hospital/lcahn School of Medicine at Mount SinaiNew YorkNew York.USA Department of Neurological Surgery New York-Presbyterian Hospital-Columbia University Irving Medical CenterNew YorkNew YorkUSA

background:Historically sinonasal malignancies were always addressed via open craniofacial surgery for an oncologic *** esthesioneuroblastomas are excised using an exclusively endoscopic approach,however,the rarity of this disease limits the availability of long-term and large scale outcomes ***:The primary objective is to evaluate the treatment modalities used and the overall survival of patients with esthesioneuroblastoma managed with exclusively endoscopic ***:In accordance with PRISMA guidelines,PubMed was queried to identify studies describing outcomes associated with endoscopic management of ***:Forty-four out of 2462 articles met inclusion criteria,totaling 399 patients with esthesioneuroblastoma treated with an exclusively endoscopic ***-two patients(18.0%)received adjuvant chemotherapy and 331 patients(83.0%)received postoperative radiation *** average age was 50.6 years old(range 6-83).Of the 399 patients,57(16.6%)were Kadish stage A,121(35.2%)were Kadish stage b,145(42.2%)were Kadish stage C,and 21(6.1%)were Kadish stage *** analysis demonstrated that 66.0%of patients had Hyams histologic GradeⅠorⅡ,while 34.0%of patients had GradeⅢorⅣ*** surgical margins were achieved in 86.9%of patients,and recurrence was identified in 10.3%of *** those with 5-year follow-up,reported overall survival was 91.1%.Conclusion:Exclusively endoscopic surgery for esthesioneuroblastoma is performed for a wide range of disease stages and grades,and the majority of these patients are also treated with adjuvant chemotherapy or radiation *** overall recurrence rate is 10.3%and 5-year survival is 91.1%.

关键词： anterior skull base endoscopic skull base surgery esthesioneuroblastoma olfactory neuroblastoma skull base

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Local Adaptive Gradient Variance Attack for Deep Fake Fingerprint Detection

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Computers, Materials & Continua 2024年第1期78卷 899-914页

作者： Chengsheng Yuan baojie Cui Zhili Zhou Xinting Li Qingming jonathan Wu Engineering Research Center of Digital Forensics Ministry of EducationNanjing University of Information Science and TechnologyNanjing210044China School of Computer Science Nanjing University of Information Science and TechnologyNanjing210044China Institute of Artificial Intelligence and blockchain Guangzhou UniversityGuangzhou510006China School of International Relations National University of Defense TechnologyNanjing210039China Department of Electrical and Computer Engineering University of WindsorWindsorN9B 3P4Canada

In recent years,deep learning has been the mainstream technology for fingerprint liveness detection(FLD)tasks because of its remarkable ***,recent studies have shown that these deep fake fingerprint detection(DFFD)models are not resistant to attacks by adversarial examples,which are generated by the introduction of subtle perturbations in the fingerprint image,allowing the model to make fake *** of the existing adversarial example generation methods are based on gradient optimization,which is easy to fall into local optimal,resulting in poor transferability of adversarial *** addition,the perturbation added to the blank area of the fingerprint image is easily perceived by the human eye,leading to poor visual *** response to the above challenges,this paper proposes a novel adversarial attack method based on local adaptive gradient variance for *** ridge texture area within the fingerprint image has been identified and designated as the region for perturbation ***,the images are fed into the targeted white-box model,and the gradient direction is optimized to compute gradient ***,an adaptive parameter search method is proposed using stochastic gradient ascent to explore the parameter values during adversarial example generation,aiming to maximize adversarial attack *** results on two publicly available fingerprint datasets show that ourmethod achieves higher attack transferability and robustness than existing methods,and the perturbation is harder to perceive.

关键词： FLD adversarial attacks adversarial examples gradient optimization transferability

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Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

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World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： Albert T Anastasio Anthony N baumann Kempland C Walley Kyle J Hitchman Conor O’Neill jonathan Kaplan Samuel b Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

bACKGROUND The study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** To elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(Pbetween combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).CONCLUSION There is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

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DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

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Engineering 2024年第7期38卷 39-51页

作者： Kai-bo Wang Yingying Wang jonathan Dickerhoff Danzhou Yang borch Department of Medicinal Chemistry and Molecular Pharmacology College of PharmacyPurdue UniversityWest LafayetteIN 47907USA Purdue Center for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Chemistry Purdue UniversityWest LafayetteIN 47907USA Purdue Institute for Drug Discovery Purdue UniversityWest LafayetteIN 47907USA Jiangsu Key Laboratory of bioactive Natural Product Research&State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed by two or more stacked Gtetrads in G-rich DNA *** structures have been found to play a crucial role in highly transcribed genes,especially in cancer-related oncogenes,making them attractive targets for cancer ***,targeting oncogene promoter G4 structures has emerged as a promising strategy to address the challenge of undruggable and drug-resistant proteins,such as MYC,bCL2,KRAS,and *** products have long been an important source of drug discovery,particularly in the fields of cancer and infectious *** progress has recently been made in the discovery of naturally occurring DNA G4-targeting *** DNA G4s,such as MYC-G4,bCL2-G4,KRAS-G4,PDGFR-b-G4,VEGF-G4,and telomeric-G4,have been identified as potential targets of natural products,including berberine,telomestatin,quindoline,sanguinarine,isaindigotone,and many ***,we summarize and evaluate recent advancements in natural and nature-derived DNA G4 binders,focusing on understanding the structural recognition of DNA G4s by small molecules derived from *** also discuss the challenges and opportunities associated with developing drugs that target DNA G4s.

关键词： G-quadruplex Natural products Alkaloids Cancer Promoter

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biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HbMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAb)by blending human bone-ECM(b)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HbMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(bMP-2)with the HbMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay bone 3D bioprinting

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Fjord-Type AIEgens based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang ben Zhong Tang jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TbC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TbC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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