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Extr.-hepatic manifestations associated with hepatitis E vir.s infection:a compr.hensive r.view of the liter.tur.

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Gastr.enter.logy r.por. 2016年第1期4卷 1-15,I0001页

作者： Fateh Bazer.achi Samir.Haffar.Sushil K Gar. john r.lake Division of Gastr.enter.logy and Hepatology University of MinnesotaMinneapolisMN 55455USA Depar.ment of Gastr.enter.logy and Hepatology University of DamascusDamascusSyrian Arab Republic

Backgr.und and aims:Hepatitis E vir.s(HEV)infection is a significant public health pr.blem that afflicts almost 20 million individuals annually and causes acute liver.injur. in 3.5 million,with appr.ximately 56000 *** with other.vir.l hepatitides,extr.-hepatic manifestations could r.pr.sent an impor.ant aspect of this *** spectr.m of these manifestations is still *** pancr.atitis and neur.logical,musculoskeletal,hematological,r.nal,and other.immune-mediated manifestations have been *** aim of this ar.icle is to compr.hensively r.view the published liter.tur. of extr.-hepatic manifestations associated with HEV *** sour.es:We sear.hed the PubMed database using the MeSH ter.“hepatitis E”and each of the extr.-hepaticmanifestations associated with HEV *** language or.date r.str.ctions wer. set in these *** r.tr.eving ar.icles with non-A,non-B hepatitis wer. *** ar.icles wer. identified thr.ugh the r.fer.nce lists of included ***:Sever.l extr.-hepatic manifestations associated with HEV infection have been *** tempor.l association between some extr.-hepatic manifestations and HEV infection and the exclusion of other.possible etiologies suggests that HEV infection could have caused some of *** to the available data,HEV infection appear. to be str.ngly associated with acute pancr.atitis,neur.logical disor.er.(with pr.mar.ly dominant per.pher.l ner.e involvement,most commonly manifested as Guillain-Bar.e´syndr.me,followed by neur.lgic amyotr.phy),hematological diseases(hemolytic anemia due to glucose phosphate dehydr.genase deficiency,and sever. thr.mbocytopenia),glomer.lonephr.tis,and mixed *** data ar. needed to clar.fy whether.an association exists with musculoskeletal or.other.immunemediated ***:HEV infection should be consider.d in patients with acute pancr.atitis,Guillain-Bar.e´syndr.me,neur.lgic amyotr.phy,hem

关键词： hepatitis E vir.s vir.l hepatitis extr.-hepatic manifestations vaccine pr.mar. pr.vention

A Conceptual Model of Our.Univer.e Der.ved fr.m the Fine Str.ctur. Constant (α)

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Amer.can Jour.al of Computational Mathematics 2023年第4期13卷 524-532页

作者： john r. Cr.r. Independent r.sear.her Lake Zurich IL USA

The Fine Str.ctur. Constant (α) is a dimensionless value that guides much of quantum physics but with no scientific insight into why this specific number. The number.defines the coupling constant for.the str.ngth of the electr.magnetic for.e and is pr.cisely tuned to make our.univer.e functional. This study intr.duces a novel appr.ach to under.tanding a conceptual model for.how this cr.tical number.is par. of a lar.er.design r.ther.than a r.ndom accident of natur.. The Fine Str.ctur. Constant (FSC) model employs a Python pr.gr.m to calculate n-dimensional pr.per.y sets for.pr.me number.univer.es wher. α equals the whole number.values 137 and 139, r.pr.senting twin pr.me univer.es without a fr.ctional constant. Each pr.per.y is defined by theor.tical pr.me number.sets that r.pr.sent focal points of matter.and wave ener.y in their.r.spective univer.es. This wor. aims to deter.ine if these pr.me number.sets can r.pr.duce the obser.ed α value, giving it a definable str.ctur.. The r.sult of the FSC model pr.duces a α value equal to 137.036, an almost exact match. Fur.her.or., the model indicates that other.twin pr.me pair. also have a r.le in our.functional univer.e, pr.viding a hier.r.hy for.atomic or.ital ener.y levels and alignment with the pr.ncipal and azimuthal quantum number.. In addition, it constr.es stable matter.as pr.per.y sets with the highest r.tio of twin pr.me elements. These r.sults pr.vide a new per.pective on a mathematical str.ctur. that shapes our.univer.e and, if valid, has the str.ctur.l complexity to guide futur. r.sear.h.

关键词： Fine Str.ctur. Constant Conceptual Model Pr.me Number. Pr.per.y Sets Quantum Physics Univer.e

Pr.of of Concept for.a Twin Pr.me Number.Univer.e Using Set Theor.

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Amer.can Jour.al of Computational Mathematics 2024年第3期14卷 305-317页

作者： john r. Cr.r. Independent r.sear.her Lake Zurich IL USA

The Fine Str.ctur. Constant (eFSC) Model attempts to give a classical definition to a magical number.that under.ies much of quantum physics. The Fine Str.ctur. Constant (α) value equal to 137.03599206 r.pr.sents a dimensionless constant that char.cter.zes the str.ngth of the electr.magnetic (EM) inter.ction between subatomic char.ed par.icles. Python-gener.ted pr.per.y counts for.the twin pr.me for.e F{139/137} show that the adjusted r.tio gives a value of α = 137.036. This implies a mathematical fr.mewor. under.ying this constant is based on twin pr.me number. and set theor.. This study attempts to demonstr.te a pr.of of concept that a hier.r.hy of fr.ctional twin pr.me (αII) for.es r.plicates the quantum natur. of the univer.e and is aligned with the Standar. Model of Par.icle Physics. An expanded eFSC Model demonstr.tes that twin pr.me for.es and their.pr.per.y sets ar. mathematically viable substitutes for.nuclear.r.actions, as demonstr.ted for.the Beta-minus decay of neutr.ns into pr.tons. Most significantly, the positive and negative pr.me number. define these nuclear.r.actants and pr.ducts as positive or.negatively char.ed ions. Fur.her.or., the eFSC Model pr.vides new insights r.gar.ing the hier.r.hy of EM for.es under.ying the quantum natur. of the univer.e.

关键词： Fine Str.ctur. Constant (α) Pr.me Number. Set Theor. Conceptual Model Quantum Physics Light and Matter Beta-Minus Decay

The Quantum Micr.ver.e: A Pr.me Number.Fr.mewor. for.Under.tanding the Univer.e

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Amer.can Jour.al of Computational Mathematics 2024年第2期14卷 264-274页

作者： john r. Cr.r. Independent r.sear.her Lake Zurich IL USA

This study aims to demonstr.te a pr.of of concept for.a novel theor. of the univer.e based on the Fine Str.ctur. Constant (α), der.ved fr.m n-dimensional pr.me number.pr.per.y sets, specifically α = 137 and α = 139. The FSC Model intr.duces a new per.pective on the fundamental natur. of our.univer.e, showing that α = 137.036 can be calculated fr.m these pr.me pr.per.y sets. The Fine Str.ctur. Constant, a cor.er.tone in Quantum Electr.dynamics (QED) and Quantum Chr.modynamics (QCD), implies an under.ying str.ctur.. This study identifies this mathematical fr.mewor. and demonstr.tes how the FSC model theor. aligns with our.cur.ent under.tanding of physics and cosmology. The r.sults unveil a hier.r.hy of α values for.twin pr.me pair. U{3/2} thr.ugh U{199/197}. These values, r.pr.sented by their.fr.ction par.s α♊ (e.g., 0.036), define the r.lative electr.magnetic for.es dr.ving quantum ener.y systems. The lower.twin pr.me pair., such as U{3/2}, exhibit higher.EM for.es that decr.ase as the twin pair. incr.ase, tur.ing dar. when they dr.p below the α♊ for.light. The r.sults pr.vide classical definitions for.Bar.onic Matter.Ener.y, Dar. Matter. Dar. Ener.y, and Antimatter.but mostly illustr.te how the combined α♊ values for.thr.e adjacent twin pr.mes, U{7/5/3/2} mir.or. the str.ng nuclear.for.e of gluons holding quar.s together.

关键词： Fine Str.ctur. Constant Fr.ctional Coupling Constants Matter.Antimatter Dar. Matter.Ener.y Quantum Gr.vity Pr.me Number. Set Theor.

Compr.hensive Clinical Hepatology

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Per.istence and gr.wth of faecal cultur.ble bacter.al indicator. in water.column and sediments of Vidy Bay,lake Geneva,Switzer.and

2006年

作者： Emer.tus Editor.Peter.D Howdle Edited by Br.ce r.Bacon john G O'Gr.dy Adr.an M Di Bisceglie john r.lake

ISBN: (纸本)9780323036757

Author.tative and highly illustr.ted in full color. this compr.hensive r.sour.e is the r.sult of a joint effor. of four.exper.enced senior.clinicians and educator.. It focuses on the medical aspects of tr.nsplantation, offer. an oasis of knowledge on key topics for.clinical pr.ctice and examination, and discusses the newest developments in the field, including NASH and chr.nic vir.l hepatitis.

关键词： Liver.iseases.

来源：畅想之星图书光盘版（南... 评论

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Jour.al of Envir.nmental Sciences 2009年第1期21卷 62-69页

作者： POTE john HALLEr.Laur.nce KOTTELAT r.gis SASTr. Vincent Ar.AGAUS Philippe WILDI Walter Univer.ity of Geneva F.-A. Forel Institute10 route de Suisse1290 VersoixSwitzerland

The aims of this study was to investigate the per.istence and the gr.wth of cultur.ble bacter.al indicator. （CBI） including total colifor.s （TC） and faecal colifor.s r.pr.sented by Escher.chia coli, enter.coccus （ENT）, and aer.bic mesophilic bacter.a （AMB） in the sur.ace sediments and the water.column of Vidy Bay flake Geneva, City of Lausanne, Switzer.and）. The study was car.ed out for.60 d using micr.cosms containing Sewage Tr.atment Plant （STP） effluent and nonster.le water.without CBI, as well as contaminated and non-contaminated sediments. The effects of water.temper.tur. and of or.anic matter.associated with sediments on the sur.ival of CBI in the sediments and the water.column wer. obser.ed. The number.of CBI colonies in the contaminated sediments of Vidy Bay and in the STP effluent was almost identical in the or.er.of 10^5-10^7, 10^4-10^6, 10^5-10^5, and 10^4-10^7 CFU/100 g sediment or.100 mL water.for.TC, E. coli, ENT, and AMB r.spectively. A degr.dation of CBI was obser.ed in the sediments wher. or.anic mater.content was low and in the water.column at a temper.tur. of 10℃ after.5 d of exper.mentation. In addition, a gr.wth of CBI was obser.ed in the sediment which is r.ch in or.anic matter.at 20℃. The r.sults of this study indicate：（1） the higher.concentr.tions of the CBI obser.ed in differ.nt points in the water.column of Vidy Bay may not be explained only by the r.cent contr.bution of the thr.e potential sour.es of the Bay contamination including STP and the Chamber.nne and Flon r.ver., but also by the per.istence, r.moval fr.m sediment and multiplication of CBI in the sediment and water.column; （2） the sediment of Vidy Bay constitute a r.ser.oir.of CBI and can even suppor. their.gr.wth; and （3） the CBI not only sur.ive in sediments, but also can be r.mobilized and incr.ased in the water.column, ther.for., it become a per.anent micr.biological pollution in Vidy Bay.

关键词： lake Geneva faecal pollution per.istence multiplication human health r.sk

患丙型肝炎的肝移植病人的免疫抑制及转归（上）

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传染病网络动态 2006年第6期 33-35页

作者： john r.lake 杨露绮（编译）

在世界范围内成人中由丙型肝炎病毒（HCV）引起的肝病是肝移植最常见的适应证。由于几乎普遍存在HCV再感染，故肝移植后丙型肝炎的复发是肝移植内、外科医生面对的最重要临床问题。此外，丙型肝炎的复发正在变成移植后一个逐渐增加的问... 详细信息

在世界范围内成人中由丙型肝炎病毒（HCV）引起的肝病是肝移植最常见的适应证。由于几乎普遍存在HCV再感染，故肝移植后丙型肝炎的复发是肝移植内、外科医生面对的最重要临床问题。此外，丙型肝炎的复发正在变成移植后一个逐渐增加的问题。由于因丙型肝炎而实施移植的百分比正在上升，所以丙型肝炎的复发不仅变成日益公认的问题，而且也显示该疾病的严重性并使移植的后果可能变得更坏。

关键词：丙型肝炎病毒(HCV) 移植病人免疫抑制转归世界范围内临床问题移植后适应证肝移植再感染

患丙型肝炎的肝移植病人的免疫抑制及转归（下）

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传染病网络动态 2006年第7期 34-35页

作者： john r.lake 杨露绮（编译）

在特异性免疫抑制剂对丙型肝炎移植病人长期结果的影响方面，存在一些疑惑，使用皮质醇治疗急性细胞排斥对感染HCV的接受者是有害的。多年前，Kings学院医院Ed Gane和同事表示皮质醇片剂与血清中HCVr.A浓度增加4到100倍有关。较高的HCV ... 详细信息

在特异性免疫抑制剂对丙型肝炎移植病人长期结果的影响方面，存在一些疑惑，使用皮质醇治疗急性细胞排斥对感染HCV的接受者是有害的。多年前，Kings学院医院Ed Gane和同事表示皮质醇片剂与血清中HCVr.A浓度增加4到100倍有关。较高的HCV r.A水平也与复发性肝炎的组织学严重程度增加有关。他们也表示皮质醇片剂与急性肝炎和较早时间复发的频率增加有关。

关键词：免疫抑制剂丙型肝炎移植病人 r.A浓度转归急性细胞排斥 HCV 皮质醇

Polychlor.nated biphenyls and omega-3 fatty acid exposur. fr.m fish consumption,and thyr.id cancer.among New Yor. angler.

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Jour.al of Envir.nmental Sciences 2016年第3期28卷 270-277页

作者： Alyson Haslam Sar. Wagner.r.bb Matthew r.Bonner.William Lindblad Joey Allegr. Ye Shen john E.Vena Depar.ment of Epidemiology and Biostatistics College of Public HealthUniversity of Georgia Depar.ment of Epidemiology and Envir.nmental Health School of Public Health and Health ProfessionsUniversity of Buffalo Depar.ment of Public Health Sciences School of MedicineMedical University of South Carolina

Fish fr.m the Gr.at lakes contain polychlor.nated biphenyls（PCBs）which have been shown to disr.pt endocr.ne function and mimic thyr.id hor.ones,but they also contain beneficial omega-3 fatty acids that may offer.pr.tection against endocr.ne *** pur.ose of this study was to examine the effects of lake Ontar.o fish consumption and the estimated consumption of PCBs and omega-3 fatty acids on the r.sk of thyr.id cancer.in a gr.up of spor. *** fr.m the New Yor. State Angler.Cohor. Study wer. followed for.cancer.incidence fr.m 1991–***-seven cases of incident thyr.id cancer.and 108 contr.ls wer. included in the *** estimated fish consumption,estimated omega-3 fatty acid consumption,and estimated PCB consumption fr.m lake Ontar.o fish wer. examined for.an association with the incidence of thyr.id cancer.while matching on sex,and contr.lling for.age and smoking *** fr.m logistic r.gr.ssion indicate no significant associations between fish consumption,shor.-ter. estimated omega-3 fatty acids,or.estimated PCB consumption fr.m Gr.at lakes fish and the development of thyr.id cancer.but it was suggested that long-ter. omega-3 fatty acid fr.m Gr.at lakes fish may be pr.tective of the development of thyr.id *** conclusion,fish consumption,with the possible concomitant PCBs,fr.m the Gr.at lakes does not appear.to incr.ase the r.sk of thyr.id cancer.in New Yor. *** r.sear.h is needed in or.er.to separ.te the individual health effects of PCBs fr.m omega-3 fatty acids contained within the fish.

关键词： Polychlor.nated biphenyls Omega-3 fatty acids Thyr.id cancer.lake Ontar.o Fish consumption