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Drug dispersion for single- and multi-lumen catheters

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Journal of Biomedical Science and Engineering 2013年第11期6卷 1021-1028页

作者： Dillon B. Schwalbach Brian D. Plourde john P. Abraham Robert E. Kohler School of Engineering University of St. Thomas St. Paul USA Translational Research Institute Gilbert USA

This study presents a comparison of the drug dispersion capability of various catheters which can be used to inject medication or stem cells into the arterial system. The study was carried out by the use of numerical simulation so that various geometric and physical operating parameters could be investigated. The blood was modeled with a power-law viscosity and the medication had two levels of viscosity to represent upper and lower bounds expected in practice. Two different medication flowrates were also incorporated into the study. Finally, the impact of an inflated balloon up-stream of the injection was studied. The artery was simply modeled as a straight circular tube with the catheters concentrically positioned. It was found that in some cases, dispersion was improved by use of a multi-lumen device, particularly when an upstream balloon was employed to regulate blood flow and drug residence time. In other cases, the dispersion from the single-lumen device was superior. Another finding was that the multi-lumen device had a reduced hydraulic resistance to blood flow, compared to the single-lumen device when an upstream balloon was inflated.

关键词： Catheter Injection Catheter Hemodynamics Intracoronary Injections Stem Cell Treatment of Infarction Heart Disease ND Infusion Catheter

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价值不是一切

鄱阳湖学刊 2021年第1期 21-35,125,126页

作者：约翰·贝拉米·福斯特保罗·伯克特彭学农(译) 美国俄勒冈大学美国印第安纳州立大学上海大学社会科学学部哲学系上海200433

当代左翼环境学者卡利斯、瓦迪维尔、雅辛和世界生态学家摩尔试图解构马克思的劳动价值论,以便把自然纳入价值体系,并将商品价格归因于生态系统服务,从而扩展对资本主义的生态批判。对上述做法,马克思和他的朋友们已作过批评,马克思之... 详细信息

当代左翼环境学者卡利斯、瓦迪维尔、雅辛和世界生态学家摩尔试图解构马克思的劳动价值论,以便把自然纳入价值体系,并将商品价格归因于生态系统服务,从而扩展对资本主义的生态批判。对上述做法,马克思和他的朋友们已作过批评,马克思之后的思想家也进行了反驳。上述后人类主义生态经济学理论家虽然提出了一些新问题,但其实质是在颠倒性地复制自然环境主义者提出的自然资本概念,这否定了自然和社会相互依存的辩证关系,放弃了劳动价值论所阐明的价值形式辩证法,最终陷入了资产阶级狭隘一元论的绝境。今天人类的可持续发展真正需要的不是对自然的彻底重估,而是一场革命性的生态和社会变革。

关键词：劳动价值论自然资本价值形式辩证法生态经济学马克思主义生态经济学

Novel Simulation Workshop Improves Performance in Vacuum Delivery

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Open Journal of Obstetrics and Gynecology 2016年第8期6卷 439-444页

作者： Katrina Calvert Mathias Epee Anne Karzcub Cliff Neppe Michael Allen Wendy Hughes paul McGurgan Richard King Alexander Maouris Dorota Doherty Panos Maouris King Edward Memorial Hospital Perth Australia Joondalup Health Campus Joondalup Australia St john of God Hospital Subiaco Perth Australia Broome Hospital Broome Australia School of Women’s and Infants’ Health University of Western Australia Crawley Australia Bond University Queensland Australia

Background: Operative vaginal delivery is a common obstetric intervention, with the potential to cause harm to mother and baby. Training in operative delivery traditionally comprised junior trainees learning the skills under supervision, then practicing and refining them independently. Recently this model has come under scrutiny, with the advent of simulation-based training suggesting a method by which the skills of safe delivery may be taught without risk. Multiple training courses exist, but few have been subjected to evaluation. Aims: The primary aim was to investigate if a simulation-based training workshop, where the development of a successful technique for vacuum delivery occurs using a collaborative, problem-solving approach, improves the rate of correct vacuum cup placement. The secondary aim was to determine if the workshop leads to improvement in theoretical knowledge of vacuum delivery. Methods: Participants on three workshops were assessed for their performance in vacuum delivery prior to and following a multimodal training program. Participants included general practitioner obstetricians, obstetric trainees and resident medical officers. Evaluation occurred using a standardised Likert-scaled rating sheet and utilising a diagrammatic representation of cup placement. Results: The participants demonstrated significant improvement (median post-pre score 1, p in the accuracy of cup placement, in a variety of practical core skills and in theoretical knowledge of vacuum delivery. Discussion: Participation in a simulation-based vacuum delivery workshop improves the performance of obstetric trainees and GP obstetricians. Further work is required to evaluate the performance of such training modalities on clinically relevant outcomes.

关键词： Vacuum Delivery Simulation Training Patient Safety

静脉滥用药物者所表现的全身性疾病——深部静脉血栓

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右江医学 1988年第2期 96-96页

作者： paul KURTIN john WAGNER 黄明怀

静脉滥用药物所带来的后果有多种多样,包括心、肺、肝及血管的并发症。深部静脉血栓是一种罕见的并发症,很少有过报道。复习有关上肢深静脉血栓形成的文献,并未见提及静脉滥用药物是病因。典型病例一36岁男患者自诉颈部、右肩和左膝关... 详细信息

静脉滥用药物所带来的后果有多种多样,包括心、肺、肝及血管的并发症。深部静脉血栓是一种罕见的并发症,很少有过报道。复习有关上肢深静脉血栓形成的文献,并未见提及静脉滥用药物是病因。典型病例一36岁男患者自诉颈部、右肩和左膝关节剧烈疼痛,症状始于六周前。当时曾用

关键词：静脉上肢血栓形成血管并发症四肢血栓栓塞并发病疾病深部静脉血栓血栓性静脉炎滥用药物

Iron and Zinc Serum Levels in Young Adult Cameroonians after Supplementation in Poor Vitamin A and Controlled Diets

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Journal of Food Science and Engineering 2014年第4期4卷 184-195页

作者： Kana Sop Marie Modestin Gouado Inocent Schweigert Florian Van Camp john Oberleas Donald AmvamZollo paul Henri Tetanye Ekoe Department of Biochemistry Faculty of Science University of Douala Douala 24157 Cameroon Institute of Nutritional Science University of Potsdam Potsdam 114-115 D-14558 Germany Department of Food Safety and Food Quality University of Gent Ghent 653 B-9000 Belgium Food and Nutrition University of Lubbok Lubbock 79423 USA Department of Biochemistry University of Ngaoundere Ngaoundere 454 Cameroon Department of Paediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundd Yaounde 2036 Cameroon

Who Realizes Constitutionalism in International Trade Law? Book Reviews:The Jurisprudence of GATT ＆ the WTO:Insights on Treaty Law and Economic *** john ***

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Who Realizes Constitutionalism in International Trade Law? B...

海啸地球科学家在应急响应中的作用:以2009年9月29日萨摩亚海啸事件中美国加州的应急响应为例

中国法学会世界贸易组织法研究会二○○七年年会

作者： Chen Bin the Research Institute of International Law of Wuhan University and paul Cézanne Aix Marseilles UniversitéⅢ,

＜正＞Over the last four decades,*** has written about nearly all aspects of international trade law,which played a key role as guide to research of GATT/*** the wake of GATT’s success in lowering tariff barriers to trade,negotiators increasingly focused on non-tariff barriers involving domestic policies and,in the process,provoked more frequent conflicts with public policies in non-trade areas,for example,environmental protection,labor and human rights standards,and competition ***,the Uruguay Round established rules for"new"areas of trade law and policy,including trade-related intellectual property protection and investment,and trade in services,resolved key problems that had hindered the effective resolution of GATT disputes,and provided benefits especially valuable to many developing *** several years’ practices, merits of the system of WTO have been verified to be successful. Without question,GATT/WTO law became the focus of present international ***,as a leading scholar in this field,significant contribution came from Jackson has far-reaching effect to international law. As the center of international trade system,WTO looks an international trade constitutionalism in this *** view of different research way,as two outstanding representatives in academia, Jackson and Petersmann put forward to different ideas about constitutionalism of international trade law despite them hold same point to truth of constitutionalism of international trade ***, it is not only a serious research but also a funny journey of thoughts.

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国际地震动态 2010年第9期31卷 3-9页

作者： Rick I. Wilson Lori A. Dengler James D. Goltz Mark R. Legg Kevin M. Millera john G. Parrish paul M. Whitmore 蒋伟（译）孙振凯（校） California Geological Survey Humboldt State University California Emergency Management Agency Legg Geophysical West Coast/Alaska Tsunami Warning Center NOAA-NWS 中国地震局地球物理研究所

加州海啸地球科学家与联邦、州和地方政府应急管理人员密切合作来帮助沿海社区防范海啸发生前、海啸过程中、海啸发生后产生的潜在影响。对于远程海啸,来自美国国家海洋和大气管理局(National Oceanic and At mospheric Administration... 详细信息

加州海啸地球科学家与联邦、州和地方政府应急管理人员密切合作来帮助沿海社区防范海啸发生前、海啸过程中、海啸发生后产生的潜在影响。对于远程海啸,来自美国国家海洋和大气管理局(National Oceanic and At mospheric Administration,简称NOAA)西海岸和阿拉斯加海啸预警中心的科学信息(预测模型、浪高、首波到达时间等)是可以利用的。加州应急管理人员必须以简洁明了的方式将海啸信息传达给最终安排在他们的管辖区采取适当应急措施的地方官员。在2009年9月29日萨摩亚海啸预警中,来自加州地质调查局和洪堡州立大学(Humboldt State University)的地球科学家在海啸来临之前为加州应急管理处在与美国国家海洋和大气管理局与其他州和地方应急管理人员进行的远程会议的信息传输方面提供了技术支持。加州地球科学家收集了一些附加的背景资料用于预测美国国家海洋和大气管理局预测模型所没有覆盖到的地区的潮汐条件和浪高。在应急响应过程中,加州地球科学家的参与明确了哪些地区处于危险中,哪些地区遭受海啸袭击的风险低。加州地球科学家参与未来海啸应急响应的行动包括以下方面:与美国国家海洋和大气管理局密切合作来简化其海啸警报信息的传递流程并扩展其预测模型的覆盖面;②为地方应急管理人员制作包括已经存在的海啸的情景资料,作为每次海啸事件的参考;③建立一个州级信息共享中心和一支海啸前应急响应队,以协助地方官员一起观测和报道海啸的影响。

关键词：地球科学家美国加州应急响应海啸事件管理人员预测模型地方官员

Discovery of Potent, Selective and Reversible Caspase-3 Inhibitors

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合成化学 2004年第Z1期12卷 13-13页

作者： André Giroux john Colucci Christopher I. Bayly Daniel J. Mckay Sophie Roy Steve Xanthoudakis john Vaillancourt Dita M. Rasper john Tam paul Tawa Donald W. Nicholson Robert J. Zamboni Department of Medicinal Chemistry Department of Biochemistry and Molecular Biology Merck Frosst Centre for Therapeutic Research Merck Frosst Canada & Co. P.O. Box 1005 Pointe-Claire-DorvalQuebec Canada H9R 4P8

Recent studies towards understanding the molecular mechanisms of apoptosis have revealed the importance of a group of cysteinyl aspartate specific proteases, the caspases, in the programmed cell death process (Hengartner, M.O. Nature 2000, 407, 770). Caspase-3, in particular,has been characterized as the dominant effector caspase involved in the proteolytic cleavage of a variety of protein substrates including cytoskeletal proteins, kinases and DNA repair enzymes during apoptosis (Nicholson, D. W. Cell Death Differ. 1999, 6, 1028). The development of potent and selective caspase-3 inhibitors has thus emerged as an attractive therapeutic target. In the presentation,the identification of a series of potent, selective and reversible non-peptidyl caspase-3 inhibitors containing a pyrazinone core (1) will be presented. SAR optimization at R1, R2, R3 and R4 led to the discovery of inhibitors such as 2 with excellent in vitro activities (IC50 against rh-caspase-3: 5 nM; IC50 against camptothecin induced apoptotic cell death in NT2 cells: 20 nM). Compounds such as 2 also displayed excellent in vivo activities in a number of animal models of acute injuries (see: Methot, N. et al, J. Exp. Med. 2004, 119, 199; Toulmond, S. et al, British J. Pharm. 2004, 141,689; Holtzman,D.M. et al, JBC, 2002, 277, 30128), and selected examples will be discussed during the presentation.

关键词： programmed cell death cytoskeletal proteins molecular mechanisms identification of animal models DNA repair in vitro

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编者按

AMBIO-人类环境杂志 2007年第8期 577-577页

作者： Will Steffen paul Crutzen john McNeill 寒江澳大利亚国立大学德国马克斯·普朗克化学研究所美国乔治敦大学

气候变化上升为世界许多地方政治生活中重要的核心,这标志着环境问题开始成为全球性问题,得以与安全、贸易、人权及其它长期存在的、多年来在国际事务中占统治地位的诸多问题相提并论了。2007年诺贝尔和平奖授予了艾尔·戈尔和政府间气... 详细信息

气候变化上升为世界许多地方政治生活中重要的核心,这标志着环境问题开始成为全球性问题,得以与安全、贸易、人权及其它长期存在的、多年来在国际事务中占统治地位的诸多问题相提并论了。2007年诺贝尔和平奖授予了艾尔·戈尔和政府间气候变化专门委员会,这突出了全球环境在当代人类事务中的重要性。它不再是"另一个环境问题",甚至不再是"另一个问题",而是迅速成为21世纪的真正问题。眼下对气候变化的兴趣也许掩盖了其它同等重要的全球变化问

关键词：气候变化气候变动人类