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Spliceosomal repression:unleashing human cell totipotency

Signal Transduction and Targeted Therapy 2024年第10期9卷 4162-4164页

作者： Felipe F.Lüttmann Kee-Pyo kim johnny kim The Center for Cardiovascular Regeneration and Immunology at TRON-Translational Oncology at the University Medical Center of the Johannes Gutenberg-University Mainz gGmbH MainzGermany Department of Medical Life Sciences College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Vascular Biology and Therapeutics Program and Department of Comparative Medicine Yale University School of MedicineNew HavenCTUSA

In a recent publication in Cell,Li et *** that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptional regulation in controlling developmental potential and provides a powerful model system for studying the process of human pre-implantation development in vitro.

关键词： al. inhibiting implantation

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Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： kim-Hung Lam Sarah Sze-Wah Ho Pik-Ling Lam johnny Cheuk-On Tang Zhao-Xiang Bian Albert Sun-Chi Chan Hua Li Wai-Yeung Wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

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Outcomes of early hospital readmission after kidney transplantation: Perspectives from a Canadian transplant centre

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World Journal of Transplantation 2023年第6期13卷 357-367页

作者： Olusegun Famure Esther Dkim Yanhong Li johnny WHuang Roman Zyla Magdalene Au Pei XuanChen Heebah Sultan Monika Ashwin Michelle Minkovich S Joseph kim Department of Nephrology Kidney TransplantToronto General HospitalToronto M5G 2N2OntarioCanada Department of Kidney Transplant Toronto General HospitalToronto M5G 2N2OntarioCanada

BACKGROUND Early hospital readmissions(EHRs)after kidney transplantation range in incidence from 18%-47%and are important and substantial healthcare quality *** can adversely impact clinical outcomes such as graft function and patient mortality as well as healthcare *** have been extensively studied in American healthcare systems,but these associations have not been explored within a Canadian *** to significant differences in the delivery of healthcare and patient outcomes,results from American studies cannot be readily applicable to Canadian populations.A better understanding of EHR can facilitate improved discharge planning and long-term outpatient management post kidney *** To explore the burden of EHR on kidney transplant recipients(KTRs)and the Canadian healthcare system in a large transplant *** This single centre cohort study included 1564 KTRs recruited from January 1,2009 to December 31,2017,with a 1-year *** defined EHR as hospitalizations within 30 d or 90 d of transplant discharge,excluding elective *** Cox and linear regression models were used to examine EHR,late hospital readmissions(defined as hospitalizations within 31-365 d for 30-d EHR and within 91-365 d for 90-d EHR),and outcomes including graft function and patient *** In this study,307(22.4%)and 394(29.6%)KTRs had 30-d and 90-d EHRs,*** such as having previous cases of rejection,being transplanted in more recent years,having a longer duration of dialysis pretransplant,and having an expanded criteria donor were associated with EHR *** cumulative probability of death censored graft failure,as well as total graft failure,was higher among the 90-d EHR group as compared to patients with no *** multivariable models found no significant association between EHR and patient mortality,patients with EHR were at an increased risk of late hospital readmissions,poorer kidney fun

关键词： Kidney Transplantation Early hospital readmissions Incidence and trends Post-transplant outcomes

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