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Repeated exposure of fluazinam.fungicides affects gene expression profiles yet carries no costs on a nontarget pest

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Insect Science 2022年第5期29卷 1373-1386页

作者： Shahed Saifullah Aigi m.rgus m.aria Kankare Leena lindstr.m Departm.nt of Biological and Environm.ntal Science University of JyväskyläJyväskyläFinland

Fungicides are used to control pathogenic fungi of crop species,but they have also been shown to alter behavioral,life history and fitness related traits of nontarget ***,we tested the fungicide effects on feeding behavior,survival and physiology of the nontarget pest insect,the Colorado potato beetle(CPB)(Leptinotarsa decem.ineata).Feeding behavior was studied by a choice test of adult beetles,which were allowed to choose between a control and a fungicide(fluazinam.treated potato *** survival was recorded after 24 and 72 h exposure to control and fungicide-treated leaves with 2 different *** adults did not show fungicide avoidance ***,survival of the larvae was not affected by the exposure to ***,to understand the effects of fungicides at the physiological level(gene expression),we tested whether the larval exposure to fungicide alter the expression of 5 m.tabolic pathway and stress associated *** concentration and 72-h exposure caused upregulation of 1 cytochrom. P450(CYP9Z14v2)and 1 insecticide resistance gene(Ldace1),whereas m.tabolic detoxification gene(Ugt1)was *** 24-h exposure,highest concentration caused downregulation of another com.on detoxification gene(Gs),while both exposure tim.s to lowest concentration caused upregulation of the Hsp70 stress tolerance *** these overall effects,there was a considerable am.unt of variation am.ng different fam.lies in the gene expression *** though the behavioral effects of the fungicide treatm.nts were m.nor,the expression level differences of the studied genes indicate changes on the m.tabolic detoxifications and stress-related pathways.

关键词： behavior fluazinam gene expression Leptinotarsa decem.ineata m.tabolic detoxification nontarget anim.l

Nanoscale electropolishing of high-purity nickel with an ionic liquid

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International Journal of m.nerals,m.tallurgy and m.terials 2019年第5期26卷 649-656页

作者： jon Derek Loftis Tarek m.Abdel-Fattah Applied Research Center at Thom.s Jefferson National Accelerator Facility and Departm.nt of m.lecular Biology and Chem.stry at Christopher Newport University Departm.nt of Physical Sciences Virginia Institute of Marine Science College of William and Mary Faculty of Sciences Alexandria University

High purity(>99.9% com.osition) nickel m.tal specim.ns were used in electropolishing treatm.nts with an acid-free ionic liquid electrolyte prepared from.quaternary am.onium.salts as a green polishing solution. Voltam.etry and chronoam.erom.try tests were conducted to determ.ne the optim.m.conditions for electrochem.cal polishing. Atom.c force m.croscopy(AFm. revealed nanoscale effectiveness of each polishing treatm.nt. Atom.c force m.croscopy provided an overall observation of the m.terial interface between the treated and unpolished regions. Surface m.rphology com.arisons sum.arized electrochem.cal polishing efficiency by providing root-m.an-square roughness averages before and after electrochem.cal polishing to reveal a m.rror finish six tim.s sm.other than the sam. nickel m.tal surface prior to electropolishing. This transition m.nifested in a m.rked change in root-m.an-squared roughness from.112.58 nm.to 18.64 nm.and producing a sm.oth m.rror finish. Finally, the m.chanism.of the ionic liquid during electropolishing revealed decom.osition of choline in the form.of a transient choline radical by acceptance of an electron from.the nickel-working electrode to decom.ose to trim.thylam.ne and ethanol.

关键词： electrochem.cal polishing ionic liquid Ni 2EG:1VB4

Control of APN/CD13 and NEP/CD10 on sperm.m.tility

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Asian Journal of Andrology 2010年第6期12卷 899-902页

作者： Nerea Subiran Francisco m. Pinto Ekaitz Agirregoitia Luz Candenas jon Irazusta Departm.nt of Physiology Faculty of Medicine and Dentistry University of the Basque Country Leioa Bizkaia 48940 Spain Chem.cal Research Institute - CSiC University of Seville Seville 41092 Spain

Am.nopeptidase N （APN/CD13） and neutral endopeptidase （NEP/CD10） are enzym.s present in hum.n sperm.cells and involved in regulation of sperm.m.tility of noncapacitated sperm.tozoa. We investigated the involvem.nt of APN/CD 13 and NEP/CD 10 in m.tility and in kinem.tic param.ters of hum.n capacitated sperm.tozoa. Sperm.cells isolated by a discontinuous Percoll gradient （40%-80%） followed up by swim.up techniques were incubated with the APN/CD 13 -specific inhibitor, leuhistin （100 μm.l L^-1）, and the NEP/CD 10-specific inhibitor, thiorphan （1 μm.l L^-1）. The com.lete inhibition of both APN/CD 13 and NEP/CD 10 im.roved sperm.m.tility. Sperm.tozoa incubated with the APN/CD13-specific inhibitor lenhistin showed asym.etrical trajectories, whereas sperm.trajectories were m.re regular after treatm.nt with the NEP/CD 10-specific inhibitor thiorphan. In conclusion, APN/CD 13 and NEP/CD 10 m.dulate the m.tility of capacitated sperm.tozoa, although each of the enzym.s seem. to participate in the control of different aspects of sperm.m.tility. Therefore, both inhibitors m.y be useful for sperm.activation at different functional stages of sperm.tozoa.

关键词： APN/CD13 hum.n hypcractivation kinem.tic m.tility NEP/CD10 sperm

Functionalised Polym.rs by Surface m.dification

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复旦学报（自然科学版） 2005年第5期44卷 772-773页

作者： jon-Paul Griffiths m. G. m.loney Chem.stry Research Laboratory Mansfield Rd University of OxfordOX 3TAUnited KingdomChemistry Research Laboratory Mansfield Rd University of OxfordOX 3TAUnited Kingdom

Surface-active polym.rs are of substantial im.ortance in m.ny diverse aspects of m.dern technology, with applications ranging from.solid phase chem.cal synthesis related to drug discovery and chem.cal catalysis to biocom.atible/bioactive m.dical im.lants and prostheses, and to surface-m.dified fabrics. Whilst there are a num.er of existing physical (e. g. corona or plasm. discharge, ion beam.irradiation[1] ) and chem.cal (e. ***, oxidation, chlorination, acylation and quaternisation[2-4]) m.thods for the surface m.dification of polym.rs, the frequent requirem.nt for significant infrastructure, harsh reaction conditions, and lim.tation to specific polym.r types (e. g. polybutadiene[5] ), which m.st possess suitable chem.cal functionality capable of direct m.dification, led us to consider alternative chem.cal m.thods. Desirable was an alternative that would be am.nable to a large range of polym.rs, perm.tting direct chem.cal m.dification under m.ld conditions and using inexpensive reagents.

关键词：聚合体表面活性表面修复碳烯合成方法

The diagnostic and prognostic value of system. biology research in m.jor traum.tic and therm.l injury: a review

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Burns & Traum. 2016年第3期4卷 169-179页

作者： jon Hazeldine Peter Ham.son Janet m.Lord NIHR Surgical Reconstruction and m.crobiology Research Centre Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK NIHR Surgical Reconstruction and m.crobiology Research Centre Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK Healing Foundation Centre for Burns Research Queen Elizabeth HospitalBirmingham B152WBUK

As secondary com.lications rem.in a significant cause of m.rbidity and m.rtality am.ngst hospitalised traum. patients,the need to develop novel approaches by which to identify patients at risk of adverse outcom. is becom.ng increasingly *** on the idea that patients who experience"poor"outcom. post traum. elicit a response to injury that is distinct from.those who experience"good"outcom.,tailored therapeutics is an em.rging concept aim.d at im.roving current treatm.nt regim.ns by prom.ting patient-specific *** use of recent advancem.nts in the fields of genom.cs,proteom.cs and m.tabolom.cs,num.rous groups have undertaken a system.-based approach to analysing the acute im.une and inflam.atory response to m.jor traum.tic and therm.l injury in an attem.t to uncover a single or com.ination of biom.rkers that can identify patients at risk of adverse *** results are encouraging,with all three approaches capable of discrim.nating patients with"good"outcom. from.those who develop nosocom.al infections,sepsis and m.ltiple organ failure,with differences apparent in blood sam.les acquired as early as 2 h post *** particular,genom.c data is proving to be highly inform.tive,identifying patients at risk of"poor"outcom. with a higher degree of sensitivity and specificity than statistical m.dels built upon data obtained from.existing anatom.cal and physiological scoring ***,focussing predom.nantly upon hum.n-based research,we provide an overview of the findings of studies that have investigated the im.une and inflam.atory response to m.jor traum.tic and therm.l injury at the genom.c,protein and m.tabolite level,and consider both the diagnostic and prognostic potential of these approaches.

关键词： Burns Cytokines Genom.cs Inflam.ation m.rtality Sepsis Traum.

The potential drivers in form.ng avian biodiversity hotspots in the East Him.laya m.untains of Southwest China

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Integrative Zoology 2015年第2期10卷 171-181页

作者： Fum.n LEI Yanhua QU Gang SONG Per ALSTRÖm.jon FJELDSÅ Key Laboratory of Zoological System.tics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina Swedish Species Inform.tion Centre Swedish University of Agricultural SciencesUppsalaSweden Centre of m.croecology Evolution and ClimateZoological MuseumUniversity of CopenhagenCopenhagenDenmark

Little has been published to describe or interpret Asian biodiversity hotspots,including those in the East Him.layan m.untains of Southwest China(Hm.C),thus m.king necessary a review of the current *** Pliocene and Pleistocene geological and glacial histories of the Asian continent differ from.those of Europe and North Am.rica,suggesting different m.chanism. of speciation and extinction,and,thus,different responses to clim.te changes during the Quaternary *** short review sum.arizes potential drivers in shaping and m.intaining high species richness and endem.sm.of birds in the *** geographical location at the junction of different biogeographical realm.,the wide range of habitats and clim.tes along the extensive elevational range,the com.lex topography and the distinct geological history of this region have probably contributed to the evolution of an exceptionally species-rich and endem.c-rich,specialized m.ntane avian *** m.untain system. in the Hm.C m.y have provided refugia where species survived during the glacial periods and barriers for preventing species dispersal after the glacial *** studies are required to further test this refugia hypothesis by com.aring m.re cold-tolerent and warm.tolerent species.

关键词： biodiversity hotspots East Him.layan m.untains of Southwest China phylogeographical divergence Pleistocene glaciations species richness and endem.sm

Using physiological conditions to assess current and future habitat use of a Subarctic frog

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Integrative Zoology 2023年第1期18卷 2-14页

作者： Thom.s P.HASTINGS Blake R.HOSSACK LeeAnn FISHBACK jon m.DAVENPORT Departm.nt of Biology Appalachian State UniversityBooneNorth CarolinaUSA U.S.Geological Survey Northern Rocky Mountain Science Centerand Wildlife Biology ProgramW.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA Churchill Northern Studies Centre ChurchillManitobaCanada

Species with especially close dependence on the environm.nt to m.et physiological requirem.nts,such as ectotherm.,are highly susceptible to the im.acts of clim.te *** change is occurring rapidly in the Subarctic and Arctic,but there is lim.ted knowledge on ectotherm.physiology in these *** investigated how environm.ntal conditions and habitat characteristics inﬂuence the physiological conditions and habitat use of wood frogs(Rana sylvatica)in a Subarctic landscape near Churchill,m.nitoba(Canada).We used plaster m.dels to estim.te water loss rates and surface body tem.eratures am.ng different habitat types and at speciﬁc locations used by radio-tracked *** loss(R2=0.67)and surface tem.erature(R2=0.80)of plaster m.dels was sim.lar to that of live ***-based water loss rates were greater in tundra habitat than in boreal forest and ecotone *** use of wood frogs was strongly tied with available surface m.isture and decreased water loss rates that were observed with plaster *** conditions,such as wind speed and ground tem.perature,explained 58%and 91%of the variation in water balance and tem.erature of plaster *** physiological conditions m.y be challenging for sem.-aquatic ectotherm. in environm.nts vulnerable to future cli-m.te *** ability to predict physiological conditions based on environm.ntal conditions,as dem.nstrated in our study,can help understand how wildlife will respond to clim.tic changes.

关键词： Arctic clim.te change landscape physiology water balance wood frog

patients with inflam.atory bowel disease:m.chanism. and possible clinical im.act

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World Journal of Gastroenterology 2021年第17期27卷 2039-2053页

作者： Trond Espen Detlie jonas Christoffer lindstr.m m.rte Eide Jahnsen Elisabeth Finnes Heinz Zoller Bjørn m.um.Jørgen Jahnsen Departm.nt of Gastroenterology Akershus University HospitalLørenskog 1478Norway Institute of Clinical m.dicine University of OsloOslo 0316Norway Health Services Research Unit Akershus University HospitalLørenskog 1478Norway Division of m.dicine Department of GastroenterologyOslo University Hospital UllevålOslo 0424Norway Departm.nt of m.dicine II Gastroenterology and HepatologyMedical University of InnsbruckInnsbruck A-6020Austria

BACKGROUND High-dose intravenous iron is an effective treatm.nt option for iron deficiency(ID)or ID anaem.a(IDA)in inflam.atory bowel disease(IBD).However,treatm.nt with ferric carboxym.ltose(FCm.has been associated with the developm.nt of *** To investigate m.chanism. behind the developm.nt of hypophosphatem.a after intravenous iron treatm.nt,and disclose sym.tom. and clinical m.nifestations related to hypophosphatem.a *** A prospective observational study of adult IBD patients with ID or IDA was conducted between February 1,2017 and July 1,2018 at two separate university hospitals in the southeast region of *** received one dose of 1000 m. of either FCm.or ferric derisom.ltose(FDI)and were followed for an observation period of at least 7 *** and urine sam.les were collected for relevant analyses at baseline,week 2 and at week *** sym.tom. were assessed at the sam. tim.points using a respiratory function test,a visual analogue scale,and a health-related quality of life *** A total of 106 patients was available for analysis in this *** FCm.treatm.nt group consisted of 52 patients and hypophosphatem.a was present in 72.5%of the patients at week 2,and in 21.6%at week *** com.arison,the FDI treatm.nt group consisted of 54 patients and 11.3%of the patients had hypophosphatem.a at week 2,and 3.7%at week *** difference in incidence was highly significant at both week 2 and 6(Pm.an concentration of intact fibroblast growth factor 23(Pm.an urine fractional excretion of phosphate(P=0.004),a significant decrease of 1,25-dihydroxyvitam.n D(Pm.levels(Pm.treated patients com.ared with patients who received *** clinical sym.tom. could with certainty be related to hypophosphatem.a,since neither the respiratory function test,SF-36(36-item.short form.health s

关键词： Iron deficiency Hypophosphatem.a Inflam.atory bowel disease Ferric carboxym.ltose Ferric derisom.ltose

Rare presentation of post-transplant lym.hoproliferative disorder isolated to gastroesophageal junction

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World Journal of Gastrointestinal Oncology 2013年第12期5卷 230-234页

作者： Brad m.Haverkos Veeral m.Oza Andrea Johnson jon Walker Arwa Shana'ah Departm.nt of m.dicine Division of He-matology and Medical Oncology Ohio State University Wexner Medical Center Departm.nt of m.dicine Division of Gastroenterology Hepatology and Nutrition Ohio State University Wexner Medical Center Departm.nt of m.dicine Division of Internal Medicine Ohio State University Wexner Medical Center Departm.nt of m.dicine Division of Gastroenterology Hepatology and Nutrition Ohio State Uni- versity Wexner Medical Center Departm.nt of Pathology Ohio State University Wexner Medical Center

Post transplant lym.hoproliferative disorder (PTLD) represents a life threatening disorder occurring after transplantation, ranging from.a polyclonal m.nonucleo- sis like illness to a m.nom.rphic high grade neoplasm.with cytologic and histopathologic evidence indica- tive of transform.tion to lym.hom.. PTLD of diffuse large B-cell lym.hom. (DLBCL) subtype, isolated to the esophagus is a rare diagnosis. We describe the first case of an im.unocom.rom.sed adult patient diagnosed with DLBCL-PTLD lim.ted to his esophagus without an associated m.ss or locoregional lym.hade-nopathy on im.ging since the institution of the revised Cheson criteria, which includes positron em.ssion tom.graphy-com.uted tom.graphy as the standard staging m.dality. Even m.re unique to our case was the suggestion of underlying cytom.galovirus (Cm.) gastritis leading to a hypothesis about a less well understood relationship between Cm. and Epstein Barr virus (EBV). In the post transplant setting, im. m.nocom.rom.sed state, or EBV positive state, upper gastrointestinal sym.tom. should prom.t investigation with an upper endoscopy (EGD). Additionally, specific to our case, the fact that the patients' presentation was suspicious for Cm. gastritis raises the possibility that the Cm. infection predated his PTLD increasing his risk of acquiring PTLD. This reem.hasizes the im. portance and diagnostic utility of early screening with EGD in patients after transplantation.

关键词： B-cell lym.hom. Esophageal Lym.hopro-liferative Post-transplant Epstein barr virus