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A Simulation Model for the Risk of Fetal Exposure Originated by the Zika Virus (VIZK)

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Health 2016年第12期8卷 1178-1186页

作者： Dalia M. muñoz Pizza Anibal muñoz Loaiza Oscar A. Manrique Arias Vanessa Abello Sossa Carlos A. Abello muñoz Steven Raigosa osorio Hans Meyer Contreras john F. Arredondo Montoya Gonzaga Ospina Patiño Irma Pérez Contreras Maria E. Cardenas Perea Miguel A. Enríquez Guerra Jesús A. Valdez García Grupo de Modelación Matemática en Epidemiología (GMME) Facultad de Educación Universidad del Quindío Quindío Colombia Facultad de Medicina Benemérita Universidad Autónoma de Puebla Puebla México

It is set and analyzed a simulation model based on non-linear ordinary differential equations to interpret the dynamics of the microcephaly incidence caused by the Zika virus in a risk group of pregnant women. This one is induced by a population of men in a reproductive age. Also, some parameters of the model were estimated for an average temperature of 23℃ and by using the adjusted functions from references [1] [2]. All system simulations were done with the Maple software and parameters values obtained from several sources (estimated, hypothetic, and form literature). It has been found that the application of contraceptive measures impacts the population of sexually active women. As result, the exposure to congenital abnormalities increases, particularly, microcephaly.

关键词： Model Microcephaly Zika Virus Basic Reproduction number Risk Group Incidence

Diagnostic Approach of Thrombocytopenia in Pregnancy: A Review

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 784-792页

作者： john Alexander Yela Cono Sandra Ximena Olaya David Ricardo murillo-Garcia Brahyan osorio Juan David Hernández Susana Lopez de Valencia Hospital Popayán Colombia Institución Universitaria Visión de las Américas Pereira Colombia The Jewish Hospital Cincinnati USA Universidad Tecnológica de Pereira Pereira Colombia

Thrombocytopenia (defined as platelet count 9/L) is present in 7% - 12% of pregnant women at delivery. Although there are mild etiologies of this condition that are often diagnosed incidentally, there are more severe causes that can be life threating. Thrombocytopenia also has a great implication in surgical risk and regional anesthesia. A structured evaluation of thrombocytopenia is necessary to allow an adequate diagnostic approach. Here we summarized the current knowledge of thrombocytopenia in pregnancy.

关键词： Pregnancy Thrombocytopenia Gestational Thrombocytopenia Preeclampsia HELLP Syndrome Immune Thrombocytopenia Thrombotic Microangiopathy Heparin-Induced Thrombocytopenia Disseminated Intravascular Coagulation

A Simulation Model for Sexual and Vectorial Transmission of Zika Virus(ZIKV)

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Open Journal of Modelling and Simulation 2017年第1期5卷 70-82页

作者： Oscar Arias Manrique Dalia M.munoz Pizza Anibal munoz Loaiza Julian A.Olarte Garcia Carlos A.Abello munoz Steven Raigosa osorio Angie Johanna osorio Hans Meyer Contreras john F.Arredondo Montoya Grupo de Modelacion Matematica en Epidemiologia(GMME) Facultad de EducacionUniversidad del QuindioQuindioColombia

nowadays the Zika virus (ZIKV) has been one of the most studied vector-borne diseases due to the considerable outbreaks that have generated around the world as well as due to the new transmission mechanisms and health complications originated. According to statistics of the InS-Colombia for July 2016, 68% of the population infected by ZIKV (confirmed cases) are pregnant women. Furthermore, the Quindío department belongs to the states with more than 50% of the total infected persons being pregnant women. Taking into account those characteristics, a theoretical model is proposed and analyzed to describe the population dynamics considering the sexual and vectorial transmission of ZIKV, with special emphasis in the consequences of the non-vectorial transmission in the population. The obtained results with simulations through the beta parameter indicate that the probability of sexual transmission between susceptible women and infected men points out the importance of campaigns to inculcate prevention measures for the safe sexual relationships between ZIKV infected population.

关键词： ZIKV Model Dynamics Sexual Transmission Vectorial Transmission

FDG and Amyloid PET in Cognitively normal Individuals at Risk for Late-Onset Alzheimer’s Disease

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Advances in Molecular Imaging 2014年第2期4卷 15-26页

作者： john murray Wai H. Tsui Yi Li Pauline McHugh Schantel Williams Megan Cummings Elizabeth Pirraglia Lilja Solnes Ricardo osorio Lidia Glodzik Shankar Vallabhajosula Alexander Drzezga Satoshi Minoshima Mony J. de Leon Lisa Mosconi new York University School of Medicine New York USA University of Cologne Cologne Germany University of Washington Seattle USA Weill Cornell Medical College New York USA

Having a parent affected by late-onset Alzheimer’s disease (AD) is a major risk factor for cognitively normal (nL) individuals. This study explores the potential of PET with 18F-FDG and the amyloid-β (Aβ) tracer 11C-Pittsburgh Compound B (PiB) for detection of individual risk in nL adults with AD-parents. Methods: FDG- and PiB-PET was performed in 119 young to late-middle aged nL individuals including 80 nL with positive family history of AD (FH+) and 39 nL with negative family history of any dementia (FH-). The FH+ group included 50 subjects with maternal (FHm) and 30 with paternal family history (FHp). Individual FDG and PiB scans were Z scored on a voxel-wise basis relative to modality-specific reference databases using automated procedures and rated as positive or negative (+/-) for AD-typical abnormalities using predefined criteria. To determine the effect of age, the cohort was separated into younger (49 ± 9 y) and older (68 ± 5 y) groups relative to the median age (60 y). Results: Among individuals of age >60 y, as compared to controls, nL FH+ showed a higher frequency of FDG+ scans vs. FH- (53% vs. 6% p nd a trend for PiB+ scans (27% vs. 11%;p = 0.19). This effect was observed for both FHm and FHp groups. Among individuals of age ≤60 y, nL FHm showed a higher frequency of FDG+ scans (29%) compared to FH- (5%, p = 0.04) and a trend compared to FHp (11%) (p = 0.07), while the distribution of PiB+ scans was not different between groups. In both age cohorts, FDG+ scans were more frequent than PiB+ scans among nL FH+, especially FHm (p nificant predictor of FH+ status. Classification according to PiB status was significantly less successful. Conclusions: Automated analysis of FDG- and PiB-PET demonstrates higher rates of abnormalities in at-risk FH+ vs FH-subjects, indicating potentially ongoing early AD-pathology in this population. The frequency of metabolic abnormalities was higher than that of Aβ pathology in the younger c

关键词： Alzheimer’s Disease Early Detection Positron Emission Tomography Amyloid Imaging Glucose Metabolism normal Aging

Diagnostic Approach of Thrombocytopenia in Pregnancy: A Review

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