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Uncoupling Oligodendrocyte Differentiation and Myelination: Dynamic Neuronal Signaling Not required

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Uncoupling Oligodendrocyte Differentiation and Myelination: ...

Screen-printed graphite electrode on polyvinyl chloride and parchment strips integrated with genetic programming for in situ nitrate sensing of aquaponic pond water

中国神经科学学会第十二届全国学术会议

作者： Sonia r.Mayoral Ainhoa Etxeberria Chin J.Shin Chew S.Yian jonah r.chan Department of Neurology University of California School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine Nanyang Technological University

Myelination in the CNS is thought to occur via two distinct, but coupled processes. First, highly proliferative and migratory oligodendrocyte precursor cells（OPCs） differentiate into mature oligodendrocytes（OLs）. Second, OL processes concentrically wrap around selected axons forming myelin. These processes occur in a spatially and temporally stereotyped manner throughout development, which implies that environmental cues are at play in the regulation of OL differentiation and myelination. It is thought that dynamic neuronal signaling involving transcriptional control and neuronal activity plays a major role in regulating these processes, but it is unclear whether this is the case in the early development of white matter tracts, such as the optic nerve, where there is synchronous and robust differentiation and myelination within a short timeframe. By eliminating dynamic neuronal signaling in the optic nerve our findings indicate that（1） OL differentiation and myelination are indeed coupled processes where myelination will occur upon differentiation if provided with a permissive substrate, and（2） dynamic neuronal signaling is not required for the majority of OL differentiation during early white matter development. We propose a model in which OL differentiation is largely regulated by extrinsic, non-neuronal factors during development, but myelination is sensitive to the biophysical properties of axonal diameter.

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Information Processing in Agriculture 2024年第2期11卷 187-201页

作者： ronnie ConcepcionⅡ Bernardo Duarte Maria Gemel Palconit jonah Jahara BaunArgel Bandala ryan rhay Vicerra Elmer Dadios Department of Manufacturing Engineering and Management De La Salle UniversityManila 1004 Philippines MArE-Marine and Environmental Sciences Centre.&ArNET-Aquatic research Infrastructure Network Associated Laboratory Faculdade de Ciencias da Universidade de LisboaCampo Grande1749-016 LisboaPortugal Departamento de Biologia Vegetal da Faculdade de Ciencias da Universidade de Lisboa Campo Grande 1749-016 LisboaPortugal Department of Electronics and Computer Engineering De La Salle UniversityManila 1004 Philppines

Nitrate is the primary water-soluble macronutrient essential for plant growth that is converted from excess fish feeds,fish effluents,and degrading biomaterials on the aquaponic pond floor,and when aquacultural malpractices occur,large amounts of it retain in the water system causing increase rate in eutrophication and toxifies fish and aquaculture *** nitrate sensor prototypes still require performing the additional steps of water sample deionization and dilution and were constructed with expensive *** response to the challenge of sensor enhancement and aquaponic water quality monitoring,this study developed sensitive,repeatable,and reproducible screen-printed graphite electrodes on polyvinyl chloride and parchment paper substrates with silver as electrode material and 60:40 graphite powder:nail polish formulated conductive ink for electrical traces,integrated with 9-gene genetic expression model as a function of peak anodic current and electrochemical test time for nitrate concentration prediction that is embedded into low-power Arduino ESP32 for in situ nitrate sensing in aquaponic pond *** SPE electrical traces were designed on the two types of *** electron microscopy with energy dispersive X-ray confirmed the electrode surface *** cyclic voltammetry using 10 to 100 mg/L KNO3 and water from three-depth regions of the actual pond established the electrochemical test time(10.5 s)and electrode potential(0.135 V)protocol necessary to produce peak current that corresponds to the strength of nitrate ions during *** findings from in situ testing revealed that the proposed sensors have strong linear predictions(r2=0.968 MSE=1.659 for nSPEv and r2=0.966 MSE=4.697 for nSPEp)in the range of 10 to 100 mg/L and best detection limit of 3.15μg/L,which are comparable to other sensors of more complex *** developed three-electrode electrochemical nitrate sensor confirms that it is reliable for bot

关键词： Aquaponic water quality Electrochemical technology Genetic programming Graphite electrode Nitrate sensor Precision agriculture Printed electronics Scanning electron microscopy Screen-printed electrode Voltammetry

Correlation of rainfall Anomalies in rwanda from September to December (SOND) with Indian Ocean Dipole (IOD) and El Nino Southern Oscillation (ENSO) Events

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Journal of Geoscience and Environment Protection 2024年第6期12卷 115-134页

作者： Frank rusanganwa Ling Zhang jonah Kazora Joseph Ndakize Sebaziga Samuel Ekwacu College of Atmospheric Science Nanjing University of Information Science and Technology Nanjing China rwanda Meteorology Agency (Meteo-rwanda) Kigali Rwanda School of Science and Technology University of Rwanda Kigali Rwanda Uganda National Meteorological Authority (UNMA) Kampala Uganda

Understanding the relationship between rainfall anomalies and large-scale systems is critical for driving adaptation and mitigation strategies in socioeconomic sectors. This study therefore aims primarily to investigate the correlation between rainfall anomalies in rwanda during the months of September to December (SOND) with the occurrences of Indian Ocean Dipole (IOD) and El Nino Southern Oscillation (ENSO) events. The study is useful for early warning and forecasting of negative effects associated with extreme rainfall anomalies across the country, using Climate Hazards Group Infrared Precipitation with Station (CHIrPS), the National Centers for Environmental Prediction (NCEP) National Center for Atmospheric research (NCAr) reanalysis sea surface temperature and ErA5 reanalysis datasets, during the period of 1983-2021. Both empirical orthogonal function (EOF), correlation analysis and composite analysis were used to delineate variability, relationship and the related atmospheric circulation between rwanda seasonal rainfall September to December (SOND) with Indian Ocean Dipole (IOD) and El-Nino Southern Oscillation (ENSO). The results for Empirical Orthogonal Function (EOF) for the reconstructed rainfall data set showed three modes. EOF-1, EOF-2 and EOF-3 with their total variance of 63.6%, 16.5% and 4.8%, Indian ocean dipole (IOD) events resulted to a strong positive correlation of rainfall anomalies and Dipole model index (DMI) (r = 0.42, p value = 0.001, DF = 37) significant at 95% confidence level. The composite analysis for the reanalysis dataset was carried out to show the circulation patterns during four different events correlated with September to December seasonal rainfall in rwanda using T-test at 95% confidence level. Wind anomaly revealed that there was a convergence of south westerly winds and easterly wind over the study area during positive Indian Ocean Diploe (PIOD) and PIOD with El Nino concurrence event years. The finding of this study will cont

关键词： Correlation rainfall Anomalies rwanda Indian Ocean Dipole El Nino Southern Oscillation

Potential Driving Systems Associated with Extreme rainfall across East Africa during October to December (OND) Season 2019

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Journal of Geoscience and Environment Protection 2024年第7期12卷 25-49页

作者： Constantine Ingeri Wang Wen Joseph Ndakize Sebaziga Vedaste Iyakaremye Samuel Ekwacu Prosper Ayabagabo Anthony Twahirwa jonah Kazora School of Atmospheric Sciences Nanjing University of Information Science and Technology Nanjing China rwanda Meteorology Agency (Meteo rwanda) Kigali Rwanda School of Science and Technology University of Rwanda (UR-CST) Kigali Rwanda Climate and Clean Air Coalition Secretariat Paris France rwanda Environment Management Authority (rEMA) Kigali Rwanda Uganda National Meteorological Authority (UNMA) Kampala Uganda Department of Earth and Climate Science University of Nairobi Nairobi Kenya

The East African (EA) region highly experiences intra-seasonal and inter-annual variation in rainfall amounts. This study investigates the driving factors for anomalous rainfall events observed during the season of October-November-December (OND) 2019 over the region. The study utilized daily rainfall data from Climate Hazards Group Infrared Precipitation with Station Data Version 2 (CHIrPSv2) and the driving systems data. Statistical spatiotemporal analysis, correlation, and composite techniques were performed to investigate the teleconnection between OND 2019 seasonal rainfall and global synoptic climate systems. The findings showed that the OND 2019 experienced seasonal rainfall that was twice or greater than its seasonal climatology and varied with location. Further, the OND 2019 rainfall showed a positive correlation with the Indian Ocean Dipole (IOD) (0.81), Nino 3 (0.51), Nino 3.4 (0.47), Nino 4 (0.40), Pacific Decadal Oscillation (PDO) (0.22), and North Tropical Atlantic (NTA) (0.02), while El Nino-Southern Oscillation (ENSO) showed a negative correlation (−0.30). The region was dominated by southeasterly warming and humid winds that originated from the Indian Ocean, while the geopotential height, vertical velocity, and vorticity anomalies were closely related to the anomalous rainfall characteristics. The study deduced that the IOD was the major synoptic system that influenced maximum rainfall during the peak season of OND 2019. This study therefore provided insights on the diagnosis study of OND 2019 anomalous rainfall and its attribution over the EA. The findings of the study will contribute to improvements in forecasting seasonal rainfall by regional climate centers and national meteorological centers within the region.

关键词： East Africa Driving Climate Systems October-November-December (OND) 2019 rainfall

Monitoring andevaluatingthepayment-for-performancepremiseofrEDD+:the caseofIndia’s ecologicalfiscaltransfers

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Ecosystem Health and Sustainability 2018年第7期4卷 11-17页

作者： jonah Busch Center for Global Development WashingtonDCUSA

Introduction:The central premise underlying international payments for reducing Emissions from Deforestation and forest Degradation(rEDD+)is that offering governments ex post payments for verified success in reducing emissions will motivate them to protect and restore ***,the extent to which performance-based payments motivate governments to protect and restore forests has yet to be evaluated *** have only quantitatively evaluated performance-based payments to non-governments for forest outcomes(*** for ecosystem services)and to governments for non-forest outcomes(***-based aid).Methods:We describe how researchers now have an opportunity to more easily evaluate performance-based payments to governments for forest outcomes thanks to India’s new ecological fiscal transfers(EFTs),which provide$6-12 billion per year to Indian states in proportion to their forest ***:India’s EFTs differ from rEDD+programs in that they pay for states’stock of forest area in the recent past rather than reductions in the rate of forest carbon loss in the ***,India’s EFTs focus on a single outcome and have many recipient governments,significant financial scale,lack of contemporaneous confounding policy changes,universal participation,and long-term data ***:These features make India’s EFTs especially useful for testing the payment-forperformance premise of rEDD+.

关键词： Ecological fiscal transfers India monitoring and evaluation payment-forperformance rEDD+

The use of fine portions from construction and demolition waste for expansive soil stabilization: A review

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Frontiers of Structural and Civil Engineering 2022年第7期16卷 803-816页

作者： Mgboawaji Claude UJILE Samuel jonah ABBEY Civil Engineering Faculty of Environment and TechnologyUniversity of the West of EnglandBristol BS161QYUK Geotechnical Engineering Faculty of Environment and TechnologyUniversity of the West of EnglandBristol BS161QYUK

Construction and demolition waste(CDW)are the largest waste products in the world today and competes as a viable recycled additive material in place of natural *** to the increase in compressive strength of different mix proportions of CDW,it is also considered for reuse in concrete and subbase *** study shows the effect of CDW in expansive soil *** chemical and mechanical properties of these materials have shown that they are capable of developing compressive strength properties for replacement of cement with significant reduction in carbon *** inherent compositional properties of recycled CDW compared in this review suggests that CDW have good filler properties in highly expansive *** of crushed brick and recycled aggregates characterised based on chemical properties of different replacement ratios suggests that CDW of good-quality aggregates reduces swell potential of expansive soils and increased mechanical strength in pavement construction.

关键词： mixed fine portions construction and demolition waste expansive soil soil stabilization

Erratum to: Born to sing! Song development in a singing primate

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Current Zoology 2024年第2期70卷 276-276页

作者： Chiara De Gregorio Filippo Carugati Vittoria Estienne Daria Valente Teresa raimondi Valeria Torti Longondraza Miaretsoa jonah ratsimbazafy Marco Gamba Cristina Giacoma Department of Lifte Sciences and Systems Biology University of Torinovia Accademia Alberina 13Torino 10125Italy Groupe d'Etude et de recherche sur les Primates de Madagascar(GErP) BP 779-Antananarivo 101Madagascar

The pagination of this article online has been updated to pages 597-608 to match the print *** Publisher sincerely apologizes for introducing this error online.

关键词： introducing sincerely match

LSTM rNN:detecting exploit kits using redirection chain sequences

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Cybersecurity 2021年第1期4卷 386-400页

作者： jonah Burgess Philip O’Kane Sakir Sezer Domhnall Carlin Centre for Secure Information Technologies(CSIT) Queen’s University BelfastNorthern Ireland Science ParkQueen’s RoadBelfast BT39DTUK

While consumers use the web to perform routine activities,they are under the constant threat of attack from malicious *** when visiting‘trusted’sites,there is always a risk that site is compromised,and,hosting a malicious *** this scenario,the injected script would typically force the victim’s browser to undergo a series of redirects before reaching an attacker-controlled domain,which,delivers the actual *** these malicious redirection chains aim to frustrate detection and analysis efforts,they could be used to help identify web-based *** upon previous work,this paper presents the first known application of a Long Short-Term Memory(LSTM)network to detect Exploit Kit(EK)traffic,utilising the structure of HTTP *** are processed as sequences,where each timestep represents a redirect and contains a unique combination of 48 *** experiment is conducted using a ground-truth dataset of 1279 EK and 5910 benign redirection ***-parameters are tuned via K-fold cross-validation(5f-CV),with the optimal configuration achieving an F1 score of 0.9878 against the unseen test ***,we compare the results of isolated feature categories to assess their importance.

关键词： Exploit kits Malware LSTM

Computer vision and augmented reality in gastrointestinal endoscopy

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Gastroenterology report 2015年第3期3卷 179-184页

作者： Nadim Mahmud jonah Cohen Kleovoulos Tsourides Tyler M.Berzin Department of Internal Medicine Brigham and Women’s HospitalHarvard Medical SchoolBoston MAUSA The Center for Advanced Endoscopy Beth Israel Deaconess Medical CenterHarvard Medical SchoolBoston MAUSA Brain and Cognitive Sciences Massachusetts Institute of TechnologyBoston MAUSA

Augmented reality(Ar)is an environment-enhancing technology,widely applied in the computer sciences,which has only recently begun to permeate the medical *** endoscopy—which relies on the integration of highdefinition video data with pathologic correlates—requires endoscopists to assimilate and process a tremendous amount of data in real *** believe that Ar is well positioned to provide computer-guided assistance with a wide variety of endoscopic applications,beginning with polyp *** this article,we review the principles of Ar,describe its potential integration into an endoscopy set-up,and envisage a series of novel *** close collaboration between physicians and computer scientists,Ar promises to contribute significant improvements to the field of endoscopy.

关键词： augmented reality gastrointestinal endoscopy colonoscopy computer vision