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Friction 2024年第3期12卷 522-538页

作者： Marta OSTOLAZA Alaitz ZABALA jon Inaki ARRIZUBIETA Iñigo LLAVORI Nagore OTEGI Aitzol LAMIKIZ Department of Mechanical Engineering University of the Basque Country UPV/EHUPlaza Torres Quevedo 1Bilbo 48013Spain Faculty of Engineering Mechanics and Industrial ProductionMondragon UnibertsitateaLoramendi 4Mondragon 20500Spain

Wear-driven tool failure is one of the main hurdles in the *** issue can be addressed through surface coating with ceramic-reinforced metal matrix ***,the maximum ceramic content is limited by *** this work,the tribological behaviour of the functionally graded Wc-ceramic-particlereinforced Stellite 6 coatings is *** that end,the wear resistance at room temperature and 400°c is ***,the tribological analysis is supported by crack sensitivity and hardness evaluation,which is of utmost importance in the processing of composite materials with *** indicate that functionally graded materials can be employed to increase the maximum admissible Wc content,hence improving the tribological behaviour,most notably at high ***,a shift from abrasive to oxidative wear is observed in high-temperature wear testing.

关键词： friction coating metal matrix composite functionally graded materials high temperature laserdirected energy deposition

Efficient Vision Transformers for Autonomous Off-Road Perception Systems

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Journal of computer and communications 2024年第9期12卷 188-207页

作者： Max H. Faykus III Adam Pickeral Ethan Marquez Melissa c. Smith jon c. calhoun Holcombe Department of Electrical and computer Engineering Clemson University Clemson SC USA

The development of autonomous vehicles has become one of the greatest research endeavors in recent years. These vehicles rely on many complex systems working in tandem to make decisions. For practical use and safety reasons, these systems must not only be accurate, but also quickly detect changes in the surrounding environment. In autonomous vehicle research, the environment perception system is one of the key components of development. Environment perception systems allow the vehicle to understand its surroundings. This is done by using cameras, light detection and ranging (LiDAR), with other sensor systems and modalities. Deep learning computer vision algorithms have been shown to be the strongest tool for translating camera data into accurate and safe traversability decisions regarding the environment surrounding a vehicle. In order for a vehicle to safely traverse an area in real time, these computer vision algorithms must be accurate and have low latency. While much research has studied autonomous driving for traversing well-structured urban environments, limited research exists evaluating perception system improvements in off-road settings. This research aims to investigate the adaptability of several existing deep-learning architectures for semantic segmentation in off-road environments. Previous studies of two convolutional Neural Network (cNN) architectures are included for comparison with new evaluation of Vision Transformer (ViT) architectures for semantic segmentation. Our results demonstrate viability of ViT architectures for off-road perception systems, having a strong segmentation accuracy, lower inference speed and memory footprint compared to previous results with cNN architectures.

关键词： Semantic Segmentation Off-Road Vision Transformers cNNs Autonomous Driving

两种富含甘氨酸的RNA结合蛋白参与选择性剪接实现对水稻耐热性的昼夜节律调控

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Science Bulletin 2024年第1期69卷 59-71页

作者：杨闯罗安妮芦海平 Seth jon Davis 刘建祥 State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China Department of Biology University of YorkYork YO105DDUK

Rice(Oryza sativa L.)production is threatened by global warming associated with extreme high temperatures,and rice heat sensitivity is differed when stress occurs between daytime and ***,the underlying molecular mechanism are largely *** show here that two glycine-rich RNA binding proteins,Os GRP3 and Os GRP162,are required for thermotolerance in rice,especially at *** rhythmic expression of Os GRP3/Os GRP162 peaks at midnight,and at these coincident times,is increased by heat *** is largely dependent on the evening complex component Os *** next found that the double mutant of Os GRP3/Os GRP162 is strikingly more sensitive to heat stress in terms of survival rate and seed setting rate when comparing to the wild-type ***,the defect in thermotolerance is more evident when heat stress occurred in nighttime than that in *** heat stress,the double mutant of Os GRP3/Os GRP162 displays globally reduced expression of heat-stress responsive genes,and increases of m RNA alternative splicing dominated by *** study thus reveals the important role of Os GRP3/Os GRP162 in thermotolerance in rice,and unravels the mechanism on how Os GRP3/Os GRP162 regulate thermotolerance in a diurnal manner.

关键词： Alternative splicing Diurnal regulation Glycine-rich protein Oryza sativa L. Thermotolerance

两种富含甘氨酸的RNA结合蛋白参与选择性剪接实现对水稻耐热性的昼夜节律调控（英文）

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Science Bulletin 2024年第1期 59-71页

作者：杨闯罗安妮芦海平 Seth jon Davis 刘建祥 State Key Laboratory of Plant Environmental Resilience College of Life Sciences Zhejiang University Department of Biology University of York

Rice(Oryza sativa L.) production is threatened by global warming associated with extreme high temperatures, and rice heat sensitivity is differed when stress occurs between daytime and nighttime. However,the underlying molecular mechanism are largely unknown. We show here that two glycine-rich RNA binding proteins, Os GRP3 and Os GRP162, are required for thermotolerance in rice, especially at nighttime. The rhythmic expression of Os GRP3/Os GRP162 peaks at midnight, and at these coincident times,is increased by heat stress. This is largely dependent on the evening complex component Os *** next found that the double mutant of Os GRP3/Os GRP162 is strikingly more sensitive to heat stress in terms of survival rate and seed setting rate when comparing to the wild-type plants. Interestingly,the defect in thermotolerance is more evident when heat stress occurred in nighttime than that in daytime. Upon heat stress, the double mutant of Os GRP3/Os GRP162 displays globally reduced expression of heat-stress responsive genes, and increases of m RNA alternative splicing dominated by *** study thus reveals the important role of Os GRP3/Os GRP162 in thermotolerance in rice, and unravels the mechanism on how Os GRP3/Os GRP162 regulate thermotolerance in a diurnal manner.

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Envita’s Precision cancer care: 35-Fold Improvement in Response Rates

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Journal of cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John c. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart christopher Aussems jon Moma Shannon Miller Zach Poteet conner coffin courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel conway chad Burk Ruth Tan-Lim Dino Prato Envita Medical centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National comprehensive cancer Network (NccN) guidelines, utilized by prominent cancer institutions. cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical centers over a two-year period. compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical centers Late-stage cancer Overall Response Rate Quality of Life circulating Tumor cells (cTcs) Mutant Allele Frequency (MAF) Precision care

Structure and Properties of Electroless Ni Deposits

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Journal of Materials Science & Technology 1996年第5期12卷 342-346页

作者： Zhang, YZ Sun, kn Wu, YY Zhang, JW Yao, M YANSHAN UNIV DEPT MAT SCI & ENGNQINHUANGDAO 066004PEOPLES R CHINA

The changes in structure and the hardness of two electroless deposited Ni-P alloy coatings (with P content of 1.5 and 9.5 wt pet) with heat treatment have been studied by XRD and TEM. The deposits containing 1.5 wt pet P can be represented as an fee NiP supersaturated solid solution of 5 similar to 10 nm microcrystallites, whereas the deposits containing 9.5 wt pet P are amorphous. The heat treatment process induces crystallization of amorphous Ni to Ni phosphides and fee Ni. Both of the deposits reach maximum hardness after annealing at 400 degrees c for 1 h. All coated steel specimens are inferior in fatigue strength to uncoated steel specimens mainly due to the poor fatigue resistance of the coating itself.

关键词： coatings

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complementary and Alternative Medicine Therapies for chronic Pain

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chinese Journal of Integrative Medicine 2016年第6期22卷 403-411页

作者： Brent A.Bauer jon c.Tilburt Amit Sood 李光熙王师菡 Division of complementary and Integrative Medicine Mayo Clinic Division of Pulmonary and critical care Medicine Mayo Clinic Guang'anmen Hospital China Academy of Chinese Medical Sciences Division of cardiovascular Diseases Mayo Clinic

ABSTRAcT Pain afflicts over 50 million people in the US, with 30.7% US adults suffering with chronic pain. Despite advances in therapies, many patients will continue to deal with ongoing symptoms that are not fully addressed by the best conventional medicine has to offer them. The patients frequently turn to therapies outside the usual purview of conventional medicine （herbs, acupuncture, meditation, etc.） called complementary and alternative medicine （cAM）. Academic and governmental groups are also starting to incorporate cAM recommendations into chronic pain management strategies. Thus, for any physician who care for patients with chronic pain, having some familiarity with these therapies--including risks and benefits--will be key to helping guide patients in making evidence-based, well informed decisions about whether or not to use such therapies. On the other hand, if a cAM therapy has evidence of both safety and efficacy then not making it available to a patient who is suffering does not meet the need of the patient. We summarize the current evidence of a wide variety of cAM modalities that have potential for helping patients with chronic pain in this article. The triad of chronic pain symptoms, ready access to information on the internet, and growing patient empowerment suggest that cAM therapies will remain a consistent part of the healthcare of patients dealing with chronic pain.

关键词： complementary and alternative medicine therapy chronic pain safety and efficacy

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Effects of low-oxygen conditions on embryo growth in the painted turtle,chrysemys picta

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Integrative Zoology 2017年第2期12卷 148-156页

作者： Gerardo A.cORDERO Matthew L.KARNATZ jon c.SVENDSEN Eric J.GANGLOFF Department of Ecology Evolutionand Organismal BiologyIowa State UniversityAmesIowaUSA Technical University of Denmark National Institute of Aquatic ResourcesFreshwater FisheriesSilkeborgDenmark Interdisciplinary centre of Marine and Environmental Research University of PortoPortoPortugal

Low-oxygen conditions(hypoxia;<21%O_(2))are considered unfavorable for growth;yet,embryos of many vertebrate taxa develop successfully in hypoxic subterranean *** enhanced tolerance to hypoxia has been demonstrated in... 详细信息

Low-oxygen conditions(hypoxia;considered unfavorable for growth;yet,embryos of many vertebrate taxa develop successfully in hypoxic subterranean *** enhanced tolerance to hypoxia has been demonstrated in adult reptiles,such as in the painted turtle(chrysemys picta),its effects on sensitive embryo life stages warrant *** tested the hypothesis that short-term hypoxia negatively affects growth during day 40 of development in ***,when O_(2) demands are highest in embryos.A brief,but severe,hypoxic event(5%O_(2) for 0.5 h)moderately affected embryo growth,causing a 13%reduction in mass(relative to a normoxic control).The same condition had no effect during day 27;instead,a nearly anoxic event(1%O_(2) for 72 h)caused a 5%mass *** embryos survived the egg incubation *** study supports the assumption that reptilian embryos are resilient to intermittently low O_(2) in subterranean *** work is needed to ascertain responses to suboptimal O_(2) levels while undergoing dynamic changes in developmental physiology.

关键词： embryo metabolism embryo respiration growth rate nest environment oxygen consumption rate

Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 527-530页

作者： Ashok Kumar BS Lakshman K Jayaveera kn Vel Murgan c Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM Department of Pharmacognosy.Sri K.V.college of Pharmacy ChickballapurKarnataka-562101India Department of Pharmacognosy PES College of PharmacyBangaloreKarnatakaIndia Department of chemistry Jawaharlal Nehru Technological University of College of EngineeringAnantapurAndhra Pradesh.India Department of Pharmacology Sri K.V.College of PharmacyChickbaltapurKarnataka-562101.India Department of Pharmacology Sri K.V.College of PharmacyChickballapurKarnataka-562101India

Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(***) and Amaranthus spinosus(***).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for ***:It was found that all the three plants showed significant pain management effect(Pcant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(Pconclusions:Methanol extracts of ***,*** and *** show potent analgesic activities,and this study provides the scientific proof for their traditional claims.

关键词： Amaranthus viridis Linn Amaranthus caudatus Linn Amaranthus spinosus Linn Analgesic Acetic acid induced writhings

Electrons matter in ferromagnetic criticality

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Science Bulletin 2021年第14期66卷 1369-1371页

作者： Joe D.Thompson jon M.Lawrence Los Alamos National Laboratory Los AlamosNM 87545USA University of california IrvineCA 92697USA

When elemental iron is cooled from high temperatures,magnetic moments carried by its d-electrons begin a continuous transition to a state of parallel aligned moments below its curie temperature T_(c)of about 1040 *** established in the mid-1900s,the statistical physics of this second order phase transition is universal,independent of the ordering temperature,material structure and chemical composition as well as the character of moment-bearing electrons.

关键词： transition 铁磁 character

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