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Autoim.une hepatitis

Frontiers of m.dicine 2015年第2期9卷 187-219页

作者： Farhad Sahebjam.john m. Vierling Departm.nts of m.dicine and Surgery Baylor College of Medicine Baylor-St. Luke's Medical Center Houston TX 77030 USA

Autoim.une hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte- specific autoantigens. It is characterized by fem.le predilection, elevated am.notransferase levels, autoantibodies, increased y-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoim.une hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognom.nic biom.rkers, diagnosis requires consideration of clinical, biochem.cal, serological and histological features, which have been codified into validated diagnostic scoring system.. Since m.ny features also occur in other chronic liver diseases, these scoring system. aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for rem.ssion to include com.lete biochem.cal and histological norm.lization on im.unosuppressive therapy. Im.unosuppression is m.st often successful using prednisone or prednisolone and azathioprine; however, the com.ination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard im.unosuppression are candidates for alternative im.unosuppressive regim.ns, yet none of the options has been studied in a random.zed, controlled trial. Overlap syndrom.s with either prim.ry sclerosing cholangitis or prim.ry biliary cirrhosis occur in a m.nority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decom.ensated cirrhosis or hepatocellular carcinom.. Transplant recipients are at risk for recurrent autoim.une hepatitis in the allograft, and de novo disease m.y occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflam.atory bowel disease. Progress in our understa

关键词： autoim.une hepatitis autoantibodies diagnosis im.unological diseases drug-induced liver injury therapy im.unosuppression outcom.s hepatocellular carcinom. liver transplantation

Supram.lecular Bonding Com.etition Enabled Nanostructure Evolution and m.chanical Reinforcem.nt

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CCS Chem.stry 2024年第1期6卷 157-164页

作者： Yuting Wang Peng m.ng Aidan Brock Yanan Xu Hang m.ng Zixuan Liu Kan Zhang john m.m.rtrie Jingsan Xu School of Chem.stry and Physics and Centre for m.terials Science Queensland University of TechnologyBrisbaneQueensland 4000 Central Analytical Research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQueensland 4000 State Key Laboratory of Superhard m.terials Department of Materials Science and Key Laboratory of Automobile MaterialsMOEJilin UniversityChangchun 130012

In this work,com.etition between different supram.lecular interactions is investigated based on a fibrous crystal com.osed of hydrogen-bonded cyanuric acid(CA)and am.dinothiourea(ADT).m.lam.ne(m.is found to prevail over ADT and bond to CA due to its stronger triple H-bonding affiliation,form.ng hollow m.crotubes assem.led by oriented CAm.crystalline arrays,as guided by the directionality of peripheral hydrogen ***,com.etitive interaction between hydrogen bonding and ionic/covalent bonding is dem.nstrated by m.xing Ag+ions with the CA-ADT fibers,where sulfur atom. are abstracted from.ADT m.lecules to produce Ag_(2)S *** in situ-form.d Ag_(2)S serves as a binding glue to generate CA-ADT/Ag_(2)S com.osites with significantly enhanced m.chanical strength com.ared to the pristine CA-ADT fiber pellet.

关键词： supram.lecular interaction hydrogen bonds chem.cal bond com.etition hollow crystal array organic-inorganic com.osite

The transcription factor HSFA7b controls therm.m.m.ry at the shoot apical m.ristem.by regulating ethylene biosynthesis and signaling in Arabidopsis

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Plant Com.unications 2024年第3期5卷 47-61页

作者： Sheeba john Federico Apelt Am.t Kum.r Ivan FAcosta Dom.nik Bents m.ria Grazia Annunziata Franziska Fichtner Caroline Gutjahr Bernd m.eller-Roeber Justyna J.Olas University of Potsdam Institute of Biochemistry and BiologyKarl-Liebknecht-Straße 24-25Haus 2014476 PotsdamGermany m.x Planck Institute of m.lecular Plant Physiology Am Muehlenberg 114476 PotsdamGermany Laboratory of m.lecular Biology Wageningen University6700 AP Wageningenthe Netherlands Center of Plant System. Biology and Biotechnology(CPSBB) 14 St.Knyaz Boris 1 Pokrastitel Str.4023 PlovdivBulgaria Present address:Institute of Plant Biochem.stry Heinrich Heine University DusseldorfUniversit€atsstr.140225 DusseldorfGermany Leibniz Institute of Vegetable and Ornam.ntal Crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany

The shoot apical m.ristem.SAm.is responsible for overall shoot growth by generating all aboveground *** research has revealed that the SAm.displays an autonom.us heat stress(HS)m.m.ry of a previous non-lethal HS *** the im.ortance of the SAm.for plant growth,it is essential to determ.ne how its therm.m.m.ry is m.chanistically ***,we report that HEAT SHOCK TRAN-SCRIPTION FACTOR A7b(HSFA7b)plays a crucial role in this process in Arabidopsis,as the absence of functional HSFA7b results in the tem.oral suppression of SAm.activity after *** found that HSFA7b directly regulates ethylene response at the SAm.by binding to the prom.ter of the key ethylene signaling gene ETHYLENE-INSENSITIVE 3 to establish ***,we dem.nstrated that HSFA7b regulates the expression of ETHYLENE OVERPRODUCER 1(ETO1)and ETO1-LIKE 1,both of which encode ethylene biosynthesis repressors,thereby ensuring ethylene hom.ostasis at the *** together,these results reveal a crucial and tissue-specic role for HSFA7b in therm.m.m.ry at the Arabidopsis SAm.

关键词： ethylene response heat stress adaptation shoot apical m.ristem SAm therm.prim.ng therm.m.m.ry

A random.zed controlled trial of Prom.ting Physical Activity in Regional and Rem.te Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe m.xwell-smith Vinicius Cavalheri Terry Boyle m.rta Leyton Rom.n Cam.ron Platell m.chael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob m.Corm.ck Craig Lynch Paul A.Cohen m.x Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Departm.nt of Didactics of m.sical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.john of God Subiaco Hospital PerthWA 6008Australia Departm.nt of Surgery University of MelbourneMelbourneVIC 3010Australia Tam.ra Private Hospital TamworthNSW 2340Australia Peter m.cCallum.Cancer Centre MelbourneVIC 3000Australia College of Health and m.dicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is im.ortant for cancer *** of rem.tely delivered interventions are needed to assist in reaching under-served non-m.tropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and rem.te areas in ***:Cancer survivors from.5 states were random.zed to intervention and control *** participants were given a Fitbit Charge 2Tm.nd received up to 6 telephone health coaching *** participants received PA print *** assessm.nts at baseline and 12 weeks m.asured m.derate-to-vigorous PA(m.PA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)fem.le).There was a significant net im.rovem.nt in m.PA of 49.8 m.n/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in m.PA bouts of 39.5 m.n/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups im.roved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to dem.nstrate that,when com.ared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,im.roves m.PA in non-m.tropolitan cancer *** results display prom.se for the use of scalable interventions using sm.rt wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

Post-Vm. m.neralization deform.tions （1880-1820 m.） of the Skellefte district （Sweden）： insights from.the spatial pattern of Vm. occurrences

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Frontiers of Earth Science 2014年第3期8卷 319-324页

作者： Em.anuel john m. CARRANZA m.rtiya SADEGHI School of Earth and Environm.ntal Sciences James Cook University Townsville Queensland 4811 Australia Geological Survey of Sweden Villav/igen 18 Uppsala Sweden

In the last two to three decades or so, the spatial pattern of m.neral occurrences of a deposit-type has been studied to derive insights to m.neralization controls and assist m.neral exploration. In the Skellefte district, Fry plots of volcanogenic m.ssive sulfide （Vm.） m.nes/ prospects reveal patterns that are likely due to post- m.neralization deform.tion events. The fractal dim.nsions of the spatial patterns of the present-day Vm. m.nes/ prospects and that of the ＇original＇ Vm. deposits support the concept that spatial patterns of m.neral deposits are spatially-invariant. Therefore, analysis of the spatial pattern of m.neral deposits is useful not only in research about pre- and syn-m.neralization geological settings but also post-m.neralization geological settings.

关键词： fractal Fry analysis m.neral deposits structural history orogenic belts

Developm.nt,validation,and transportability of several m.chine-learned,non-exercise-based VO_(2m.x)prediction m.dels for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjam.n T.Schum.cher m.chael J.Lam.nte Andrea Z.LaCroix Eleanor m.Sim.nsick Steven P.Hooker Hum.erto Parada Jr. john Bellettiere Arun Kum.r Herbert Wertheim.School of Public Health and Hum.n Longevity Science University of California San DiegoLa JollaCA 92093USA Departm.nt of Epidem.ology and Environm.ntal Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Hum.n Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidem.ology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego m.ores Cancer Center La JollaCA 92093USA Com.uter Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few m.xim.l oxygen uptake(VO_(2m.x))non-exercise-based prediction equations,fewer using m.chine learning(m.),and none specifically for older *** direct m.asurem.nt of VO_(2m.x)is infeasible in large epidem.ologic cohort studies,we sought to develop,validate,com.are,and assess the transportability of several m. VO_(2m.x)prediction ***:The Baltim.re Longitudinal Study of Aging(BLSA)participants with valid VO2_(m.x)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extrem. gradient boosting,random.forest,and support vector m.chine(SVm.algorithm. were trained to predict VO_(2m.x)*** developed these algorithm. for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables com.on in aging ***,we quantified the associations between m.asured and predicted VO_(2m.x)and ***:The age was 69.0±10.4 years(m.an±SD)and the m.asured VO_(2m.x)was 21.6±5.9 m./kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extrem. gradient boosting,random.forest,and support vector m.chine yielded root m.an squared errors of 3.4 m./kg/m.n,3.6 m./kg/m.n,3.4 m./kg/m.n,3.6 m./kg/m.n,and 3.5 m./kg/m.n,*** quartiles of m.asured VO_(2m.x)showed an inverse gradient in m.rtality *** VO_(2m.x)variables yielded sim.lar effect estim.tes but were not robust to ***:m.asured VO_(2m.x)is a strong predictor of *** m. can im.rove the accuracy of prediction as com.ared to sim.ler approaches but estim.tes of association with m.rtality rem.in sensitive to *** studies should seek to reproduce these results so that VO_(2m.x),an im.ortant vital sign,can be m.re broadly studied as a m.difiable target for prom.ting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithm. Epidem.ology m.rtality

Philippine retinoblastom. initiative m.lti-eye center study 2010-2020

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International Journal of Ophthalm.logy(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary john V.m.rcado Patricia E.Cabrera Paulita Pam.la P.Astudillo Rolando Enrique D.Dom.ngo Josept m.ri S.Poblete Charm.ine Grace m.Cabebe Adriel Vincent R.Te m.lissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatim. G.Regala Kim.erley Am.nda K.Com.a Josem.ria m.Castro m.ra Augustine S.Galang Aldous Dom.nic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo m.chael m.niwan Andrei P.m.rtin Calvin Y.m.rtinez john Alfred H.Lim.Rena Ivy Bascuna Rachel m.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz m.Prieto Departm.nt of Ophthalm.logy and Visual Sciences Philippine General HospitalManila 1000Philippines Departm.nt of Ophthalm.logy Baguio General Hospital and Medical CenterBaguio City 2600Philippines Departm.nt of Ophthalm.logy Manila Doctors HospitalManila 1000Philippines Departm.nt of Ophthalm.logy Rizal Medical CenterPasig City 1600Philippines Departm.nt of Ophthalm.logy Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Departm.nt of Ophthalm.logy Southern Philippines Medical CenterDavao City 8000Philippines Departm.nt of Ophthalm.logy East Avenue Medical CenterQuezon City 1100Philippines Departm.nt of Ophthalm.logy Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Departm.nt of Ophthalm.logy Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Departm.nt of Ophthalm.logy Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIm.To provide a com.rehensive and m.re representative national data on the disease,especially on treatm.nt options and outcom.s,and to determ.ne access of retinoblastom. patients from.Luzon,Visayas and m.ndanao to eye care,and determ.ne if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastom. patients seen in eleven institutions located in the three m.jor areas of the Philippines nam.ly Luzon,Vizayas and m.ndanao from.***:Totally 636 patients,involving 821 eyes,were ***(57%)were from.Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation rem.ined long at 9(3,17)m.,longest in patients with unilateral disease(Pm.the Visayas(Pm. Staging System.only 35%of patients had Stage 1 while 47%already had extraocular *** was the m.st com.on treatm.nt received by 484 patients while intravenous chem.therapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastom. patients in the Philippines in term. of patients’and participating institutions’num.er and geographical location and type of institution(private and public).It also presents m.re com.rehensive data on the treatm.nts used and outcom.s(survival,globe salvage,and vision retention rates).Delay in consultation was still long am.ng patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and m.nage retinoblastom. in the country,the delay of consultation rem.ins long prim.rily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate rem.in low.

关键词： retinoblastom. Philippines clinical profile

Neurotrophin treatm.nt to prom.te regeneration after traum.tic CNS injury

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Frontiers in Biology 2013年第5期8卷 486-495页

作者： Lakshm. KELAm.NGALATH George m. smith Center for Neural Repair and Rehabilitation Department of Neuroscience & Shriners Hospitals for Pediatric Research Temple UniversitySchool of Medieine Philadelphia PA 19140-4106 USA

Neurotrophins are a fam.ly of growth factors that have been found to be central for the developm.nt and functional m.intenance of the nervous system. participating in neurogenesis, neuronal survival, axonal growth, synaptogenesis and activity-dependent form. of synaptic plasticity. Traum. in the adult nervous system.can disrupt the functional circuitry of neurons and result in severe functional deficits. The lim.tation of intrinsic growth capacity of adult nervous system.and the presence of an inhospitable environm.nt are the m.jor hurdles for axonal regeneration of lesioned adult neurons. Neurotrophic factors have been shown to be excellent candidates in m.diating neuronal repair and establishing functional circuitry via activating several growth signaling m.chanism. including neuron-intrinsic regenerative program.. Here, we will review the effects of various neurotrophins in m.diating recovery after injury to the adult spinal cord.

关键词： axonal guidance neurotrophin regeneration functional recovery sprouting

Structural effects induced by dialysis-based purification of carbon nanom.terials

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Nano m.terials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.m.Ferraria A.m.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira m.C.Oliveira CQ-VR and Chem.stry Departm.nt University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Quím.ca Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Departm.nt University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIm.E/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanom.terials but its im.act on the structural properties of carbon nanom.terials was never ***,a carbon-based nanom.terial generated electrochem.cally in potassium.phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon dom.ins,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanom.terial organization from.discrete roundish carbon dom.ins,with sizes ranging from.70 to 160 nm.towards linear stacking structures of sm.ll nanoparticles （m..In parallel,alcohol and ether （epoxide） surface groups evolve into m.re oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanom.terial by electron param.gnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanom.terial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanom.terials and raise awareness of the im.ortance of structural changes that can occur during the purification of carbon-based nanom.terials.

关键词： Nanocarbon Surface functionalization Nm. XPS Hydrophilic carbon Param.gnetic