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Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score

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Asian Journal of Andrology 2014年第6期16卷 897-901页

作者： Xin-Hai Hu Henning Cammann Hellmuth-A Meyer Klaus Jung Hong-Biao Lu Natalia Levas Ahmed Magheli Carsten Stephan jonas busch Department of Urology Charite - Universitatsmedizin Berlin Berlin Germany Institute of Medical Informatics Charite - Universitatsmedizin Berlin Berlin Germany Berlin Institute for Urologic Research Berlin Germany Department of Urology Changzhou No. 2 People's Hospital Changzhou China Stanford University School of Medicine Stanford CA USA.

Many computer models for predicting the risk of prostate cancer have been developed including for prediction of biochemical recurrence （BCR）. However, models for individual BCR free probability at individual time-points after a BCR free period are rare. Follow-up data from 1656 patients who underwent laparoscopic radical prostatectomy （LRP） were used to develop an artificial neural network （ANN） to predict BCR and to compare it with a logistic regression （LR） model using clinical and pathologic parameters, prostate-specific antigen （PSA）, margin status （RO/1）, pathological stage （pT）, and Gleason Score （GS）. For individual BCR prediction at any given time after operation, additional ANN, and LR models were calculated every 6 months for up to 7.5 years of follow-up. The areas under the receiver operating characteristic （ROC） curve （AUC） for the ANN （0.754） and LR models （0.755） calculated immediately following LRP, were larger than that for GS （AUC： 0.715; P= 0.0015 and 0.001）, pT or PSA （AUC： 0.619; Palways 〈0.0001） alone. The GS predicted the BCR better than PSA （P = 0.0001）, but there was no difference between the ANN and LR models （P = 0.39）. Our ANN and LR models predicted individual BCR risk from radical prostatectomy for up to 10 years postoperative. ANN and LR models equally and significantly improved the prediction of BCR compared with PSA and GS alone. When the GS and ANN output values are combined, a more accurate BCR prediction is possible, especially in high-risk patients with GS ≥7.

关键词： artificial neural network prostate cancer recurrence

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Sports activity patterns and cardio-metabolic health over time among adults in Germany: Results of a nationwide 12-year follow-up study

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Journal of Sport and Health Science 2021年第4期10卷 439-446页

作者： Lars Gabrys Jens Baumert Christin Heidemann Markus busch jonas David Finger University of Applied Sciences of Sport and Management 14471 PotsdamGermany Robert Koch Institute Department of Epidemiology and Health Monitoring12101 BerlinGermany

Background:Physical activity is favorable for health,and vigorous sports activity is particularly *** study investigates the association between changes in sports participation patterns over time and cardio-metabolic and self-perceived health ***:Data from 3752 adults(18-79 years of age)who participated in 2 national health interview and examination surveys in 1997-1999 and 2008-2011 were included,with a mean follow-up time of about 12 years.A change in self-reported sports activity was analyzed with respect to the incidence of type 2 diabetes,coronary heart disease(CHD),hypertension,obesity,dyslipidemia,metabolic syndrome,and poor self-perceived *** with pre-existing disease or risk factor of interest at baseline were excluded from the *** sufficiently active in sports was specified as doing sports for at least 1-2 h per week,and 4 activity categories were defined:1)inactive at both time points(inactive-inactive),2)inactive at baseline and active at follow-up(inactive-active),3)active at baseline and inactive at follow-up(active-inactive),and 4)active at both time points(active-active).Associations between sports activity engagement and health outcomes were estimated by logistic regression models with different stages of ***:Not engaging in any regular sports activity at both time points(inactive-inactive)was associated with higher rates of type 2 diabetes(odds ratio(OR)=1.82,95%confidence interval(95%CI):1.08-3.08),CHD(OR=1.82,95%CI:1.16-2.84),hypertension(OR=1.36,95%CI:1.03-1.81),metabolic syndrome(OR=1.58,95%CI:1.08-2.32),and poor self-perceived health(OR=2.54,95%CI:1.83-3.53)compared to doing regular sports for a minimum of 1-2 h per week over time(active-active).In case of change from inactivity to any regular sports activity(inactive-active),the rate of risk factor occurrence was not statistically different from the active-active reference group except for poor self-perceived health,but it wa

关键词： Cohort Epidemiology Non-communicable disease Physical activity Public health

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The interaction between a shaped charge jet and a single moving plate

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Defence Technology（防务技术） 2024年第1期31卷 1-13页

作者： Andreas Helte jonas Lundgren jonas Candle FOI WeaponsProtection and SecuritySE-16490StockholmSweden

Reactive armour is a very efficient add-on armour against shaped charge *** reactive armour consists of one or several plates that are accelerated by an *** but less violent acceleration of plates can also be achieved in a completely inert reactive *** be efficient against elongated jets,the motion of the plates needs to be inclined against the jet such that a sliding contact between the jet and the plates is *** sliding contact causes a deflection and thinning of the *** certain circumstances,the contact will become unstable,leading to severe disturbances on the *** disturbances will drastically reduce the jet penetration performance and it is therefore of interest to study the conditions that leads to an unstable *** studies on the interaction between shaped charge jets and flyer plates have shown that it is mainly the forward moving plate in an explosive reactive armour that is effective in disturbing the *** is usually attributed to the higher plate-to-jet mass flux ratio involved in the collision of the forward moving plate compared to the backward moving *** slow moving plates,as occurs in inert reactive armour,the difference in mass flux for the forward and backward moving plate is much lesser,and it is therefore of interest to study if other factors than the mass flux influences on the protection *** this work,experiments have been performed where a plate is accelerated along its length,interacting with a shaped charge jet that is fired at an oblique angle to the plate’s normal,either against or along the plate’s *** arrangement corresponds to a jet interacting with a flyer plate from a reactive armour,with the exception that the collision velocity is the same for both types of obliquities in these *** experiments show that disturbances on the jet are different in the two cases even though the collision velocities are the *** simulatio

关键词： Reactive armour Flyer plate Shaped charge jet

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Simple and robust 3D MINFLUX excitation with a variable phase plate

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Light(Science & Applications) 2024年第7期13卷 1354-1363页

作者： Takahiro Deguchi jonas Ries European Molecular Biology Laboratory Cell Biology and BiophysicsHeidelbergGermany. Max Perutz Labs Vienna Biocenter Campus(VBC)ViennaAustria. University of Vienna Center for Molecular BiologyDepartment of Structural and Computational BiologyViennaAustria. University of Vienna Faculty of PhysicsViennaAustria

MINFLUX has achieved extraordinary resolution in superresolution imaging and single fluorophore *** is based on localizing single fluorophores by rapid probing with a patterned beam that features a local intensity *** implementations,however,are complex and expensive and are limited in speed and ***,we show that a combination of an electro-optical modulator with a segmented birefringent element such as a spatial light modulator produces a variable phase plate for which the phase can be scanned on the MHz *** or top-hat phase patterns generate high-contrast compact excitation point-spread functions for MINFLUX localization in the x,y,and z-direction,respectively,which can be scanned across a fluorophore within a microsecond,switched within 60 microseconds and alternated among different excitation *** discuss how to compensate for non-optimal performance of the components and present a robust 3D and multi-color MINFLUX excitation module,which we envision as an integral component of a high-performance and cost-effective open-source MINFLUX.

关键词： excitation phase switched

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Efficient transport pricing-why,what,and when?

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Communications in Transportation Research 2021年第1期1卷 31-38页

作者： jonas Eliasson Linköping University Swedish National Transport AdministrationSweden

Striking a balance between societal benefits and costs of transportation lies at the heart of transport planning and transport systems *** transport and urbanization enable the many benefits of modern socieities through specialization of labour,production and lifestyles-but these trends simultaneously increase the drawbacks of transportation,such as carbon emissions,congestion,noise and air quality *** developments and improved infrastrastructure can help reduce these drawbacks,but they do not solve the fundamental problem that those reaping the benefits of transport-travellers,firms,customers-do not perceive the full social costs of *** balance transport costs and benefits,efficient pricing is *** a wealth of theoretical arguments,technical developments and substantial practical experience,efficient transport pricing is still *** on the example of urban congestion pricing,this paper summarizes why transport pricing is needed,lessons learnt from practical experience,and what the main obstacles *** two most important obstacles seem to be political power struggles between different levels of governments,and that even if total social gains vastly exceed total social losses,the losses tend to be more salient;losers tend to be easy to identify,while winners tend to be more dispersed and perhaps only exist in the future.

关键词： Congestion charges Road pricing Congestion pricing Intelligent transportation systems

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Fast MATLAB assembly of FEM matrices in 2D and 3D using cell-array approach

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 167-186页

作者： jonas Koko Clermont Universit´e Universit´e Blaise Pascal LIMOSBP 10448F-63000 Clermont-FerrandFrance CNRSUMR 6158LIMOSF-63173 AubiereFrance

We propose a MATLAB implementation of the P1 finite element method for the numerical solutions of the Poisson problem and the linear elasticity problem in two-dimensional(2D)and three-dimensional(3D).The code consists of vectorized(and short)assembling functions for the matrices(mass and stiffness)and the right-hand *** for the P1 finite element,the element mass matrix and right-hand side are simple,the implementation uses only the MATLAB function sparse on the elements *** the stiffness matrix,to obtain a MATLAB implementation close to the standard form,cell-arrays are used to store the gradients of the element basis *** assembling procedure can then use matrix/vector products on small size *** experiments show that our implementation is fast,scalable with respect to time,and outperforms existing vectorized MATLAB FEM codes.

关键词： MATLAB code vectorization finite element stiffness matrix mass matrix

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A Low Mach Number IMEX Flux Splitting for the Level Set Ghost Fluid Method

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Communications on Applied Mathematics and Computation 2023年第2期5卷 722-750页

作者： jonas Zeifang Andrea Beck Faculty of Sciences Hasselt UniversityAgoralaan Gebouw DBE-3590 DiepenbeekBelgium Institute of Aerodynamics and Gas Dynamics University of StuttgartPfaffenwaldring 2170569 StuttgartGermany Laboratory of Fluid Dynamics and Technical Flows Otto von Guericke University MagdeburgUniversitatsplatz 239106 MagdeburgGermany

Considering droplet phenomena at low Mach numbers,large differences in the magnitude of the occurring characteristic waves are *** acoustic phenomena often play a minor role in such applications,classical explicit schemes which resolve these waves suffer from a very restrictive timestep *** this work,a novel scheme based on a specific level set ghost fluid method and an implicit-explicit(IMEX)flux splitting is proposed to overcome this timestep restriction.A fully implicit narrow band around the sharp phase interface is combined with a splitting of the convective and acoustic phenomena away from the *** this part of the domain,the IMEX Runge-Kutta time discretization and the high order discontinuous Galerkin spectral element method are applied to achieve high accuracies in the bulk *** is shown that for low Mach numbers a significant gain in computational time can be achieved compared to a fully explicit ***-tions to typical droplet dynamic phenomena validate the proposed method and illustrate its capabilities.

关键词： IMEX flux splitting Level set method Ghost fluid method Low Mach number flows

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Induced pluripotent stem cells(iPSCs):molecular mechanisms of induction and applications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2065-2090页

作者： jonas Cerneckis Hongxia Cai Yanhong Shi Department of Neurodegenerative Diseases Beckman Research Institute of City of HopeDuarteCA 91010USA Irell&Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA

The induced pluripotent stem cell(iPSC)technology has transformed in vitro research and holds great promise to advance regenerative *** have the capacity for an almost unlimited expansion,are amenable to genetic engineering,and can be differentiated into most somatic cell *** have been widely applied to model human development and diseases,perform drug screening,and develop cell *** this review,we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic *** begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and led to successful generation of *** consider the molecular mechanisms and dynamics of somatic cell reprogramming as well as the numerous methods available to induce ***,we discuss various iPSC-based cellular models,from mono-cultures of a single cell type to complex three-dimensional organoids,and how these models can be applied to elucidate the mechanisms of human development and *** use examples of neurological disorders,coronavirus disease 2019(COVID-19),and cancer to highlight the diversity of disease-specific phenotypes that can be modeled using iPSC-derived *** also consider how iPSC-derived cellular models can be used in high-throughput drug screening and drug toxicity ***,we discuss the process of developing autologous and allogeneic iPSC-based cell therapies and their potential to alleviate human diseases.

关键词： mechanisms programming holds

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Advances in myopia research anatomical findings in highly myopic eyes

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Eye and Vision 2020年第1期7卷 434-443页

作者： Jost B.jonas Ya Xing Wang Li Dong Yin Guo Songhomitra Panda-jonas Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karis-UniversityUniversitäts-AugenklinikTheodor-Kutzer-Ufer 1-368167 MannheimGermany Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Institute of OphthalmologyBeijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical UniversityBeijingChina Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina

Background:The goal of this review is to summarize structural and anatomical changes associated with high *** text:Axial elongation in myopic eyes is associated with retinal thinning and a reduced density of retinal pigment epithelium(RPE)cells in the equatorial *** of the retina and choriocapillaris and RPE cell density in the macula are independent of axial *** and scleral thickness decrease with longer axial length in the posterior hemisphere of the eye,most marked at the posterior *** any eye region,thickness of Bruch’s membrane(BM)is independent of axial *** opening,as the inner layer of the optic nerve head layers,is shifted in temporal direction in moderately elongated eyes(axial length26.5 mm),BM opening enlarges with longer axial *** leads to a circular gamma *** a parallel manner,the peripapillary scleral flange and the lamina cribrosa get longer and thinner with longer axial length in highly myopic *** elongated peripapillary scleral flange forms the equivalent of parapapillary delta zone,and the elongated lamina cribrosa is the equivalent of the myopic secondary *** prevalence of BM defects in the macular region increases with longer axial length in highly myopic *** staphylomas are characterized by marked scleral thinning and spatially correlated BM defects,while thickness and density of the choriocapillaris,RPE and BM do not differ markedly between staphylomatous versus non-staphylomatous eyes in the respective ***:High axial myopia is associated with a thinning of the sclera and choroid posteriorly and thinnin

关键词： High myopia Myopia Bruch’s membrane Optic nerve head Optic disc Parapapillary gamma zone Parapapillary delta zone Lamina cribrosa Anatomical changes

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ΔN-Bcl-xL, a therapeutic target for neuroprotection

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Neural Regeneration Research 2017年第11期12卷 1791-1794页

作者： Han-A Park Elizabeth A.jonas Department of Human Nutrition and Hospitality Management College of Human Environmental ScienceThe University of Alabama Department of Internal Medicine Section of EndocrinologyYale University

The B-cell lymphoma-extra large （Bcl-xL） is a mitochondrial anti-apoptotic protein that plays a role in neuroprotection. However, during excitotoxic stimulation, Bcl-xL undergoes caspase-dependent cleavage and produces a fragmented form, △N-Bcl-xL. Accumulation of △N-Bcl-xL is associated with mitochon- drial dysfunction and neuronal death. Therefore, strategies to inhibit the activity or formation of △N-Bcl- xL protect the brain against excitotoxic injuries. Our team found that the pharmacological inhibitor △BT- 737 exerts dose dependent effects in primary neurons. When primary hippocampal neurons were treated with 1 μM ABT-737, glutamate-mediated mitochondrial damage and neuronal death were exacerbated, whereas 10 nM △BT-737, a 100-fold lower concentration, protected mitochondrial function and enhanced neuronal viability against glutamate toxicity. In addition, we suggested acute vs. prolonged formation of △N-Bcl-xL may have different effects on mitochondrial or neuronal functions. Unlike acute production of △N-Bcl-xL by glutamate, overexpression of △N-Bcl-xL did not cause drastic changes in neuronal viability. We predicted that neurons undergo adaptation and may activate altered metabolism to compensate for △N-Bcl-xL-mediated mitochondrial dysfunction. Although the detailed mechanism of ABT-mediated neurotoxicity neuroprotection is still unclear, our study shows that the mitochondrial membrane protein △N-Bcl-xL is a central target for interventions.

关键词： B-cell lymphoma-extra large △N-Bcl-xL mitochondria ABT-737

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