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Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress

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Cellular & Molecular Immunology 2024年第1期21卷 91-94页

作者： Shengduo Pei jonas Sjölund Yueyun Pan Kristian Pietras Mikael C.I.Karlsson Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholmSweden Division of Translational Cancer Research Department of Laboratory MedicineLund University Cancer CentreLund UniversityLundSweden

Invariant natural killer T(iNKT)cells are part of the family of unconventional T cells,and they recognize glycolipid antigens presented on the MhC class I like molecule CD1^([1]).In humans there are five CD1 molecules named CD1a to CD1e,whereas mice use only CD1d for lipid ***,iNKT cells can elicit both cytotoxicity similarly to conventional CD8 T cells and secrete cytokines that influence the adaptive immune response including providing direct T cell help to B cells^([2]).In the context of tumors,they can use both release of granzyme B and use Fas-mediated mechanisms for killing of tumor *** iNKT cells use a restricted TCR repertoire and CD1 molecules are non-heterogenous the risk of graft vs host disease is limited and thus these T cells have been an attractive option for off the shelf immunotherapy to treat cancer^([3]).

关键词： killer CD1d Cancer

Identity(ies)and Transnationalization of Brazilian Evangelical Churches in Portugal:Case study of World Cathedral of hope and Victory in Christ Churches

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Cultural and Religious Studies 2024年第3期12卷 133-145页

作者： jonas Pereira de Oliveira Júnior University of Porto PortoPortugal

The presence of evangelicals in Brazil is a social and religious phenomenon that has aroused interest of many scholars due to its rapid and significant expansion in recent decades and its projection beyond national *** evangelical denominations that stand out in this scenario are Pentecostal churches,which have developed intense missionary activity in several countries,including *** this article,we intend to analyze features and challenges of Brazilian evangelical churches:World Cathedral of hope(CIME)(Catedral Mundial da Esperança-ICME)and Assembly of God Victory in Christ(ADVEC)(Assembleia de Deus Vitória em Cristo-ADVEC)that operate in Portugal,seeking to understand issues of identity and belonging of these communities,their models of transnationalization,its evangelization strategies and its adaptations to Portuguese context,in the period from 2000 to 2020.

关键词： identity transnationalization secularization Brazilian migration

从几内亚的角度看电子商务发展对企业增长的影响

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从几内亚的角度看电子商务发展对企业增长的影响

作者： GNEKQYA jonas 江西财经大学

学位级别：硕士

how aromatic dissolved organic matter differs in competitiveness against organic micropollutant adsorption

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Environmental Science and Ecotechnology 2024年第5期21卷 92-102页

作者： Qi Wang Oliver JLechtenfeld Luuk CRietveld jonas Schuster Mathias Ernst Roberta hofman-Caris Jan Kaesler Chunmiao Wang Min Yang Jianwei Yu Frederik Zietzschmann Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of Sciences100085BeijingChina Delft University of Technology Department of Water ManagementPO Box 50482600GADelftthe Netherlands Department of Analytical Chemistry Research Group BioGeoOmicsHelmholtz Centre for Environmental ResearchUFZPermoserstr.1504318LeipzigGermany Berliner Wasserbetriebe LaboratoryMotardstr.3513629BerlinGermany Institute for Water Resources and Water Supply Hamburg University of TechnologyAm Schwarzenberg-Campus 321073HamburgGermany KWR Watercycle Research Institute 3433PENieuwegeinthe Netherlands ProVISCentre for Chemical Microscopy Helmholtz Centre for Environmental ResearchUFZPermoserstr.1504318LeipzigGermany Wageningen University and Research Department of Environmental TechnologyBornse Weilanden 96708 WGWageningenthe Netherlands University of Chinese Academy of Sciences 100049BeijingChina

Activated carbon is employed for the adsorption of organic micropollutants(OMPs)from water,typically present in concentrations ranging from ng L1 to mg L***,the efficacy of OMP removal is considerably deteriorated due to competitive adsorption from background dissolved organic matter(DOM),present at substantially higher concentrations in mg L*** the characteristics of competitive DOM is crucial in predicting OMP adsorption efficiencies across diverse natural *** weight(MW),aromaticity,and polarity influence DOM *** the aromaticity-related metrics,such as UV254,of low MW DOM were proposed to correlate with DOM competitiveness,the method suffers from limitations in understanding the interplay of polarity and aromaticity in determining DOM ***,we elucidate the intricate influence of aromaticity and polarity in low MW DOM competition,spanning from a fraction level to a compound level,by employing direct sample injection liquid chromatography coupled with ultrahigh-resolution Fouriertransform ion cyclotron resonance mass *** exchange resin pre-treatment eliminated 93%of UV254-active DOM,predominantly aromatic and polar DOM,and only minimally alleviated DOM *** characterization revealed that nonpolar molecular formulas(constituting 26%PAC-adsorbable DOM)with medium aromaticity contributed more to the DOM *** analysis indicated that the competitiveness of highly aromatic LMW DOM compounds was strongly counterbalanced by increased *** aromaticity-derived p-p interaction cannot facilitate the competitive adsorption of hydrophilic DOM *** results underscore the constraints of depending solely on aromaticity-based approaches as the exclusive interpretive measure for DOM *** a broader context,this study demonstrates an effect-oriented DOM analysis,elucidating counterbalancing interactions of DOM molecular properties

关键词： Activated carbon Organic micropollutants Dissolved organic matter(DOM) Multi-component adsorption Fourier-transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)

Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management

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Asian Journal of Urology 2024年第1期11卷 42-47页

作者： Randi M.Pose Sophie Knipper jonas Ekrutt Mara Kölker Pierre Tennstedt hans heinzer Derya Tilki Florian Langer Markus Graefen Martini-Klinik Prostate Cancer Centre University Hospital Hamburg-EppendorfGermany Department of Urology University Hospital Hamburg-EppendorfGermany Department of hematology and Oncology University Medical Centre Hamburg-EppendorfHamburgGermany

Objective:To examine the perioperative impact of factor V Leiden mutation on thromboembolic events'risk in radical prostatectomy(RP)*** an incidence of about 5%,factor V Leiden mutation is the most common hereditary hypercoagulability among Caucasians and rarer in *** increased risk of thromboembolic events is three-to seven-fold in heterozygous and to 80-fold in homozygous ***:Within our prospectively collected database,we analysed 33006 prostate cancer patients treated with RP between December 2001 and December *** those,patients with factor V Leiden mutation were *** patients received individualised recommendation of haemostaseologists for perioperative *** complications(deep vein thrombosis and pulmonary embolism)were assessed during hospital stay,as well as according to patient reported outcomes within the first 3 months after ***:Overall,85(0.3%)patients with known factor V Leiden mutation were *** age was 65(interquartile range:61-68)*** was at least one thrombosis in 53(62.4%)patients and 31(36.5%)patients had at least one embolic event in their medical history before *** all 85 patients with factor V Leiden mutation,we experienced no thromboembolic complications within the first 3 months after ***:In our cohort of patients with factor V Leiden mutation,no thromboembolic events were observed after RP with an individualised perioperative coagulation management *** may reassure patients with this hereditary condition who are counselled for RP.

关键词： Prostatecancer Prostatectomy Factor V Leiden mutation Thromboembolism Thrombophilia

护理人员对医院护理科研学术氛围感知的质性研究

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International Journal of Nursing Sciences 2024年第2期11卷 233-240页

作者： Ejercito Mangawa Balay-odao jonas Preposi Cruz Joseph UAlmazan Department of Medicine School of MedicineNazarbayev UniversityAstanaKazakhstan

目的医疗机构面临的挑战是建立一种促进护理科研发展的组织文化。护理科研的建设一直被认为是护理学科进步的重要组成部分。因此,本研究描述了护士对所在医院护理科研学术氛围的看法。方法采用半结构式个人访谈法收集资料。于2022年12月... 详细信息

目的医疗机构面临的挑战是建立一种促进护理科研发展的组织文化。护理科研的建设一直被认为是护理学科进步的重要组成部分。因此,本研究描述了护士对所在医院护理科研学术氛围的看法。方法采用半结构式个人访谈法收集资料。于2022年12月至2023年4月,在菲律宾东部1所医院选取17名护士参与研究。采用Braun和Clarke主题分析法对数据进行分析。结果共提炼出3个主题及7个副主题:影响护士的行为和绩效(帮助获取研究信息和学习、灵活性和适应性、护士之间的合作与沟通),影响护士的研究参与(领导策略、培训与专业发展),以及影响医院对变化的适应(组织绩效与成功、护士参与和工作满意度)。结论积极的护理研究文化对塑造护士的行为和绩效、参与护理研究以及医院对变化的适应具有至关重要的作用,因此对医院护理研究文化的益处提供了支持。总之,提炼出的主题有助于护理管理者更深入地了解护理研究文化对医疗保健系统各层面的影响。

关键词：文化医院护理人员菲律宾定性研究研究

high-rate metal-free MXene microsupercapacitors on paper substrates

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Carbon Energy 2024年第5期6卷 94-104页

作者： han Xue Po‐han huang Lee‐Lun Lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun jonas Weissenrieder Kristinn BGylfason Frank Niklaus Jiantong Li School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden School of Engineering Sciences KTH Royal Institute of TechnologyStockholmSweden

MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on ***,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser *** a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper ***,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive *** heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.

关键词： direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability

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不朽与现代性

世界哲学 2024年第2期 113-126页

作者： [美]h.约纳斯方秋明(译) 林伟毅(译) 不详苏州科技大学政治系福建师范大学马克思主义学院

文章批判了自古以来的两种不朽观,分别为经验性的不朽,包括英名不朽和影响不朽;非经验性的不朽,包括灵魂不朽和实体不朽。这些都被现代性否定了,契合现代性的不朽观是行动不朽,它是自我超越领域的不朽,是指我们存在的某种东西可能通达... 详细信息

文章批判了自古以来的两种不朽观,分别为经验性的不朽,包括英名不朽和影响不朽;非经验性的不朽,包括灵魂不朽和实体不朽。这些都被现代性否定了,契合现代性的不朽观是行动不朽,它是自我超越领域的不朽,是指我们存在的某种东西可能通达了不死性,也就是说我们的世俗行为对超越领域发生影响而产生的不朽。受犹太教中的生命册和诺斯替宗教中上帝的终极形象的启发,文章在这两种象征方式的基础上提出了非全能的上帝形象这个“试验性神话”,认为人类的行为会建构或伤害上帝的形象,只有通过向善的责任行为,维护受到威胁的人类存在,完善上帝的不朽形象,才能获得自身的不朽。

关键词：英名不朽影响不朽灵魂不朽实体不朽行动不朽

Software and Mobile Apps as a Strategy for Productivity Improvement in the Construction Industry

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Journal of Building Construction and Planning Research 2024年第1期12卷 1-35页

作者： Stanley Owuotey Bonney jonas Ekow Yankah Kofi Owusu Adjei Chris Kurbom Tieru Department of Built Environment University of Environment and Sustainable Development Somanya Ghana Department of Construction Technology and Management Cape Coast Technical University Cape Coast Ghana Department of Building Technology Kumasi Technical University Kumasi Ghana

The construction industry, known for its low productivity, is increasingly utilising software and mobile apps to enhance efficiency. however, more comprehensive research is needed to understand the effectiveness of these technology applications. The PRISMA principles utilised a scoping review methodology to ascertain pertinent studies and extract significant findings. From 2013 onwards, articles containing data on mobile applications or software designed to enhance productivity in the construction sector were obtained from multiple databases, including Emerald Insight, Science Direct, IEEE Xplore, and Google Scholar. After evaluating 2604 articles, 30 were determined to be pertinent to the study and were subsequently analysed for the review. The review identified five key themes: effectiveness, benefits, successful implementation examples, obstacles and limitations, and a comprehensive list of software and mobile apps. In addition, 71 software and mobile apps have shown potentially how these technologies can improve communication, collaboration, project management, real-time collaboration, document management, and on-the-go project information and estimating processes in the construction industry, increasing efficiency and productivity. The findings highlight the potential of these technologies such as Automation, Radio-Frequency Identification (RFID), Building Information Modeling (BIM), Augmented Reality (AR), Virtual Reality (VR), and Internet of Things (IoT) to improve efficiency and communication in the construction industry. Despite challenges such as cost, lack of awareness, resistance to change, compatibility concerns, human resources, technological and security concerns and licensing issues, the study identifies specific mobile applications and software with the potential to enhance efficiency significantly, improve productivity and streamline workflows. The broader societal impacts of construction software and mobile app development include increased effic

关键词： Software Mobile apps Productivity Technologies Construction Industry