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GRId GENERATION ANd NUmERICAL SImULATION OF 2-d RIVER FLOW

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Journal of Hydrodynamics 2001年第2期13卷 50-54页

作者： Zhao, m.d. Li, Y.T. dept. of River Eng. Wuhan Univ. Wuhan 430072 China

This paper presents new weighting functions in grid generation and new discretizing scheme of momentum equations in numerical simulation of river flow. By using the new weighting functions, the curvilinear grid could be concentrated as desired near the assigned points or lines in physical plane. By using the new discretizing scheme, the difficulties caused by movable boundary and dry riverbed can be overcome. As an application, the flow in the Wuhan Section of Yangtze River is simulated. The computational results are in good agreement with the measured results. The new method is applicable to the numerical simulation of 2-d river flow with irregular region and moveable boundary.

关键词： Computer simulation Flow of fluids mathematical m.d.ls Poisson equation Two dimensional

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBim.d.Institute of Biom.d.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury m.d.ls,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschm.d.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschm.d. damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest miller School of m.d.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirm.d.that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

HAGEN POISEUILLE FLOW OF A GRANULAR mATERIAL IN A CYLINdER

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Journal of Hydrodynamics 2001年第2期13卷 91-95页

作者： Liu, m.J. Tao, m.d. dept. of mech. and Eng. Sci. Fudan Univ. Shanghai 200433 China

The equations of motion for rapid flow of a granular material were derived and their solutions representing flow driven by a body force along an infinitely-long cylinder were obtained by the numerical method.

关键词： Boundary conditions Cylinders (shapes) Equations of motion Flow of solids Numerical methods

PROPERTIES, WELdABILITY ANd APPLICATIONS OF AdVANCEd WROUGHT SUPERALLOYS FOR GAS TURBINE ENGINES

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Acta metallurgica Sinica(English Letters) 2005年第1期18卷 1-14页

作者： d.L. Klarstrom V.R. Ishwar m.d. Rowe Haynes International Inc. Kokomo Indiana IN 46904-9013 USAHaynes International Inc. Kokomo Indiana IN 46904-9013 USAHaynes International Inc. Kokomo Indiana IN 46904-9013 USA

Alloy selection and alloy design both require consideration of an array of material attributes, including in-service properties, weldability and fabricability. Critical properties of advanced wrought superalloys for gas turbine applications include high temperature strength, thermal stability, oxidation resistance and fatigue resistance. In this paper, the properties of twelve wrought solid-solution-strengthened and six age-hardenable superalloys are compared. Weldability is an important attribute and can be a major limiting factor in the use of certain alloys. Weldability test methods are discussed and the resistance of alloys to solidification cracking and strain-age cracking is compared. The use of weldability testing in the development of m.d.rn wrought su-peralloys is discussed with several examples cited. Finally, alloy selection for gas turbine components is outlined, taking into account both alloy properties and fabricability.

关键词： wrought superalloys mechanical properties strain-age cracking of weldments selection and application of wrought superalloys

Preliminary performance analysis and optimization based on 1d neutronics m.d.l for Indian dEmO HCCB blanket

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Plasma Science and Technology 2020年第8期22卷 184-191页

作者： d AGGARWAL C dANANI m Z YOUSSEF Institute for Plasma Research GandhinagarGujarat 382428India Homi Bhabha National Institute(HBNI) AnushaktinagarMumbai 400094India University of California-Los Angeles Los AngelesCA 90095United States of America

India,under its breeding blanket R&d program for dEmO,is focusing on the development of two tritium breeding blanket concepts;namely the lead-lithium-cooled ceramic breeder and the helium-cooled ceramic breeder(HCCB).The study presented in this paper focuses on the neutronic design analysis and optimization from the tritium breeding perspective of the HCCB *** Indian concept has an edge-on configuration and is one of the variants of the helium-cooled solid breeder blanket concepts proposed by several partner countries in *** Indian HCCB blanket having lithium titanate(Li2TiO3)as the tritium breeder and beryllium(Be)as the neutron multiplier with reduced-activation ferritic/martensitic steel structure aims at utilizing the low-energy neutrons at the rear part of the *** aim of the optimization study is to minimize the radial blanket thickness while ensuring tritium self-sufficiency and provide data for further neutronic design and thermal-hydraulic layout of the HCCB *** is found that inboard and outboard blanket thicknesses of 40 cm and 60 cm,respectively,can give a tritium breeding ratio(TBR)>1.3,with 60%6Li enrichment,which is assum.d.to be sufficient to cover potential tritium losses and associated *** results also demonstrated that the Be packing fraction(PF)has a more profound impact on the TBR as compared to 6Li enrichment and the PF of Li2TiO3.

关键词： dEmO helium-cooled ceramic breeder blanket neutronic optimization study tritium breeding ratio

Notes on the Landmark development of CBR in China

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中国康复医学杂志 2009年第1期24卷 3-4页

作者： dahong Zhuo, m.d. Faculty of Rehabilitation m.d.cine Sun Yat-Sen University WHO Collaborating Centre for Rehabilitation

Community-based rehabilitation has a history of 22 years in *** spite of the preliminary achievement and experiences obtained by the pioneering and trial projects,it was not until the beginning of the new century that CBR in China experienced a landmark *** is characterized by a number of favorable policy by the government for CBR;the mechanism facilitating primary health care with CBR,a new work-force system of CBR reorganized with better motivation and efficiency,99 demonstration projects of CBR bringing about benchmark promotion effect and the active involvement in CBR by social resources agents.

关键词： CBR 中国医疗卫生行业发展历史