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World Journal of Traditional Chinese Medicine 2024年第2期10卷 149-158页

作者： Eric Wei Chiang chan Hung Tuck chan Siu Kuin Wong Department of Food Science and Nutrition Faculty of Applied SciencesUCSI UniversityCherasKuala LumpurMalaysia Secretariat of International Society for Mangrove Ecosystems Faculty of AgricultureUniversity of the RyukyusOkinawaJapan School of Foundation Studies Xiamen University MalaysiaSepangSelangorMalaysia

The rich chemical constituents and diverse pharmacological properties of Ramulus Mori(RM) or the twig of Morus alba with evidence supported by clinical trials and patents are reviewed. Known as Sangzhi in Chinese, RM is widely used in traditional Chinese medicine to treat gout, arthritis, and rheumatism. Chemical constituents include flavonoids, benzofurans, alkaloids, stilbenes, chalcones, phenolic acids, and coumarins. Bioactivities of RM include antidiabetic, anti-obesity, anti-inflammatory, antityrosinase, neuroprotective, antioxidant, hepatoprotective, cytoprotective, renoprotective, antihyperuricemic, analgesic, antifungal, DNA protective, anticancer, gastroprotective, cardioprotective, anti-hair aging, anti-arthritic, and antiplatelet aggregation properties. The most active compounds from RM are mulberrin, oxyresveratrol, and mulberroside A. All four clinical trials on RM are focused on the treatment of diabetes. The patents entail using RM extracts as cosmetics for skin whitening and as agents for hypoglycemia. Topics for further research on RM are suggested.

关键词： Clinical trials mulberrin mulberroside A oxyresveratrol patents Sangzhi

Construction of a High‑Performance Composite Solid Electrolyte Through In‑Situ Polymerization within a Self‑Supported Porous Garnet Framework

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Nano-Micro Letters 2024年第5期16卷 56-70页

作者： An‑Giang Nguyen Min‑Ho Lee Jaekook Kim chan‑Jin Park Department of Materials Science and Engineering Chonnam National University77 Yongbong‑roBuk‑guGwangju 61186South Korea

Composite solid electrolytes(CSEs)have emerged as promising candidates for safe and high-energy–density solid-state lithium metal batteries(SSLMBs).However,concurrently achieving exceptional ionic conductivity and interface compatibility between the electrolyte and electrode presents a significant challenge in the development of high-performance CSEs for *** overcome these challenges,we present a method involving the in-situ polymerization of a monomer within a self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZT)to produce the *** synergy of the continuous conductive LLZT network,well-organized polymer,and their interface can enhance the ionic conductivity of the CSE at room ***,the in-situ polymerization process can also con-struct the integration and compatibility of the solid electrolyte–solid electrode *** synthesized CSE exhibited a high ionic conductivity of 1.117 mS cm^(-1),a significant lithium transference number of 0.627,and exhibited electrochemical stability up to 5.06 V ***/Li+at 30℃.Moreover,the Li|CSE|LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cell delivered a discharge capacity of 105.1 mAh g^(-1) after 400 cycles at 0.5 C and 30℃,corresponding to a capacity retention of 61%.This methodology could be extended to a variety of ceramic,polymer electrolytes,or battery systems,thereby offering a viable strategy to improve the electrochemical properties of CSEs for high-energy–density SSLMBs.

关键词： Scalable tape-casting method Self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Composite solid electrolyte LiF-and B-rich interphase layers

In situ infrared, Raman and X-ray spectroscopy for the mechanistic understanding of hydrogen evolution reaction

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Journal of Energy Chemistry 2024年第3期90卷 632-651,I0014页

作者： Andi Haryanto Kyounghoon Jung chan Woo Lee Dong-Wan Kim Department of Chemistry Kookmin UniversitySeoul 02707Republic of Korea School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

Hydrogen production by water reduction reactions has received considerable attention because hydrogen is considered a clean-energy carrier,key for a sustainable energy *** methods have been widely used to study the reaction mechanism of the hydrogen evolution reaction(HER),but the calculation results need to be supported by experimental results and direct evidence to confirm the mechanistic *** this review,we discuss the fundamental principles of the in situ spectroscopic strategy and a theoretical model for a mechanistic understanding of the *** addition,we investigate recent studies by in situ Fourier transform infrared(FTIR),Raman spectroscopy,and X-ray absorption spectroscopy(XAS) and cover new findings that occur at the catalyst-electrolyte interface during *** spectroscopic strategies provide practical ways to elucidate catalyst phase,reaction intermediate,catalyst-electrolyte interface,intermediate binding energy,metal valency state,and coordination environment during HER.

关键词： Hydrogen evolution reaction Infrared spectroscopy Raman spectroscopy X-ray absorption spectroscopy Reaction mechanism

Detection of Turbulence Anomalies Using a Symbolic Classifier Algorithm in Airborne Quick Access Record(QAR)Data Analysis

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Advances in Atmospheric Sciences 2024年第7期41卷 1438-1449页

作者： Zibo ZHUANG Kunyun LIN Hongying ZHANG Pak-Wai chan Flight Academy Civil Aviation University of ChinaTianjin 300300China School of Electronic Information and Automation Civil Aviation University of ChinaTianjin 300300China Aviation Weather Services Hong Kong ObservatoryHong KongChina

As the risks associated with air turbulence are intensified by climate change and the growth of the aviation industry,it has become imperative to monitor and mitigate these threats to ensure civil aviation *** eddy dissipation rate(EDR)has been established as the standard metric for quantifying turbulence in civil *** study aims to explore a universally applicable symbolic classification approach based on genetic programming to detect turbulence anomalies using quick access recorder(QAR)*** detection of atmospheric turbulence is approached as an anomaly detection *** evaluations demonstrate that this approach performs on par with direct EDR calculation methods in identifying turbulence ***,comparisons with alternative machine learning techniques indicate that the proposed technique is the optimal methodology currently *** summary,the use of symbolic classification via genetic programming enables accurate turbulence detection from QAR data,comparable to that with established EDR approaches and surpassing that achieved with machine learning *** finding highlights the potential of integrating symbolic classifiers into turbulence monitoring systems to enhance civil aviation safety amidst rising environmental and operational hazards.

关键词： turbulence detection symbolic classifier quick access recorder data

Magnetically controllable multimode interference in topological photonic crystals

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Light(Science & Applications) 2024年第5期13卷 998-1005页

作者： Weiyuan Tang Mudi Wang Shaojie Ma Che Ting chan Shuang Zhang New Cornerstone Science Laboratory Department of PhysicsThe University of Hong KongHong KongChina. Department of Physics The Hong Kong University of Science and TechnologyHong KongChina. Department of Optical Science and Engineering Fudan UniversityShanghai 200433China

Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp *** number of topological edge states relies on the difference between the bulk Chern numbers across the boundary,as dictated by the bulk edge *** interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic *** this work,we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different *** successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of *** work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.

关键词： multimode controllable microwave

A computation design method for architectural artifacts adapted from traditional Kagome bamboo basketry techniques

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Frontiers of Architectural Research 2024年第2期13卷 249-264页

作者： Hiroyuki Shinohara Tung Hoi Peter chan School of Architecture The Chinese University of Hong KongHong KongChina

This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven *** is a trihexagonal pattern employed in traditional bamboo basketry as a triaxial weaving system,resulting in an object with a self-bracing capacity without the use of fasteners owing to its interlacing *** existing studies and tools have addressed triaxial weaving design and representation,the current consideration of the advantages of weaving with bamboo is *** address this research gap,this study develops a computational design method based on studies on bamboo *** allows for the representation and exploration of design geometries using combinations of regular triangular meshes for the fabrication of Kagome woven bamboo artifacts.A full-scale mock-up was fabricated to evaluate the effectiveness of the *** mock-up demonstrated the self-bracing properties of Kagome,but there were discrepancies between the mock-up and the *** affecting bamboo weaving on an architectural scale have been identified within this study to inform future research on woven bamboo structures.

关键词： Traditionalbamboo craft Triaxialmaterial interlacing Bamboo Computational design methods Mesh block combinationsystem Architecturalwoven artifact

Enhancing Identity Protection in Metaverse-Based Psychological Counseling System

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Computers, Materials & Continua 2024年第1期78卷 617-632页

作者： Jun Lee Hanna Lee Seong chan Lee Hyun Kwon Department of Game Software Hoseo UniversityAsan-si31499Korea Yatav Enter Seoul04799Korea Department of Artificial Intelligence and Data Science Korea Military AcademySeoul01805Korea

Non-face-to-face psychological counseling systems rely on network technologies to anonymize information regard-ing client ***,these systems often face challenges concerning voice data leaks and the suboptimal communication of the client’s non-verbal expressions,such as facial cues,to the *** study proposes a metaverse-based psychological counseling system designed to enhance client identity protection while ensuring efficient information delivery to counselors during non-face-to-face *** proposed systemincorporates a voicemodulation function that instantlymodifies/masks the client’s voice to safeguard their ***,it employs real-time client facial expression recognition using an ensemble of decision trees to mirror the client’s non-verbal expressions through their avatar in the metaverse *** system is adaptable for use on personal computers and smartphones,offering users the flexibility to access metaverse-based psychological counseling across diverse *** performance evaluation of the proposed system confirmed that the voice modulation and real-time facial expression replication consistently achieve an average speed of 48.32 frames per second or higher,even when tested on the least powerful smartphone ***,a total of 550 actual psychological counseling sessions were conducted,and the average satisfaction rating reached 4.46 on a 5-point *** indicates that clients experienced improved identity protection compared to conventional non-face-to-face metaverse counseling ***,the counselor successfully addressed the challenge of conveying non-verbal cues from clients who typically struggled with non-face-to-face psychological *** proposed systemholds significant potential for applications in interactive discussions and educational activities in the metaverse.

关键词： Metaverse counseling system face tracking identity protection

New evidence for the epigenetic regulation of skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao Charles K.F.chan Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

Enhanced Strength-Ductility Synergy in Submerged Friction Stir Processing ER2319 Alloy Manufactured by Wire-Arc Additive Manufacturing via Creating Ultrafine Microstructure

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 793-807页

作者： Jinpeng Hu Tao Sun Fujun Cao Yifu Shen Zhiyuan Yang chan Guo College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics(NUAA)Nanjing 210016China

Submerged friction stir processing(SFSP)with flowing water was employed to alleviate the porosities and coarse-grained structure introduced by wire-arc *** a result,uniform and ultrafine grained(UFG)structure with average grain size of 0.83μm was achieved with the help of sharply reduced heat input and holding time at elevated *** optimized UFG structure enabled a superior combination of strength and ductility with high ultimate tensile strength and elongation of 273.17 MPa and 15.39%.Specifically,grain refinement strengthening and decentralized θ(Al_(2)Cu)phase in the sample subjected to SFSP made great contributions to the enhanced *** addition,the decrease in residual stresses and removal of pores substantially enhance the *** rates of cooling and low temperature cycling,which are facilitated by the water-cooling environment throughout the machining process,are vital in obtaining superior *** work provides a new method for developing a uniform and UFG structure with excellent mechanical properties.

关键词： Submerged friction stir processing Wire-arc additive manufacturing Al-Cu alloy Residual stress Strengthening and toughening mechanism Ultrafine grained microstructure

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin