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High Voltage 2021年第1期6卷 82-94页

作者： johnatan m.rodríguez‐serna Ricardo Albarracín‐Sánchez Department of Electrical and Electronic Engineering Automatic Controland Applied PhysicsSchool of Industrial Design and Engineering(ETSIDI)Universidad Politécnica de Madrid(UPM)MadridSpain Department of Electrical Engineering Universidad de AntioquiaMedellínColombia

Electrical trees are defects originated and driven by partial discharges(PD)activity and this is the reason why their modelling and simulation are fundamental for the ageing mechanisms comprehension and diagnosis analyses of insulation systems compound by solid *** study presents a brief review of the different models implemented to simulate PD in electrical trees inside solid *** addition,an improved deterministic model as well as a stochastic model are presented,which allow predicting adequately the PD pulses distribution,in magnitudes and phase,for non‐conducting electrical trees of different shape and *** case studies were simulated and their results exhibit good agreement when compared with measurements presented in the *** is concluded that the main parameters that state the PD behaviour in trees are the inception and extinction voltage mag-nitudes,including their probability distributions,and the tree *** models can be used for prognosis analysis based on on‐line measurements.

关键词： solid conducting electrical

Finite-element-analysis models for numerical simulation of partial discharges in spherical cavities within solid dielectrics:a review and a novel method

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High Voltage 2020年第5期5卷 556-568页

作者： johnatan m.rodríguez-serna Ricardo Albarracín-Sánchez Abdullahi A.mas'ud Department of Electrical and Electronic Engineering Automatic Controland Applied PhysicsSchool of Industrial Design and Engineering(ETSIDI)Universidad Politécnica de Madrid(UPM)Ronda de Valencia 328012MadridSpain 2Department of Electrical EngineeringUniversidad de AntioquiaCalle 67 No.53-108MedellínColombia 3Department of Electrical and Electronic Engineering TechnologyJubail Industrial College31961JubailSaudi Arabia

During the last two decades,partial discharges(PDs)modelling methods have been used as a complement of insulation diagnosis systems of electrical ***-element-analysis models for simulating PDs in cavities within solid dielectric materials are reviewed and a novel model is presented,which combines the main advantages of electrostatic and electric current *** theoretical background is presented and some limitations and restrictions are discussed.A case of study was implemented for three different ageing conditions and simulation results exhibit good agreement with reported values by other authors in the *** analysis of variations of PD behaviour with ageing as a function of temperature and pressure is briefly *** is concluded that more research is needed to include physical and chemical interactions on the void surface and that the cavity surface conductivity plays a fundamental role in the PD simulations at advanced ageing conditions.

关键词： element analysis solid

Rheumatoid Factor and Anti Citrulinated Peptide. Relation with Remission and Progression in Rheumatoid Arthritis with Biologic Agent Therapy, during a One-Year Follow-Up

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Open Journal of Rheumatology and Autoimmune Diseases 2014年第1期4卷 34-38页

作者： Asunción Acosta Pereira Berta magallares López Esther moga Naranjo Arturo rodríguez de la serna Division of Rheumatology Department of Internal Medicine Hospital Sant Pau Barcelona Spain.

The aim of this study is to assess the variations of the RF and ACCP in RA patients treated with biologics in actual clinical practice (real) conditions for a one-year follow-up from the first biologic medication. The evaluated patients with a diagnosis of RA, according to the American College of Rheumatology (ACR) 1987 were selected from the outpatient consult of Rheumatology of the “Hospital de Sant Pau” during one month (November 2012). We collected and analyzed data from 41 patients with RA and positivity for RF and/or ACCP. Of the 41 patients had given FR and ACCP at 3, 6 and 12 months respectively in 18 and 10 patients. In 22 patients had given DAS 28 at 3, 6 and 12 months respectively. The mean age of the sample is 55 years (range 29-79), with a mean disease progression 9 years (4 months to 32 years). 70% are women. 33 patients (80.5%) initiated treatment with anti-TNF and 8 (19.5%) with other no anti-TNF mechanism of action. There was a statistically significant (p = 0.001, ANOVA) decrease in DAS 28 (average decrease of 1.6 points) at 3 months is maintained at 6 and 12 m and no significant differences in their evolution by separating anti-TNF drugs vs. other biological agents (different mechanisms of action (p = 0.285). So we have not detected a correlation between DAS 28 and FR or ACCP along the first 12 months of biological treatment. In our experience we did not find a correlation between DAS 28 and RF or ACCP, thus RF and ACCP do not appear to predict the response to treatment.

关键词： Rheumatoid Arthritis Rheumatoid Factor Anticitrulin Antibodies

OTB-morph:One-time Biometrics via morphing

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machine Intelligence Research 2023年第6期20卷 855-871页

作者： mahdi Ghafourian Julian Fierrez Ruben Vera-rodriguez Aythami morales Ignacio serna Biometrics and Data Pattern Analytics Laboratory(BiDA Lab) Universidad Autonoma de MadridMadrid28049Spain

Cancelable biometrics are a group of techniques to transform the input biometric to an irreversible feature intentionally using a transformation function and usually a key in order to provide security and privacy in biometric recognition *** transformation is repeatable enabling subsequent biometric *** paper introduces a new idea to be exploited as a transformation function for cancelable biometrics aimed at protecting templates against iterative optimization *** proposed scheme is based on time-varying keys(random biometrics in our case)and morphing *** experimental implementation of the proposed scheme is given for face *** results confirm that the proposed approach is able to withstand leakage attacks while improving the recognition performance.

关键词： Biometrics face recognition template protection morphing security

Extremal Coalitions for Influence Games Through Swarm Intelligence-Based methods

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Computers, materials & Continua 2022年第3期70卷 6305-6321页

作者： Fabián Riquelme rodrigo Olivares Francisco munoz Xavier molinero maria serna Escuela de Ingeniería Informática Universidad de ValparaísoValparaísoChile Computer Science Department Universitat Politècnica de CatalunyaBarcelonaSpain mathematics Department Universitat Politècnica de CatalunyaTerrassaSpain

An influence game is a simple game represented over an influence graph(i.e.,a labeled,weighted graph)on which the influence spread phenomenon is *** games allow applying different properties and parameters coming from cooperative game theory to the contexts of social network analysis,decision-systems,voting systems,and collective *** exact calculation of several of these properties and parameters is computationally hard,even for a small number of *** examples of these parameters are the length and the width of a *** length of a game is the size of its smaller winning coalition,while the width of a game is the size of its larger losing *** parameters are relevant to know the levels of difficulty in reaching agreements in collective decision-making *** the above,new bio-inspired metaheuristic algorithms have recently been developed to solve the NP-hard influence maximization problem in an efficient and approximate way,being able to find small winning coalitions that maximize the influence spread within an influence *** this article,we apply some variations of this solution to find extreme winning and losing coalitions,and thus efficient approximate solutions for the length and the width of influence *** a case study,we consider two real social networks,one formed by the 58 members of the European Union Council under nice voting rules,and the other formed by the 705 members of the European Parliament,connected by political *** are promising and show that it is feasible to generate approximate solutions for the length and width parameters of influence games,in reduced solving time.

关键词： Influence game influence spread collective behavior swarm intelligence bio-inspired computing

Electrochemical Corrosion Study in H₂SO₄ of NiAl with Cu Additions, microstructure and micro-Hardness at Room Temperature

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Journal of minerals and materials Characterization and Engineering 2022年第3期10卷 225-241页

作者： Jesús m. Colín de la Cruz Sergio A. serna Barquera Alvaro Torres-Islas Arturo molina-Ocampo Edgar Valenzuela José G. González rodríguez Universidad Autónoma del Estado de morelos Facultad de Ciencias Químicas e Ingeniería UAEM-FCQeI. Av. Universidad 1001Colonia Chamilpa Cuernavaca Morelos México Universidad Autónoma del Estado de morelos Centro de Investigación en Ingeniería y Ciencias Aplicadas UAEM-CIICAp Cuernavaca Morelos México UABC Baja California Sur México

For many years, intermetallic materials promise applications in a wide variety of technology areas. NiAl intermetallic compound is material that exhibits important characteristics such as high corrosion resistance and low density besides its ability to retain strength and stiffness at elevated temperatures. However NiAl intermetallic is too hard, brittle and exhibits very low ductility at room temperature being the reason because this material is not yet available for structural applications. In order to increase the ductility of the NiAl intermetallic compound, the addition of a third alloying element has been proved, nevertheless it is important to determine if such additions decrease or increase the hardness and the corrosion resistance of the alloy. So, the present investigation reports the corrosion performance of the NiAl intermetallic compound modified with Cu, emphasizing the EIS analysis and the relation between physical parameters and the modelling equations used in the Equivalent Electric Circuit. It was found that the addition of Cu promotes the formation of the γ’-Ni3Al phase in Cu contents greater than 15 at. %, in addition to a decrease in micro hardness and an increment in the Icorr values. In this way, the electrochemical characterization evidenced a high corrosion resistance of these intermetallic alloys.

关键词： NiAl-Cu Corrosion Behavior Electrochemical Impedance Spectrum Vickers micro Hardness microstructure

Effects of dielectric stoichiometry on the photoluminescence properties of encapsulated WSe2 monolayers

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Nano Research 2018年第3期11卷 1399-1414页

作者： Javier martfn-Sanchez Antonio mariscal marta De Luca Aitana Tarazaga martin-Luengo Georg Gramse Alma Halilovic Rosalia serna Alberta Bonanni Ilaria Zardo Rinaldo Trotta Armando Rastelli Institute of Semiconductor and Solid State Physics Johannes Kepler University Linz Altenbergerstrasse 69 A-4040 Linz Austria Laser Processing Group Instituto de Optica CSIC C/Serrano 121 28006 Madrid Spain Department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Institute for Biophysics Johannes Kepler University Linz Gruberstrasse 40 A-4020 Linz Austria

Two-dimensional transition metal dichalcogenide semiconductors have emerged as promising candidates for optoelectronic devices with unprecedented properties and ultra-compact footprints. However, the high sensitivity of atomically thin materials to the surrounding dielectric media imposes severe limitations on their practical applicability. Hence, to enable the effective integration of these materials in devices, the development of reliable encapsulation procedures that preserve their physical properties is required. Here, the excitonic photoluminescence （at room temperature and 10 K） is assessed on mechanically exfoliated WSe2 monolayer flakes encapsulated with SiOx and AlxOy layers by means of chemical and physical deposition techniques. Conformal coating on untreated and non- functionalized flakes is successfully achieved by all the techniques examined, with the exception of atomic layer deposition, for which a cluster-like oxide coating is formed. No significant compositional or strain state changes in the flakes are detected upon encapsulation, independently of the technique adopted. Remarkably, our results show that the optical emission of the flakes is strongly influenced by the stoichiometry quality of the encapsulating oxide. When the encapsulation is carried out with slightly sub-stoichiometric oxides, two remarkable phenomena are observed. First, dominant trion （charged exciton） photoluminescence is detected at room temperature, revealing a clear electrical doping of the monolayers. Second, a strong decrease in the optical emission of the monolayers is observed, and attributed to non-radiative recombination processes and/or carrier transfer from the flake to the oxide. Power- and temperature-dependent photoluminescence measurements further confirm that stoichiometric oxides obtained by physical deposition lead to a successful encapsulation, opening a promising route for the development of integrated two-dimensional devices.

关键词： two dimensional (2D)materials dielectric encapsulation transition metaldichalcogenides semiconductors photoluminescence WSe2

Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system

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Synthetic and Systems Biotechnology 2021年第3期6卷 231-241页

作者： Alexander Van de Steen Rana Khalife Noelle Colant Hasan mustafa Khan matas Deveikis Saverio Charalambous Clare m.Robinson Rupali Dabas Sofia Esteban serna Diana A.Catana Konstantin Pildish Vladimir Kalinovskiy Kenth Gustafsson Stefanie Frank Department of Biochemical Engineering University College LondonUK Natural Sciences University College LondonUK Division of Biosciences University College LondonUK UCL iGEm Student Team 2019 UK

The development of Drug Delivery Systems(DDS)has led to increasingly efficient therapies for the treatment and detection of various *** use a range of nanoscale delivery platforms produced from polymeric of inorganic materials,such as micelles,and metal and polymeric nanoparticles,but their variant chemical composition make alterations to their size,shape,or structures inherently *** encoded protein nanocages are highly promising DDS candidates because of their modular composition,ease of recombinant production in a range of hosts,control over assembly and loading of cargo molecules and *** example of naturally occurring nanocompartments are encapsulins,recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine *** we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein(DARPin)on the outer surface and to encapsulate a cytotoxic *** DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2(HER2)on breast cancer cells,as demonstrated in an in vitro cell culture *** encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator(miniSOG),from a single plasmid in Escherichia *** encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis,indicating that the system is functional and *** DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries,allowing use of new DARPins of known specificities,and through the proven flexibility of the encapsulin cargo loading mechanism,allowing selection of cargo proteins

关键词： Encapsulin Drug delivery system Cytotoxic protein DARPin

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia maría Trujillo-rodriguez Ana serna-Gallego Esperanza muñoz-muela maría de los Reyes Jiménez-Leon mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-mateos Josémiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-martínez Carmen Infante-Domínguez marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo márquez Josémanuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero maría Dolores Avilés maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba máximo Bernabeu-Wittel Candela Caballero-Eraso macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa michelle Espinoza Carmen Ferrándiz-millón marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-mancera Emilio García Horacio García-Delgado manuel García-Gutiérrez maría Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-melero marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-márquez Daniel macías-García Guillermo martín-Gutiérrez Luis martín-Villén Josémolina Aurora morillo maría Dolores Navarro-Amuedo Dolores Nieto-martín Francisco Ortega maría Paniagua-García Amelia Peña-rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

Chemical Degradation of Indigo Potassium Tetrasulfonate Dye by Advanced Oxidation Processes

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Journal of Environmental Protection 2014年第13期5卷 1342-1351页

作者： Veronica Camargo Elba Ortiz Hugo Solis Carlos m. Cortes-Romero Sandra Loera-serna Carlos J. Perez Department of Basic Sciences Universidad Autónoma Metropolitana Azcapotzalco Mexico City Mexico Division of Industrial and Systems Engineering Universidad Politecnica del Valle de México Estado de Mexico Mexico

The experimental degradation of a water soluble dye, potassium indigo tetrasulfonate salt, has been studied using stand-alone ozonation and photocatalytic oxidation process. Progress of the dye oxidation was followed by UV-VIS spectrophotometric measurements at controlled operating conditions. The organic content of reaction samples was measured to verify the process efficiency in dye mineralization. According to current results, almost complete color removal was obtained for ozonation within about 1 h reaction time. The reduction of the organic load was almost 80% from its original while initial sulphur content decreased to 32.5%. Dye conversion of 100% was obtained by means of a photocatalytic process using TiO2 as catalyst at 294 nm irradiated UV light. This complete color removal for the catalytic process was observed within 7 min of reaction time. The calculated initial rate of reaction of photocatalysis treatment was 8 times faster than that of ozonolysis. However, the remaining organic load of photocatalysis was almost 88% from its original while the final sulphur content was 27.3%. This contrasting behavior of the performance of the type of oxidation process stressed importance of physicochemical phenomena and intermediates molecules present during dye degradation. An insightful and mechanistic aspect of the dye oxidation was developed by performing quantumchemical calculations.

关键词： Indigo Potassium Tetrasulfonate Advanced Oxidation Processes Chemical Degradation Theoretical Calculations