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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly form.d.oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating m.d.ls,is essential to better understand the pathogenesis of demyelinating ***,comparing injury m.d.ls across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from.d.verse studies across different animal m.d.ls,we can enhance our understanding of myelin pathology in central nervous system.d.sorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal m.d.ls demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Percolation analysis of large-scale wireless balloon networks

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digital Communications and Networks 2019年第2期5卷 84-93页

作者： m.d. Nashid Anjum Honggang Wang Hua Fang University of massachusetts dartmouth 285 Old Westport RdDartmouthMA 02747USA

Recent advancements in wireless technology have tested Wireless Balloon Networks (WBNs) as an ideal solution for the provision of internet facilities in deprived and challenging areas. A few high profile companies, such as Google, Space data Inc., etc., have already m.d. news by initiating projects based on high-altitude WBNs in order to provide internet facilities in remote areas. Unfortunately, the technical details have mainly been kept confidential so far. In this paper, we attempt to analyze the percolation properties of large-scale WBNs, considering both homogenous and heterogenous wireless nodes. In order to do so, we m.d.led a WBN as a large-scale random network where the path-loss m.d.ls of homogenous and heterogenous WBNs were reduced to Gdm (Gilbert's disk m.d.l) and RGdm (Random Gilbert's disk m.d.l), respectively. The bounds of the critical density regime were derived for both percolation m.d.ls. Additionally, this paper implemented an experimental test bed for the WBN percolation m.d.l. Consequently, the findings of this research may prove crucial in estimating critical network properties.

关键词： Percolation Connectivity WBN PPP Gdm

Study on Cytokines IL-2,IL-6,IL-10 in Patients of Chronic Allergic Rhinitis Treated with Acupuncture

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Journal of Traditional Chinese m.d.cine 2002年第2期22卷 104-111页

作者： FILOmENA BANGRAZI PETTI m.Sc.Ph.d. ALdO LIGUORI m.d. FLORA IPPOLITI m.d.Ph.d. Paracelso Chair

OBJECTIVES: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. mETHOdS: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). RESULTS: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P

关键词： Acupuncture Therapy Adult Cd4-Positive T-Lymphocytes Female Humans Interleukin-10 Interleukin-2 Interleukin-6 male m.d.le Aged Rhinitis, Allergic, Perennial

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse m.d.l of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de m.d.cine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal m.d.l of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor m.d.lator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a m.d.rate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor m.d.lator sexual dimorphism spinal cord injury trauma

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN d.SINGH R.VAISH V.S.CHAUHAN School of mechanical and materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is m.d.led using the C0finite element method(FEm), and an in-house code is developed in the mATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The m.d.l is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, m.d.lus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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dielectric and infrared properties of SrTiO_3 single crystal doped by 3d (V,mn,Fe,Ni) and 4f (Nd,Sm,Er) ions

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Chinese Physics B 2014年第2期23卷 369-374页

作者： S.maletic d.maletic I.Petronijevic J.dojcilovic d.m.Popovic Faculty of Physics University of Belgrade Institute of Physics University of Belgrade

In this study, the effects of doping by 3d （V, mn, Fe, Ni） and 4f （Nd, Sm, Er） ions on dielectric and infrared properties of SrTiO3 （STO） single crystals are investigated. It is well known that doping of the SrTiO3 can change the dielectric properties of the STO from an insulator to an n-type semiconductor, and even to a metallic conductor. dielectric and infrared （IR） properties of the undoped STO and doped STO single crystals are analyzed using dielectric spectroscopy （80 kHz-5 mHz）, transmission （200 cm^-1-4000 cm^-1）, and reflection spectroscopy （50 cm^-1-2000 cm^-1）. It is found that doping by the 3d ions reduces the value of dielectric permittivity, but the trend of temperature dependence of the dielectric permittivity remains almost unchanged. On the other hand, dielectric spectroscopy measurements for samples doped by 4f ions show the anomalous behaviors of the dielectric permittivity at temperatures around the temperature of the structural phase transition. There are two fractures of temperature dependences of inverse dielectric permittivity εr^-1 （T）. Transmittance spectroscopy measurements show that there are differences in the shape of the spectrum in the m.d.IR region between the undoped STO and the one doped by 4f ions. The differences in the reflectance spectrum between the STO：Nd and STO are analyzed in detail.

关键词： doping dielectric properties phase transitions infrared spectroscopy

NUTRITIONFORCHILdANdAdOLESCENTATHLETES

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中国运动医学杂志 2000年第4期19卷 443-447页

作者： Oded Bar-Or m.d. Children’s Exercise & Nutrition Centre mc master University Hamilton Ontario Canada

dynamic scheduling and analysis of real time systems with multiprocessors

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digital Communications and Networks 2016年第3期2卷 130-138页

作者： m.d. Nashid Anjum Honggang Wang University of massachusetts dartmouth 285 Old Westport Rd Dartmouth MA 02747 USA

This research work considers a scenario of cloud computing job-shop scheduling problems. We consider rn realtime jobs with various lengths and n machines with different computational speeds and costs. Each job has a deadline to be met, and the profit of processing a packet of a job differs from other jobs. moreover, considered deadlines are either hard or soft and a penalty is applied if a deadline is missed where the penalty is considered as an exponential function of time. The scheduling problem has been formulated as a mixed integer non-linear programming problem whose objective is to maximize netprofit. The formulated problem is computationally hard and not solvable in deterministic polynomial time. This research work proposes an algorithm nam.d.the Tube-tap algorithm as a solution to this scheduling optimization problem. Extensive simulation shows that the proposed algorithm outperforms existing solutions in terms of maximizing net-profit and preserving deadlines.

关键词： Job-shop scheduling problemsJSPLPTSPTLSEddTube-tapmINLP