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Advances in Atmospheric Sciences 2003年第4期20卷 487-495页

作者： Xun ZHUThe johns hopkins University Applied Physics Laboratory, MD 20723-6099, USA Applied Physics Laboratory The Johns Hopkins University USA

The classic two-level or equivalent two-level model that includes only the statistical equilibrium of radiative and thermal processes of excitation and quenching between two vibrational energy levels is extended by adding chemical production to the rate equations. The modifications to the non-local thermodynamic equilibrium source function and cooling rate are parameterized by ϕc, which characterizes the ratio of chemical production to collisional quenching. For applications of broadband emission of O3 at 9.6 μm, the non-LTE effect of chemical production on the cooling rate and limb emission is proportional to the ratio of O to O3. For a typical [O]/[O3], the maximum enhancements of limb radiance and cooling rate are about 15%–30% and 0.03–0.05 K day−1, respectively, both occurring near the mesopause regions. This suggests that the broadband limb radiance above ∼80 km is sensitive to O3 density but not sensitive to the direct cooling rate along the line-of-sight, which makes O3 retrieval feasible but the direct cooling rate retrieval difficult by using the O3 9.6 μm band limb emission.

关键词： non-LTE radiative transfer ozone cooling ozone retrieval space weather

ECOLOGICAL CONSEQUENCES OFSOIL EROSION AND SEDIMENTATION

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International Journal of Sediment Research 1999年第2期14卷 355-361页

作者： Grace S. BRUSH (johns hopkins University , Baltimore, Maryland, USA)

Sediment erosion and siltation in waterways can have ecological consequences as disastrous economically as those related to transport and flooding of adjacent lands. The impact of sediment erosion and deposition on human societies is recorded in many historical documents. The paleoecological record also provides evidence of the long-term effects of siltation. Sedimentation rates in the Chesapeake Bay estuary, in mid-Atlantic USA, have doubled and quadrupled over the last 200 to 300 years with the initiation and intensification of agriculture. The result has been filling in of many estuarine tributaries and the transformation of the estuary from a benthic to a planktonic ecosystem. This change took place as light became limiting in the water column and benthic plants could no longer photosynthesize, resulting in a proliferation of planktonic algae. Planktonic algal growth was also fueled by fertilizers attached to eroded soil particles. leading ultimately to eutrophication within the water column and anoxia of the bottom waters.

关键词： Sedimentation Civilizations Land use Sediment cores

Gene Screen for Breast Cancer Better than Pathologist's "Eye"

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当代外语研究 2006年第11期 6-7页

作者： johns hopkins 姜彬 Medical Institutions

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又... 详细信息

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又有了新的突破。

关键词：研究人员肿瘤医学研究中心霍普金斯大学特殊类化学成分新方法人体器官病理学家诊断方式

Chemical biology of ion channels

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Chemical biology of ion channels

The Degree of Symmetry of Certain Compact Smooth Manifolds II

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Min Li johns hopkins Ion Channel Center,johns hopkins University,USA

＜正＞Ion channels are important molecules for membrane excitability in the nervous system and signal transduction in non-excitable *** conventional high throughput technologies and automated electrophysiology,we have screened large compound libraries in the order of more than 300,000 structures for modulators of several classes of ion *** characterizations of these active compounds are under way and have begun to reveal both diverse and novel regulatory *** information provides new insights into chemical regulation and drug development for ion channels.

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Chinese Annals of Mathematics,Series B 2007年第2期28卷 195-204页

作者： Bin XU Department of Mathematics, University of Science and Technology of China, Hefei 230026, China Chern Institute of Mathematics, Nankai University, Tianjin 300071, China Department of Mathematics, johns hopkins University, Baltimore, MD 21218, USA. Department of Mathematics University of Science and Technology of China Hefei China Chern Institute of Mathematics Nankai University Tianjin China Department of Mathematics Johns Hopkins University Baltimore USA

We give the sharp estimates for the degree of symmetry and the semi-simple degree of symmetry of certain compact fiber bundles with non-trivial four dimensional fibers in the sense of cobordism, by virtue of the rigidity theorem of harmonic maps due to Schoen and Yau (Topology, 18, 1979, 361-380). As a corollary of this estimate, we compute the degree of symmetry and the semi-simple degree of symmetry of CP2×V, where V is a closed smooth manifold admitting a real analytic Riemannian metric of non-positive curvature. In addition, by the Albanese map, we obtain the sharp estimate of the degree of symmetry of a compact smooth manifold with some restrictions on its one dimensional cohomology.

关键词： Degree of symmetry Fiber bundle Cobordism Non-positive Curvature Harmonic map First cohomology

Cell-specific Regulation of APOBEC3F by Interferons

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Acta Biochimica et Biophysica Sinica 2007年第4期39卷 297-304页

作者： Songcheng YING~1# Xuzhao ZHANG~1# Phuong Thi Nguyen SARKIS~2# Rongzhen XU~1 Xiaofang YU~(1,2*) 1 Second Affiliated Hospital,Cancer Institute,School of Medicine,Zhejiang University,Hangzhou 310009,China 2 Department of Molecular Microbiology and Immunology,johns hopkins BIoomberg School of Public Health,Baltimore.Maryland 21205,USA Second Affiliated Hospital Cancer Institute School of Medicine Zhejiang UniversityHangzhou 310009 China Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public HealthBaltimore Maryland 21205 USA

Human cytidine deaminase APOBEC3F（A3F）has broad anti-viral activity against hepatitis Bvirus and retroviruses including human immunodeficiency virus type ***,its regulation in viralnatural target cells such CD4+T lymphocytes,macrophages,and primary liver cells has not been *** we showed that A3F was up-regulated by interferon（IFN）-α in primary hepatocytes andmultiple liver cell lines as well as *** the IFN-α signaling pathway was active in Tlymphoid cells and induction of other IFN stimulated genes such as PKR was detected,A3F and APOBEC3G（A3G）were not induced by IFN-α in these ***,additional factors other than known IFN-stimulatedgenes also regulated IFN-α-induced A3F expression distinctly.A3F and A3G expression levels in primaryhepatocytes,especially after IFN-α stimulation,were comparable to those in CD4~ T lymphocytes in *** variations of A3F and A3G expression in primary hepatocytes from various subjectswere *** variations in A3F and/or A3G regulation and expression might influence the clinicaloutcomes of hepatitis B infection.

关键词： APOBEC3F interferon human immunodeficiency virus type 1 hepatitis B virus cytidine deaminase

单独用眼压来筛选青光眼一个过时的、应槟弃的概念

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英国医学杂志中文版 2019年第3期22卷 132-134页

作者： Henry D Jampel johns hopkins 杨一佺(译) 不详首都医科大学附属北京同仁医院眼科

在一篇链接文章中,Chan及其团队(doi: 10.1136/bmj.j3889,摘要见本期第134页)曾报道EPIC-Norfolk队列中的眼压分布和青光眼患病率情况。EPIC-Norfolk队列研究是一个以英国社区人群为基础的横截面观察性研究幕作者通过对人群眼压分布和... 详细信息

在一篇链接文章中,Chan及其团队(doi: 10.1136/bmj.j3889,摘要见本期第134页)曾报道EPIC-Norfolk队列中的眼压分布和青光眼患病率情况。EPIC-Norfolk队列研究是一个以英国社区人群为基础的横截面观察性研究幕作者通过对人群眼压分布和青光眼患病率的分析,认为仅单独用眼压来诊断青光眼是不够的。这个观点的重要性不言而喻,因为在英国国家健康体系(NHS)门诊患者中,青光眼和疑似青光眼患者占比高居第六位.

关键词：青光眼患者眼压筛选社区人群队列研究门诊患者健康体系患病率

The Green formula and heredity of algebras

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Science China Mathematics 2005年第5期48卷 610-617页

作者： ZHANG Guanglian & WANG Shuai Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China Yancheng Teachers College, Yancheng 224002, China Department of Mathematics, johns hopkins University, Baltimore, MD21218, U.S.A. Department of Mathematical Sciences Tsinghua University Beijing China Yancheng Teachers College Yancheng China Department of Mathematics Johns Hopkins University Baltimore USA

Let A be a finite dimensional algebra over a field k with q elements. It is shown that the Green formula is true in mod-A if and only if A is a hereditary algebra.

关键词： Green formula idempotent ideal hereditary algebra.

RECENT PROGRESS IN GAS BUBBLE DYNAMICS

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Journal of Hydrodynamics 1989年第3期1卷 1-10页

作者： Andrea Prosperetti Department of Mechanical Engineering The Johns Hopkins University Baltimore MD 21218' USA

Some recent work on bubble dynamics and bubbly liquids is outlined. The problem of compressibility corrections to the equation of motion of the bubble radius is addressed. A precise method for the calculation of the bubble internal pressure is described and some limit cases considered. Some numerical examples are included to illustrate the theoretical predictions. An experimental indication of the correctness of the theory is given by 'bubble-levitation' experiments. For bubbly liquids at small gas volume fractions results are shown for a 'shock-tube' problem and for the propagation of a sinusoidal pressure pulse through a thin layer of bubbly liquid.

关键词： RECENT PROGRESS IN GAS BUBBLE DYNAMICS

Microarray, SAGE and their applications to cardiovascular diseases

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Cell Research 2002年第2期12卷 105-115页

作者： SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, johns hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore USA Department of Biological Science University of Delaware Newark USA Department of Surgery University of Maryland Baltimore USA

The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE

关键词： Microarray SAGE cardiovascular diseases RNA gene expression profiling.