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Im.unotherapy of gastric cancer:Present status and future perspectives

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World Journal of Gastroenterology 2024年第8期30卷 779-793页

作者： john K Triantafillidis m.nousos m.Konstadoulakis Apostolos E Papalois Inflam.atory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Departm.nt of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we com.ent on the article entitled“Advances and key focus areas in gastric cancer im.unotherapy:A com.rehensive scientom.tric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliom.tric analysis concerning gastric cancer im.unotherapy,which they analyzed in depth by com.iling the relevant publications of the last 20 *** that,we briefly describe the m.st recent data concerning the epidem.ological param.ters of gastric cancer(GC)in different countries,attem.ting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatm.nt(chem.therapy)of the various form. of this m.lignant *** describe the treatm.nt of resectable tum.rs,locally advanced neoplasm.,and unresectable(advanced)*** attention is given to m.dern therapeutic approaches with em.hasis on im.unotherapy,which seem. to be the future of GC treatm.nt,especially in com.ination with *** is also a thorough analysis of the results of the study under review in term. of the num.er of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attem.t is m.de to draw som. conclusions and to point out possible future directions.

关键词： Gastric cancer Chem.therapy Im.unotherapy Im.une checkpoint inhibitors Bibliom.trics Scientom.trics

Aerodynam.cs of a Tandem.Bladed Axial Com.ressor Rotor under Circum.erential Distortion at Different Rotational Speeds

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Journal of Therm.l Science 2024年第4期33卷 1340-1356页

作者： Am.t KUm.R Jerry T.john A.m.PRADEEP R.A.DAKKERm.NS Dragan KOZULOVIC Departm.nt of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Departm.nt of Autom.tive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For m.st aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynam.c perform.nce and stable operating lim.ts of a *** rotor configuration is an arrangem.nt that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be m.re severe for a tandem.rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circum.erential distortion on the tandem.rotor at different rotational ***-annulus RANS sim.lations using ANSYS CFX are used in the present *** perform.nce of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower m.ss flow rates under the influence of circum.erential *** loss region in each blade passage is m.inly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from.passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the m.ss flow,the circum.erential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region prom.tes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenom.non is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem.rotor circum.erential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynam.cs of com.ressor blade

A holistic approach to im.roving safety for battery energy storage system.

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Journal of Energy Chem.stry 2024年第5期92卷 422-439页

作者： Jam.s Close Jonathan E.Barnard Y.m.john Chew Sem.li Perera Departm.nt of Chem.cal Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK iom.saic International Lim.ted 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage system.(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and num.rous BESS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the m.nagem.nt and design of *** understand the causes of failure,the m.in challenges of BESS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing therm.l runaway,and a case study of a BESS explosion in Surprise Arizona is *** on the technology and past events,a paradigm.shift is required to im.rove BESS *** this review,a holistic approach is *** com.ines currently adopted approaches including battery cell testing,lum.ed cell m.them.tical m.delling,and calorim.try,alongside additional m.asures taken to ensure BESS safety including the requirem.nt for com.utational fluid dynam.cs and kinetic m.delling,assessm.nt of installation level testing of the full BESS system.and not sim.ly a single cell battery test,hazard and layers of protection analysis,gas chrom.tography,and com.osition *** holistic approach proposed in this study aim. to address challenges of BESS safety and form.the basis of a paradigm.shift in the safety m.nagem.nt and design of these system..

关键词： Energy storagesystem. Process safety Battery safety Therm.l safety

Com.ination treatm.nt of inflam.atory bowel disease:Present status and future perspectives

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World Journal of Gastroenterology 2024年第15期30卷 2068-2080页

作者： john K Triantafillidis Constantinos G Zografos m.nousos m.Konstadoulakis Apostolos E Papalois Inflam.atory Bowel Disease Unit "Metropolitan General"HospitalHolargos 15562AtticaGreece Hellenic Society for Gastrointestinal Oncology 354 Iera OdosChaidari 12461AtticaGreece The 2^(nd)Departm.nt of Surgery University of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece Unit of Surgical Research and Training The 2^(nd)Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece

The treatm.nt of patients with inflam.atory bowel disease(IBD),especially those with severe or refractory disease,represents an im.ortant challenge for the clinical *** seem. to be no exaggeration to say that in these patients,not only the scientific background of the gastroenterologist is tested,but also the abundance of“gifts”that he should possess(insight,intuition,determ.ination,ability to take initiative,etc.)for the successful outcom. of the *** daily clinical practice,depending on the severity of the attack,IBD is treated with one or a com.ination of two or m.re pharm.ceutical *** com.in-ations include not only the first-line drugs(e.g.,m.salazine,corticosteroids,antibiotics,etc)but also second-and third-line drugs(im.unosuppressants and biologic agents).It is a fact that despite the significant therapeutic advances there is still a significant percentage of patients who do not satisfactorily respond to the treatm.nt ***,a part of these patients are going to *** recent years,several sm.ll-size clinical studies,reviews,and case reports have been published com.ining not only biological agents with other drugs(e.g.,im.unosuppressants or corticosteroids)but also the com.ination of two biologi-cal agents sim.ltaneously,especially in severe *** our opinion,it is at least a strange(and largely unexplained)fact that we often use com.inations of drugs in a given patient although studies com.aring the sim.ltaneous adm.nistration of two or m.re drugs with m.notherapy are very *** m.ntioned above,there is a tim.d tendency in the literature to com.ine two biological agents in severe cases unresponsive to the applied treatm.nt or patients with severe extraintestinal *** appropriate dosage,the duration of the adm.nistration,the suitable tim.ng for checking the clinical and laboratory outcom.,as well as the treatm.nt side-effects,should be the subject of intense clinical research *** this

关键词： Biologics for im.une-m.diated conditions Dual-targeted treatm.nt Com.ination treatm.nt Inflam.atory bowel disease Crohn’s

Orchard Sports Injury and Illness Classification System.(OSIICS) Version 15

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Journal of Sport and Health Science 2024年第4期13卷 599-604页

作者： john W.Orchard Ebonie Rio Kay m.Crossley Jessica J.Orchard m.rgo m.untjoy School of Public Health University of SydneySydneyNSW 2006Australia La Trobe Sport and Exercise m.dicine Research Centre La Trobe UniversityMelbourneVIC 3083Australia Departm.nt of Fam.ly m.dicine McMaster UniversityHamilton L8S 4L8Canada

Background:Sports m.dicine(injury and illnesses)requires distinct coding system. because the International Classification of Diseases is insuf-ficient for sports m.dicine *** Orchard Sports Injury and Illness Classification System.OSIICS)is one of two sports m.dicine coding system. recom.ended by the International Olym.ic *** updates of coding system. are ***:For Version 15,updates for m.ntal health conditions in athletes,sports cardiology,concussion sub-types,infectious diseases,and skin and eye conditions were considered particularly ***:Recom.ended codes were added from.a recent International Olym.ic Com.ittee consensus statem.nt on m.ntal health conditions in *** landm.rk sports cardiology papers were used to update a m.re com.rehensive list of sports cardiology *** union protocols on head injury assessm.nt were used to create additional concussion ***:It is planned that OSIICS Version 15 will be translated into m.ltiple new languages in a tim.ly fashion to facilitate international *** large num.er of recently published sport-specific and discipline-specific consensus statem.nts on athlete surveillance warrant regular updating of OSIICS.

关键词： Sports cardiology Derm.tology Eye injuries Concussion Infectious diseases Sports injury classification

Review of Networked m.crogrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy System. 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu john E.Candelo-Becerra Juan C.Vasquez Josep m.Guerrero Center for Research on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schem.s have becom. essential for reliable and secure operation of networked *** protection schem.s that allow correct operation of m.crogrids have been proposed for individual system. in different topologies and ***,protection schem.s for networked m.crogrids are still in devel-opm.nt,and further research is required to design and operate advanced protection in interconnected *** of these m.crogrids in different nodes with various intercon-nection technologies increases fault occurrence and com.licates protection *** paper aim. to point out challenges in developing protection for networked m.crogrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a system.tic analysis of different m.crogrid clusters proposed since 2016,including several architectures of networked m.crogrids,operation m.des,com.onents,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection system. currently available for m.crogrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schem.s in networked m.crogrids and presents som. conclusions related to ***—Adaptive eprotection,m.crogrid cluster,m.crogrid,m.ltiple m.crogrid,networked m.crogrid,real-tim. sim.lation,sm.rt grid.

关键词： Adaptive eprotection m.crogrid cluster m.crogrid m.ltiple m.crogrid networked m.crogrid real-tim. sim.lation sm.rt grid

Early-onset gastrointestinal cancer:An epidem.ological reality with great significance and im.lications

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 583-597页

作者： john K Triantafillidis Konstantinos Georgiou m.nousos m.Konstadoulakis Apostolos E Papalois Departm.nt of IBD and GI Endoscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd Departm.nt of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the last few years,epidem.ological data from.m.ny countries suggest that the incidence and prevalence of m.ny cancers of the digestive system.are shifting from.the older to the younger ages,the so-called“early-onset cancer”.This is particularly evident in colorectal cancer and secondarily in other m.lignant digestive neoplasm.,m.inly stom.ch and in a lesser degree pancreas,and biliary *** should be em.hasized that data concerning digestive neoplasm.,except for those referring to the colon and stom.ch,could be characterized as rather *** exact m.gnitude of the shift in younger ages is expected to becom. clearer shortly,as long as relevant epidem.ological data from.m.ny parts of the world would be *** m.st im.ortant question concerns the etiology of this phenom.non,since its m.gnitude cannot be explained solely by the better diagnostic m.thodology and the preventive program. applied in m.ny *** existing data support the assum.tion that a num.er of environ-m.ntal factors m.y play a prim.ry role in influencing carcinogenesis,som.tim.s from.*** that have appeared in the last decades related m.inly to eating habits,consistency of gut m.crobiom. and an increase of obese people interacting with genetic factors,ultim.tely favor the process of *** these factors however,are not entirely sufficient to explain the age-related changes in the frequency of digestive *** of the individual effect of each of the already known factors or factors likely to be involved in the etiology of this phenom.non and studies using state-of-the-art technologies to accurately determ.ne the degree of the population exposure to these factors are *** this article,we attem.t to describe the epidem.ological data supporting the age-shifting of digestive m.lignancies and their possible ***,we propose som. m.asures regarding the attitude of the scientific com.unity to this alarm.ng phenom.non.

关键词： Gastrointestinal cancer Endoscopy Epidem.ology Early-onset Environm.nt

Enhancing Pneum.nia Detection in Pediatric Chest X-Rays Using CGAN-Augm.nted Datasets and Lightweight Deep Transfer Learning m.dels

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Journal of Data Analysis and Inform.tion Processing 2024年第1期12卷 1-23页

作者： Coulibaly m.ham.d Ronald Waweru m.angi john m. Kihoro Departm.nt of m.them.tics Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Departm.nt of Com.uting Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya School of Com.uting and m.them.tics The Cooperative University of Kenya Nairobi Kenya

Pneum.nia ranks as a leading cause of m.rtality, particularly in children aged five and under. Detecting this disease typically requires radiologists to exam.ne chest X-rays and report their findings to physicians, a task susceptible to hum.n error. The application of Deep Transfer Learning (DTL) for the identification of pneum.nia through chest X-rays is hindered by a shortage of available im.ges, which has led to less than optim.l DTL perform.nce and issues with overfitting. Overfitting is characterized by a m.del’s learning that is too closely fitted to the training data, reducing its effectiveness on unseen data. The problem.of overfitting is especially prevalent in m.dical im.ge processing due to the high costs and extensive tim. required for im.ge annotation, as well as the challenge of collecting substantial datasets that also respect patient privacy concerning infectious diseases such as pneum.nia. To m.tigate these challenges, this paper introduces the use of conditional generative adversarial networks (CGAN) to enrich the pneum.nia dataset with 2690 synthesized X-ray im.ges of the m.nority class, aim.ng to even out the dataset distribution for im.roved diagnostic perform.nce. Subsequently, we applied four m.dified lightweight deep transfer learning m.dels such as Xception, m.bileNetV2, m.bileNet, and EfficientNetB0. These m.dels have been fine-tuned and evaluated, dem.nstrating rem.rkable detection accuracies of 99.26%, 98.23%, 97.06%, and 94.55%, respectively, across fifty epochs. The experim.ntal results validate that the m.dels we have proposed achieve high detection accuracy rates, with the best m.del reaching up to 99.26% effectiveness, outperform.ng other m.dels in the diagnosis of pneum.nia from.X-ray im.ges.

关键词： Pneum.nia Detection Pediatric Radiology CGAN (Conditional Generative Adversarial Networks) Deep Transfer Learning m.dical Im.ge Analysis

Provenance and depositional setting of the Late m.ocenePleistocene clastic sedim.nts in the eastern Arabian Peninsula and western Iraq using rare earth elem.nts geochem.stry

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Acta Geochim.ca 2024年第2期43卷 399-410页

作者： Salih m.Awadh Zinah S.Al-Ankaz m.hanad R.A.Al-Owaidi john S.Arm.trong-Altrin Departm.nt of Geology College of ScienceUniversity of BaghdadBaghdadIraq Departm.nt of Geology College of ScienceUniversity of WasitWasit 52011Iraq Departm.nt of Applied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unidad de Procesos Oceanicos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico Departm.nt of m.rine Sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sandstones of the Late m.ocene–Pliocene Dibdibba Form.tion in the Najaf–Karbala Plateau and Basra were exam.ned to determ.ne their source rocks and origin. The rare earth elem.nts(REE) and trace elem.nts(Sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from.a single source. The steep light rare earth elem.nts(LREE) and flat, heavy rare earth elem.nt(HREE) patterns, negative Eu anom.ly, and high ΣREE contents in sandstones suggest its derivation from.a suggests that a passive continental m.rgin environm.nt and originated from.felsic source rocks. The average concentration of ΣREE is 93.5 ppm. which is lower than that of the average crustal com.ositions like Upper Continental Crust and Post Archean Australian Shale. The higher proportion of LREE com.ared to HREE im.lies that these sandstones were recycled and derived from.a distal source. The Th/Co, Th/Sc, La/Sc, La/Co, Eu/Eu*and(La/Lu)cn elem.ntal ratios indicated that these Late m.ocene–Pliocene sandstones were derived from.felsic rocks located in the m.rginal region of the Arabian Shield.

关键词： REE Dibdibba form.tion Clastic sedim.nts Passive continental m.rgin