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GiT-based structural geologic feature analysis of the southern segment of Longmenshan fault zone for earthquake evidence

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Journal of Mountain Science 2016年第5期13卷 906-916页

作者： YE Cheng-ming CUI Peng Saied PIRASTEH jonathan LI MENG Qingkai bI Xiao-jia ZHANG Jian-qiang Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China Key Lab.of Earth Exploration and Information Technology of Ministry of Education Chengdu University of TechnologyChengdu 610059China Department of Geography and Environmental Management Faculty of EnvironmentUniversity of WaterlooWaterlooOntarioCanada N2L 3G1Canada Chengdu Earthquake Mitigation bureau Chengdu 610042China

The Longmenshan fault is a thrust fault which runs along the base of the Longmen Mountains in Siehuan province, southwestern China. The southern segment of the fault had two distinct responses to the Ms 8 Wenehuan and Ms 7 Lushan earthquakes. This study determines characteristics of the structural geology of the Longmenshan fault to evaluate how it influenced the two aforementioned earthquakes. This research was done within a Geo- information Technologies （GiT） environment based on multi-source remote sensing and crustal movement data extracted from the Global Positioning System （GPS）. The spatial distribution of the southern segment of the Longmenshan fault zone was comprehensively analyzed to study both earthquakes. The study revealed that the Wenehuan and Lushan earthquakes occurred on two relatively independent faults. In addition, there was a nearly constant-velocity crustal movement zone between the two epicenters that probably had a compressive stress with slow motion. Furthermore, the central fault and a mountain back fault gradually merged from north to south. The Lushan earthquake of the Wenchuan earthquake. was not an affershock The research showed that fault zones within 30-50 km of State Highway 318 are intensive and complex. In addition, crustal movement velocity decreased rapidly, with a strong multi-directional shear zone. Thus, activity in that zone was likely stronger than in the northern part over the medium to long term.

关键词： Longmenshan fault zone Geoinformation Technologies (GiT) Remote Sensing (RS) Earthquake Crustal movement

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Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

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Signal Transduction and Targeted Therapy 2019年第1期4卷 636-647页

作者： Eliseos J.Mucaki jonathan Z.L.Zhao Daniel J.Lizotte Peter K.Rogan Department of biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Department of Computer Science Faculty of ScienceWestern UniversityLondonON N6A 2C1Canada Department of Epidemiology&biostatistics Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Cytognomix Inc.LondonON N5X 3X5Canada Department of Oncology Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada

The selection of effective genes that accurately predict chemotherapy responses might improve cancer *** compare optimized gene signatures for cisplatin,carboplatin,and oxaliplatin responses in the same cell lines and validate each signature using data from patients with *** support vector machine learning is used to derive gene sets whose expression is related to the cell line GI 50 values by backwards feature selection with *** genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI 50 *** of gene signatures at different thresholds are combined to reduce the dependence on specific GI 50 values for predicting drug *** most accurate gene signatures for each platin are:cisplatin:bARD1,bCL2,bCL2L1,CDKN2C,FAAP24,FEN1,MAP3K1,MAPK13,MAPK3,NFKb1,NFKb2,SLC22A5,SLC31A2,TLR4,and TWIST1;carboplatin:AKT1,EIF3K,ERCC1,GNGT1,GSR,MTHFR,NEDD4L,NLRP1,NRAS,RAF1,SGK1,TIGD1,TP53,VEGFb,and VEGFC;and oxaliplatin:bRAF,FCGR2A,IGF1,MSH2,NAGK,NFE2L2,NQO1,PANK3,SLC47A1,SLCO1b1,and *** from The Cancer Genome Atlas(TCGA)patients with bladder,ovarian,and colorectal cancer were used to test the cisplatin,carboplatin,and oxaliplatin signatures,resulting in 71.0%,60.2%,and 54.5%accuracies in predicting disease recurrence and 59%,61%,and 72%accuracies in predicting remission,*** cisplatin signature predicted 100%of recurrence in non-smoking patients with bladder cancer(57%disease-free;N=19),and 79%recurrence in smokers(62%disease-free;N=35).This approach should be adaptable to other studies of chemotherapy responses,regardless of the drug or cancer types.

关键词： bladder chemotherapy signature

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Materials and extracellular matrix rigidity highlighted in tissue damages and diseases:Implication for biomaterials design and therapeutic targets

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bioactive Materials 2023年第2期20卷 381-403页

作者： Jae Hee Park Seung bin Jo Jung-Hwan Lee Hae-Hyoung Lee jonathan CKnowles Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science and bK21 NbM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Department of biomaterials Science College of DentistryDankook UniversityCheonan31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea Division of biomaterials and Tissue Engineering UCL Eastman Dental InstituteUniversity College LondonRoyal Free HospitalRowland Hill StreetLondonNW32PFUnited Kingdom

Rigidity(or stiffness)of materials and extracellular matrix has proven to be one of the most significant extracellular physicochemical cues that can control diverse cell behaviors,such as contractility,motility,and spreading,and the resultant pathophysiological *** 2D materials engineered with tunable rigidity have enabled researchers to elucidate the roles of matrix biophysical cues in diverse cellular events,including migration,lineage specification,and mechanical ***,the recent findings accumulated under 3D environments with viscoelastic and remodeling properties pointed to the importance of dynamically changing rigidity in cell fate control,tissue repair,and disease ***,here we aim to highlight the works related with material/matrix-rigidity-mediated cell and tissue behaviors,with a brief outlook into the studies on the effects of material/matrix rigidity on cell behaviors in 2D systems,further discussion of the events and considerations in tissue-mimicking 3D conditions,and then examination of the in vivo findings that concern material/matrix *** current discussion will help understand the material/matrix-rigidity-mediated biological phenomena and further leverage the concepts to find therapeutic targets and to design implantable materials for the treatment of damaged and diseased tissues.

关键词： Matrix rigidity biophysical cue Cell and tissue engineering 3D biomaterials conditions Therapeutic targets

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Adaptive immunity of materials: Implications for tissue healing and regeneration

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bioactive Materials 2024年第11期41卷 499-522页

作者： Jung-Hwan Lee Seong-Jin Shin Jun Hee Lee jonathan CKnowles Hae-Hyoung Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of biomaterials Science College of DentistryDankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and bK21 NbM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea UCL Eastman Dental Institute University College LondonLondon NW32PXUnited Kingdom

Recent cumulative findings signify the adaptive immunity of materials as a key agenda in tissue healing that can improve regenerative events and outcomes. Modulating immune responses, mainly the recruitment and functions of T and b cells and their further interplay with innate immune cells (e.g., dendritic cells, macrophages) can be orchestrated by materials. For instance, decellularized matrices have been shown to promote muscle healing by inducing T helper 2 (Th2) cell immunity, while synthetic biopolymers exhibit differential effects on b cell responses and fibrosis compared decellularized matrices. We discuss the recent findings on how implantable materials instruct the adaptive immune events and the subsequent tissue healing process. In particular, we dissect the materials’ physicochemical properties (shape, size, topology, degradation, rigidity, and matrix dynamic mechanics) to demonstrate the relations of these parameters with the adaptive immune responses in vitro and the underlying biological mechanisms. Furthermore, we present evidence of recent in vivo phenomena, including tissue healing, cancer progression, and fibrosis, wherein biomaterials potentially shape adaptive immune cell functions and in vivo outcomes. Our discussion will help understand the materials-regulated immunology events more deeply, and offer the design rationale of materials with tunable matrix properties for accelerated tissue repair and regeneration.

关键词： Adaptive immunity Materials interactions Tissue healing Physicochemical properties Immune cell interplay

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Rice Husk bio-Chars as Adsorbent for Methylene blue and Ethinylestradiol from Water

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Journal of Renewable Materials 2020年第3期8卷 275-287页

作者： jonathan Lacuesta Iris beatriz Vega Erramuspe Liji Sobhana Dennis Kronlund Jouko Peltonen Soledad Gutiérrez Pedro Fardim Department of Chemical Engineering University of the RepublicJulio Herrera y Reissig 565Montevideo11300Uruguay Laboratory of Fibre and Cellulose Technology Åbo Akademi UniversityPorthansgatan 3Turku/ÅboFI-20500Finland Laboratory of Physical Chemistry and Center of Excellence for Functional Materials Åbo Akademi UniversityPorthansgatan 3Turku/ÅboFI-20500Finland Department of Chemical Engineering KU LeuvenCelestijnenlaan 200FLeuvenB-3001Belgium

biobased adsorbents are eco-friendly materials used for water and wastewater treatment and air *** research work explores the potential use of rice husk chars as a low-cost adsorbent for pollutants from water,such as methylene blue and *** husk chars are prepared by combustion of rice husks(RH-Char)or pre-treated rice husks(PT-Char).A third char(M-Char)supplied by a local company which uses rice husks as combustion material is also *** chars are characterized by field emission scanning electron microscopy(FE-SEM)in conjunction with energy dispersive X-ray spectroscopy(EDX),X-ray powder diffraction(XRD),and zeta-potential *** three bio-chars are tested as adsorbent for the removal of two wastewater contaminants:methylene blue(Mb)and ethinylestradiol(EE2).According to the results,RH-Char and PT-Char present zeta-potential values near−52 mV,whereas M-Char shows a zeta-potential value of−32 *** RH-Char and PTChar are rich in amorphous SiO_(2) and M-Char has crystalline SiO_(2)(cristobalite).The bio-chars remove Mb and EE2 efficiently showing the following results for the adsorption capacity of Mb(inμmol g^(−1)):769.2(RH-Char),41.2(PT-Char),and 31.7(M-Char).The adsorption capacity values for EE2(inμmol g^(−1))are:33.1(RH-Char),19.1(PT-Char),and 16.9(M-Char).The information gathered in the present work evidences the potential of rice husks bio-chars for bio-remediation and may in future contribute to the conversion of a side-stream from the rice industry into value-added materials.

关键词： Rice husk bio-char thermal treatment adsorption methylene blue ethinylestradiol

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Phosphorus Fertilizer Effects on Near-Surface Soil Aggregation in Furrow-Irrigated Rice on a Silt-Loam Soil

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Agricultural Sciences 2023年第6期14卷 819-842页

作者： jonathan b. brye Diego Della Lunga Kristofor R. brye Chandler Arel Shane Ylagan Department of Crop Soil and Environmental Sciences University of Arkansas Fayetteville AR USA

Well-aggregated soil has been shown to improve soil infiltration and reduce runoff and soil erosion, making well-aggregated soil important for productive, sustainable agriculture. One factor that may influence near-surface soil aggregate stability is fertilizer application. Rapid dissolution of fertilizers, which are mostly salts, can potentially disperse clays and destabilize aggregates. The objective of this study was to evaluate the potential effect of various fertilizer-phosphorus (P) and -nitrogen (N) sources [i.e., triple superphosphate (TSP), monoammonium phosphate (MAP), chemically precipitated struvite (CPST), electrochemically precipitated struvite (ECST), environmentally smart nitrogen (ESN)] and soil depth on water-stable aggregates (WSA) in furrow-irrigated rice on a silt-loam soil (Typic Albaqualf). Total WSA (TWSA) concentration was unaffected (P > 0.05) by fertilizer treatment or soil depth, while WSA concentration was numerically largest (P ∙g-1), which did not differ from CPST, ECST, and ESN in the 0 - 5 cm depth or the unamended control in the 0 - 5 and 5 - 10 cm depths, and was at least 1.7 times larger than ESN in the 5 - 10 cm depth (0.03 g∙g-1). Results indicated that WSA concentration among non-struvite fertilizer-P sources was generally similar to that from the struvite fertilizer materials. Principal component analysis determined that 32% of the variation of TWSA was mainly explained by changes in soil bulk density, pH, and electrical conductivity. Long-term, continual annual application of fertilizer-P and N could negatively impact soil aggregate stability, soil structure, and potentially erosion.

关键词： Arkansas Rice Production Salt Index Soil Aggregate Stability Soil Structure Struvite

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Nonlinear silicon photonics on CMOS-compatible tellurium oxide

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Photonics Research 2020年第12期8卷 1904-1909页

作者： NEETESH SINGH HAMIDU M.MbONDE HENRY C.FRANKIS ERICH IPPEN jonathan D.b.bRADLEY FRANZ X.KÄRTNER Centre for Free Electron Laser Science(CFEL)-DESY and University of Hamburg 22607 HamburgGermany Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Engineering Physics McMaster UniversityHamiltonOntario L8S 4L7Canada

Silicon photonics is coming of age;however,it is still lacking a monolithic platform for optical sources and nonlinear functionalities prompting heterogeneous integration of different materials tailored to different *** we demonstrate tellurium oxide as a complementary metal oxide semiconductor silicon photonics platform for nonlinear functionalities,which is already becoming an established platform for sources and *** show broadband supercontinuum generation covering the entire telecom window and show for the first time to our knowledge third-harmonic generation in its integrated *** with the nowavailable lasers and amplifiers on integrated Te O_(2) this work paves the way for a monolithic TeO_(2)-based nonlinear silicon photonics platform.

关键词： oxide Together prompt

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Day Case Haemorrhoidectomy under Local Anaesthesia and Conscious Sedation

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International Journal of Clinical Medicine 2015年第6期6卷 392-398页

作者： jonathan C. b. Dakubo Antoinette A. bediako-bowan Josephine Nsaful Anastasia Ampofo Department of Surgery School of Medicine and Dentistry University of Ghana Accra Ghana Department of Obstetrics and Gynaecology Korle-Bu Teaching Hospital Accra Ghana

background: Excisional haemorrhoidectomy engenders considerable pain and has popularly been managed as an in-patient procedure. There has been anxiety over a major complication occurring in the community instead of in the hospital which is still pervasive in the developing world despite evidence to the contrary. Aim: It compared the post operative complications, time to bowel action, and post-operative pain scores in patients who had open haemorrhoidectomy either under spinal anaesthesia as in-patient or under local anaesthesia as day case procedure. Materials and Methods: The study involved two populations of patients who underwent open haemorrhoidectomy either under spinal anesthesia or under local anaesthesia with conscious sedation at the Korle bu Teaching Hospital between 2008 and 2013. Results: It involved 275 patients made up of 145 and 130 in the spinal and local aneasthesia groups respectively. Their mean age was 43.1, SD ± 13.2 and median 41 years. Complications occurred in 44 patients (16%), 24 and 20 in the spinal and local aneasthesia groups respectively, with bleeding being the most frequent [11/44, (25%)] and significant. More wound bleeding occurred in the spinal than the local anaesthesia group, 7 vs. 2 patients. Except one day only (p = 0.0001) the mean pain scores on days 2, 3, 5 and 7 were statistically significantly lower in the spinal group than in the local group. The median time to bowel motion was 4 days in both groups. Conclusion: The post operative outcomes in the two populations were similar except the more frequent bleeding noted in the spinal anaesthesia group. Day case haemorrhoidectomy is safe in centres where day case surgery is routinely performed.

关键词： Post-Operative Pain Piles Anaesthesia Technique Milligan-Morgan Haemorrhoidectomy Ambulatory Surgery

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Survival Rates Following Skeletal Metastases—A Twenty-Year Analysis

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Open Journal of Orthopedics 2015年第9期5卷 288-296页

作者： Mohannad b. Ammori Sunil Panchani jonathan J. Gregory James Wylie Ashok Paul Department of Orthopaedic Surgery Royal Gwent Hospital Newport UK Department of Orthopaedic Surgery Manchester Royal Infirmary Manchester UK The Christie Hospital Manchester UK

Introduction: The aims of this study were to establish an estimate of the prognosis and to identify the variables predictive of survival following the diagnosis of metastatic bone disease. Materials and Methods: Ninety-seven patients diagnosed with skeletal metastases confirmed by histological examination between 1991 and 2010 were selected. Data were retrospectively collected including age and sex, sites and histology of the primary tumour and skeletal metastases, presence of visceral metastases, pathological fracture, and the treatment received. Results: Ninety-three patients (95.9%) were deceased. The overall rate of survival was 47% at 6 months, 31% at one year and 10% at three years. Multivariate analysis confirmed the grade of malignancy, age and systemic therapy as independent predictors of survival. Discussion and Conclusion: The prognosis of patients with skeletal metastases should be estimated according to the site and histology of the primary tumour, grade of malignancy and age at the time of presentation.

关键词： Oncology Skeletal Metastases Survival

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A SUMMARY OF RESEARCH ADVANCES ON TROPICAL CYCLONE INTENSITY CHANGE FROM 2014-2018

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Tropical Cyclone Research and Review 2019年第4期8卷 219-225页

作者： Eric A.Hendricks Scott A.braun jonathan L.Vigh Joseph b.Courtney National Center for Atmospheric Research NASA Goddard Space Flight Center bureau of Meteorology

This contribution summarizes key research advances on tropical cyclone(TC) intensity change from 2014-2018 from the Ninth International Workshop on Tropical Cyclones(IWTC-9). Research advances on intensity change have occurred on many fronts, including improved understanding of the role of vertical wind shear(VWS) and its impact on convection, surface fluxes, ocean eddies, dry/dusty air intrusions, eyewall replacement cycles(ERCs), spiral rainband dynamics, eyewall instability and inner-core mixing, and the mechanisms by which TCs intensify. This summary highlights a number of these important advances. Additionally, some new and emerging topics on TC intensity change have recently been elucidated: the important role of vortex structure on the subsequent intensification rate, the maximum potential intensification rate(MPIR), and the role of upper level outflow on TC intensity change.

关键词： tropical cyclone intensity change external influences internal influences

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